公开(公告)号：US20150224122A1

公开(公告)日：2015-08-13

申请号：US14694699

申请日：2015-04-23

Applicant: BOARD OF TRUSTEES OF NORTHERN ILLINOIS UNIVERSITY

Inventor： Elizabeth R. Gaillard ,  James P. Dillon

IPC: A61K31/661

CPC classification number: A61K31/661

Abstract: A prodrug having antioxidant activity, including a phosphorylated compound having a thiol group. A method of treating oxidative stress by administering a prodrug of a phosphorylated compound including a thiol group, removing a phosphate group of the prodrug, and treating oxidative stress. A method of increasing bioavailability of a thiol compound by creating a prodrug by phosphorylating a thiol compound, administering the prodrug, preventing first pass metabolism of the prodrug, removing a phosphate group from the prodrug, and providing active drug to a site in need of therapy from oxidative stress. A method of preventing radiation damage to healthy tissue by administering a prodrug comprising a phosphorylated compound including a thiol group, removing a phosphate group of the prodrug to provide active drug, and preventing radiation damage to healthy tissue.

公开(公告)号：US10512402B2

公开(公告)日：2019-12-24

申请号：US15557727

申请日：2016-04-22

Applicant: BOARD OF TRUSTEES OF NORTHERN ILLINOIS UNIVERSITY

Inventor： Elizabeth R. Gaillard ,  Devi Kalyan Karumanchi

IPC: A61B5/00 ,  A61B6/00

Abstract: Materials and methods are disclosed for screening advanced glycation end-products from the mammalian ocular lens proteins to quantify early biomarkers for the diagnosis of diabetes mellitus and related complications.

公开(公告)号：US09629857B2

公开(公告)日：2017-04-25

申请号：US14694699

申请日：2015-04-23

Applicant: BOARD OF TRUSTEES OF NORTHERN ILLINOIS UNIVERSITY

Inventor： Elizabeth R. Gaillard ,  James P. Dillon

IPC: A61K31/661

CPC classification number: A61K31/661

Abstract: A prodrug having antioxidant activity, including a phosphorylated compound having a thiol group. A method of treating oxidative stress by administering a prodrug of a phosphorylated compound including a thiol group, removing a phosphate group of the prodrug, and treating oxidative stress. A method of increasing bioavailability of a thiol compound by creating a prodrug by phosphorylating a thiol compound, administering the prodrug, preventing first pass metabolism of the prodrug, removing a phosphate group from the prodrug, and providing active drug to a site in need of therapy from oxidative stress. A method of preventing radiation damage to healthy tissue by administering a prodrug comprising a phosphorylated compound including a thiol group, removing a phosphate group of the prodrug to provide active drug, and preventing radiation damage to healthy tissue.

公开(公告)号：US09579331B2

公开(公告)日：2017-02-28

申请号：US14694729

申请日：2015-04-23

Applicant: BOARD OF TRUSTEES OF NORTHERN ILLINOIS UNIVERSITY

Inventor： Elizabeth R. Gaillard ,  James P. Dillon

IPC: A61K31/661

CPC classification number: A61K31/661

Abstract: A prodrug having antioxidant activity, including a phosphorylated compound having a thiol group. A method of treating oxidative stress by administering a prodrug of a phosphorylated compound including a thiol group, removing a phosphate group of the prodrug, and treating oxidative stress. A method of increasing bioavailability of a thiol compound by creating a prodrug by phosphorylating a thiol compound, administering the prodrug, preventing first pass metabolism of the prodrug, removing a phosphate group from the prodrug, and providing active drug to a site in need of therapy from oxidative stress. A method of preventing radiation damage to healthy tissue by administering a prodrug comprising a phosphorylated compound including a thiol group, removing a phosphate group of the prodrug to provide active drug, and preventing radiation damage to healthy tissue.

Abstract translation: 具有抗氧化活性的前药，包括具有硫醇基的磷酸化化合物。 通过给予包含硫醇基的磷酸化化合物的前体药物，去除前药的磷酸酯基团以及治疗氧化应激来治疗氧化应激的方法。 一种提高硫醇化合物生物利用度的方法，通过磷酸化硫醇化合物，施用前体药物，防止前药的首过代谢，从前药中除去磷酸基团，并向需要治疗的部位提供活性药物 从氧化应激。 通过施用包含硫醇基的磷酸化化合物的前药，除去前药的磷酸酯基以提供活性药物，以及防止对健康组织的辐射损伤来防止对健康组织的辐射损伤的方法。

公开(公告)号：US20150224123A1

公开(公告)日：2015-08-13

申请号：US14694729

申请日：2015-04-23

Applicant: BOARD OF TRUSTEES OF NORTHERN ILLINOIS UNIVERSITY

Inventor： Elizabeth R. Gaillard ,  James P. Dillon

IPC: A61K31/661

CPC classification number: A61K31/661

Abstract: A prodrug having antioxidant activity, including a phosphorylated compound having a thiol group. A method of treating oxidative stress by administering a prodrug of a phosphorylated compound including a thiol group, removing a phosphate group of the prodrug, and treating oxidative stress. A method of increasing bioavailability of a thiol compound by creating a prodrug by phosphorylating a thiol compound, administering the prodrug, preventing first pass metabolism of the prodrug, removing a phosphate group from the prodrug, and providing active drug to a site in need of therapy from oxidative stress. A method of preventing radiation damage to healthy tissue by administering a prodrug comprising a phosphorylated compound including a thiol group, removing a phosphate group of the prodrug to provide active drug, and preventing radiation damage to healthy tissue.