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公开(公告)号：US09491934B2
公开(公告)日：2016-11-15
申请号：US13068878
申请日：2011-05-23
申请人： George Norbert Cox, III , Casey Christopher Case , Stephen P. Eisenberg , Eric Edward Jarvis , Sharon Kaye Spratt
发明人： George Norbert Cox, III , Casey Christopher Case , Stephen P. Eisenberg , Eric Edward Jarvis , Sharon Kaye Spratt
IPC分类号： C12N15/63 , A61K48/00 , C07K14/47 , A01K67/027 , C12Q1/68 , C12Q1/66 , C12N15/67 , C12N15/82 , G01N33/50 , C07K14/52 , C12N15/85
CPC分类号： A01K67/0275 , A01K2217/05 , A61K48/00 , A61K48/005 , C07K14/47 , C07K14/52 , C07K2319/00 , C07K2319/71 , C07K2319/81 , C12N15/63 , C12N15/67 , C12N15/8216 , C12N15/85 , C12N2830/002 , C12N2830/005 , C12N2830/008 , C12N2830/85 , C12Q1/66 , C12Q1/6897 , G01N33/5091
摘要： The present invention provides methods for modulating expression of endogenous cellular genes using recombinant zinc finger proteins.
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2.发明授权Repressing endogenous CCR5 gene expression in cells using engineered zinc finger proteins 有权使用工程化锌指蛋白抑制细胞内源性CCR5基因表达公开(公告)号：US08268618B2
公开(公告)日：2012-09-18
申请号：US11505044
申请日：2006-08-16
申请人： George Norbert Cox, III , Casey Christopher Case , Stephen P. Eisenberg , Eric Edward Jarvis , Sharon Kaye Spratt
发明人： George Norbert Cox, III , Casey Christopher Case , Stephen P. Eisenberg , Eric Edward Jarvis , Sharon Kaye Spratt
CPC分类号： A01K67/0275 , A01K2217/05 , A61K48/00 , A61K48/005 , C07K14/47 , C07K14/52 , C07K2319/00 , C07K2319/71 , C07K2319/81 , C12N15/63 , C12N15/67 , C12N15/8216 , C12N15/85 , C12N2830/002 , C12N2830/005 , C12N2830/008 , C12N2830/85 , C12Q1/66 , C12Q1/6897 , G01N33/5091
摘要： The present invention provides methods for modulating expression of endogenous cellular genes using recombinant zinc finger proteins.
摘要翻译： 本发明提供了使用重组锌指蛋白调节内源细胞基因表达的方法。
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3.发明申请Regulation of endogenous gene expression in cells using zinc finger proteins 审中-公开使用锌指蛋白调节细胞内源性基因表达公开(公告)号：US20100261271A1
公开(公告)日：2010-10-14
申请号：US11521291
申请日：2006-09-14
申请人： George Norbert Cox, III , Casey Christopher Case , Stephen P. Eisenberg , Eric Edward Jarvis , Sharon Kaye Spratt
发明人： George Norbert Cox, III , Casey Christopher Case , Stephen P. Eisenberg , Eric Edward Jarvis , Sharon Kaye Spratt
IPC分类号： C12N5/10
CPC分类号： A01K67/0275 , A01K2217/05 , A61K48/00 , A61K48/005 , C07K14/47 , C07K14/52 , C07K2319/00 , C07K2319/71 , C07K2319/81 , C12N15/63 , C12N15/67 , C12N15/8216 , C12N15/85 , C12N2830/002 , C12N2830/005 , C12N2830/008 , C12N2830/85 , C12Q1/66 , C12Q1/6897 , G01N33/5091
摘要： The present invention provides methods for modulating expression of endogenous cellular genes using recombinant zinc finger proteins.
