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公开(公告)号：US11371993B2
公开(公告)日：2022-06-28
申请号：US16245822
申请日：2019-01-11
发明人： Peter Hoffmann , Martin Oehler , Karina Martin
IPC分类号： G01N33/574 , G01N33/564 , C07K16/30 , G01N33/68
摘要： The present invention relates to the identification of biological markers of ovarian cancer. Specifically, cancer-associated autoantibodies to ANXA1, ARP3, SAHH, SERPH, ARAP1, OTUB1, ATP1A1, UBA1, and CFAH have been identified in subjects with early stage ovarian cancer. These autoantibodies can be utilised for a range of purposes including methods for detecting ovarian cancer, methods for screening for early stage ovarian cancer, and methods for assessing treatment response as well as disease progression and recurrence. The autoantibodies also represent prognostic markers of ovarian cancer development.
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公开(公告)号：USPP29674P3
公开(公告)日：2018-09-18
申请号：US14999565
申请日：2016-05-26
IPC分类号： A01H5/08
摘要： A new and distinct almond variety of Prunus dulcis named ‘CAPELLA’, particularly characterized by self-fertility and very high production. Other desirable characteristics include early to medium harvest time, well-sealed hard shells, and high quality, sweet kernels with high oleic acid content.
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公开(公告)号：US20170347509P1
公开(公告)日：2017-11-30
申请号：US14999564
申请日：2016-05-26
IPC分类号： A01H5/08
CPC分类号： A01H6/7427 , A01H5/08
摘要： A new and distinct almond variety of Prunus dulcis named ‘MIRA’, particularly characterized by self-fertility and very high production. Other desirable characteristics include early harvest time, well-sealed semihard shells, and high quality, sweet kernels with high oil content.
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公开(公告)号：US09559485B2
公开(公告)日：2017-01-31
申请号：US14888228
申请日：2014-05-02
发明人： Ori Henderson Sapir , Jesper Munch , David Ottaway
CPC分类号： H01S3/091 , H01S3/067 , H01S3/094042 , H01S3/094092 , H01S3/094096 , H01S3/1608 , H01S3/161 , H01S3/1616 , H01S3/173
摘要： A dual wavelength pumping system and method have been developed to improve the efficiency of laser systems operating in the raid infrared region has been developed, in a conventional system the ions are excited from a ground state to an upper lasing state using a light pump. They then undergo a laser transition to leave the ion in a long lived post lasing excited state from which it eventually decays back to the ground state. In contrast they present system uses a first light pump to pump ions from the ground state to the post lasing state, and a second light pump to pump ions from the post lasing state to the upper lasing state. This system thus exploits the long lifetime of the post lasing state to enable it to become a virtual ground state for the second laser allowing continued cycling of ions between the upper lasing state and the post lasing state. A system using an Erbium, doped fiber generated a 3.5 μm laser output with an average power of over 250 mW and an initial slope, efficiency of 25.4% (previous system have only generates less than 10 mW of power with efficiencies of 3%).
摘要翻译： 已经开发了双波长泵浦系统和方法来提高在雷达红外区域中操作的激光系统的效率，在常规系统中，使用光泵将离子从基态激发到高激光状态。 然后，它们进行激光转换以使离子处于长时间的后激光激发态，从而最终衰减回到基态。 相比之下，它们呈现系统使用第一光泵将离子从基态泵送到柱后激光状态，以及第二光泵将离子从柱后激光状态泵送到上部激光状态。 因此，该系统利用后激光状态的长寿命，使其成为第二激光器的虚拟基态，允许在上部激光状态和后激光状态之间继续循环循环。 使用铒掺杂光纤的系统产生平均功率超过250mW的3.5μm激光输出和初始斜率，效率为25.4％（先前的系统仅产生小于10mW的功率，效率为3％）。
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5.发明授权公开(公告)号：US09217704B2
公开(公告)日：2015-12-22
申请号：US14416335
申请日：2013-07-23
CPC分类号： G01N21/251 , A47J37/06 , A47J37/085 , G01N2201/062
摘要： The present disclosure provides a device for characterizing a chromatic property of foodstuff. The device includes a light source arranged to emit light having at least two wavelengths or wavelength ranges. The light source is further arranged to direct the light to a surface of at least the foodstuff. The device also includes a detector positioned to detect at least a portion of reflected light and arranged to generate an output that is indicative of an intensity of detected reflected light. The device is arranged such that respective outputs are generated for the at least two wavelengths or wavelength ranges. A relation between the output for one of the at least two wavelengths or wavelength ranges and the output for the other or another one of the at least two wavelengths or wavelength ranges is indicative of the chromatic property of the surface of the foodstuff.
