Invention Grant
US5773209A Treatment for atherosclerosis and other cardiovascular and inflammatory
diseases
失效
治疗动脉粥样硬化和其他心血管和炎症疾病
- Patent Title: Treatment for atherosclerosis and other cardiovascular and inflammatory diseases
- Patent Title (中): 治疗动脉粥样硬化和其他心血管和炎症疾病
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Application No.: US484059Application Date: 1995-06-07
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Publication No.: US5773209APublication Date: 1998-06-30
- Inventor: Russell M. Medford , R. Wayne Alexander , Sampath Parthasarathy , Bobby V. Khan
- Applicant: Russell M. Medford , R. Wayne Alexander , Sampath Parthasarathy , Bobby V. Khan
- Applicant Address: GA Atlanta
- Assignee: Emory University
- Current Assignee: Emory University
- Current Assignee Address: GA Atlanta
- Main IPC: G01N33/50
- IPC: G01N33/50 ; A61K31/10 ; A61K31/105 ; A61K31/145 ; A61K31/185 ; A61K31/198 ; A61K31/26 ; A61K31/27 ; A61K31/28 ; A61K31/325 ; A61K31/365 ; A61K31/40 ; A61K31/455 ; A61K31/55 ; A61K38/00 ; A61K45/00 ; A61K45/06 ; A61K49/00 ; A61P9/00 ; A61P9/08 ; A61P9/10 ; A61P11/00 ; A61P17/00 ; A61P29/00 ; A61P35/00 ; A61P43/00 ; C07C333/04 ; C07C333/08 ; C07C333/16 ; C07D295/21 ; G01N33/15 ; G01N33/68 ; G01N33/92 ; G01N33/53
Abstract:
A method for the treatment of cardiovascular diseases and noncardiovascular inflammatory diseases that are mediated by VCAM-1 is provided that includes the removal, decrease in the concentration of, or prevention of the formation of oxidized polyunsaturated fatty acids, or interferes with a complex formed between a polyunsaturated fatty acid or an oxidized polyunsaturated fatty acid and a protein or peptide that mediates the expression of VCAM-1. A method is also provided for suppressing the expression of a redox-sensitive gene or activating a gene that is suppressed through a redox-sensitive pathway, that includes administering an effective amount of a substance that prevents the oxidation of the oxidized signal, and typically, the oxidation of a polyunsaturated fatty acid, or interferes with a complex formed between the oxidized signal and a protein or peptide that mediates the expression of the redox gene.
Public/Granted literature
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