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    Method of Production of a Holographic Sensor
    3.
    发明申请
    Method of Production of a Holographic Sensor 审中-公开
    全息传感器的制作方法

    公开(公告)号：US20110187026A1

    公开(公告)日：2011-08-04

    申请号：US13122086

    申请日：2009-10-08

    Applicant: Christopher Robin Lowe ,  Colin Alexander Bennett Davidson ,  Jeffrey Blyth

    Inventor： Christopher Robin Lowe ,  Colin Alexander Bennett Davidson ,  Jeffrey Blyth

    IPC: B23K26/36

    CPC classification number: G03H1/0465 ,  G03H1/00 ,  G03H1/0005 ,  G03H1/0244 ,  G03H1/0248 ,  G03H1/0486 ,  G03H2001/0044 ,  G03H2001/0415 ,  G03H2001/186 ,  G03H2001/2231 ,  G03H2222/33 ,  G03H2240/20 ,  G03H2260/16 ,  G03H2260/62 ,  G03H2270/52

    Abstract: A method for the production of a holographic sensor which comprises a support medium supporting a reflection hologram wherein the support medium interacts with its physical or chemical environment to create an optical response which is a change in one or more optical properties of the hologram, the method comprising the steps of: a) introducing a colloidal dispersion of a recording material into the support medium; and b) ablating the colloidal particles of the recording material using a pulsed laser to form the holographic element in the support medium. The method of production can be used to introduce a reflection holographic grating into a hydrophobic support medium, in particular, polydimethylsiloxane (PDMS), which possesses an extraordinary ability to swell in the presence of both liquid and/or gaseous low molecular weight hydrocarbons and organic solvents and thus has many applications as a holographic sensor.

    Abstract translation: 一种用于生产全息传感器的方法，其包括支撑反射全息图的支撑介质，其中支撑介质与其物理或化学环境相互作用以产生作为全息图的一个或多个光学特性的变化的光学响应，该方法 包括以下步骤：a）将记录材料的胶体分散体引入载体介质中; 和b）使用脉冲激光烧蚀记录材料的胶体颗粒，以在支撑介质中形成全息元件。 生产方法可用于将反射全息光栅引入到疏水性支持介质，特别是聚二甲基硅氧烷（PDMS）中，聚二甲基硅氧烷（PDMS）在液态和/或气态低分子量烃和有机物存在下具有非凡的溶胀能力 溶剂，因此作为全息传感器具有许多应用。

    Use of holographic sensor
    4.
    发明授权
    Use of holographic sensor 失效
    全息传感器的使用

    公开(公告)号：US07968349B2

    公开(公告)日：2011-06-28

    申请号：US12063726

    申请日：2006-08-23

    Applicant: Christopher Robin Lowe ,  Alexander James Marshall

    Inventor： Christopher Robin Lowe ,  Alexander James Marshall

    IPC: G01N33/548

    CPC classification number: C12Q1/6825 ,  G01N21/4788 ,  G01N33/54373 ,  Y10S436/805 ,  Y10T436/25

    Abstract: The present invention relates to a process for the detection of an analyte in a sample, comprising a) bringing the sample into contact with a first ligand which binds specifically to the analyte and which is immobilized on a substrate, and b) prior to or subsequent to step (a), bringing the sample into contact with a second ligand which binds specifically to the analyte and which includes a label: wherein the substrate comprises a holographic sensor comprising a support medium having a hologram disposed therein or thereon and the label causes an optical property of the sensor to change by interaction of the sensor with the label or, following the additional step of contacting the substrate with a reagent, by interaction of the sensor with a species produced by reaction of the label with the reagent, thereby indicating the presence of bound analyte.

    Abstract translation: 本发明涉及一种用于检测样品中分析物的方法，其包括a）使样品与特异性结合分析物的第一配体接触并固定在底物上，以及b）在之前或之后 到步骤（a），使样品与特异性结合分析物结合并包括标签的第二配体接触：其中所述基底包括全息传感器，其包括具有设置在其中或其上的全息图的支撑介质，并且所述标签引起 通过传感器与标签的相互作用来改变传感器的光学特性，或者通过传感器与通过标签与试剂的反应产生的物质的相互作用，接着将基板与试剂接触的附加步骤，从而指示传感器 存在结合的分析物。

    Hologram containing sensor
    8.
    发明授权
    Hologram containing sensor 失效
    全息图传感器

    公开(公告)号：US5989923A

    公开(公告)日：1999-11-23

    申请号：US718311

    申请日：1996-10-28

    Applicant: Christopher Robin Lowe ,  Roger Bradley Millington ,  Jeffrey Blyth ,  Andrew Geoffrey Mayes

    Inventor： Christopher Robin Lowe ,  Roger Bradley Millington ,  Jeffrey Blyth ,  Andrew Geoffrey Mayes

    IPC: G01N21/47 ,  G01N21/75 ,  G01N33/543 ,  G02B5/32 ,  G03H1/02 ,  G03H1/18 ,  G01N33/552

    CPC classification number: G03H1/18 ,  G01N21/4788 ,  G01N21/75 ,  G01N33/54373 ,  G02B5/32 ,  G03H1/0005 ,  G03H1/0248 ,  G03H2001/0033 ,  G03H2001/0044 ,  G03H2001/186 ,  G03H2222/47 ,  Y10S435/808 ,  Y10S436/805

    Abstract: The invention relates to a sensor (9) comprising a hologram (17) supported on or within a holographic support medium (10).A species to be detected is reactive with a substance disposed throughout, the sensor (9). Optionally, a chemical reactive with a species to be detected or a specific binding conjugate of a species to be detected is disposed throughout part of or all of the sensor (9).The resulting reaction(s) cause(s) variation(s) in the hologram (17) or holographic support medium (10) which in turn varies one or more optical characteristic(s) of the hologram (17).The variation in the optical characteristic(s) of the hologram (17) and/or the holographic support medium (10), preferably give(s) rise to a wavelength shift in incident radiation. The variation of the optical parameter is related to the species to be detected.The advantages of the sensor are that it is cheap, easy to manufacture and, once calibrated, reliable and robust.

    Abstract translation: PCT No.PCT / GB95 / 00668 Sec。 371日期1996年10月28日第 102（e）日期1996年10月28日PCT 1995年3月27日PCT PCT。 第WO95 / 26499号公报 日期1995年10月5日本发明涉及一种包括支撑在全息支撑介质（10）上或其内的全息图（17）的传感器（9）。 要检测的物种与设置在整个传感器（9）中的物质反应。 任选地，传感器（9）的整个部分或全部设置与被检测物质或待检测物种的特异性结合缀合物反应的化学物质。 所产生的反应导致全息图（17）或全息支撑介质（10）中的变化，其反过来改变全息图（17）的一个或多个光学特性。 全息图（17）和/或全息支持介质（10）的光学特性的变化优选地在入射辐射中产生波长偏移。 光学参数的变化与要检测的物种有关。 传感器的优点是便宜，易于制造，并且一旦校准，可靠和鲁棒。

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