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    ANTICANCER AGENT SENSITIVITY-DETERMINING MARKER
    2.
    发明申请
    ANTICANCER AGENT SENSITIVITY-DETERMINING MARKER 有权
    ANTICANCER AGENT敏感性确定标记

    公开(公告)号：US20120220618A1

    公开(公告)日：2012-08-30

    申请号：US13505175

    申请日：2010-10-29

    申请人： Yusuke Tanigawara ,  Tetsuya Suzuki ,  Akito Nishimuta ,  Shinji Sugimoto ,  Yoshiaki Igarashi

    发明人： Yusuke Tanigawara ,  Tetsuya Suzuki ,  Akito Nishimuta ,  Shinji Sugimoto ,  Yoshiaki Igarashi

    IPC分类号： A61K31/4375 ,  G01N27/62 ,  A61P35/00 ,  C07D491/22

    CPC分类号： A61K31/4745 ,  G01N33/18 ,  G01N33/5011 ,  G01N33/574 ,  G01N33/6848 ,  G01N2500/00 ,  G01N2800/52

    摘要： To provide a marker for determining sensitivity of a patient to an anti-cancer agent, and novel cancer therapeutic means employing the marker.The marker for determining sensitivity to an anti-cancer agent is formed of one or more substances selected from the group consisting of a substance or a fragment thereof detected as an anion at m/z of 149.05 to 149.06, a substance or a fragment thereof detected as an anion at m/z of 152.99 to 153.00, a substance or a fragment thereof detected as a cation at m/z of 724.34 to 724.35, the peaks being determined by means of a mass spectrometer, glycerol 3-phosphate, dihydrobiopterin, GABA, lactic acid, asparagine, aspartic acid, 2-methylbutyroylcarnitine, 1-methyladenosine, and glutathione, and a substance involved in a metabolic pathway of any of these substances.

    摘要翻译： 提供用于确定患者对抗癌剂的敏感性的标记物，以及采用该标记物的新型癌症治疗方法。 用于确定对抗癌剂的敏感性的标记物由选自以m / z为149.05至149.06作为阴离子检测的物质或片段的一种或多种物质形成，检测到其物质或片段 作为m / z为152.99〜153.00的阴离子，以m / z为724.34〜724.35检测为阳离子的物质或其片段，通过质谱仪，甘油3-磷酸，二氢生物蝶呤，GABA ，乳酸，天冬酰胺，天冬氨酸，2-甲基丁酰基肉碱，1-甲基腺苷和谷胱甘肽，以及涉及任何这些物质的代谢途径的物质。

    METHOD FOR DETERMINATION OF SENSITIVITY TO ANTI-CANCER AGENT
    3.
    发明申请
    METHOD FOR DETERMINATION OF SENSITIVITY TO ANTI-CANCER AGENT 有权
    用于确定抗癌剂敏感性的方法

    公开(公告)号：US20120214831A1

    公开(公告)日：2012-08-23

    申请号：US13504985

    申请日：2010-10-29

    申请人： Yusuke Tanigawara ,  Sayo Suzuki ,  Yusuke Ikoma ,  Akito Nishimuta ,  Tetsuya Suzuki ,  Shinji Sugimoto

    发明人： Yusuke Tanigawara ,  Sayo Suzuki ,  Yusuke Ikoma ,  Akito Nishimuta ,  Tetsuya Suzuki ,  Shinji Sugimoto

    IPC分类号： A61K31/505 ,  A61P35/00 ,  A61K31/282 ,  C40B30/10 ,  G01N33/53

    CPC分类号： A61K31/513 ,  A61K31/555 ,  G01N30/7233 ,  G01N33/574 ,  G01N33/57419 ,  G01N2333/4727 ,  G01N2800/52

    摘要： To provide a marker for determining sensitivity of a patient to an anti-cancer agent, and novel cancer therapeutic means employing the marker.The marker for determining sensitivity to an anti-cancer agent is formed of a protein selected from the group consisting of a protein or a fragment thereof which is detected as a peak at m/z of 5,300 to 5,400, a protein or a fragment thereof which is detected as a peak at m/z of 6,130 to 6,230, a protein or a fragment thereof which is detected as a peak at m/z of 7,000 to 7,080, a protein or a fragment thereof which is detected as a peak at m/z of 7,840 to 7,920, a protein or a fragment thereof which is detected as a peak at m/z of 8,920 to 9,000, a protein or a fragment thereof which is detected as a peak at m/z of 12,440 to 12,560, a protein or a fragment thereof which is detected as a peak at m/z of 17,100 to 17,270, a protein or a fragment thereof which is detected as a peak at m/z of 18,290 to 18,470, a protein or a fragment thereof which is detected as a peak at m/z of 24,660 to 24,750, a protein or a fragment thereof which is detected as a peak at m/z of 35,980 to 36,290, a protein or a fragment thereof which is detected as a peak at m/z of 8,650 to 8,750, a protein or a fragment thereof which is detected as a peak at m/z of 9,100 to 9,200, a protein or a fragment thereof which is detected as a peak at m/z of 11,760 to 11,890, and S100A10, the peaks being determined by means of a mass spectrometer.

