公开(公告)号：US11753422B2

公开(公告)日：2023-09-12

申请号：US17406275

申请日：2021-08-19

Applicant: ALLIANCE FOR SUSTAINABLE ENERGY, LLC ,  BOARD OF TRUSTEES OF NORTHERN ILLINOIS UNIVERSITY

Inventor： Kai Zhu ,  Jinhui Tong ,  Tao Xu ,  Xun Li

IPC: C07F7/24 ,  H01G9/20 ,  H01G9/00 ,  C07F7/22 ,  C01B4/00 ,  H10K85/30 ,  H10K30/20 ,  H10K30/30 ,  H10K71/12

CPC classification number: C07F7/24 ,  C01B4/00 ,  C07F7/22 ,  H01G9/0036 ,  H01G9/2009 ,  H10K30/20 ,  H10K30/30 ,  H10K71/12 ,  H10K85/30 ,  C01P2002/34 ,  Y02E10/542 ,  Y02E10/549

Abstract: The present disclosure relates to a composition that includes a material of at least one of a perovskite structure, a perovskite-like structure, and/or a perovskitoid structure, where the material includes an isotope of an element, the isotope has more neutrons than protons, and the isotope is incorporated into the perovskite structure, the perovskite-like structure, and/or the perovskitoid structure. In some embodiments of the present disclosure, the isotope may make up between greater than 0% and 100% of the element.

公开(公告)号：US20200299670A1

公开(公告)日：2020-09-24

申请号：US16826135

申请日：2020-03-20

Applicant: UCHICAGO ARGONNE, LLC ,  BOARD OF TRUSTEES OF NORTHERN ILLINOIS UNIVERSITY

Inventor： Tao Li ,  Gyorgy Babnigg ,  Jessica L. Johnson ,  Erik Sarnello

IPC: C12N11/084 ,  C12N11/096 ,  C12N9/42 ,  C12N9/18

Abstract: Biocatalysts disclosed herein can have a core and a shell, with the core including a polymer having a pyridine functional group, and the shell including an enzyme that interacts with the polymer. The biocatalysts disclosed herein can have improved stability, control, and activity as compared to the enzyme in a free, non-interacted state.

公开(公告)号：US20180271098A1

公开(公告)日：2018-09-27

申请号：US15933608

申请日：2018-03-23

Applicant: BOARD OF TRUSTEES OF NORTHERN ILLINOIS UNIVERSITY

Inventor： Timothy J. Hagen ,  Michael Thompson ,  Jeremy R. Troxell ,  Brian E. Hartnett

IPC: A01N43/82 ,  C07D413/04 ,  C07D417/04 ,  C07D209/12 ,  A01N43/36

CPC classification number: A01N43/82 ,  A01N43/36 ,  C07D209/12 ,  C07D413/04 ,  C07D417/04

Abstract: Antimicrobial resistance is rising at an alarming rate. The methylerythritol phosphate (MEP) pathway is a metabolic pathway that produces the isoprenoids isopentyl pyrophosphate (IPP) and dimethylallyl pyrophosphate (DMAPP). Notably, the MEP pathway is present in bacteria and not mammals, which made the enzymes of the MEP pathway attractive targets for discovering new anti-infective agents due to reduced chances of off-target interactions leading to side effects. The biophysical properties of 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (IspD) and 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (IspE) were determined to aid discovery of novel inhibitors. Thermal shift screening was used as an initial filter to narrow down a library of compounds with thermal shifts greater than 1° C., which could indicate binding to the IspD and IspE enzymes. Follow-up studies were performed using isothermal titration calorimetry and enzymatic inhibition assays. Results from these studies have revealed compounds with high micromolar inhibition of both IspD from Escherichia coli and IspE from Burkholderia thailandensis. The hit compounds are used for future development of more potent IspD and IspE inhibitors.

公开(公告)号：US20180230457A1

公开(公告)日：2018-08-16

申请号：US15886271

申请日：2018-02-01

Applicant: BOARD OF TRUSTEES OF NORTHERN ILLINOIS UNIVERSITY

Inventor： James R. Horn

IPC: C12N15/10 ,  C07K16/40 ,  C07K16/44 ,  G01N33/68

CPC classification number: C12N15/1037 ,  C07K16/40 ,  C07K16/44 ,  C07K2317/14 ,  C07K2317/22 ,  C07K2317/569 ,  C07K2317/90 ,  C07K2317/92 ,  C40B30/04 ,  G01N33/6854

Abstract: Methods and compositions are disclosed for introducing molecular switch functionality into a protein affinity reagent to render its binding to a target molecule sensitive to an environmental trigger, such as pH, while maintaining binding affinity to the target molecule. Combinatorial libraries created by the method are also disclosed.

