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公开(公告)号：US20240242958A1
公开(公告)日：2024-07-18
申请号：US18559108
申请日：2022-05-03
发明人： Igor Chernushevich , Pavel Ryumin , Takashi Baba
CPC分类号： H01J49/4225 , H01J49/38 , H01J49/4245
摘要： During an accumulation time period of each time cycle of an ion guide and before a ramped AC voltage is applied to at least one set of axial rods to eject ions according to m/z value, a number of steps are performed. Ions are received from outside of the ion guide through an entrance aperture and into a first cell. A low DC voltage is applied to a barrier electrode to receive ions from the first cell into a second cell. And, a high DC voltage is applied to an exit electrode to prevent ions from exiting the ion guide. During a cooling time period before the AC time period, a high DC voltage is applied to the barrier electrode to trap and cool ions in the second cell and to continue to receive ions into the first cell without being affected by the ramped AC voltage.
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2.发明授权公开(公告)号：US11821868B2
公开(公告)日：2023-11-21
申请号：US17205528
申请日：2021-03-18
IPC分类号： G01N27/626 , H01J49/16 , G01N1/38 , H01J49/38
CPC分类号： G01N27/628 , G01N1/38 , H01J49/165 , H01J49/38
摘要： A method for detecting and analyzing olefins in petroleum by electrospray ionization mass spectrometry can include obtaining a hydrocarbon sample comprising at least about 90 wt % of saturate compounds; producing a solution comprising the hydrocarbon sample and a metal salt, the metal salt comprising a metal ion; forming olefin-metal ion complexes by electrospray ionization; and detecting the olefin-metal ion complexes using mass spectrometry.
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3.发明申请公开(公告)号：US20210302371A1
公开(公告)日：2021-09-30
申请号：US17205528
申请日：2021-03-18
IPC分类号： G01N27/626 , H01J49/16 , G01N1/38 , H01J49/38
摘要： A method for detecting and analyzing olefins in petroleum by electrospray ionization mass spectrometry can include obtaining a hydrocarbon sample comprising at least about 90 wt % of saturate compounds; producing a solution comprising the hydrocarbon sample and a metal salt, the metal salt comprising a metal ion; forming olefin-metal ion complexes by electrospray ionization; and detecting the olefin-metal ion complexes using mass spectrometry.
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公开(公告)号：US20200335321A1
公开(公告)日：2020-10-22
申请号：US16332570
申请日：2017-09-12
摘要： A method of carrying out mass spectrometry, comprising: using an electrostatic or electrodynamic ion trap to contain a plurality of ions, each ion having a mass to charge ratio, the ions having a first plurality of mass to charge ratios, each ion following a path within the electrostatic or electrodynamic ion trap having a radius; and for each of a second plurality of the mass to charge ratios: modulating the radii of the ions in a mass to charge ratio-dependent fashion dependent upon the mass to charge ratio; fragmenting the ions thus modulated in a radius-dependent fashion; and determining a mass spectrum of the ions.
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公开(公告)号：US10755907B2
公开(公告)日：2020-08-25
申请号：US15131300
申请日：2016-04-18
摘要： A method of producing a mass spectrum from a time-varying transient signal detected in a mass spectrometer, the method comprising: performing a Fourier transform of the transient signal to produce a first set of complex amplitudes wherein each of the complex amplitudes corresponds to a respective frequency of a first set of frequencies; generating a second set of complex amplitudes, wherein each of the complex amplitudes corresponds to a respective frequency of a second set of frequencies with a minimum spacing less than the inverse of the duration of the transient signal; optimizing the second set of complex amplitudes to produce an improved second set; generating a mass spectrum from at least some of the improved second set of complex amplitudes; wherein optimizing the second set of complex amplitudes to produce an improved second set of complex amplitudes is based on an objective function subject to some phase constraints.
