公开(公告)号：US20050176028A1

公开(公告)日：2005-08-11

申请号：US10966406

申请日：2004-10-15

申请人： Robert Hofmeister ,  Christian Itin ,  Francis Carr ,  Patrick Bauerle ,  Anita Hamilton ,  Stephen Williams

发明人： Robert Hofmeister ,  Christian Itin ,  Francis Carr ,  Patrick Bauerle ,  Anita Hamilton ,  Stephen Williams

IPC分类号： C07K16/28 ,  C07K16/46 ,  C12Q1/68 ,  C07H21/04 ,  C07K14/74 ,  G01N33/53 ,  G01N33/567

CPC分类号： C07K16/461 ,  A61K2039/505 ,  C07K16/2809 ,  C07K2317/24 ,  C07K2317/622

摘要： The invention provides CD3 specific binding molecules and nucleic acid sequences encoding said CD3 specific binding molecules. Further aspects of the invention are vectors and host cells comprising said nucleic acid sequence, a process for the production of the construct of the invention and compositions comprising said construct. The invention also provides the use of said constructs for the preparation of pharmacutical compositions for the treatment of particular diseases, a method for the treatment of particular diseases and a kit comprising the binding construct of the invention.

摘要翻译： 本发明提供CD3特异性结合分子和编码所述CD3特异性结合分子的核酸序列。 本发明的其它方面是包含所述核酸序列的载体和宿主细胞，用于生产本发明构建体的方法和包含所述构建体的组合物。 本发明还提供所述构建体用于制备用于治疗特定疾病的药物组合物，用于治疗特定疾病的方法和包含本发明的结合构建体的试剂盒的用途。

公开(公告)号：US06780582B1

公开(公告)日：2004-08-24

申请号：US09574692

申请日：2000-05-17

申请人： Peter Wagner ,  Steffen Nock ,  Dana Ault-Riche ,  Christian Itin

发明人： Peter Wagner ,  Steffen Nock ,  Dana Ault-Riche ,  Christian Itin

IPC分类号： G01N33543

CPC分类号： B82Y5/00 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00617 ,  B01J2219/00619 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/00635 ,  B01J2219/00637 ,  B01J2219/00644 ,  B01J2219/00659 ,  B01J2219/00702 ,  B01J2219/00725 ,  B82Y30/00 ,  C40B40/10 ,  G01N33/54393 ,  G01N33/551

摘要： Arrays of protein-capture agents useful for the simultaneous detection of a plurality of proteins which are the expression products, or fragments thereof, of a cell or population of cells in an organism are provided. A variety of antibody arrays, in particular, are described. Methods of both making and using the arrays of protein-capture agents are also disclosed. The invention arrays are particularly useful for various proteomics applications including assessing patterns of protein expression and modification in cells.

摘要翻译： 提供了可用于同时检测生物体中细胞或细胞群的表达产物或其片段的多种蛋白质的蛋白质捕获剂的阵列。 特别描述了各种抗体阵列。 还公开了制备和使用蛋白质捕获剂的阵列的方法。 本发明阵列对于各种蛋白质组学应用特别有用，包​​括评估细胞中蛋白质表达和修饰的模式。

公开(公告)号：US06630358B1

公开(公告)日：2003-10-07

申请号：US09570363

申请日：2000-05-12

申请人： Peter Wagner ,  Dana Ault-Riche ,  Steffen Nock ,  Christian Itin

发明人： Peter Wagner ,  Dana Ault-Riche ,  Steffen Nock ,  Christian Itin

IPC分类号： G01N33543

CPC分类号： G01N33/6845 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00617 ,  B01J2219/00619 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/0063 ,  B01J2219/00635 ,  B01J2219/00637 ,  B01J2219/00641 ,  B01J2219/00659 ,  B01J2219/00702 ,  B01J2219/00725 ,  B82Y5/00 ,  B82Y30/00 ,  C07K2319/20 ,  C40B40/10 ,  G01N33/54393 ,  G01N33/551

摘要： Protein arrays for the parallel, in vitro screening of biomolecular activity are provided. Methods of using the protein arrays are also disclosed. On the arrays, a plurality of different proteins, such as different members of a single protein family, are immobilized on one or more organic thinfilms on the substrate surface. The protein arrays are particularly useful in drug development, proteomics, and clinical diagnostics.

公开(公告)号：US06596545B1

公开(公告)日：2003-07-22

申请号：US09353554

申请日：1999-07-14

申请人： Peter Wagner ,  Dana Ault-Riche ,  Steffen Nock ,  Christian Itin

发明人： Peter Wagner ,  Dana Ault-Riche ,  Steffen Nock ,  Christian Itin

IPC分类号： G01N33543

CPC分类号： B82Y30/00 ,  Y10S435/805 ,  Y10S435/81 ,  Y10T436/143333

摘要： Devices for the parallel, in vitro screening of biomolecular activity using miniaturized microfabricated devices are provided. The biomolecules immobilized on the surface of the devices of the present invention include proteins, polypeptides, polynucleotides, polysaccharides, phospolipids, and related unnatural polymers of biological relevance. These devices are useful drug development, functional proteomics and clinical diagnostics and are preferably used for the parallel screening of families of related proteins.

