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    Systems and Methods for Scaling Injection Waveform Amplitude During Ion Isolation
    2.
    发明申请
    Systems and Methods for Scaling Injection Waveform Amplitude During Ion Isolation 审中-公开

    公开(公告)号：US20180130649A1

    公开(公告)日：2018-05-10

    申请号：US15808036

    申请日：2017-11-09

    Applicant: Thermo Finnigan LLC

    Inventor： Philip M. REMES

    IPC: H01J49/00 ,  H01J49/42

    CPC classification number: H01J49/0031 ,  H01J49/422 ,  H01J49/4265 ,  H01J49/428

    Abstract: This disclosure describes a method of adjusting the amplitude of broadband waveforms for isolation, especially during injection to a multipole trapping device. Isolation during injection to a trapping device is known to be an effective way of accumulating a desired population of ions while rejecting unwanted species. The waveform amplitude required to eject unwanted species varies as a function of isolation time, but using automated gain control, the time required to accumulate a given population of ions may vary over several orders of magnitude. Thus, when the injection times are very long, precursor ions of interest are resonated for a long time and may be inadvertently ejected from the trap, using conventional methods. By setting the waveform amplitude lower for longer accumulation times, good isolation efficiency can be maintained for the precursor, while still rejecting unwanted ions.

    SEGMENTED LINEAR ION TRAP FOR ENHANCED ION ACTIVATION AND STORAGE
    3.
    发明申请
    SEGMENTED LINEAR ION TRAP FOR ENHANCED ION ACTIVATION AND STORAGE 有权

    公开(公告)号：US20170221694A1

    公开(公告)日：2017-08-03

    申请号：US15015101

    申请日：2016-02-03

    Applicant: FASMATECH SCIENCE & TECHNOLOGY LTD.

    Inventor： DIMITRIS PAPANASTASIOU ,  EMMANUEL RAPTAKIS

    IPC: H01J49/42

    CPC classification number: H01J49/4225 ,  H01J49/005 ,  H01J49/0054 ,  H01J49/062 ,  H01J49/426 ,  H01J49/4265

    Abstract: A linear ion trap includes at least two discrete trapping regions for processing ions, a RF electrical potential generator, a multi-output DC electrical potential generator, and a control unit. The RF electrical potential generator produces two RF waveforms each applied to a pair of pole electrodes of the linear ion trap forming a RF trapping field component to trap ions radially. The multi-output DC electrical potential generator produces multiple DC field components superimposed to the RF field component and distributed across the length of the linear ion trap to control ions axially. The control unit switches the DC electrical potentials and corresponding DC field components collectively forming a first trapping region populated with ions to alter ion potential energy from a first level to a second level, and enables a first ion processing step in at least one of the first and second levels.

    Multiple ion injection in mass spectrometry
    4.
    发明授权
    Multiple ion injection in mass spectrometry 有权
    多重离子注入质谱法

    公开(公告)号：US09536717B2

    公开(公告)日：2017-01-03

    申请号：US14201560

    申请日：2014-03-07

    Applicant: Thermo Finnigan LLC

    Inventor： Alexander A. Makarov ,  Oliver Lange ,  Stevan R. Horning

    IPC: H01J49/00 ,  H01J49/42 ,  H01J49/14

    CPC classification number: H01J49/0009 ,  H01J49/0031 ,  H01J49/004 ,  H01J49/14 ,  H01J49/4265

    Abstract: This invention relates to mass spectrometry that includes ion trapping in at least one of the stages of mass analysis. In particular, although not exclusively, this invention relates to tandem mass spectrometry where precursor ions and fragment ions are analyzed. A method of mass spectrometry is provided comprising the sequential steps of: accumulating in an ion store a sample of one type of ions to be analyzed; accumulating in the ion store a sample of another type of ions to be analyzed; and mass analyzing the combined samples of the ions; wherein the method comprises accumulating the sample of the one type of ions and/or the sample of another type of ions to achieve a target number of ions based on the results of a previous measurement of the respective type of ions.