    摘要翻译： 提供用于确定患者对抗癌剂的敏感性的标记物，以及采用该标记物的新型癌症治疗方法。 用于确定对抗癌剂的敏感性的标记物由选自蛋白质或其片段的蛋白质或其片段的蛋白质或其片段形成，所述蛋白质或其片段以m / z为峰值检测为5,300至5,400，其蛋白质或其片段 被检测为m / z为6,130至6,230的峰，其蛋白质或其片段被检测为m / z为7,000至7,080的峰，其蛋白质或其片段被检测为m / 检测为m / z为8,920至9,000的峰的蛋白质或其片段为7,840至7,920，其蛋白质或其片段被检测为m / z为12,440至12,560的峰，蛋白质或其片段 或其片段，其检测为m / z为17,100至17,270的峰，其蛋白质或其片段被检测为m / z为18,290至18,470的峰，其蛋白质或其片段被检测为 m / z的峰值为24,660〜24,750，是以m / z为35,980〜36,290的峰值检测出的蛋白质或其片段， 被检测为m / z为8,650〜8,750的峰的ein或其片段，检测为m / z为9,100〜9,200的峰的蛋白质或其片段，检测到的蛋白质或其片段 作为m / z为11,760〜11,890的峰，S100A10为峰，通过质谱仪测定。

    Anticancer agent sensitivity-determining marker
    5.
    发明授权
    Anticancer agent sensitivity-determining marker 有权
    抗癌剂灵敏度决定标记

    公开(公告)号：US08809362B2

    公开(公告)日：2014-08-19

    申请号：US13505175

    申请日：2010-10-29

    申请人： Yusuke Tanigawara ,  Tetsuya Suzuki ,  Akito Nishimuta ,  Shinji Sugimoto ,  Yoshiaki Igarashi

    发明人： Yusuke Tanigawara ,  Tetsuya Suzuki ,  Akito Nishimuta ,  Shinji Sugimoto ,  Yoshiaki Igarashi

    IPC分类号： A61K31/4375 ,  A61P35/00 ,  A61K31/4745 ,  G01N33/50 ,  G01N33/574 ,  G01N33/18

    CPC分类号： A61K31/4745 ,  G01N33/18 ,  G01N33/5011 ,  G01N33/574 ,  G01N33/6848 ,  G01N2500/00 ,  G01N2800/52

    摘要： To provide a marker for determining sensitivity of a patient to an anti-cancer agent, and novel cancer therapeutic means employing the marker.The marker for determining sensitivity to an anti-cancer agent is formed of one or more substances selected from the group consisting of a substance or a fragment thereof detected as an anion at m/z of 149.05 to 149.06, a substance or a fragment thereof detected as an anion at m/z of 152.99 to 153.00, a substance or a fragment thereof detected as a cation at m/z of 724.34 to 724.35, the peaks being determined by means of a mass spectrometer, glycerol 3-phosphate, dihydrobiopterin, GABA, lactic acid, asparagine, aspartic acid, 2-methylbutyroylcarnitine, 1-methyladenosine, and glutathione, and a substance involved in a metabolic pathway of any of these substances.

    摘要翻译： 提供用于确定患者对抗癌剂的敏感性的标记物，以及采用该标记物的新型癌症治疗方法。 用于确定对抗癌剂的敏感性的标记物由选自以m / z为149.05至149.06作为阴离子检测的物质或其片段的一种或多种物质形成，检测到其物质或片段 作为m / z为152.99〜153.00的阴离子，以m / z为724.34〜724.35检测为阳离子的物质或其片段，通过质谱仪，甘油3-磷酸，二氢生物蝶呤，GABA ，乳酸，天冬酰胺，天冬氨酸，2-甲基丁酰基肉碱，1-甲基腺苷和谷胱甘肽，以及涉及任何这些物质的代谢途径的物质。