摘要翻译： 提供了使用微型微加工装置并行，体外筛选生物分子活性的装置。 固定在本发明装置表面上的生物分子包括具有生物相关性的蛋白质，多肽，多核苷酸，多糖，磷脂和相关的非天然聚合物。 这些装置是有用的药物开发，功能蛋白质组学和临床诊断，并且优选用于相关蛋白家族的并行筛选。

公开(公告)号：US10000574B2

公开(公告)日：2018-06-19

申请号：US10580660

申请日：2004-11-26

申请人： Robert Hofmeister ,  Nadja Prang ,  Andreas Wolf ,  Frank Hanakam ,  Thomas Urbig ,  Christian Itin ,  Patrick Baeuerle

发明人： Robert Hofmeister ,  Nadja Prang ,  Andreas Wolf ,  Frank Hanakam ,  Thomas Urbig ,  Christian Itin ,  Patrick Baeuerle

IPC分类号： C07K16/30 ,  C07K16/28

CPC分类号： C07K16/30 ,  C07K16/2803 ,  C07K16/2809 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/56

摘要： The present invention relates to compositions comprising polypeptides, especially polypeptides capable of specifically binding predetermined antigens. The polypeptide in the composition comprises at least two antigen binding sites. These at least two antigen binding sites are located on a single polypeptide chain. One of the at least two antigen binding sites specifically binds the human CD3 antigen. The polypeptide may exist in both monomeric form and multimeric form. The multimeric form of the polypeptide constitutes no more than 5% of the total weight of the combined monomeric and multimeric forms of said polypeptide.

公开(公告)号：US20050136050A1

公开(公告)日：2005-06-23

申请号：US10743697

申请日：2003-12-22

申请人： Peter Kufer ,  Meera Berry ,  Patrick Baeuerle ,  Christian Itin

发明人： Peter Kufer ,  Meera Berry ,  Patrick Baeuerle ,  Christian Itin

IPC分类号： C07K14/705 ,  C07K16/28 ,  C07K16/30 ,  C07K16/46 ,  C12N15/85 ,  A61K39/395 ,  C07K16/44

CPC分类号： C07K16/30 ,  C07K14/70567 ,  C07K16/2809 ,  C07K2317/31 ,  C07K2317/569 ,  C07K2317/622 ,  C07K2319/00 ,  C07K2319/21 ,  C07K2319/33 ,  C12N15/8509 ,  C12N2830/008 ,  C12N2830/48

摘要： The present invention discloses bispecific antibodies comprising two antibody variable domains on a single polypeptide chain, wherein a first portion of the bispecific antibody is capable of recruiting the activity of a human immune effector cell by specifically binding to an effector antigen on the human immune effector cell, the first portion consisting of one antibody variable domain, and a second portion of the bispecific antibody specifically binding to a target antigen other than the effector antigen, the target antigen on a target cell other than the human immune effector cell, the second portion comprising one antibody variable domain.

摘要翻译： 本发明公开了在单个多肽链上包含两个抗体可变结构域的双特异性抗体，其中双特异性抗体的第一部分能够通过特异性结合人免疫效应细胞上的效应物抗原募集人免疫效应细胞的活性 ，第一部分由一个抗体可变结构域组成，第二部分特异性结合除效应物抗原之外的靶抗原的双特异性抗体，除人免疫效应细胞以外的靶细胞上的靶抗原，第二部分包含 一个抗体可变结构域。

公开(公告)号：US06406921B1

公开(公告)日：2002-06-18

申请号：US09115455

申请日：1998-07-14

申请人： Peter Wagner ,  Dana Ault-Riche ,  Steffen Nock ,  Christian Itin

发明人： Peter Wagner ,  Dana Ault-Riche ,  Steffen Nock ,  Christian Itin

IPC分类号： G01N33543

CPC分类号： G01N33/6845 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00617 ,  B01J2219/00619 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/0063 ,  B01J2219/00635 ,  B01J2219/00637 ,  B01J2219/00641 ,  B01J2219/00659 ,  B01J2219/00702 ,  B01J2219/00725 ,  B82Y5/00 ,  B82Y30/00 ,  C07K2319/20 ,  C40B40/10 ,  G01N33/54393 ,  G01N33/551

摘要： Protein arrays and protein-coated substrates for the parallel, in vitro screening of biomolecular activity are provided. Methods of using the protein-coated substrates and protein arrays are also disclosed. A plurality of different members of a single protein family may be immobilized on the protein-coated substrate or array. The protein-coated substrates and protein arrays are particularly useful in high-throughput drug screening and clinical diagnostics.

