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    METHOD FOR CULTURING CELLS OR MICROORGANISMS
    1.
    发明申请
    METHOD FOR CULTURING CELLS OR MICROORGANISMS 审中-公开
    培养细胞或微生物的方法

    公开(公告)号：US20120244602A1

    公开(公告)日：2012-09-27

    申请号：US13485085

    申请日：2012-05-31

    申请人： Taisei OKUMURA ,  Mamoru NUMATA ,  Shuzo KOJIMA ,  Yasuhisa NAGATA ,  Naoki TAHARA ,  Hiroyuki KUROKI ,  Masato KUKIZAKI ,  Tomohiro TANAKA

    发明人： Taisei OKUMURA ,  Mamoru NUMATA ,  Shuzo KOJIMA ,  Yasuhisa NAGATA ,  Naoki TAHARA ,  Hiroyuki KUROKI ,  Masato KUKIZAKI ,  Tomohiro TANAKA

    IPC分类号： C12N1/20 ,  C12M1/04 ,  C12N1/12 ,  C12N1/16 ,  C12N1/14

    CPC分类号： C12N1/20 ,  B01F3/0412 ,  B01F3/04262 ,  B01F7/00383 ,  B01F7/1625

    摘要： A method for culturing cells or microorganisms by dissolving oxygen or carbon dioxide in a culture solution containing a nutrient including: supplying gas containing oxygen or carbon dioxide into inside of a glass porous body being configured to have cylindrical shape and a large number of uniformly fine pores in the outer surface and being configured to seal the end of the glass porous body; generating bubbles that have a 50% diameter of 200 μm or less in a volume-based particle size distribution from the outer surface of the porous body by using gas containing oxygen or carbon dioxide that is supplied from an unsealed end of the glass porous body; suppressing aggregation of the bubbles by at least one of a cell-protecting agent for protecting the cells and a protein hydrolysate included in the culture solution; and dissolving oxygen or carbon dioxide in the culture solution.

    摘要翻译： 一种通过将氧或二氧化碳溶解在含有营养物的培养液中培养细胞或微生物的方法，包括：将含有氧或二氧化碳的气体供给到玻璃多孔体的内部，该玻璃多孔体被构造成具有圆筒形状和大量均匀的细孔 在外表面上并被构造成密封玻璃多孔体的端部; 通过使用从玻璃多孔体的未密封端供给的含有氧气或二氧化碳的气体，从多孔体的外表面产生体积型粒径分布中的直径为200μm以下的直径为200μm以下的气泡; 通过保护细胞的细胞保护剂和培养液中包含的蛋白质水解物中的至少一种来抑制气泡的聚集; 并将氧或二氧化碳溶解在培养液中。

    Method for producing monodisperse bubbles
    2.
    发明授权
    Method for producing monodisperse bubbles 有权
    生产单分散泡沫的方法

    公开(公告)号：US07591452B2

    公开(公告)日：2009-09-22

    申请号：US10572375

    申请日：2004-12-13

    申请人： Yasuaki Kohama ,  Masato Kukizaki ,  Tadao Nakashima

    发明人： Yasuaki Kohama ,  Masato Kukizaki ,  Tadao Nakashima

    IPC分类号： B01F3/04

    CPC分类号： B01F3/04262 ,  Y10S261/26

    摘要： The invention provides a method for producing bubbles that exhibit an excellent monodispersity. The invention relates to a method for generating bubbles by the injection and dispersion of a gas through a porous body into a liquid, wherein the value produced by dividing the pore diameter that accounts for 10% of the total pore volume in the relative cumulative pore distribution curve of the porous body by the pore diameter that accounts for 90% of the total pore volume in the relative cumulative pore dismeter distribution curve of the porous body is 1 to 1.5.

