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公开(公告)号：US20160339026A1
公开(公告)日：2016-11-24
申请号：US14874258
申请日：2015-10-02
申请人： Senomyx, Inc.
发明人： Alain Noncovich , Jane Ung , Timothy Davis , Joseph R. Fotsing , Rachel D.A. Kimmich , Chad Priest , Donald S. Karanewsky , Lyudmyla Chumakova , Andrew Patron , Paul Brust , Guy Servant
IPC分类号： A61K31/515 , A61K31/4155 , A61K31/4152 , A61K31/4406 , A61K31/513 , A61K31/4166 , A61K31/165 , A61K9/00 , A61K31/4439
CPC分类号： A61K31/515 , A61K8/49 , A61K8/4913 , A61K8/4926 , A61K8/494 , A61K8/4953 , A61K8/4986 , A61K9/0014 , A61K31/165 , A61K31/381 , A61K31/40 , A61K31/4152 , A61K31/4162 , A61K31/4166 , A61K31/4245 , A61K31/427 , A61K31/4439 , A61K31/513 , A61K2800/244 , A61Q19/00
摘要： The present disclosure relates to topical compositions comprising one or more compounds which are cooling agents.
摘要翻译： 本公开涉及包含一种或多种作为冷却剂的化合物的局部组合物。
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公开(公告)号：US20160251372A1
公开(公告)日：2016-09-01
申请号：US15059142
申请日：2016-03-02
申请人： SENOMYX, INC.
发明人： Catherine Tachdjian , Xiao Qing Tang , Donald S. Karanewsky , Guy Servant , Xiaodong Li , Feng Zhang , Qing Chen , Hong Zhang , Timothy Davis , Vincent Darmohusodo , Melissa Wong , Victor Selchau
IPC分类号： C07D495/04 , A61K47/22 , A23L2/56 , C07D401/12 , C07D405/12 , C07D215/54 , C07D471/04
CPC分类号： C07D495/04 , A23L2/56 , A23L27/2054 , A23L27/88 , A23V2002/00 , A61K47/22 , C07D215/54 , C07D215/60 , C07D401/12 , C07D405/12 , C07D471/04 , C07D491/048
摘要： The present invention includes compounds having structural formula (I), or pharmaceutically acceptable salts, solvate, and/or ester thereof. These compounds are useful as sweet flavor modifiers. The present invention also includes compositions comprising the present compounds and methods of enhancing the sweet taste of ingestible compositions. Furthermore, the present invention provides methods for preparing the compounds.
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公开(公告)号：US20150265711A1
公开(公告)日：2015-09-24
申请号：US14731224
申请日：2015-06-04
申请人： SENOMYX, INC.
发明人： Catherine Tachdjian , Xiao Qing Tang , Donald S. Karanewsky , Guy Servant , Xiaodong Li , Feng Zhang , Qing Chen , Hong Zhang , Timothy Davis , Vincent Darmohusodo , Melissa Wong , Victor Selchau
CPC分类号： C07D495/04 , A23L2/56 , A23L27/2054 , A23L27/88 , A23V2002/00 , A61K47/22 , C07D215/54 , C07D215/60 , C07D401/12 , C07D405/12 , C07D471/04 , C07D491/048
摘要： The present invention includes compounds having structural formula (I), or pharmaceutically acceptable salts, solvate, and/or ester thereof. These compounds are useful as sweet flavor modifiers. The present invention also includes compositions comprising the present compounds and methods of enhancing the sweet taste of ingestible compositions. Furthermore, the present invention provides methods for preparing the compounds.
摘要翻译： 本发明包括具有结构式（I）的化合物或其药学上可接受的盐，溶剂化物和/或酯。 这些化合物可用作甜味调味剂。 本发明还包括包含本发明化合物的组合物和增强可摄入组合物的甜味的方法。 此外，本发明提供了制备化合物的方法。
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公开(公告)号：US10087154B2
公开(公告)日：2018-10-02
申请号：US15664179
申请日：2017-07-31
申请人： Senomyx, Inc.
发明人： Catherine Tachdjian , Donald S. Karanewsky , Xiao-Qing Tang , Qing Chen , Peter Leeming , Tayyab Rashid , Daniel Levin
IPC分类号： C07D285/16 , C07C303/40 , C07C255/57 , C07C253/30 , C07C231/14 , C07C231/02 , C01B21/096 , C07C307/10 , C07C255/59 , C07C255/54 , C07C237/44 , C07C235/20
摘要： The present invention includes methods/processes and intermediates for preparing compounds having structural Formula (I): wherein X is alkyl, substituted alkyl, alkenyl, substituted alkenyl, heteroalkyl, substituted heteroalkyl, heteroalkenyl, or substituted heteroalkenyl.
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公开(公告)号：US20180086751A1
公开(公告)日：2018-03-29
申请号：US15829568
申请日：2017-12-01
申请人： Senomyx, Inc.
IPC分类号： C07D417/12 , C07D285/16 , A61K31/549 , A23L27/00 , A23L27/30 , A23L2/60
CPC分类号： C07D417/12 , A23L2/60 , A23L27/30 , A23L27/88 , A61K31/549 , C07D285/16 , C12G3/06
摘要： Formulations comprising one or more sweetener and one or more flavor modifying compound are provided herein, wherein the formulation is provided for use in ingestible products, such as food or beverage products or pharmaceutical, or for use in non-comestible products, such as cosmetic or hygienic products. The formulations include combinations of any one or more sweetener in combination with any one or more flavor modifying compound described or referenced herein.
