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公开(公告)号：US20160126079A1
公开(公告)日：2016-05-05
申请号：US14897690
申请日：2014-06-11
发明人： Mikko Sipilä , Heikki Junninen , Douglas Worsnop
CPC分类号： H01J49/145 , G01N27/622 , H01J49/0077 , H01J49/12 , H01J49/26
摘要： A device for ionizing sample particles of a sample gas flow comprises a first flow tube for providing the sample gas flow, and an introducing means for providing H2SO4 molecules to an interaction region. In addition the device comprises a generator for producing reagent primary ions from particles of candidate reagent gas flow essentially in a primary ion production region. The device is configured to introduce said reagent primary ions with H2SO4 molecules in said interaction region in order to arrange interaction between the reagent primary ions and the H2SO4 molecules, thereby producing HSO4− ions and again to produce HSO4− ion clusters comprising HSO4− ions and at least two H2SO4 molecules via interactions of HSO4− with other H2SO4 molecules in said interaction region. Furthermore the device is configured to introduce said HSO4− ion clusters with the sample particles of the sample gas flow in order to provide reactions between said HSO4− ion clusters and the sample particles, and thereby provide a sample cluster comprising the HSO4− ion clusters and said base sample to be determined.
摘要翻译： 用于离子化样品气流的样品颗粒的装置包括用于提供样品气体流的第一流管和用于向相互作用区域提供H 2 SO 4分子的引入装置。 此外，该装置包括用于从基本上在一次离子产生区域中的候选反应物气体流的颗粒产生试剂初级离子的发生器。 该装置被配置为在所述相互作用区域中引入所述试剂初级离子与H 2 SO 4分子，以便布置试剂初级离子和H 2 SO 4分子之间的相互作用，由此产生HSO 4 - 离子，并再次产生包含HSO 4 - 离子的HSO 4 - 离子簇， 通过HSO4-与所述相互作用区域中的其它H 2 SO 4分子的相互作用，至少两个H 2 SO 4分子。 此外，该装置被配置为将所述HSO 4离子簇与样品气体流的样品颗粒引入，以便提供所述HSO 4离子簇和样品颗粒之间的反应，从而提供包含HSO 4离子簇的样品簇和 表示要测定的基础样品。
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公开(公告)号：US09263223B2
公开(公告)日：2016-02-16
申请号：US13870166
申请日：2013-04-25
申请人： Bruker Daltonik GmbH
发明人： Michael Duerr , Christoph Gebhardt
CPC分类号： H01J27/026 , H01J49/0481 , H01J49/142
摘要： The invention relates to devices and methods in mass spectrometers for the generation of ions of heavy molecules, especially biomolecules, by bombarding them with uncharged clusters of molecules. The analyte ions which are generated or released by cluster bombardment of analyte substances on the surface of sample support plates show a broad distribution of their kinetic energies, which prevents good ion-optical focusing. In the invention, the kinetic energies are homogenized in a higher-density collision gas. The collision gas is preferably located in an RF ion guide, more preferably an RF ion funnel, which can transfer the ions to the mass analyzer. The collision gas may be introduced with temporal pulsing, coordinated or synchronized with the pulsed supersonic gas jet. The collision gas may be pumped off again before the next supersonic gas pulse. In an advantageous embodiment, the collision gas can originate from the supersonic gas jet itself.