    摘要翻译： 本发明提供一种表现出优异的单分散性的生产气泡的方法。 本发明涉及一种通过将气体通过多孔体注入和分散到液体中来产生气泡的方法，其中通过将占总孔体积的10％的孔径除以相对累积孔分布产生的值 多孔体的相对累积孔隙度分布曲线中孔体积的总孔隙体积的90％的多孔体的曲线为1〜1.5。

    Method of forming monodisperse bubble
    3.
    发明申请
    Method of forming monodisperse bubble 有权
    形成单分散泡沫的方法

    公开(公告)号：US20060284325A1

    公开(公告)日：2006-12-21

    申请号：US10572375

    申请日：2004-12-13

    申请人： Yasuaki Kohama ,  Masato Kukizaki ,  Tadao Nakashima

    发明人： Yasuaki Kohama ,  Masato Kukizaki ,  Tadao Nakashima

    IPC分类号： B01F3/04

    CPC分类号： B01F3/04262 ,  Y10S261/26

    摘要： The invention provides a method for producing bubbles that exhibit an excellent monodispersity. The invention relates to a method for generating bubbles by the injection and dispersion of a gas through a porous body into a liquid, wherein the value produced by dividing the pore diameter that accounts for 10% of the total pore volume in the relative cumulative pore distribution curve of the porous body by the pore diameter that accounts for 90% of the total pore volume in the relative cumulative pore dismeter distribution curve of the porous body is 1 to 1.5.

    摘要翻译： 本发明提供一种表现出优异的单分散性的生产气泡的方法。 本发明涉及一种通过将气体通过多孔体注入和分散到液体中来产生气泡的方法，其中通过将占总孔体积的10％的孔径除以相对累积孔分布产生的值 多孔体的相对累积孔隙度分布曲线中孔体积的总孔隙体积的90％的多孔体的曲线为1〜1.5。

    Phosphorylation-inhibiting agent or dephosphorylating agent for PTEN
    5.
    发明授权
    Phosphorylation-inhibiting agent or dephosphorylating agent for PTEN 有权
    PTEN的磷酸化抑制剂或去磷酸化剂

    公开(公告)号：US09023343B2

    公开(公告)日：2015-05-05

    申请号：US13263876

    申请日：2010-03-26

    申请人： Kazuhiro Morishita ,  Shingo Nakahata ,  Makoto Hamasaki

    发明人： Kazuhiro Morishita ,  Shingo Nakahata ,  Makoto Hamasaki

    IPC分类号： A61K38/46 ,  C12N15/00 ,  G01N33/53 ,  C12Q1/48 ,  A61K31/223 ,  A61K31/7088 ,  C07K16/40 ,  C07K16/44 ,  C12N9/12 ,  C12N9/18 ,  A61K48/00

    CPC分类号： C12Q1/485 ,  A61K31/223 ,  A61K31/7088 ,  A61K48/005 ,  C07K16/40 ,  C07K16/44 ,  C07K2317/34 ,  C12N9/12 ,  C12N9/18 ,  G01N2500/00 ,  A61K2300/00

    摘要： Provided is a preventive, progression inhibitor or remedy for a disease one of the causes of which is the activation of the P13K/AKT signaling pathway or vice versa. A phosphorylation-inhibiting and/or dephosphorylating agent, which has an effect of inhibiting the phosphorylation at least at one of the phosphorylation sites of PTEN protein selected from the group consisting of T382, T383 and S380 and/or an effect of dephosphorylating the same, is prepared. Alternatively, a phosphorylation-inhibiting or dephosphorylating agent for PTEN is screened by a method comprising a step for confirming an ability of a test substance to inhibit the phosphorylation at least at one of the phosphorylation sites of PTEN protein selected from the group consisting of T382, T383 and S380 or a dephosphorylation ability thereof. Then, a substance having an effect opposite to the inhibition of PTEN phosphorylation or dephosphorylation thereof, e.g., an antibody against the phosphorylation-inhibiting or dephosphorylating agent for PTEN obtained above, is also obtained.

