公开(公告)号：US10087154B2

公开(公告)日：2018-10-02

申请号：US15664179

申请日：2017-07-31

Applicant: Senomyx, Inc.

Inventor： Catherine Tachdjian ,  Donald S. Karanewsky ,  Xiao-Qing Tang ,  Qing Chen ,  Peter Leeming ,  Tayyab Rashid ,  Daniel Levin

IPC: C07D285/16 ,  C07C303/40 ,  C07C255/57 ,  C07C253/30 ,  C07C231/14 ,  C07C231/02 ,  C01B21/096 ,  C07C307/10 ,  C07C255/59 ,  C07C255/54 ,  C07C237/44 ,  C07C235/20

Abstract: The present invention includes methods/processes and intermediates for preparing compounds having structural Formula (I): wherein X is alkyl, substituted alkyl, alkenyl, substituted alkenyl, heteroalkyl, substituted heteroalkyl, heteroalkenyl, or substituted heteroalkenyl.

公开(公告)号：US10078087B2

公开(公告)日：2018-09-18

申请号：US12278064

申请日：2007-01-26

Applicant: Bryan Moyer ,  Min Lu ,  Fernando Echeverri ,  Hong Chang

Inventor： Bryan Moyer ,  Min Lu ,  Fernando Echeverri ,  Hong Chang

IPC: G01N33/68 ,  G01N33/02 ,  G01N33/14

CPC classification number: G01N33/6872 ,  G01N33/02 ,  G01N33/14

Abstract: This invention relates to electrophysiological assays that measure sodium conductance activity of a delta human epithelial sodium channel (ENaC) in the presence and absence of delta hENaC enhancers. Also, the invention generally relates to assays for identifying compounds that enhance the activity of delta hENaC, especially in an oocyte expression system. These compounds have potential application in modulating (enhancing) salty taste perception.

公开(公告)号：US09840471B2

公开(公告)日：2017-12-12

申请号：US14768146

申请日：2014-02-19

Applicant: Senomyx, Inc.

Inventor： Lyudmyla Chumakova ,  Andrew Patron ,  Chad Priest ,  Donald Karanewsky ,  Rachel Kimmich ,  Brant Clayton Boren ,  Jeffrey Robert Hammaker ,  Volodymyr Chumakov ,  Wen Zhao ,  Alain Noncovich ,  Jane Ung

IPC: C07D231/20 ,  C07D405/06 ,  C07D403/06 ,  C07D401/06 ,  C07D239/22 ,  C07D213/50 ,  C07D409/06 ,  C07D207/333 ,  C07D333/22 ,  C07D233/78 ,  C07D235/02 ,  C07D207/32 ,  A23L2/52 ,  C07C233/31 ,  C07D207/26 ,  C07D239/62 ,  A23L33/10

CPC classification number: C07D231/20 ,  A23L2/52 ,  A23L33/10 ,  A23V2002/00 ,  C07C233/31 ,  C07C2601/04 ,  C07C2601/14 ,  C07C2601/16 ,  C07D207/26 ,  C07D207/32 ,  C07D207/333 ,  C07D213/50 ,  C07D233/78 ,  C07D235/02 ,  C07D239/22 ,  C07D239/62 ,  C07D333/22 ,  C07D401/06 ,  C07D403/06 ,  C07D405/06 ,  C07D409/06

Abstract: The present invention includes compounds useful as modulators of TRPM8, such as compounds of Formulae (Ia), (Ib) and (Ic), and the subgenus and species thereof; personal products containing those compounds; and the use of those compounds and the personal products, particularly the use of increasing or inducing chemesthetic sensations, such as cooling or cold sensations.

公开(公告)号：US09778270B2

公开(公告)日：2017-10-03

申请号：US14850598

申请日：2015-09-10

Applicant: SENOMYX, INC.

Inventor： Jon Elliot Adler

IPC: C07K14/705 ,  G01N33/74 ,  C07H21/04 ,  G01N33/566 ,  G01N33/58 ,  A61K38/00

CPC classification number: G01N33/74 ,  A01K2217/05 ,  A61K38/00 ,  C07H21/04 ,  C07K14/705 ,  C07K2319/00 ,  G01N33/566 ,  G01N33/582 ,  G01N2333/726 ,  G01N2500/00 ,  G01N2500/04

Abstract: Newly identified mammalian taste-cell-specific G Protein-Coupled Receptors and the genes encoding said receptors are described. Specifically, T2R taste G Protein-Coupled Receptors that are believed to be involved in bitter taste sensation, and the genes encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular tastant in a mammal are also described, as are methods for generating a novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes.

公开(公告)号：US09739776B2

公开(公告)日：2017-08-22

申请号：US14824936

申请日：2015-08-12

Applicant: SENOMYX, INC.

