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21 条记录 (耗时 0.016 秒)

    Water intrusion test for filters
    2.
    发明授权
    Water intrusion test for filters 失效
    滤水器入水试验

    公开(公告)号：US5786528A

    公开(公告)日：1998-07-28

    申请号：US711755

    申请日：1996-09-10

    申请人： Anthony J. Dileo ,  Richard W. Gray

    发明人： Anthony J. Dileo ,  Richard W. Gray

    IPC分类号： B01D65/10 ,  G01N15/08

    CPC分类号： B01D65/102 ,  G01N15/0826 ,  G01N15/088

    摘要： An improved water flow test for determining the integrity and/or pore size distribution of a porous filter is disclosed. The improvement involves the ability to determine and take into account the changes in filter structure due to filter compaction or creep resulting from compressive forces when pressure is applied to the surfaces of the filter. By proper characterization of the filter under test, the initial system volume and the volume change associated with pressurizing the filter can be accurately determined at all points in time during a test cycle. As a result, composite flowrate changes (i.e. the flow due to filter compaction/creep plus the flow due to liquid intrusion) can be evaluated to distinguish between various flow components to accurately determine the pore size of the filter being tested or a filter defect.

    摘要翻译： 公开了用于确定多孔过滤器的完整性和/或孔径分布的改进的水流试验。 改进包括确定和考虑过滤器结构的变化的能力，这是由于当压力施加到过滤器的表面时由于过滤器压实或由压缩力引起的蠕变。 通过测试过滤器的正确表征，可以在测试周期内的所有时间点精确地确定与过滤器加压相关的初始系统体积和体积变化。 结果，可以评估复合流量的变化（即由于过滤器压实/蠕变加上由于液体侵入引起的流动）的流量变化，以区分各种流动成分以精确地确定被测试的过滤器的孔径或过滤器缺陷。

    Integrity test for membranes
    4.
    发明授权
    Integrity test for membranes 失效
    膜的完整性测试

    公开(公告)号：US5282380A

    公开(公告)日：1994-02-01

    申请号：US906730

    申请日：1992-06-30

    申请人： Anthony J. DiLeo ,  Michael W. Phillips

    发明人： Anthony J. DiLeo ,  Michael W. Phillips

    IPC分类号： B01D65/10 ,  G01N15/08

    CPC分类号： B01D65/102 ,  G01N15/0826 ,  G01N2015/086

    摘要： A process is provided for rapidly and non-destructively evaluating the particle retention characteristics of porous membranes using a novel liquid-porosimetric technique. A ratio of two membrane permeabilities is measured at preselected operating conditions using a pair of mutually immiscible fluids, one of which is employed as a membrane wetting agent and the other used as an intrusion fluid. The first operating condition, a particular transmembrane pressure, is chosen so as to selectively intrude those pores accessible to a given sized particle, such as a virus. The second operating condition, either a second preselected transmembrane pressure or a water permeability measurement, is chosen such that nearly all of the membrane pores are intruded. The ratio of the two permeabilities obtained with each set of operating conditions is thus the percentage of total flow through the membrane pores accessible to a given sized particle. By experimentally measuring this permeability ratio on membranes with known particle retention behavior, a calibration curve relating the permeability ratio to the particle retention characteristics can be constructed. From this standard correlation, the particle retention capabilities of an unchallenged membrane can be predicted in a non-destructive manner solely by measuring its permeability ratio.

    摘要翻译： 提供了使用新的液体 - 孔隙率法快速且非破坏性地评估多孔膜的颗粒保留特性的方法。 使用一对相互混溶的流体在预选的操作条件下测量两个膜渗透性的比例，其中一种用作膜润湿剂，另一种用作侵入流体。 选择第一操作条件，特定的跨膜压力，以便选择性地侵入给定大小的颗粒例如病毒可接近的那些孔。 选择第二操作条件，即第二预选跨膜压力或透水性测量，使得几乎所有的膜孔都被侵入。 因此，通过每组操作条件获得的两个渗透率的比例是通过给定尺寸颗粒可接近的膜孔的总流量的百分比。 通过实验测量具有已知颗粒保留行为的膜的渗透率比，可以构建将渗透率与颗粒保持特性相关联的校准曲线。 从这个标准的相关性，单独通过测量其渗透率比，无损检测的膜的颗粒保留能力可以非破坏性地预测。

    Membrane, process and system for isolating virus from solution
    6.
    发明授权
    Membrane, process and system for isolating virus from solution 失效
    从溶液中分离病毒的膜，过程和系统

    公开(公告)号：US5017292A

    公开(公告)日：1991-05-21

    申请号：US521784

    申请日：1990-05-10

    申请人： Anthony J. DiLeo ,  Anthony E. Allegrezza, Jr. ,  Edmund T. Burke

    发明人： Anthony J. DiLeo ,  Anthony E. Allegrezza, Jr. ,  Edmund T. Burke

    IPC分类号： B01D69/12 ,  A61L2/00 ,  A61L2/02 ,  B01D61/14 ,  B01D69/02 ,  B01D71/34 ,  C07K1/34

    CPC分类号： B01D61/145 ,  A61L2/0017 ,  A61L2/022 ,  B01D61/142 ,  B01D69/02 ,  B01D69/12 ,  C07K1/34

    摘要： A composite membrane and process utilizing the membrane which is capable of selectively removing particles such as viral particles from a solution such as a protein solution is provided. The membrane comprises a porous membrane substrate, a surface skin having ultrafiltration separation properties and an intermediate porous zone between the substrate and the skin which intermediate zone has an average pore size smaller than that of the substrate. The intermediate zone is free of voids which break the skin and which directly fluid communicate with the substrate. The composite is capable of a log reduction value of at least 3 (99.9% removal) of particles selectively from solution.

    摘要翻译： 提供一种复合膜和利用该膜的方法，其能够从诸如蛋白质溶液的溶液中选择性地除去诸如病毒颗粒的颗粒。 膜包括多孔膜基底，具有超滤分离性能的表面皮肤和在基底和皮肤之间的中间多孔区，该中间区的平均孔径小于基底的平均孔径。 中间区域没有空隙，其破坏皮肤并且与基底直接流体连通。 复合材料能够从溶液中选择性地减少至少3（99.9％去除）颗粒的对数减少值。

    Diafiltration method
    7.
    发明授权
    Diafiltration method 失效
    渗滤法

    公开(公告)号：US4728430A

    公开(公告)日：1988-03-01

    申请号：US828105

    申请日：1986-02-10

    申请人： Anthony J. DiLeo ,  Gaston de los Reyes ,  Lisa M. Waranch

    发明人： Anthony J. DiLeo ,  Gaston de los Reyes ,  Lisa M. Waranch

    IPC分类号： A61M1/02 ,  A61M1/34 ,  B01D13/00

    CPC分类号： A61M1/3472 ,  A61M1/3482 ,  A61M2205/7563

    摘要： A process and apparatus is provided for separating whole blood from a patient into a cellular component and a plasma component and for separating the plasma component into a high molecular weight plasma fraction and a low molecular weight plasma fraction and wherein anticoagulant is added to the whole blood and a physiologically acceptable liquid diluent is added to the plasma component. The rate of addition of the diluent is governed by the following equation: ##EQU1## called Equation 1.

    摘要翻译： 提供了一种将患者的全血分离为细胞成分和血浆成分并将血浆成分分离成高分子量血浆级分和低分子量血浆级分的方法和装置，其中将抗凝血剂加入到全血中 并将生理上可接受的液体稀释剂加入到血浆组分中。 稀释剂的添加速度由以下等式控制： + TR 称为等式1。