    摘要翻译： 提供预防性，进展抑制剂或疾病的补救方法，其原因之一是激活P13K / AKT信号传导途径，反之亦然。 一种磷酸化抑制剂和/或去磷酸化剂，其至少在选自T382，T383和S380的PTEN蛋白的磷酸化位点之一处抑制磷酸化和/或使其去磷酸化的作用， 准备好了 或者，通过包括以下方法筛选用于PTEN的磷酸化抑制剂或去磷酸化剂，所述方法包括用于确认测试物质至少在PTEN蛋白的一个磷酸化位点抑制磷酸化的能力的步骤，所述磷酸化位点选自T382， T383和S380或其去磷酸化能力。 然后，也可获得具有与抑制PTEN磷酸化或其去磷酸化作用相反的作用的物质，例如针对上述获得的PTEN的磷酸化抑制或去磷酸化剂的抗体。

    Agent for inhibiting production of hepatitis C virus and its use
    6.
    发明授权
    Agent for inhibiting production of hepatitis C virus and its use 有权
    用于抑制丙型肝炎病毒生产的药剂及其用途

    公开(公告)号：US08846751B2

    公开(公告)日：2014-09-30

    申请号：US13204219

    申请日：2011-08-05

    申请人： Masahiko Takeshita ,  Hirohito Tsubouchi ,  Hirofumi Uto ,  Hiroaki Kataoka ,  Takanori Kai ,  Hideaki Hirabaru ,  Miho Sakai ,  Ena Akamatsu

    发明人： Masahiko Takeshita ,  Hirohito Tsubouchi ,  Hirofumi Uto ,  Hiroaki Kataoka ,  Takanori Kai ,  Hideaki Hirabaru ,  Miho Sakai ,  Ena Akamatsu

    IPC分类号： A01N43/16 ,  C07D311/62 ,  A61K31/74 ,  A61K36/45

    CPC分类号： A61K31/74 ,  A61K36/45 ,  C07D311/62

    摘要： This invention provides an agent for inhibiting production of hepatitis C virus with notable anti-HCV activity and without side-effects. The agent comprises a proanthocyanidin polymer composition illustrated in the following the general formula (1), wherein R1 is hydrogen or hydroxyl, R2 is hydroxyl, R3 is hydrogen when R1 is either hydrogen or hydroxyl, but R3 is possibly hydroxyl when R1 is either hydrogen or hydroxyl to the extent that both R1 and R3 being hydroxyl is at most 40 percents in the proanthocyanidin polymer composition said units of flavan-3-ol being bonded each other in any one of three patterns as follows; (i) a bond between carbon at the position 4 and carbon at the position 8, (ii) a bond between carbon at the position 4 and carbon at the position 6, (iii) a bond between carbon at the position 4 and carbon at the position 8, and between carbon, at the position 2 and oxygen at the position 7.

    摘要翻译： 本发明提供用于抑制具有显着的抗HCV活性并且没有副作用的丙型肝炎病毒生产的药剂。 该试剂包含如下通式（1）所示的原花青素聚合物组合物，其中R 1为氢或羟基，R 2为羟基，R 3为氢时，R 1为氢或羟基，但当R 1为氢时，R 3为羟基 或羟基，其中R 1和R 3为羟基在原花色素聚合物组合物中至多为40％的程度，所述黄烷-3-醇单元以如下三种模式中的任一种彼此结合; （i）位置4的碳和位置8的碳之间的键，（ii）位置4的碳与位置6的碳之间的键;（iii）位置4的碳与碳之间的键 位置8，碳之间，位置2和位置7处的氧。

    AGENT FOR INHIBITING PRODUCTION OF HEPATITIS C VIRUS AND ITS USE
    7.
    发明申请
    AGENT FOR INHIBITING PRODUCTION OF HEPATITIS C VIRUS AND ITS USE 审中-公开
    禁止生产乙型肝炎病毒及其使用的药剂

    公开(公告)号：US20100055065A1

    公开(公告)日：2010-03-04

    申请号：US12546281

    申请日：2009-08-24

    申请人： Masahiko TAKESHITA ,  Hirohito TSUBOUCHI ,  Hirofumi UTO ,  Hiroaki KATAOKA ,  Takanori KAI ,  Hideaki HIRABARU ,  Miho SAKAI ,  Ena AKAMATSU