Inventor： Bryan Moyer ,  Albert Zlotnik ,  Peter Hevezi ,  Hortensia Soto ,  Dalia Kalabat ,  Min Lu ,  Na Gao ,  Evan Carl White

IPC: C12N5/071 ,  G01N33/566 ,  C12Q1/68 ,  C40B30/04 ,  C40B40/10 ,  G01N33/50 ,  G01N33/68

CPC classification number: G01N33/566 ,  C12Q1/6806 ,  C12Q1/6876 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158 ,  C40B30/04 ,  C40B40/10 ,  G01N33/5005 ,  G01N33/5044 ,  G01N33/6872 ,  G01N2333/726 ,  G01N2500/10

Abstract: This invention relates to novel rationale and methods for identifying human and primate taste-specific genes, including genes involved in salty taste perception, especially human salty taste perception, but also genes involved in sweet, bitter, umami, and sour taste perception, and genes involved in other taste cell or taste receptor related activities such as digestive function and digestive related diseases, taste cell turnover, immunoregulation of the oral and digestive tract, and metabolic regulation such as in diabetes and obesity, the genes identified using these methods, and assays for identifying taste modulators (enhancers or blockers) and potential therapeutics using these genes. These compounds have potential application in modulating (enhancing or blocking) taste perception, especially salty taste perception and as potential therapeutics. In addition, this invention relates to novel methods for identifying taste-specific genes that can be used as markers for different taste cell types, including sweet, bitter, umami, sour, salty, and other taste cells in mammals as well as assays that measure the activity of the sweet, bitter, umami, or sour receptor in the presence of these genes to identify modulators of sweet, bitter, umami, and sour taste and to identify therapeutics especially for treating digestive or metabolic disorders, taste loss, and oral infections. Particularly, the genes identified herein and antibodies or oligos thereto can be used as markers to identify and/or purify specific taste cells e.g., from taste cell suspensions by use of FACS or magnetic bead cell selection or other known cell purification and isolation procedures.

公开(公告)号：US09695162B2

公开(公告)日：2017-07-04

申请号：US15290691

申请日：2016-10-11

Applicant: SENOMYX, INC.

Inventor： Sara Adamski-Werner ,  Vincent Darmohusodo ,  Catherine Tachdjian ,  Donald Karanewsky ,  Goran Petrovic ,  Rachel Kimmich ,  Joseph R. Fotsing

IPC: C07D417/14 ,  C07D417/12 ,  C07D471/04 ,  C07D473/00 ,  C07D498/04 ,  A23L27/20 ,  A23L33/15

CPC classification number: C07D417/12 ,  A23L27/2056 ,  A23L33/15 ,  A23V2002/00 ,  C07D417/14 ,  C07D471/04 ,  C07D473/00 ,  C07D498/04

Abstract: The present invention includes compounds having structural formula (Ia): or salts or solvates thereof. These compounds are useful as sweet flavor modifiers. The present invention also includes compositions comprising the present compounds and methods of enhancing the sweet taste of compositions.

公开(公告)号：US09687015B2

公开(公告)日：2017-06-27

申请号：US15224421

申请日：2016-07-29

Applicant: Senomyx, Inc.

Inventor： Catherine Tachdjian ,  Donald Karanewsky ,  Sara Werner ,  Vincent Darmohusodo ,  Jeff Yamamoto

IPC: C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  A23L27/00 ,  A23L2/56 ,  A23L2/60 ,  A23L29/30

CPC classification number: C07D417/12 ,  A23L2/56 ,  A23L2/60 ,  A23L5/00 ,  A23L7/00 ,  A23L27/88 ,  A23L29/30 ,  A23L29/35 ,  A23V2002/00 ,  C07D417/14 ,  C07D471/04

Abstract: The present invention includes compounds having structural formula (Ia): or salts or solvates thereof. These compounds are useful as sweet flavor modifiers. The present invention also includes compositions comprising the present compounds and methods of modulating the sweet taste of compositions.

公开(公告)号：US09481722B2

公开(公告)日：2016-11-01

申请号：US13886668

申请日：2013-05-03

Applicant: SENOMYX, INC.

Inventor： Jon Elliot Adler ,  Xiaodong Li ,  Lena Luukkonen ,  Shawn O'Connell ,  Sergey Zozulya

IPC: G01N33/68 ,  C07K14/705 ,  C07K14/72 ,  G01N33/74 ,  G06F19/12 ,  C12Q1/68 ,  G01N33/50

CPC classification number: C07K14/723 ,  C07K14/705 ,  C07K2319/00 ,  C12Q1/6883 ,  G01N33/5041 ,  G01N33/6872 ,  G01N33/74 ,  G01N2333/726 ,  G06F19/12

Abstract: Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular taste stimulus in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.