    Abstract translation: 本发明涉及在质谱分析的至少一个阶段中包括离子捕获的质谱。 具体地说，尽管并非排他地，本发明涉及分析前体离子和碎片离子的串联质谱法。 提供了一种质谱法，其包括以下顺序步骤：在离子存储中积聚待分析的一种类型离子的样品; 在离子存储中积聚待分析的另一种类型的离子的样品; 并对离子的组合样品进行质量分析; 其中所述方法包括基于先前测量各种类型离子的结果累积一种类型离子的样品和/或另一类型离子的样品以实现目标数目的离子。

    Methods of operating a fourier transform mass analyzer
    5.
    发明授权
    Methods of operating a fourier transform mass analyzer 有权

    公开(公告)号：US09455128B2

    公开(公告)日：2016-09-27

    申请号：US14741360

    申请日：2015-06-16

    Applicant: Thermo Finnigan LLC

    Inventor： Philip M. Remes ,  Michael W. Senko

    IPC: H01J49/42 ,  H01J49/00

    CPC classification number: H01J49/0031 ,  H01J49/38 ,  H01J49/4245 ,  H01J49/4265

    Abstract: A method is disclosed for operating a mass spectrometer having a Fourier Transform (FT) analyzer, such as an orbital electrostatic trap mass analyzer, to avoid peak coalescence and/or other phenomena arising from frequency-shifting caused by ion-ion interactions. Ions of a first group are mass analyzed, for example in a quadrupole ion trap analyzer, to generate a mass spectrum. The estimated frequency shift of the characteristic periodic motion in the FT analyzer is calculated for one or more ion species of interest based on the intensities of adjacent (closely m/z-spaced) ion species. If the estimated frequency shift(s) for the one or more ion species exceeds a threshold, then a target ion population for an FT analyzer scan is adjusted downwardly to a value that produces a shift of acceptable value. An analytical scan of a second ion group is performed at the adjusted target ion population.

    Method and Apparatus for Mass Analysis Utilizing Ion Charge Feedback
    6.
    发明申请
    Method and Apparatus for Mass Analysis Utilizing Ion Charge Feedback 有权
    使用离子电荷反馈进行质量分析的方法和装置

    公开(公告)号：US20160233078A1

    公开(公告)日：2016-08-11

    申请号：US15131117

    申请日：2016-04-18

    Applicant: Thermo Fisher Scientific (Bremen) GmbH

    Inventor： Jan-Peter HAUSCHILD ,  Oliver LANGE ,  Ulf FRÖHLICH ,  Andreas WIEGHAUS ,  Alexander KHOLOMEEV ,  Alexander MAKAROV

    IPC: H01J49/42 ,  H01J49/04 ,  H01J49/00

    CPC classification number: H01J49/4265 ,  H01J49/0031 ,  H01J49/027 ,  H01J49/04 ,  H01J49/38 ,  H01J49/4245 ,  H01J49/425

    Abstract: A method of mass analysis and a mass spectrometer are provided wherein a batch of ions is accumulated in a mass analyser; the batch of ions accumulated in the mass analyser is detected using image current detection to provide a detected signal; the number of ions in the batch of ions accumulated in the mass analyser is controlled using an algorithm based on a previous detected signal obtained using image current detection from a previous batch of ions accumulated in the mass analyser; wherein one or more parameters of the algorithm are adjusted based on a measurement of ion current or charge obtained using an independent detector located outside of the mass analyser.

    Abstract translation: 提供质量分析方法和质谱仪，其中一批离子积聚在质量分析器中; 使用图像电流检测来检测在质量分析器中累积的一批离子以提供检测信号; 使用基于使用从质量分析器中累积的前一批离子的图像电流检测获得的先前检测信号的算法来控制在质量分析器中积聚的一批离子中的离子数量; 其中基于使用位于质量分析器外部的独立检测器获得的离子电流或电荷的测量来调整算法的一个或多个参数。

    Imaging mass spectrometry method and device
    8.
    发明授权
    Imaging mass spectrometry method and device 有权
    成像质谱法和装置

    公开(公告)号：US09263242B2

    公开(公告)日：2016-02-16

    申请号：US14722930

    申请日：2015-05-27

    Applicant: Thermo Fisher Scientific (Bremen) GmbH

    Inventor： Alexander A. Makarov

    IPC: H01J49/00

    CPC classification number: H01J49/0004 ,  H01J49/0031 ,  H01J49/40 ,  H01J49/4265

    Abstract: A method of performing imaging mass spectrometry of a sample. The method comprises performing a first mass analysis of the sample using a first mass analyzer comprising a multi-pixel ion detector to obtain first mass spectral data representative of pixels of the sample. The method further comprises identifying clusters of pixels sharing one or more characteristics of first mass spectral data. The method also comprises performing a second mass analysis of the sample using a second mass analyzer to obtain second mass spectral data at at least one location in each cluster, wherein the number of locations is significantly less than the number of pixels in each cluster, said second mass analysis being of higher resolution than said first mass analysis. Also a mass spectrometry apparatus configured for carrying out the method.