    发明人： Masahiko TAKESHITA ,  Hirohito TSUBOUCHI ,  Hirofumi UTO ,  Hiroaki KATAOKA ,  Takanori KAI ,  Hideaki HIRABARU ,  Miho SAKAI ,  Ena AKAMATSU

    IPC分类号： A61K31/74

    CPC分类号： A61K31/74 ,  A61K36/45 ,  C07D311/62

    摘要： This invention provides an agent for inhibiting production of hepatitis C virus with notable anti-HCV activity and without side-effects. The agent comprises a proanthocyanidin polymer composition illustrated in the following the general formula (1), wherein R1 is hydrogen or hydroxyl, R2 is hydroxyl, R3 is hydrogen when R1 is either hydrogen or hydroxyl, but R3 is possibly hydroxyl when R1 is either hydrogen or hydroxyl to the extent that both R1 and R3 being hydroxyl is at most 40 percents in the proanthocyanidin polymer composition said units of flavan-3-ol being bonded each other in any one of three patterns as follows; (i) a bond between carbon at the position 4 and carbon at the position 8, (ii) a bond between carbon at the position 4 and carbon at the position 6, (iii) a bond between carbon at the position 4 and carbon at the position 8, and between carbon at the position 2 and oxygen at the position 7.

    摘要翻译： 本发明提供用于抑制具有显着的抗HCV活性并且没有副作用的丙型肝炎病毒生产的药剂。 该试剂包含如下通式（1）所示的原花青素聚合物组合物，其中R 1为氢或羟基，R 2为羟基，R 3为氢时，R 1为氢或羟基，但当R 1为氢时，R 3为羟基 或羟基，其中R 1和R 3为羟基在原花色素聚合物组合物中至多为40％的程度，所述黄烷-3-醇单元以如下三种模式中的任一种彼此结合; （i）位置4的碳和位置8的碳之间的键，（ii）位置4的碳与位置6的碳之间的键;（iii）位置4的碳与碳之间的键 位置8，位置2的碳和位置7的氧之间。

    ANALYSIS ASSISTANCE DEVICE, ANALYSIS ASSISTANCE METHOD, NON-TRANSITORY COMPUTER READABLE MEDIUM STORING ANALYSIS ASSISTANCE PROGRAM AND ANALYSIS SYSTEM
    10.
    发明申请
    ANALYSIS ASSISTANCE DEVICE, ANALYSIS ASSISTANCE METHOD, NON-TRANSITORY COMPUTER READABLE MEDIUM STORING ANALYSIS ASSISTANCE PROGRAM AND ANALYSIS SYSTEM 有权

    公开(公告)号：US20220026403A1

    公开(公告)日：2022-01-27

    申请号：US17380532

    申请日：2021-07-20

    申请人： SHIMADZU CORPORATION ,  MIYAZAKI PREFECTURE ,  KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION

    发明人： Yuka FUJITO ,  Miho SAKAI ,  Takeshi BAMBA

    IPC分类号： G01N30/32 ,  G01N30/88

    摘要： A supercritical fluid chromatograph includes a liquid sender that supplies a mobile phase including a supercritical fluid to a supply flow path, first and second back pressure regulators that are respectively provided in first and second flow paths into which a path from the liquid sender branches and an analysis column provided at a position farther upstream than the first back pressure regulator in the first flow path. An analysis assistance device that assists determination of an analysis condition of the supercritical fluid chromatograph includes a storage that stores a relationship between a sample introduction ratio representing a ratio of an amount of a sample to be introduced into the first flow path with respect to an amount of a sample to be introduced into the second flow path, and a differential pressure between the first and second back pressure regulators as a first relationship, a receiver that receives one value of a value of the sample introduction ratio and a value of the differential pressure, a first calculator that calculates the other value of the sample introduction ratio and the differential pressure from the one received value based on the first relationship and a presenter that presents the calculated value.