公开(公告)号：US5846959A

公开(公告)日：1998-12-08

申请号：US471537

申请日：1995-06-06

Applicant: Russell M. Medford ,  R. Wayne Alexander ,  Sampath Parthasarathy ,  Bobby V. Khan

Inventor： Russell M. Medford ,  R. Wayne Alexander ,  Sampath Parthasarathy ,  Bobby V. Khan

IPC: G01N33/50 ,  A61K31/10 ,  A61K31/105 ,  A61K31/145 ,  A61K31/185 ,  A61K31/198 ,  A61K31/26 ,  A61K31/27 ,  A61K31/28 ,  A61K31/325 ,  A61K31/365 ,  A61K31/40 ,  A61K31/455 ,  A61K31/55 ,  A61K38/00 ,  A61K45/00 ,  A61K45/06 ,  A61K49/00 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P11/00 ,  A61P17/00 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07C333/04 ,  C07C333/08 ,  C07C333/16 ,  C07D295/21 ,  G01N33/15 ,  G01N33/68 ,  G01N33/92 ,  A61K31/60 ,  A61K31/56 ,  A61K31/37

CPC classification number: C07D295/21 ,  A61K31/145 ,  A61K31/185 ,  A61K31/198 ,  A61K31/325 ,  A61K31/40 ,  A61K45/06 ,  C07C333/04 ,  C07C333/08 ,  C07C333/16 ,  G01N33/68 ,  G01N33/92 ,  G01N2333/70503 ,  G01N2333/7056 ,  G01N2500/00 ,  G01N2800/323 ,  Y10S514/824 ,  Y10S514/825 ,  Y10S514/826 ,  Y10S514/861 ,  Y10S514/863 ,  Y10T436/201666

Abstract: A method for the treatment of cardiovascular diseases and noncardiovascular inflammatory diseases that are mediated by VCAM-1 is provided that includes the removal, decrease in the concentration of, or prevention of the formation of oxidized polyunsaturated fatty acids, or interferes with a complex formed between a polyunsaturated fatty acid or an oxidized polyunsaturated fatty acid and a protein or peptide that mediates the expression of VCAM-1. A method is also provided for suppressing the expression of a redox-sensitive gene or activating a gene that is suppressed through a redox-sensitive pathway, that includes administering an effective amount of a substance that prevents the oxidation of the oxidized signal, and typically, the oxidation of a polyunsaturated fatty acid, or interferes with a complex formed between the oxidized signal and a protein or peptide that mediates the expression of the redox gene.

公开(公告)号：US5811449A

公开(公告)日：1998-09-22

申请号：US483335

申请日：1995-06-07

Applicant: Russell M. Medford ,  R. Wayne Alexander ,  Sampath Parthasarathy ,  Bobby V. Khan

Inventor： Russell M. Medford ,  R. Wayne Alexander ,  Sampath Parthasarathy ,  Bobby V. Khan

IPC: G01N33/50 ,  A61K31/10 ,  A61K31/105 ,  A61K31/145 ,  A61K31/185 ,  A61K31/198 ,  A61K31/26 ,  A61K31/27 ,  A61K31/28 ,  A61K31/325 ,  A61K31/365 ,  A61K31/40 ,  A61K31/455 ,  A61K31/55 ,  A61K38/00 ,  A61K45/00 ,  A61K45/06 ,  A61K49/00 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P11/00 ,  A61P17/00 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07C333/04 ,  C07C333/08 ,  C07C333/16 ,  C07D295/21 ,  G01N33/15 ,  G01N33/68 ,  G01N33/92 ,  A61K31/54 ,  A61K31/265

CPC classification number: C07D295/21 ,  A61K31/145 ,  A61K31/185 ,  A61K31/198 ,  A61K31/325 ,  A61K31/40 ,  A61K45/06 ,  C07C333/04 ,  C07C333/08 ,  C07C333/16 ,  G01N33/68 ,  G01N33/92 ,  G01N2333/70503 ,  G01N2333/7056 ,  G01N2500/00 ,  G01N2800/323 ,  Y10S514/824 ,  Y10S514/825 ,  Y10S514/826 ,  Y10S514/861 ,  Y10S514/863 ,  Y10T436/201666

