公开(公告)号：US08846751B2

公开(公告)日：2014-09-30

申请号：US13204219

申请日：2011-08-05

申请人： Masahiko Takeshita ,  Hirohito Tsubouchi ,  Hirofumi Uto ,  Hiroaki Kataoka ,  Takanori Kai ,  Hideaki Hirabaru ,  Miho Sakai ,  Ena Akamatsu

发明人： Masahiko Takeshita ,  Hirohito Tsubouchi ,  Hirofumi Uto ,  Hiroaki Kataoka ,  Takanori Kai ,  Hideaki Hirabaru ,  Miho Sakai ,  Ena Akamatsu

IPC分类号： A01N43/16 ,  C07D311/62 ,  A61K31/74 ,  A61K36/45

CPC分类号： A61K31/74 ,  A61K36/45 ,  C07D311/62

摘要： This invention provides an agent for inhibiting production of hepatitis C virus with notable anti-HCV activity and without side-effects. The agent comprises a proanthocyanidin polymer composition illustrated in the following the general formula (1), wherein R1 is hydrogen or hydroxyl, R2 is hydroxyl, R3 is hydrogen when R1 is either hydrogen or hydroxyl, but R3 is possibly hydroxyl when R1 is either hydrogen or hydroxyl to the extent that both R1 and R3 being hydroxyl is at most 40 percents in the proanthocyanidin polymer composition said units of flavan-3-ol being bonded each other in any one of three patterns as follows; (i) a bond between carbon at the position 4 and carbon at the position 8, (ii) a bond between carbon at the position 4 and carbon at the position 6, (iii) a bond between carbon at the position 4 and carbon at the position 8, and between carbon, at the position 2 and oxygen at the position 7.

摘要翻译： 本发明提供用于抑制具有显着的抗HCV活性并且没有副作用的丙型肝炎病毒生产的药剂。 该试剂包含如下通式（1）所示的原花青素聚合物组合物，其中R 1为氢或羟基，R 2为羟基，R 3为氢时，R 1为氢或羟基，但当R 1为氢时，R 3为羟基 或羟基，其中R 1和R 3为羟基在原花色素聚合物组合物中至多为40％的程度，所述黄烷-3-醇单元以如下三种模式中的任一种彼此结合; （i）位置4的碳和位置8的碳之间的键，（ii）位置4的碳与位置6的碳之间的键;（iii）位置4的碳与碳之间的键 位置8，碳之间，位置2和位置7处的氧。