摘要翻译： 本发明涉及用于通过用不带电荷的分子团轰击它们来产生重分子，特别是生物分子的离子的质谱仪中的装置和方法。 通过在样品支撑板表面上的分析物质的聚集轰击产生或释放的分析物离子显示出其动能的广泛分布，这阻止了良好的离子光学聚焦。 在本发明中，动能在较高密度的碰撞气体中均质化。 碰撞气体优选位于RF离子导向件中，更优选地位于可以将离子转移到质量分析器的RF离子漏斗中。 碰撞气体可以与脉冲超音速气体射流一起引入时间脉冲，协调或同步。 碰撞气体可能在下一个超音速气体脉冲之前被再次泵出。 在有利的实施例中，碰撞气体可以源于超音速气体射流本身。
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83.发明授权Anion generating and electron capture dissociation apparatus using cold electrons 有权阴离子产生和电子捕获离解装置使用冷电子公开(公告)号：US09230791B2
公开(公告)日：2016-01-05
申请号：US14358809
申请日：2011-11-28
申请人： Hyun Sik Kim , Seung Young Kim , Mo Yang
发明人： Hyun Sik Kim , Seung Young Kim , Mo Yang
IPC分类号： H01J49/08 , H01J49/10 , H01J43/04 , H01J49/00 , H01J49/42 , H01J27/02 , H01J49/14 , H01J43/24 , H01J49/38
CPC分类号： H01J49/08 , H01J27/028 , H01J43/04 , H01J43/246 , H01J49/0045 , H01J49/0054 , H01J49/10 , H01J49/147 , H01J49/38 , H01J49/426
摘要： An anion generating and electron capture dissociation apparatus using cold electrons, which comprises a cold electron generation module configured to generate a large quantity of cold electrons from ultraviolet photons radiated into a mass spectrometer vacuum chamber which is in a high vacuum state has a plurality of ultraviolet diodes configured to emit the ultraviolet photons in the mass spectrometer vacuum chamber. Micro-channel plate (MCP) electron multiplier plates induce and amplify initial electron emissions of the ultraviolet photons from the ultraviolet diodes, and generate a large quantity of electron beams from a rear plate. An electron focusing lens is configured to focus the electron beams amplified through the MCP electron multiplier plates. A grid is configured to adjust energy and an electric current of the electron beams together with the electron focusing lens.
摘要翻译： 使用冷电子的阴离子产生和电子捕获解离装置，其包括被配置为从辐射到处于高真空状态的质谱仪真空室的紫外光子产生大量冷电子的冷电子发生模块，具有多个紫外线 配置为在质谱仪真空室中发射紫外光子的二极管。 微通道板（MCP）电子倍增板诱导和放大来自紫外二极管的紫外光子的初始电子发射，并从背板产生大量的电子束。 电子聚焦透镜被配置为聚焦通过MCP电子倍增器板放大的电子束。 栅格被配置为与电子聚焦透镜一起调节电子束的能量和电流。
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公开(公告)号：US09230789B2
公开(公告)日：2016-01-05
申请号：US12931272
申请日：2011-01-27
申请人： Alexander Laue , Albrecht Glasmachers , Christian Hendrich , Dirk Preikszas , Michel Aliman , Hubert Mantz , Ulrike Zeile , Holger Dömer
发明人： Alexander Laue , Albrecht Glasmachers , Christian Hendrich , Dirk Preikszas , Michel Aliman , Hubert Mantz , Ulrike Zeile , Holger Dömer
CPC分类号： H01J49/065 , H01J49/067 , H01J49/068 , H01J49/14 , H01J49/4225 , H01J49/4235
摘要： An apparatus for focusing and for storage of ions and an apparatus for separation of a first pressure area from a second pressure area are disclosed, in particular for an analysis apparatus for ions. A particle beam device may have at least one of the abovementioned apparatuses. A container for holding ions and at least one multipole unit are provided. The multipole unit has a through-opening with a longitudinal axis as well as a multiplicity of electrodes. A first set of the electrodes is at a first radial distance from the longitudinal axis. A second set of the electrodes is in each case at a second radial distance from the longitudinal axis. The first radial distance is less than the second radial distance. Alternatively or additionally, the apparatus may have an elongated opening with a radial extent. The opening has a longitudinal extent which is greater than the radial extent.