Abstract: A method for the treatment of cardiovascular diseases and noncardiovascular inflammatory diseases that are mediated by VCAM-1 is provided that includes the removal, decrease in the concentration of, or prevention of the formation of oxidized polyunsaturated fatty acids, or interferes with a complex formed between a polyunsaturated fatty acid or an oxidized polyunsaturated fatty acid and a protein or peptide that mediates the expression of VCAM-1. A method is also provided for suppressing the expression of a redox-sensitive gene or activating a gene that is suppressed through a redox-sensitive pathway, that includes administering an effective amount of a substance that prevents the oxidation of the oxidized signal, and typically, the oxidation of a polyunsaturated fatty acid, or interferes with a complex formed between the oxidized signal and a protein or peptide that mediates the expression of the redox gene.

公开(公告)号：US20100173936A1

公开(公告)日：2010-07-08

申请号：US12591560

申请日：2009-11-23

Applicant: Bobby V. Khan ,  Sampath Parthasarathy

Inventor： Bobby V. Khan ,  Sampath Parthasarathy

IPC: A61K31/47 ,  A61K31/385 ,  A61K31/20 ,  A61P3/00 ,  A61K31/40

CPC classification number: A61K31/385 ,  A61K31/435 ,  A61K2300/00

Abstract: Compositions are provided which can be useful in treating a renin-angiotensin aldosterone system-related disorder. These compositions include renin-angiotensin aldosterone system inhibitors and lipoic acid compounds, as well as other therapeutic agents, and are useful in treating hypertension, stroke, metabolic syndrome, or other renin-angiotensin aldosterone system-related disorders in a subject. The compositions are also useful in improving vasodilation, reducing proteinuria, and reducing insulin resistance in a subject. Pharmaceutical compositions and methods of treatment using the compositions are further provided.

Abstract translation: 提供可用于治疗肾素 - 血管紧张素醛固酮系统相关疾病的组合物。 这些组合物包括肾素 - 血管紧张素醛固酮系统抑制剂和硫辛酸化合物以及其它治疗剂，并且可用于治疗受试者中的高血压，中风，代谢综合征或其他肾素 - 血管紧张素醛固酮系统相关疾病。 该组合物还可用于改善受试者的血管舒张，减少蛋白尿和降低胰岛素抵抗。 还提供了使用该组合物的药物组合物和治疗方法。

公开(公告)号：US5807884A

公开(公告)日：1998-09-15

申请号：US317399

申请日：1994-10-04

Applicant: Russell M. Medford ,  R. Wayne Alexander ,  Sampath Parthasarathy ,  Bobby V. Khan

Inventor： Russell M. Medford ,  R. Wayne Alexander ,  Sampath Parthasarathy ,  Bobby V. Khan

IPC: G01N33/50 ,  A61K31/10 ,  A61K31/105 ,  A61K31/145 ,  A61K31/185 ,  A61K31/198 ,  A61K31/26 ,  A61K31/27 ,  A61K31/28 ,  A61K31/325 ,  A61K31/365 ,  A61K31/40 ,  A61K31/455 ,  A61K31/55 ,  A61K38/00 ,  A61K45/00 ,  A61K45/06 ,  A61K49/00 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P11/00 ,  A61P17/00 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07C333/04 ,  C07C333/08 ,  C07C333/16 ,  C07D295/21 ,  G01N33/15 ,  G01N33/68 ,  G01N33/92 ,  A61K31/54 ,  A61K31/265

CPC classification number: C07D295/21 ,  A61K31/145 ,  A61K31/185 ,  A61K31/198 ,  A61K31/325 ,  A61K31/40 ,  A61K45/06 ,  C07C333/04 ,  C07C333/08 ,  C07C333/16 ,  G01N33/68 ,  G01N33/92 ,  G01N2333/70503 ,  G01N2333/7056 ,  G01N2500/00 ,  G01N2800/323 ,  Y10S514/824 ,  Y10S514/825 ,  Y10S514/826 ,  Y10S514/861 ,  Y10S514/863 ,  Y10T436/201666

Abstract: A method for the treatment of cardiovascular diseases and noncardiovascular inflammatory diseases that are mediated by VCAM-1 is provided that includes the removal, decrease in the concentration of, or prevention of the formation of oxidized polyunsaturated fatty acids, or interferes with a complex formed between a polyunsaturated fatty acid or an oxidized polyunsaturated fatty acid and a protein or peptide that mediates the expression of VCAM-1. A method is also provided for suppressing the expression of a redox-sensitive gene or activating a gene that is suppressed through a redox-sensitive pathway, that includes administering an effective amount of a substance that prevents the oxidation of the oxidized signal, and typically, the oxidation of a polyunsaturated fatty acid, or interferes with a complex formed between the oxidized signal and a protein or peptide that mediates the expression of the redox gene.