摘要翻译： 本公开提供了用于表征食品的色彩特性的装置。 该装置包括布置成发射具有至少两个波长或波长范围的光的光源。 光源还被布置成将光引导到至少食品的表面。 该装置还包括一个检测器，定位成检测反射光的至少一部分并被布置成产生指示检测到的反射光的强度的输出。 该装置被布置成使得针对至少两个波长或波长范围产生相应的输出。 所述至少两个波长或波长范围中的一个的输出与所述至少两个波长或波长范围中的另一个或另一个的输出之间的关系表示所述食品的表面的色度特性。
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公开(公告)号：US09108978B2
公开(公告)日：2015-08-18
申请号：US14346646
申请日：2012-09-21
发明人： Andrew Abell , Steven Polyak , Grant Booker , John Wallace , Tatiana Soares da Costa , Angie Jarrad , William Tieu , Kelly Lee Keeling , Daniel Sejer Pedersen , Nicole Pendini , Matthew Wilce , Min Yin Yap
IPC分类号： C07D495/04 , C07F9/6561 , C07H19/20 , C07H19/167
CPC分类号： C07D495/04 , C07D519/00 , C07F9/6561 , C07F9/65616 , C07H19/167
摘要： A new class of biotin protein ligase (BPL) inhibitors that have antibacterial activity against multiple Staphylococcus aureus isolates, including clinically important methicillin-resistant S. aureus (MRSA) are disclosed that are non-toxic.
摘要翻译： 公开了一类对多种金黄色葡萄球菌分离株具有抗菌活性的新型生物素蛋白连接酶（BPL）抑制剂，包括临床上重要的耐甲氧西林金黄色葡萄球菌（MRSA），无毒性。
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公开(公告)号：US20150203599A1
公开(公告)日：2015-07-23
申请号：US14419364
申请日：2013-08-02
CPC分类号： C08B37/0057 , C08B37/0003 , C12N9/1051 , C12N9/1077 , C12N15/8246 , C12P19/04 , C12Y204/01012 , C12Y204/02024
摘要： The present disclosure relates generally to polysaccharide synthases. The present disclosure reveals that a subset of the CesA gene family encode XynS xylan synthases. As a result of the identification of XynS nucleic acids, and corresponding amino acid sequences that encode XynS xylan synthases, the present invention provides, inter alia, methods and compositions for modulating the level and/or activity of xylan synthase in a cell and/or modulating the level of xylan produced by a cell.
摘要翻译： 本公开一般涉及多糖合酶。 本公开揭示了CesA基因家族的一个子集编码XynS木聚糖合酶。 作为XynS核酸鉴定和编码XynS木聚糖合酶的相应氨基酸序列的结果，本发明尤其提供了调节细胞中木聚糖合成酶和/或活性的水平和/或活性的方法和组合物，和/或 调节细胞产生的木聚糖水平。
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公开(公告)号：US20150010914A1
公开(公告)日：2015-01-08
申请号：US14373332
申请日：2013-01-17
IPC分类号： G01N33/574 , C12Q1/68
CPC分类号： G01N33/57446 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , C12Q2600/16 , G01N33/5023 , G01N33/57488 , G01N33/92 , G01N2333/65 , G01N2333/76 , G01N2333/775 , G01N2333/811 , G01N2800/52 , G01N2800/60
摘要： The present invention provides biological markers associated with gastric cancer. In particular, the present invention provides a method of diagnosing gastric cancer (GC) in a subject, the method including: measuring an expression level of one or more proteins in the subject, wherein the one or more proteins are selected from the group consisting of vitamin D binding protein (VDBP), clusterin, insulin like growth factor binding protein complex acid labile subunit (IGFALS), and afamin; comparing the expression level of the or each protein in the subject to a reference expression level for the or each protein; and diagnosing GC in the subject on the basis of the comparison. On the basis of the identification of biological markers associated with gastric cancer, the present invention also provides a method of determining if a subject is susceptible to developing gastric cancer, a method of assessing progression of gastric cancer in a subject, a method for screening a candidate therapeutic agent useful for treating gastric cancer in a subject, and a kit for diagnosing gastric cancer in a subject.
摘要翻译： 本发明提供与胃癌相关的生物标志物。 特别地，本发明提供了一种诊断受试者胃癌（GC）的方法，所述方法包括：测量受试者中一种或多种蛋白质的表达水平，其中所述一种或多种蛋白质选自 维生素D结合蛋白（VDBP），聚集蛋白，胰岛素样生长因子结合蛋白复合酸不稳定亚基（IGFALS）和微生物; 将受试者中或每种蛋白质的表达水平与该蛋白质或每种蛋白质的参考表达水平进行比较; 并根据比较诊断对象的GC。 本发明基于与胃癌相关的生物标志物的鉴定，还提供了确定受试者是否易于发生胃癌的方法，评估受试者胃癌进展的方法，筛选方法 可用于治疗受试者的胃癌的候选治疗剂和用于诊断受试者的胃癌的试剂盒。
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公开(公告)号：US10190130B2
公开(公告)日：2019-01-29
申请号：US15621132
申请日：2017-06-13
申请人： Adelaide Research & Innovation Pty Ltd , Grains Research & Development Corporation , The University of Melbourne
摘要： The present invention relates generally to polysaccharide synthases. More particularly, the present invention relates to (1,3;1,4)-β-D-glucan synthases. The present invention provides, among other things, methods for influencing the level of (1,3;1,4)-β-D-glucan produced by a cell and nucleic acid and amino acid sequences which encode (1,3;1,4)-β-D-glucan synthases.
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公开(公告)号：USPP29423P3
公开(公告)日：2018-06-26
申请号：US14999570
申请日：2016-05-26
IPC分类号： A01H5/08
CPC分类号： A01H6/7427 , A01H5/08
摘要： A new and distinct almond variety of Prunus dulcis named ‘MAXIMA’, particularly characterized by large kernels and very high production. Other desirable characteristics include early to medium harvest time, well-sealed semihard shells, and high quality, sweet kernels with high oil and vitamin E content.
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