公开(公告)号：US06365418B1

公开(公告)日：2002-04-02

申请号：US09574748

申请日：2000-05-18

申请人： Peter Wagner ,  Steffen Nock ,  Dana Ault-Riche ,  Christian Itin

发明人： Peter Wagner ,  Steffen Nock ,  Dana Ault-Riche ,  Christian Itin

IPC分类号： G01N33543

CPC分类号： G01N33/6845 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00617 ,  B01J2219/00619 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/0063 ,  B01J2219/00635 ,  B01J2219/00637 ,  B01J2219/00641 ,  B01J2219/00659 ,  B01J2219/00702 ,  B01J2219/00725 ,  B82Y5/00 ,  B82Y30/00 ,  C07K2319/20 ,  C40B40/10 ,  G01N33/54393 ,  G01N33/551

摘要： Arrays of protein-capture agents useful for the simultaneous detection of a plurality of proteins which are the expression products, or fragments thereof, of a cell or population of cells in an organism are provided. A variety of antibody arrays, in particular, are described. Methods of both making and using the arrays of protein-capture agents are also disclosed. The invention arrays are particularly useful for various proteomics applications including assessing patterns of protein expression and modification in cells.

摘要翻译： 提供了可用于同时检测生物体中细胞或细胞群体的表达产物或其片段的多种蛋白质的蛋白质捕获剂的阵列。 特别描述了各种抗体阵列。 还公开了制备和使用蛋白质捕获剂的阵列的方法。 本发明阵列对于各种蛋白质组学应用特别有用，包​​括评估细胞中蛋白质表达和修饰的模式。

公开(公告)号：US06329209B1

公开(公告)日：2001-12-11

申请号：US09353555

申请日：1999-07-14

申请人： Peter Wagner ,  Steffen Nock ,  Dana Ault-Riche ,  Christian Itin

发明人： Peter Wagner ,  Steffen Nock ,  Dana Ault-Riche ,  Christian Itin

IPC分类号： G01N33543

CPC分类号： G01N33/6845 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00617 ,  B01J2219/00619 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/0063 ,  B01J2219/00635 ,  B01J2219/00637 ,  B01J2219/00641 ,  B01J2219/00659 ,  B01J2219/00702 ,  B01J2219/00725 ,  B82Y5/00 ,  B82Y30/00 ,  C07K2319/20 ,  C40B40/10 ,  G01N33/54393 ,  G01N33/551

摘要： Arrays of protein-capture agents useful for the simultaneous detection of a plurality of proteins which are the expression products, or fragments thereof, of a cell or population of cells in an organism are provided. A variety of antibody arrays, in particular, are described. Methods of both making and using the arrays of protein-capture agents are also disclosed. The invention arrays are particularly useful for various proteomics applications including assessing patterns of protein expression and modification in cells.

摘要翻译： 提供了可用于同时检测生物体中细胞或细胞群体的表达产物或其片段的多种蛋白质的蛋白质捕获剂的阵列。 特别描述了各种抗体阵列。 还公开了制备和使用蛋白质捕获剂的阵列的方法。 本发明阵列对于各种蛋白质组学应用特别有用，包​​括评估细胞中蛋白质表达和修饰的模式。

公开(公告)号：US20070249529A1

公开(公告)日：2007-10-25

申请号：US10580660

申请日：2004-11-26

申请人： Robert Hofmeister ,  Nadja Prang ,  Andreas Wolf ,  Frank Hanakam ,  Thomas Urbig ,  Christian Itin ,  Patrick Baeuerle

发明人： Robert Hofmeister ,  Nadja Prang ,  Andreas Wolf ,  Frank Hanakam ,  Thomas Urbig ,  Christian Itin ,  Patrick Baeuerle

IPC分类号： A61K38/17 ,  C07K1/16 ,  C07K14/47

CPC分类号： C07K16/30 ,  C07K16/2803 ,  C07K16/2809 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/56

摘要： The present invention relates to compositions comprising polypeptides, especially polypeptides capable of specifically binding predetermined antigens. The polypeptide in the composition comprises at least two antigen binding sites. These at least two antigen binding sites are located on a single polypeptide chain. One of the at least two antigen binding sites specifically binds the human CD3 antigen. The polypeptide may exist in both monomeric form and multimeric form. The multimeric form of the polypeptide constitutes no more than 5% of the total weight of the combined monomeric and multimeric forms of said polypeptide.

摘要翻译： 本发明涉及包含多肽，特别是能够特异性结合预定抗原的多肽的组合物。 组合物中的多肽包含至少两个抗原结合位点。 这些至少两个抗原结合位点位于单个多肽链上。 至少两个抗原结合位点之一特异性结合人CD3抗原。 多肽可以以单体形式和多聚体形式存在。 所述多肽的多聚体形式构成所述多肽的组合单体和多聚体形式的总重量的不超过5％。