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6.发明授权Identification of human T2R receptors that respond to bitter compounds that elicit the bitter taste in compositions, and the use thereof in assays to identify compounds that inhibit (block) bitter taste in compositions and use thereof 有权识别在组合物中引起苦味的苦味化合物响应的人T2R受体，以及其在测定中用于鉴定组合物中抑制（阻断）苦味的化合物及其用途的用途公开(公告)号：US09247759B2
公开(公告)日：2016-02-02
申请号：US13896913
申请日：2013-05-17
申请人： SENOMYX, INC.
IPC分类号： C07D261/06 , C07D413/14 , A61K31/44 , A61K31/42 , A23L1/22 , A23L1/226 , A61K31/135 , A61K31/4439 , A61K31/485 , A61K31/60 , A61K31/704 , A61K45/06 , A23F5/46
CPC分类号： A23L1/22083 , A23F5/465 , A23L27/2056 , A23L27/86 , A61K31/135 , A61K31/4439 , A61K31/485 , A61K31/60 , A61K31/704 , A61K45/06 , A61K2300/00
摘要： The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds present in, e.g., coffee. Also, the invention relates to the discovery of specific compounds and compositions containing that function as bitter taste blockers and the use thereof as bitter taste blockers or flavor modulators in, e.g., coffee and coffee flavored foods, beverages and medicaments. Also, the present invention relates to the discovery of a compound that antagonizes numerous different human T2Rs and the use thereof in assays and as a bitter taste blocker in compositions for ingestion by humans and animals.
摘要翻译： 本发明涉及T2R味觉受体家族中的特定人味受体对存在于例如咖啡中的特定苦味化合物的反应的发现。 此外，本发明涉及含有作为苦味抑制剂的特定化合物和组合物的发现，以及其作为例如咖啡和咖啡风味食品，饮料和药物中的苦味抑制剂或风味调节剂的用途。 此外，本发明涉及一种拮抗多种不同人类T2R的化合物的发现及其在测定中的用途以及用于摄取人类和动物的组合物中的苦味阻滞剂。
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公开(公告)号：US10308621B2
公开(公告)日：2019-06-04
申请号：US16119380
申请日：2018-08-31
申请人： Senomyx, Inc.
发明人： Catherine Tachdjian , Donald S. Karanewsky , Xiao-Qing Tang , Qing Chen , Peter Leeming , Tayyab Rashid , Daniel Levin
IPC分类号： C07D285/16 , C01B21/096 , C07C235/20 , C07C237/44 , C07C255/54 , C07C255/59 , C07C307/10 , C07C231/02 , C07C231/14 , C07C253/30 , C07C255/57 , C07C303/40
摘要： The present invention includes methods/processes and intermediates for preparing sulfamoyl chloride:
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公开(公告)号：US09834544B2
公开(公告)日：2017-12-05
申请号：US14337764
申请日：2014-07-22
申请人： SENOMYX, INC.
发明人： Catherine Tachdjian , Xiao Qing Tang , Donald S. Karanewsky , Guy Servant , Xiaodong Li , Feng Zhang , Qing Chen , Hong Zhang , Timothy James Davis , Vincent Darmohusodo , Melissa S. Wong , Victor Selchau
IPC分类号： C07D405/12 , A23L2/60 , C07D401/12 , C07D215/54 , C07D451/06 , A61K47/22 , C07D215/42 , A23L27/00
CPC分类号： C07D405/12 , A23L2/60 , A23L27/88 , A23V2002/00 , A61K47/22 , C07D215/42 , C07D215/54 , C07D401/12 , C07D451/06
摘要： The present invention includes compounds having structural formula (I), or salts or solvates thereof. These compounds are useful as sweet flavor modifiers. The present invention also includes compositions comprising the present compounds and methods of enhancing the sweet taste of compositions.
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公开(公告)号：US20170327479A1
公开(公告)日：2017-11-16
申请号：US15664179
申请日：2017-07-31
申请人： Senomyx, Inc.
发明人： Catherine Tachdjian , Donald S. Karanewsky , Xiao-Qing Tang , Qing Chen , Peter Leeming , Tayyab Rashid , Daniel Levin
IPC分类号： C07D285/16 , C07C303/40 , C07C255/59 , C07C255/57 , C07C253/30 , C01B21/096 , C07C237/44 , C07C235/20 , C07C231/14 , C07C231/02 , C07C307/10 , C07C255/54
CPC分类号： C07D285/16 , C01B21/096 , C07C231/02 , C07C231/14 , C07C235/20 , C07C237/44 , C07C253/30 , C07C255/54 , C07C255/57 , C07C255/59 , C07C303/40 , C07C307/10
摘要： The present invention includes methods/processes and intermediates for preparing compounds having structural Formula (I): wherein X is alkyl, substituted alkyl, alkenyl, substituted alkenyl, heteroalkyl, substituted heteroalkyl, heteroalkenyl, or substituted heteroalkenyl.
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公开(公告)号：US20170105432A1
公开(公告)日：2017-04-20
申请号：US14885770
申请日：2015-10-16
申请人： Senomyx, Inc.
CPC分类号： A61K9/0053 , A23L2/56 , A23L2/60 , A23L27/2054 , A23L27/2056 , A23L27/30 , A23L27/88
摘要： Formulations comprising one or more sweetener and one or more flavor modifying compound are provided herein, wherein the formulation is provided for use in ingestible products, such as food or beverage products or pharmaceutical, or for use in non-comestible products, such as cosmetic or hygienic products.
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