摘要翻译： 公开了一种用于聚焦和存储离子的装置和用于将第一压力区域与第二压力区域分离的装置，特别是用于离子分析装置。 粒子束装置可以具有上述装置中的至少一个。 提供了用于保持离子和至少一个多极单元的容器。 多极单元具有纵向轴线的通孔以及多个电极。 第一组电极处于距纵向轴线的第一径向距离处。 在每种情况下，第二组电极距离纵向轴线的第二径向距离。 第一径向距离小于第二径向距离。 或者或另外，该装置可以具有径向范围的细长开口。 开口具有大于径向范围的纵向范围。
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公开(公告)号：US20150380228A1
公开(公告)日：2015-12-31
申请号：US14767920
申请日：2014-02-19
发明人： Pierre Schanen
CPC分类号： H01J49/147 , H01J27/205 , H01J49/0027 , H01J49/40
摘要： An analytical apparatus (1) for mass spectrometry comprises an electron impact ioniser including an electron emitter (22) and an ionisation target zone (18). The target zone (18) is arranged to be populated with matter to be ionised for analysis. An electron extracting element (36) is aligned with an electron pathway (34) defined between the electron emitter (22) and the ionisation target zone (18). The electron extracting element (36) is configured to accelerate electrons away from the emitter (22) along the electron pathway (34) between the emitter (22) and the extracting element (36) and to decelerate the electrons along the electron pathway (34) between the extracting element (36) and the ionisation target zone (18) to enable soft ionisation while avoiding the effects of coulombic repulsion at the electron source (22).
摘要翻译： 用于质谱的分析装置（1）包括包括电子发射器（22）和电离目标区（18）的电子碰撞离子发生器。 目标区域（18）被布置成填充有待离子化的物质用于分析。 电子提取元件（36）与限定在电子发射器（22）和电离目标区域（18）之间的电子通路（34）对准。 电子提取元件（36）被配置为沿着发射器（22）和提取元件（36）之间的电子通路（34）将电子加速离开发射极（22），并使电子沿电子通路（34）减速 ）提供元件（36）和电离目标区域（18）之间以实现软电离，同时避免电子源（22）处的库仑排斥的影响。
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公开(公告)号：US09188564B2
公开(公告)日：2015-11-17
申请号：US13261590
申请日：2011-08-17
申请人： Philipp Sulzer , Alfons Jordan , Eugen Hartungen , Tilmann Mark
发明人： Philipp Sulzer , Alfons Jordan , Eugen Hartungen , Tilmann Mark
CPC分类号： G01N27/62 , H01J49/145 , Y10T436/24
摘要： The invention provides a method and system for analyzing a gas for the presence of a reactant compound via reaction of primary ions of a specific type. A source gas is introduced to a reaction chamber and ionized in this chamber. The pressure in the reaction chamber is adjusted to avoid the formation of protonated species and other impurities. The primary ions generated in the reaction chamber are transferred to a drift tube. The gas to be analyzed is diluted with a carrier gas and the resulting mixture is introduced into the drift tube. The ionization energy of the carrier gas is equal to or higher than the ionization energy of the primary ions. The product ions resulting in the drift tube from a reaction of the primary ions with the reactant present in the gas to be analyzed are then detected, for example using a mass spectrometer. Preferably, an existing PTR-MS setup is used to perform the method of the present invention.
摘要翻译： 本发明提供了一种用于通过特定类型的初级离子的反应分析气体存在反应物化合物的方法和系统。 将源气体引入反应室并在该室中离子化。 调整反应室中的压力以避免质子化物质和其它杂质的形成。 在反应室中产生的主要离子被转移到漂移管中。 待分析的气体用载气稀释，并将所得混合物引入漂移管中。 载气的电离能等于或高于初级离子的电离能。 然后，例如使用质谱仪来检测产生离子的原子离子与待分析气体中存在的反应物的反应产生的漂移管。 优选地，使用现有的PTR-MS设置来执行本发明的方法。
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87.发明授权Methods and devices for calibrating the mobility axis of an ion mobility spectrum 有权用于校准离子迁移谱的迁移率轴的方法和装置公开(公告)号：US09153423B2
公开(公告)日：2015-10-06
申请号：US14487285
申请日：2014-09-16
申请人： Bruker Daltonik GmbH
发明人： Andreas Beil , Michael Blaschke
CPC分类号： H01J49/0009 , G01N27/622 , G01N33/0006
摘要： Methods and devices are provided for calibrating the mobility axis of an ion mobility spectrum and determining the mobility characteristic of ion species from an ion mobility spectrum, in particular for calibrating the drift time axis of an ion mobility spectrum acquired by a drift type ion mobility spectrometer (IMS). An ion mobility spectrometer uses an ion source that comprises a first ionization region which is fluidly coupled to a sample source, a second ionization region which is spatially separated from the first ionization region and fluidly coupled to a calibrant reservoir, and electrical means for controlling the transfer of sample ions from the first region into the second ionization region or into a third region of the ion source wherein the third region is fluidly coupled to the first and second ionization region and located closer to a mobility analyzer than the first and second ionization region.