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6.发明授权公开(公告)号：US10302624B2
公开(公告)日：2019-05-28
申请号：US15143064
申请日：2016-04-29
发明人： Dayan Goodenowe
摘要： The present invention relates to methods for the diagnosis and risk assessment of plasmalogen deficiency mediated diseases of aging. The present invention describes the relationship between plasmalogen biosynthesis dysfunction and the biochemical and clinical manifestations of age related disorders. Specifically the present invention describes an increased prevalence of colon cancer, prostate cancer, lung cancer, breast cancer, ovary cancer, kidney cancer, cognitive impairment and dementia in subjects suffering from adult onset plasmalogen biosynthesis disorder (AO-PBD).
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公开(公告)号：US20180226238A1
公开(公告)日：2018-08-09
申请号：US15887520
申请日：2018-02-02
发明人： Jens GRIEP-RAMING
CPC分类号： H01J49/0031 , G01N30/7233 , G01N30/8658 , G01N2030/324 , H01J49/0036 , H01J49/0459 , H01J49/282 , H01J49/38 , H01J49/40
摘要： A method of isotope ratio mass spectrometry comprising: flowing a liquid mobile phase through a separation device; reducing the flow rate of the mobile phase through the separation device for at least a portion of time that at least one molecular species is emerging from the separation device to achieve a desired isotope ratio precision, wherein the flow rate is reduced from a first rate to a second rate corresponding to a higher theoretical plate height of the separation device; and mass analyzing the molecular species that has emerged from the separation device at least while the flow rate is reduced; and determining at least one isotope ratio from the intensities of mass peaks of at least two isotopologues, wherein the mass analysis is performed with mass resolving power high enough to resolve the two most abundant mass peaks at the nominal mass of at least one of the isotopologues.
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公开(公告)号：US09741551B2
公开(公告)日：2017-08-22
申请号：US15332734
申请日：2016-10-24
CPC分类号： H01J49/282 , H01J49/027 , H01J49/08 , H01J49/38 , H01J49/4245
摘要： Mass analyzers and methods of ion detection for a mass analyzer are provided. An electrostatic field generator provides an electrostatic field causing ion packets to oscillate along a direction. A pulse transient signal is detected over a time duration that is significantly shorter than a period of the ion oscillation or using pulse detection electrodes having a width that is significantly smaller than a span of ion harmonic motion. A harmonic transient signal is also detected. Ion intensity with respect to mass-to-charge ratio is then identified based on the pulse transient signal and the harmonic transient signal.
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公开(公告)号：US09698002B2
公开(公告)日：2017-07-04
申请号：US15131117
申请日：2016-04-18
发明人： Jan-Peter Hauschild , Oliver Lange , Ulf Fröhlich , Andreas Wieghaus , Alexander Kholomeev , Alexander Makarov
CPC分类号： H01J49/4265 , H01J49/0031 , H01J49/027 , H01J49/04 , H01J49/38 , H01J49/4245 , H01J49/425
摘要： A method of mass analysis and a mass spectrometer are provided wherein a batch of ions is accumulated in a mass analyzer; the batch of ions accumulated in the mass analyzer is detected using image current detection to provide a detected signal; the number of ions in the batch of ions accumulated in the mass analyzer is controlled using an algorithm based on a previous detected signal obtained using image current detection from a previous batch of ions accumulated in the mass analyzer; wherein one or more parameters of the algorithm are adjusted based on a measurement of ion current or charge obtained using an independent detector located outside of the mass analyzer.
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公开(公告)号：US09659761B2
公开(公告)日：2017-05-23
申请号：US14024419
申请日：2013-09-11
申请人： Bruker Daltonik GmbH
CPC分类号： H01J49/38 , H01J49/0027 , H01J49/34
摘要： A method and apparatus of compensating a magnetic field inhomogeneity in a dynamically harmonized FT-ICR cell is presented, based on adding of extra electrodes into the cell, the extra electrodes being shaped in such a way that the averaged electric field created by these electrodes produces a counter force to the forces caused by the inhomogeneous magnetic field on the cycling ions.
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