公开(公告)号：US20170355700A1

公开(公告)日：2017-12-14

申请号：US15611512

申请日：2017-06-01

Applicant: BOARD OF TRUSTEES OF NORTHERN ILLINOIS UNIVERSITY

Inventor： Timothy J. Hagen ,  Joy M. Blain ,  Gashaw M. Goshu ,  Brian E. Hartnett

IPC: C07D487/04 ,  A61K31/519

CPC classification number: C07D487/04 ,  A61K31/519 ,  A61K45/06 ,  Y02A50/411 ,  A61K2300/00

Abstract: Pyrazolopyrimidine compounds for inhibition of isoprenoid biosynthesis have a formula (I) or a pharmaceutically acceptable salt thereof. In formula (I), R1 includes an alkyl group and R2 includes an optionally substituted moiety selected from the group consisting of an optionally substituted benzyl group, an optionally substituted phenethyl group, an optionally substituted ethanol group, an optionally substituted ethyl acetate group, an optionally substituted methyl furan group, an optionally substituted 3-ethyl indole group, and a lower alkyl group. Compositions containing pyrazolopyrimidine compounds and methods for using pyrazolopyrimidine compounds are described.

公开(公告)号：US09309232B2

公开(公告)日：2016-04-12

申请号：US14390548

申请日：2013-04-23

Applicant: BOARD OF TRUSTEES OF NORTHERN ILLINOIS UNIVERSITY ,  EMERALD BIOSTRUCTURES, INC.

Inventor： Timothy J. Hagen ,  Zheng Zhang ,  Zachary Lazowski ,  Michael Clare ,  Darren W. Begley

IPC: A61K31/506 ,  C07D405/12 ,  C07D403/12 ,  C07F9/6571 ,  C07D239/47 ,  C07D417/12 ,  A61K45/06 ,  A61K31/4164 ,  C07D233/64 ,  C07D401/12 ,  C07D403/06 ,  C07D405/06 ,  A61K31/4174 ,  C07D413/12

CPC classification number: C07D233/64 ,  A61K31/4164 ,  A61K31/4174 ,  A61K31/4178 ,  A61K31/506 ,  A61K45/06 ,  C07D239/47 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  C07F9/657136 ,  Y02A50/411 ,  A61K2300/00

Abstract: Antibacterial IspF inhibitor compounds and compositions are described. Methods include administering described compounds and compositions to treat bacterial or parasitic infections and to inhibit or parasite or bacterial growth.

Abstract translation: 描述了抗菌IspF抑制剂化合物和组合物。 方法包括施用所述化合物和组合物以治疗细菌或寄生虫感染并抑制或寄生或细菌生长。

公开(公告)号：US20160033659A1

公开(公告)日：2016-02-04

申请号：US14811046

申请日：2015-07-28

Applicant: BOARD OF TRUSTEES OF NORTHERN ILLINOIS UNIVERSITY ,  FERMI RESEARCH ALLIANCE, LLC

Inventor： George Coutrakon ,  Paul Rubinov ,  Vishnu Zutshi ,  Alexandre S. Dychkant ,  Bela Erdelyi ,  Victor Rykalin ,  Sergey Uzunyan ,  Greg Selberg ,  John Rauch ,  Peter Wilson

IPC: G01T1/24 ,  G01T1/161

CPC classification number: G01T1/248 ,  G01T1/201 ,  G01T1/2985

Abstract: A high performance computer system for three dimensional proton computed tomography and method of imaging an object are disclosed. The system includes a proton computed tomography (pCT) detector assembly with an arrangement of fibers attached to silicon photo multipliers (SiPMs). An electronic circuit amplifies and digitizes signals received from the SiPMs and communicates the digitized data over a network for image reconstruction.