公开(公告)号：US5773209A

公开(公告)日：1998-06-30

申请号：US484059

申请日：1995-06-07

Applicant: Russell M. Medford ,  R. Wayne Alexander ,  Sampath Parthasarathy ,  Bobby V. Khan

Inventor： Russell M. Medford ,  R. Wayne Alexander ,  Sampath Parthasarathy ,  Bobby V. Khan

IPC: G01N33/50 ,  A61K31/10 ,  A61K31/105 ,  A61K31/145 ,  A61K31/185 ,  A61K31/198 ,  A61K31/26 ,  A61K31/27 ,  A61K31/28 ,  A61K31/325 ,  A61K31/365 ,  A61K31/40 ,  A61K31/455 ,  A61K31/55 ,  A61K38/00 ,  A61K45/00 ,  A61K45/06 ,  A61K49/00 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P11/00 ,  A61P17/00 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07C333/04 ,  C07C333/08 ,  C07C333/16 ,  C07D295/21 ,  G01N33/15 ,  G01N33/68 ,  G01N33/92 ,  G01N33/53

CPC classification number: C07D295/21 ,  A61K31/145 ,  A61K31/185 ,  A61K31/198 ,  A61K31/325 ,  A61K31/40 ,  A61K45/06 ,  C07C333/04 ,  C07C333/08 ,  C07C333/16 ,  G01N33/68 ,  G01N33/92 ,  G01N2333/70503 ,  G01N2333/7056 ,  G01N2500/00 ,  G01N2800/323 ,  Y10S514/824 ,  Y10S514/825 ,  Y10S514/826 ,  Y10S514/861 ,  Y10S514/863 ,  Y10T436/201666

Abstract: A method for the treatment of cardiovascular diseases and noncardiovascular inflammatory diseases that are mediated by VCAM-1 is provided that includes the removal, decrease in the concentration of, or prevention of the formation of oxidized polyunsaturated fatty acids, or interferes with a complex formed between a polyunsaturated fatty acid or an oxidized polyunsaturated fatty acid and a protein or peptide that mediates the expression of VCAM-1. A method is also provided for suppressing the expression of a redox-sensitive gene or activating a gene that is suppressed through a redox-sensitive pathway, that includes administering an effective amount of a substance that prevents the oxidation of the oxidized signal, and typically, the oxidation of a polyunsaturated fatty acid, or interferes with a complex formed between the oxidized signal and a protein or peptide that mediates the expression of the redox gene.

Abstract translation: 提供了一种治疗由VCAM-1介导的心血管疾病和非心血管炎性疾病的方法，其包括去除，降低浓度或预防氧化的多不饱和脂肪酸的形成，或干扰形成 多不饱和脂肪酸或氧化多不饱和脂肪酸和介导VCAM-1表达的蛋白质或肽。 还提供了抑制氧化还原敏感基因表达或激活通过氧化还原敏感途径抑制的基因的方法，其包括施用有效量的防止氧化信号氧化的物质，通常， 多不饱和脂肪酸的氧化，或干扰氧化信号与介导氧化还原基因表达的蛋白质或肽之间形成的复合物。

公开(公告)号：US5750351A

公开(公告)日：1998-05-12

申请号：US474530

申请日：1995-06-07

Applicant: Russell M. Medford ,  R. Wayne Alexander ,  Sampath Parthasarathy ,  Bobby V. Khan

Inventor： Russell M. Medford ,  R. Wayne Alexander ,  Sampath Parthasarathy ,  Bobby V. Khan

