Abstract:
A collapsible and expandable ice dispensing tubing apparatus having a first end and an opposite second end, the apparatus comprising: a hollow flexible body having a first opening formed at the first end and an opposite second opening formed at the second end, the body comprising a sheath and at least one reinforcing member for communication through the body from the first opening to the second opening; a first collar formed on the body at the first end and an opposite second collar formed on the body at the second end; and a fastener configured to selectively engage the first and second collars so as to selectively maintain the apparatus in a collapsed configuration. The apparatus may be employed in conjunction with other devices for selectively dispensing ice from an ice dispensing machine into a container.
Abstract:
A series of 5,6-dihydro-1-benzothiophen-7(4H)-one derivatives, and analogues thereof, which are substituted in the 2-position by an optionally substituted morpholin-4-yl moiety, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.
Abstract:
A series of 5,6-dihydro-1-benzothiophen-7(4H)-one derivatives, and analogues thereof, which are substituted in the 2-position by an optionally substituted morpholin-4-yl moiety, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.
Abstract:
An array of discrete sensors disposed on a substrate, each sensor comprising a holographic support medium and a hologram disposed throughout the volume of the medium, whereby interaction with an analyte results in a variation of a property of the medium.
Abstract:
A sensor for the detection of an analyte comprising a cis-diol moiety, which comprises a holographic element comprising a medium and a hologram disposed throughout the volume of the medium, wherein an optical characteristic of the element changes as a result of a variation of a physical property occurring throughout the volume of the medium, and wherein the medium is a polymer comprising a group of formula (I): wherein n is 0, 1, 2, 3 or 4; each X (if present) is independently is an atom or group which, viaan electronic effect, promotes formation of a tetrahedral geometry about the boron atom; and Y is a spacer which, when n is 0 or otherwise optionally, is an atom or group which, via an electronic effect, promotes formation of a tetrahedral geometry about the boron atom. Such a sensor may be used for the detection of glucose.
Abstract:
The present invention pertains to compositions and methods for treating disease states which are capable of being modulated by inhibition of phosphodiesterase IV or Tumour Necrosis Factor, or that is a pathological condition associated with a function of phosphodiesterase IV, eosinophil accumulation or a function of the eosinophil, said method comprising administering to a person or animal in need of such treatment an effective amount of the compound of a formula wherein R1 is C1-3 alkyl optionally substituted with one or more fluorines; R2 is CH2OCH3 or 2 or 3-tetrahydrofuranyl; R3 is a pyrazole, imidazole or isoxazole group of partial formula (A), (B) or (C) R4 is C 1-3 alkyl; and R5 and R6, which may be the same or different, each represents C1-3 alkyl, halogen, CF3 or CN; or a pharmaceutically-acceptable salt thereof
Abstract translation:本发明涉及用于治疗能够通过抑制磷酸二酯酶IV或肿瘤坏死因子调节的疾病状态的组合物和方法,或者是与磷酸二酯酶IV,嗜酸性粒细胞积累或嗜酸性粒细胞的功能相关的病理状况 所述方法包括向需要这种治疗的人或动物施用有效量的化学式R 1是任选被一个或多个氟取代的C 1-3烷基; R 2是CH 2 OCH 3或2或3-四氢呋喃基; R 3是 部分式(A),(B)或(C)R 4的吡唑,咪唑或异恶唑基是C 1-3烷基; 和R 5和R 6可以相同或不同,各自表示C 1-3烷基,卤素,CF 3或CN;或其药学上可接受的盐
Abstract:
Chemically resistant, strong fluorinated copolymer adsorbent particles for use in carrying out chromatographic separations are prepared by high shear, anaerobic reaction of a di-unsaturated crosslinking agent with a polyfluorinated monomer in the presence of poly(vinyl alcohol) and a porogen.
Abstract:
This invention relates to binding members, especially antibody molecules, specific for interleukin 1 receptor 1 (IL-1R1). For example, isolated binding members specific for IL-1R1 which competes with IL-1 and IL-1Ra for binding to IL-1R1 and binds Il-1R1 with a KD of 10 pM or less when measured by Kinexa™. The binding members are useful for, inter alia, treatment of disorders mediated by IL-1R1 including rheumatoid arthritis, asthma and chronic obstructive pulmonary disease (COPD).