    Abstract translation: 进行样品的成像质谱法的方法。 该方法包括使用包括多像素离子检测器的第一质量分析器来进行样品的第一质量分析，以获得表示样品像素的第一质谱数据。 该方法还包括识别共享第一质谱数据的一个或多个特征的像素簇。 该方法还包括使用第二质量分析器对样品进行第二质量分析，以在每个簇中的至少一个位置处获得第二质谱数据，其中位置数目明显小于每个簇中的像素数，所述 第二质量分析具有比所述第一质量分析更高的分辨率。 也是配置为执行该方法的质谱装置。

    Methods for predictive automatic gain control for hybrid mass spectrometers
    9.
    发明授权
    Methods for predictive automatic gain control for hybrid mass spectrometers 有权
    混合质谱仪预测自动增益控制方法

    公开(公告)号：US09165755B2

    公开(公告)日：2015-10-20

    申请号：US14297092

    申请日：2014-06-05

    Applicant: Thermo Finnigan LLC

    Inventor： Philip M. Remes ,  Michael W. Senko ,  Justin Blethrow

    IPC: H01J49/00 ,  H01J49/26 ,  H01J49/42

    CPC classification number: H01J49/4265 ,  H01J49/0009 ,  H01J49/0027 ,  H01J49/0031 ,  H01J49/0036 ,  H01J49/004 ,  H01J49/26

    Abstract: A method for mass analyzing ions comprising a restricted range mass-to-charge (m/z) ratios comprising (i) performing a survey mass analysis, using a first mass analyzer employing indirect detection of ions by image current detection, to measure a flux of ions having m/z ratios within said range and (ii) performing a dependent mass analysis, using a second mass analyzer, of an optimal quantity of ions having m/z ratios within said range, said optimal quantity collected for a time period determined by the measured ion flux, the method characterized in that: the time period is determined using a corrected ion flux that includes a correction that comprises an estimate of the quantity of ions that are undetected by the first mass analyzer.

    Abstract translation: 一种用于质量分析离子的方法，包括受限范围的质荷比（m / z）比，其包括：（i）使用通过图像电流检测间接检测离子的第一质量分析器进行测量质量分析，以测量通量 的离子，其m / z比在所述范围内，并且（ii）使用第二质量分析器进行在所述范围内具有m / z比的最佳离子量的依赖质量分析，所述最佳量在所确定的时间段内收集 通过测量的离子通量，该方法的特征在于：使用包括校正的校正离子通量来确定时间段，该校正包括由第一质量分析器未检测到的离子量的估计。

    MASS SPECTROMETER
    10.
    发明申请
    MASS SPECTROMETER 有权
    质谱仪

    公开(公告)号：US20140339422A1

    公开(公告)日：2014-11-20

    申请号：US14359744

    申请日：2011-11-22

    Applicant: Akihiko Niwa

    Inventor： Akihiko Niwa

    IPC: H01J49/00 ,  G01N30/72

    CPC classification number: H01J49/0081 ,  G01N30/72 ,  G01N30/8696 ,  H01J49/0031 ,  H01J49/004 ,  H01J49/4265

    Abstract: A mass spectrometer including chromatogram creation means for creating a chromatogram showing changes over time in an ion intensity within a predetermined mass range based on the MS analysis results, and timing determination means for determining a timing to perform MS/MS analysis based on the chromatogram. The timing determination means determines, as a timing to perform MS/MS analysis, a point in time at which a signal intensity in the chromatogram reaches a predetermined upper limit after exceeding a predetermined lower limit or a point in time at which a signal intensity in the chromatogram reaches a top of a peak without reaching the upper limit after exceeding the lower limit. It is thus possible to collect precursor ions at a timing at which the signal intensity of a peak originating from sample components is highest between the upper limit and lower limit, thereby obtaining a high quality MS/MS spectrum.

    Abstract translation: 一种质谱仪，包括色谱图创建装置，用于根据MS分析结果产生表示在预定质量范围内的离子强度随时间变化的色谱图;以及定时确定装置，用于基于色谱图确定进行MS / MS分析的时间。 定时确定装置确定作为执行MS / MS分析的定时，在超过预定下限之后色谱图中的信号强度达到预定上限的时间点或时间段内的信号强度 色谱图达到峰值的上限，而不超过下限值则达到上限。 因此，可以在来自样品成分的峰值的信号强度在上限和下限之间的时刻收集前体离子，从而获得高质量的MS / MS谱。

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