摘要翻译： 提供了用于校准离子迁移谱的迁移率轴的方法和装置，并且确定离子迁移谱的离子种类的迁移率特性，特别是用于校准由漂移型离子迁移谱仪获得的离子迁移谱的漂移时间轴 （IMS）。 离子迁移谱仪使用离子源，其包括流体耦合到样品源的第一电离区域，与第一离子化区域空间分离并流体耦合到校准物储存器的第二离子化区域和用于控制 将样品离子从第一区域转移到第二离子化区域或离子源的第三区域中，其中第三区域流体耦合到第一和第二电离区域并且位于比第一和第二电离区域更靠近迁移率分析器 。
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公开(公告)号：US09147568B2
公开(公告)日：2015-09-29
申请号：US14265766
申请日：2014-04-30
申请人： Ionoptika Limited
CPC分类号： H01J49/142 , H01J27/026 , H01J49/0031
摘要： A mass spectrometer for producing a primary beam of ions for bombarding a sample under vacuum. The mass spectrometer includes a detector for detecting a secondary beam of ions released from the sample. The primary beam of ions includes water clusters where each water cluster contains between 1 and 10,000 water molecules. The primary beam of ions, in one embodiment, is produced by adiabatic expansion of water vapor. An auxiliary beam of ions for bombarding the sample includes a different species to those of the primary beam of ions.
摘要翻译： 用于产生用于在真空下轰击样品的一次离子束的质谱仪。 质谱仪包括用于检测从样品释放的次级次级束的检测器。 主要离子束包括水簇，其中每个水簇含有1至10,000个水分子。 在一个实施方案中，主要离子束是通过水汽的绝热膨胀产生的。 用于轰击样品的辅助离子束包括与主离子束不同的物质。
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公开(公告)号：US08981290B2
公开(公告)日：2015-03-17
申请号：US14229489
申请日：2014-03-28
CPC分类号： H01J49/147 , H01J49/0054
摘要： Apparatus and methods are provided that enable the interaction of low energy electrons and positrons with sample ions to facilitate electron capture dissociation (EGO) and positron capture dissociation (PGO), respectively, within multipole ion guide structures.
摘要翻译： 提供了能够使低能电子和正电子与样品离子相互作用的装置和方法，以便分别在多极离子导向结构内的电子俘获解离（EGO）和正电子俘获解离（PGO）。
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公开(公告)号：US20140353489A1
公开(公告)日：2014-12-04
申请号：US14368797
申请日：2012-12-28
申请人： MediMass, Kft.
发明人： Daniel Szalay , Lajos Godorhazy , Zoltan Takats
CPC分类号： H01J49/142 , H01J49/0031 , H01J49/0445 , H01J49/0454 , H01J49/14 , H01J49/16
摘要： According to some embodiments, systems and methods for surface impact ionization of liquid phase and aerosol samples are provided. The method includes accelerating a liquid or aerosol sample, colliding the sample with a solid collision surface thereby disintegrating the sample into both molecular ionic species (e.g., gaseous molecular ions) and molecular neutral species (e.g., gaseous sample), and transporting the disintegrated sample to an ion analyzer. Some embodiments of the method further comprise discarding the molecular neutral species. Such embodiments transport substantially only the molecular ionic species to the ion analyzer.
摘要翻译： 根据一些实施例，提供了液相和气溶胶样品的表面碰撞电离的系统和方法。 该方法包括加速液体或气溶胶样品，将样品与固体碰撞表面碰撞，从而将样品分解成分子离子物质（例如气态分子离子）和分子中性物质（例如气态样品），并将分解的样品 到离子分析仪。 该方法的一些实施方案还包括丢弃分子中性物质。 这样的实施例基本上只将分子离子物质转移到离子分析器。
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