IPC: G01N33/50 ,  A61K31/10 ,  A61K31/105 ,  A61K31/145 ,  A61K31/185 ,  A61K31/198 ,  A61K31/26 ,  A61K31/27 ,  A61K31/28 ,  A61K31/325 ,  A61K31/365 ,  A61K31/40 ,  A61K31/455 ,  A61K31/55 ,  A61K38/00 ,  A61K45/00 ,  A61K45/06 ,  A61K49/00 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P11/00 ,  A61P17/00 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07C333/04 ,  C07C333/08 ,  C07C333/16 ,  C07D295/21 ,  G01N33/15 ,  G01N33/68 ,  G01N33/92 ,  G01N33/53 ,  A61K31/54 ,  A61K31/265

CPC classification number: C07D295/21 ,  A61K31/145 ,  A61K31/185 ,  A61K31/198 ,  A61K31/325 ,  A61K31/40 ,  A61K45/06 ,  C07C333/04 ,  C07C333/08 ,  C07C333/16 ,  G01N33/68 ,  G01N33/92 ,  G01N2333/70503 ,  G01N2333/7056 ,  G01N2500/00 ,  G01N2800/323 ,  Y10S514/824 ,  Y10S514/825 ,  Y10S514/826 ,  Y10S514/861 ,  Y10S514/863 ,  Y10T436/201666

Abstract: A method for the treatment of cardiovascular diseases and noncardiovascular inflammatory diseases that are mediated by VCAM-1 is provided that includes the removal, decrease in the concentration of, or prevention of the formation of oxidized polyunsaturated fatty acids, or interferes with a complex formed between a polyunsaturated fatty acid or an oxidized polyunsaturated fatty acid and a protein or peptide that mediates the expression of VCAM-1. A method is also provided for suppressing the expression of a redox-sensitive gene or activating a gene that is suppressed through a redox-sensitive pathway, that includes administering an effective amount of a substance that prevents the oxidation of the oxidized signal, and typically, the oxidation of a polyunsaturated fatty acid, or interferes with a complex formed between the oxidized signal and a protein or peptide that mediates the expression of the redox gene.

公开(公告)号：US5773231A

公开(公告)日：1998-06-30

申请号：US473272

申请日：1995-06-07

Applicant: Russell M. Medford ,  R. Wayne Alexander ,  Sampath Parthasarathy ,  Bobby V. Khan

Inventor： Russell M. Medford ,  R. Wayne Alexander ,  Sampath Parthasarathy ,  Bobby V. Khan

IPC: G01N33/50 ,  A61K31/10 ,  A61K31/105 ,  A61K31/145 ,  A61K31/185 ,  A61K31/198 ,  A61K31/26 ,  A61K31/27 ,  A61K31/28 ,  A61K31/325 ,  A61K31/365 ,  A61K31/40 ,  A61K31/455 ,  A61K31/55 ,  A61K38/00 ,  A61K45/00 ,  A61K45/06 ,  A61K49/00 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P11/00 ,  A61P17/00 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07C333/04 ,  C07C333/08 ,  C07C333/16 ,  C07D295/21 ,  G01N33/15 ,  G01N33/68 ,  G01N33/92 ,  G01N33/53

CPC classification number: C07D295/21 ,  A61K31/145 ,  A61K31/185 ,  A61K31/198 ,  A61K31/325 ,  A61K31/40 ,  A61K45/06 ,  C07C333/04 ,  C07C333/08 ,  C07C333/16 ,  G01N33/68 ,  G01N33/92 ,  G01N2333/70503 ,  G01N2333/7056 ,  G01N2500/00 ,  G01N2800/323 ,  Y10S514/824 ,  Y10S514/825 ,  Y10S514/826 ,  Y10S514/861 ,  Y10S514/863 ,  Y10T436/201666

Abstract: A method for the treatment of cardiovascular diseases and noncardiovascular inflammatory diseases that are mediated by VCAM-1 is provided that includes the removal, decrease in the concentration of, or prevention of the formation of oxidized polyunsaturated fatty acids, or interferes with a complex formed between a polyunsaturated fatty acid or an oxidized polyunsaturated fatty acid and a protein or peptide that mediates the expression of VCAM-1. A method is also provided for suppressing the expression of a redox-sensitive gene or activating a gene that is suppressed through a redox-sensitive pathway, that includes administering an effective amount of a substance that prevents the oxidation of the oxidized signal, and typically, the oxidation of a polyunsaturated fatty acid, or interferes with a complex formed between the oxidized signal and a protein or peptide that mediates the expression of the redox gene.