摘要翻译： 本发明提供了使用重组锌指蛋白调节内源细胞基因表达的方法。
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公开(公告)号：US07070934B2
公开(公告)日：2006-07-04
申请号：US10456444
申请日：2003-06-05
申请人： George Norbert Cox, III , Casey Christopher Case , Stephen P. Eisenberg , Eric Edward Jarvis , Sharon Kaye Spratt
发明人： George Norbert Cox, III , Casey Christopher Case , Stephen P. Eisenberg , Eric Edward Jarvis , Sharon Kaye Spratt
CPC分类号： A61K31/57
摘要： Disclosed herein are compositions comprising an engineered zinc finger protein and a nuclear hormone receptor transcriptional control domain, polynucleotides encoding one or more components of the compositions, methods of making the compositions and methods of using these compositions, for example to modulate gene expression and/or to generate transgenic plants or animals.
摘要翻译： 本文公开了包含工程化锌指蛋白和核激素受体转录控制结构域的组合物，编码组合物的一种或多种组分的多核苷酸，制备组合物的方法和使用这些组合物的方法，例如调节基因表达和/或 以产生转基因植物或动物。
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公开(公告)号：US20100279406A1
公开(公告)日：2010-11-04
申请号：US11524165
申请日：2006-09-20
申请人： George Norbert Cox, III , Casey Christopher Case , Stephen P. Eisenberg , Eric Edward Jarvis , Sharon Kaye Spratt
发明人： George Norbert Cox, III , Casey Christopher Case , Stephen P. Eisenberg , Eric Edward Jarvis , Sharon Kaye Spratt
IPC分类号： C12N5/00
CPC分类号： A01K67/0275 , A01K2217/05 , A61K48/00 , A61K48/005 , C07K14/47 , C07K14/52 , C07K2319/00 , C07K2319/71 , C07K2319/81 , C12N15/63 , C12N15/67 , C12N15/8216 , C12N15/85 , C12N2830/002 , C12N2830/005 , C12N2830/008 , C12N2830/85 , C12Q1/66 , C12Q1/6897 , G01N33/5091
摘要： The present invention provides methods for altering tumor growth using zinc finger proteins.
摘要翻译： 本发明提供了使用锌指蛋白改变肿瘤生长的方法。
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公开(公告)号：US06979539B2
公开(公告)日：2005-12-27
申请号：US09897844
申请日：2001-07-02
申请人： George Norbert Cox, III , Casey Christopher Case , Stephen P. Eisenberg , Eric Edward Jarvis , Sharon Kaye Spratt
发明人： George Norbert Cox, III , Casey Christopher Case , Stephen P. Eisenberg , Eric Edward Jarvis , Sharon Kaye Spratt
IPC分类号： C12N15/09 , A61K31/711 , A61K35/76 , A61K38/16 , A61K48/00 , A61P7/00 , A61P7/06 , A61P9/00 , A61P9/10 , A61P11/00 , A61P17/06 , A61P19/02 , A61P21/00 , A61P21/04 , A61P25/28 , A61P27/02 , A61P29/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P31/18 , A61P35/00 , A61P37/00 , C07K14/46 , C07K14/47 , C07K14/52 , C12N5/10 , C12N9/64 , C12N15/12 , C12N15/63 , C12N15/67 , C12N15/82 , C12N15/85 , C12P21/04 , C12Q1/68 , C12N15/64 , C12N15/11
CPC分类号： A01K67/0275 , A01K2217/05 , A61K48/00 , A61K48/005 , C07K14/47 , C07K14/52 , C07K2319/00 , C07K2319/71 , C07K2319/81 , C12N15/63 , C12N15/67 , C12N15/8216 , C12N15/85 , C12N2830/002 , C12N2830/005 , C12N2830/008 , C12N2830/85 , C12Q1/66 , C12Q1/6897 , G01N33/5091
摘要： The present invention provides methods for modulating expression of endogenous cellular genes using recombinant zinc finger proteins.
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公开(公告)号：US06534261B1
公开(公告)日：2003-03-18
申请号：US09229037
申请日：1999-01-12
申请人： George Norbert Cox, III , Casey Christopher Case , Stephen P. Eisenberg , Eric Edward Jarvis , Sharon Kaye Spratt
发明人： George Norbert Cox, III , Casey Christopher Case , Stephen P. Eisenberg , Eric Edward Jarvis , Sharon Kaye Spratt
IPC分类号： C12Q168
CPC分类号： A01K67/0275 , A01K2217/05 , A61K48/00 , A61K48/005 , C07K14/47 , C07K14/52 , C07K2319/00 , C07K2319/71 , C07K2319/81 , C12N15/63 , C12N15/67 , C12N15/8216 , C12N15/85 , C12N2830/002 , C12N2830/005 , C12N2830/008 , C12N2830/85 , C12Q1/66 , C12Q1/6897 , G01N33/5091
摘要： The present invention provides methods for modulating expression of endogenous cellular genes using recombinant zinc finger proteins.