Abstract translation: 公开了用于三维质子计算机断层摄影的高性能计算机系统和对象成像方法。 该系统包括质子计算机断层摄影（pCT）检测器组件，其具有连接到硅光电倍增器（SiPM）的光纤布置。 电子电路放大并数字化从SiPM接收的信号，并通过网络传送数字化数据进行图像重构。

公开(公告)号：US09140810B2

公开(公告)日：2015-09-22

申请号：US14319684

申请日：2014-06-30

Applicant: BOARD OF TRUSTEES OF NORTHERN ILLINOIS UNIVERSITY ,  FERMI RESEARCH ALLIANCE, LLC ,  UNIVERSITY OF WOLLONGONG

Inventor： Nicholas Karonis ,  George Coutrakon ,  Kirk Duffin ,  Bela Erdelyi ,  Kevin Naglich ,  Scott Penfold ,  Paul Rubinov ,  Victor Rykalin ,  Vishnu Zutshi

IPC: G01N23/04 ,  G01T1/29 ,  G01T1/20

CPC classification number: G01T1/29 ,  G01T1/201

Abstract: A proton computed tomography (pCT) detector system, including two tracking detectors in sequence on a first side of an object to be imaged, two tracking detectors in sequence on an opposite side of the object to be imaged, a calorimeter, and a computer cluster, wherein the tracking detectors include plastic scintillation fibers. All fibers in the detector system are read out by Silicon Photomultipliers (SiPM). A method of imaging an object by emitting protons from a source through two tracking detectors, through and around the object, and through two opposite tracking detectors, detecting energy of the protons with a calorimeter, and imaging the object.

Abstract translation: 一种质子计算机断层摄影（pCT）检测器系统，包括在待成像对象的第一侧上的两个跟踪检测器，依次在待成像对象的另一侧上的两个跟踪检测器，量热计和计算机集群 其中跟踪检测器包括塑料闪烁纤维。 检测器系统中的所有光纤由硅光电倍增管（SiPM）读出。 一种通过从源通过两个跟踪检测器，物体周围和周围的物质以及通过两个相对的跟踪检测器发射质子来成像物体的方法，用量热计检测质子的能量，并对物体进行成像。

公开(公告)号：US20150224122A1

公开(公告)日：2015-08-13

申请号：US14694699

申请日：2015-04-23

Applicant: BOARD OF TRUSTEES OF NORTHERN ILLINOIS UNIVERSITY

Inventor： Elizabeth R. Gaillard ,  James P. Dillon

IPC: A61K31/661

CPC classification number: A61K31/661

Abstract: A prodrug having antioxidant activity, including a phosphorylated compound having a thiol group. A method of treating oxidative stress by administering a prodrug of a phosphorylated compound including a thiol group, removing a phosphate group of the prodrug, and treating oxidative stress. A method of increasing bioavailability of a thiol compound by creating a prodrug by phosphorylating a thiol compound, administering the prodrug, preventing first pass metabolism of the prodrug, removing a phosphate group from the prodrug, and providing active drug to a site in need of therapy from oxidative stress. A method of preventing radiation damage to healthy tissue by administering a prodrug comprising a phosphorylated compound including a thiol group, removing a phosphate group of the prodrug to provide active drug, and preventing radiation damage to healthy tissue.

公开(公告)号：US20150201309A1

公开(公告)日：2015-07-16

申请号：US14668620

申请日：2015-03-25

Applicant: Board of Trustees of Northern Illinois University

Inventor： Lichuan Liu

IPC: H04W4/02

CPC classification number: H04W4/025 ,  G01S5/0289 ,  G01S5/10

Abstract: A system and method for wireless sensor networks (WSN) positioning that is cost-effective, scalable, can be easily implemented, and provides improved performance and accuracy. A plurality of reference nodes with known locations transmit linear frequency modulation continuous waves (FMCW), while sensor nodes receive these waves and calculate the range difference among them based on the time frequency difference arrival (TFDA). The location information of the sensor nodes is obtained through the solving of a set of hyperbolic equations. Multidimensional scaling may be used or hybrid optimizing algorithm (HOA) processing to combine steepest-descent processing with Taylor series expansion to increase accuracy.

Abstract translation: 可以容易地实现具有成本效益，可扩展性的无线传感器网络（WSN）定位的系统和方法，并提供改进的性能和准确性。 具有已知位置的多个参考节点发射线性频率调制连续波（FMCW），而传感器节点接收这些波，并且基于时间差异到达（TFDA）计算它们之间的距离差。 传感器节点的位置信息通过求解一组双曲线方程得到。 可以使用多维缩放或混合优化算法（HOA）处理来将最大下降处理与泰勒级数展开相结合以增加精度。