公开(公告)号：US09476869B2

公开(公告)日：2016-10-25

申请号：US14338003

申请日：2014-07-22

Applicant: SENOMYX, INC.

Inventor： Jon E. Adler ,  Xiaodong Li ,  Lena Luukkonen ,  Hong Xu ,  Fernando Echeverri

IPC: G01N33/50 ,  C07K14/72 ,  G01N33/74

CPC classification number: G01N33/5041 ,  C07K14/723 ,  G01N33/5008 ,  G01N33/5023 ,  G01N33/74 ,  G01N2333/705 ,  G01N2333/726 ,  G01N2500/00

Abstract: Newly identified mammalian taste-cell-specific G protein-coupled receptors which function as hetero-oligomeric complexes in the sweet taste transduction pathway, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in sweet taste signaling as hetero-oligomeric complexes, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for identifying putative taste modulating compounds using such hetero-oligomeric complexes also described, as is a novel surface expression facilitating peptide useful for targeting integral plasma membrane proteins to the surface of a cell.

Abstract translation: 描述了在甜味转导途径中作为异寡聚复合物起作用的新鉴定的哺乳动物味细胞特异性G蛋白偶联受体，以及编码所述受体的基因和cDNA。 具体来说，描述了作为异寡聚复合物的甜味信号传导中起作用的T1R G蛋白偶联受体，以及编码相同基因和cDNA的方法，以及用于分离这些基因并分离和表达此类受体的方法。 还描述了使用这种异寡​​聚复合物鉴定推定的味觉调节化合物的方法，以及用于靶向细胞表面的整合质膜蛋白的新颖的表达表达促进肽。

公开(公告)号：US09394287B2

公开(公告)日：2016-07-19

申请号：US13883349

申请日：2011-11-04

Applicant: Chad Priest ,  Alain Noncovich ,  Andrew Patron ,  Jane Ung

Inventor： Chad Priest ,  Alain Noncovich ,  Andrew Patron ,  Jane Ung

IPC: C07D409/12 ,  C07D213/40 ,  C07D213/75 ,  C07D231/40 ,  C07D277/28 ,  C07D307/52 ,  C07D333/20 ,  C07D333/24 ,  C07D333/32 ,  C07D405/12 ,  C07D407/12 ,  C07D409/14 ,  C07D413/12 ,  C07D471/04 ,  A61K8/42 ,  A61K8/69 ,  A61K8/49 ,  C07C233/11 ,  C07C235/20 ,  C07C235/24 ,  C07C235/34 ,  C07D417/12 ,  A61Q19/00 ,  A01N43/10 ,  A01N43/40 ,  A01N43/56 ,  A01N43/60 ,  A01N43/76 ,  A01N43/80 ,  A01N43/90 ,  A23L1/22 ,  A61Q1/02 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q9/02 ,  A61Q11/00 ,  A61Q15/00 ,  A61Q17/02 ,  A61Q17/04 ,  A61Q19/10

CPC classification number: A61K31/497 ,  A01N37/18 ,  A01N43/10 ,  A01N43/40 ,  A01N43/56 ,  A01N43/60 ,  A01N43/76 ,  A01N43/78 ,  A01N43/80 ,  A01N43/90 ,  A23L27/88 ,  A23L33/10 ,  A23V2002/00 ,  A61K8/42 ,  A61K8/49 ,  A61K8/4926 ,  A61K8/494 ,  A61K8/4973 ,  A61K8/4986 ,  A61K8/69 ,  A61K31/165 ,  A61K31/381 ,  A61K31/415 ,  A61K31/4155 ,  A61K31/422 ,  A61K31/426 ,  A61K31/437 ,  A61K31/4409 ,  A61K31/4436 ,  A61K2800/10 ,  A61K2800/40 ,  A61Q1/02 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q9/02 ,  A61Q11/00 ,  A61Q15/00 ,  A61Q17/02 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/001 ,  A61Q19/10 ,  C07C233/11 ,  C07C235/20 ,  C07C235/24 ,  C07C235/34 ,  C07C2601/14 ,  C07D213/40 ,  C07D213/75 ,  C07D231/40 ,  C07D277/28 ,  C07D307/52 ,  C07D333/20 ,  C07D333/24 ,  C07D333/32 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04

Abstract: The present invention includes compounds useful as modulators of TRPM8, such as compounds of Formula (I) and the subgenus and species thereof; personal products containing those compounds; and the use of those compounds and the personal products, particularly the use of increasing or inducing chemesthetic sensations, such as cooling or cold sensations.

Abstract translation: 本发明包括可用作TRPM8的调节剂的化合物，例如式（I）的化合物及其亚属及其种类; 含有这些化合物的个人产品; 以及这些化合物和个人产品的使用，特别是使用增加或诱导化学感觉，例如冷却或冷感觉。