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8.发明申请Regulation of endogenous gene expression in cells using zinc finger proteins 审中-公开使用锌指蛋白调节细胞内源性基因表达公开(公告)号：US20120294838A1
公开(公告)日：2012-11-22
申请号：US13068878
申请日：2011-05-23
申请人： George Norbert Cox III , Casey Christopher Case , Stephen P. Eisenberg , Eric Edward Jarvis , Sharon Kaye Spratt
发明人： George Norbert Cox III , Casey Christopher Case , Stephen P. Eisenberg , Eric Edward Jarvis , Sharon Kaye Spratt
IPC分类号： C12N15/86 , C12N15/867 , C12N15/861 , C12N15/864 , C12N15/869 , A61K35/12 , A61P35/00 , A61P31/10 , A61P33/02 , A61P31/04 , A61P31/12 , A61P9/10 , A61P9/00 , A61P19/02 , A61P37/00 , A61K48/00 , C12N5/071
CPC分类号： A01K67/0275 , A01K2217/05 , A61K48/00 , A61K48/005 , C07K14/47 , C07K14/52 , C07K2319/00 , C07K2319/71 , C07K2319/81 , C12N15/63 , C12N15/67 , C12N15/8216 , C12N15/85 , C12N2830/002 , C12N2830/005 , C12N2830/008 , C12N2830/85 , C12Q1/66 , C12Q1/6897 , G01N33/5091
摘要： The present invention provides methods for modulating expression of endogenous cellular genes using recombinant zinc finger proteins.
摘要翻译： 本发明提供了使用重组锌指蛋白调节内源细胞基因表达的方法。
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公开(公告)号：US20110247087A1
公开(公告)日：2011-10-06
申请号：US13068877
申请日：2011-05-23
申请人： George Norbert Cox, III , Casey Christopher Case , Stephen P. Eisenberg , Eric Edward Jarvis , Sharon Kaye Spratt
发明人： George Norbert Cox, III , Casey Christopher Case , Stephen P. Eisenberg , Eric Edward Jarvis , Sharon Kaye Spratt
CPC分类号： A01K67/0275 , A01K2217/05 , A61K48/00 , A61K48/005 , C07K14/47 , C07K14/52 , C07K2319/00 , C07K2319/71 , C07K2319/81 , C12N15/63 , C12N15/67 , C12N15/8216 , C12N15/85 , C12N2830/002 , C12N2830/005 , C12N2830/008 , C12N2830/85 , C12Q1/66 , C12Q1/6897 , G01N33/5091
摘要： The present invention provides methods for modulating expression of endogenous cellular genes using recombinant zinc finger proteins.
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10.发明授权公开(公告)号：US07985887B2
公开(公告)日：2011-07-26
申请号：US11505775
申请日：2006-08-17
申请人： George Norbert Cox, III , Casey Christopher Case , Stephen P. Eisenberg , Eric Edward Jarvis , Sharon Kaye Spratt
发明人： George Norbert Cox, III , Casey Christopher Case , Stephen P. Eisenberg , Eric Edward Jarvis , Sharon Kaye Spratt
CPC分类号： A01K67/0275 , A01K2217/05 , A61K48/00 , A61K48/005 , C07K14/47 , C07K14/52 , C07K2319/00 , C07K2319/71 , C07K2319/81 , C12N15/63 , C12N15/67 , C12N15/8216 , C12N15/85 , C12N2830/002 , C12N2830/005 , C12N2830/008 , C12N2830/85 , C12Q1/66 , C12Q1/6897 , G01N33/5091
摘要： The present invention provides methods for modulating expression of endogenous cellular genes using recombinant zinc finger proteins.
摘要翻译： 本发明提供了使用重组锌指蛋白调节内源细胞基因表达的方法。
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