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公开(公告)号：US11133160B2
公开(公告)日：2021-09-28
申请号：US16306238
申请日：2017-06-02
申请人： THERMO FINNIGAN LLC , THERMO FISHER SCIENTIFIC (BREMEN) GMBH , BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
发明人： Dustin D. Holden , Jens Griep-Raming , Alexander A. Makarov , Jennifer S. Brodbelt , Yevgeniy Zhuk , Jae C. Schwartz
摘要： Systems, methods, and devices to dissociate ions using one or more light emitting diodes (LEDs). A mass spectrometer for ion dissociation includes an ion source for providing ions for dissociation, a mass analyzer, and a photodissociation (PD) device. The PD device includes an ion transport device. The ion transport device is configured perform one or more of: transporting the ions through the PD device, and trapping the ions within a region of the PD device. The PD device also includes one or more LEDs positioned to irradiate the ions in the PD device, resulting in fragmentation of the ions.
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公开(公告)号：US11114290B1
公开(公告)日：2021-09-07
申请号：US16868783
申请日：2020-05-07
发明人： Joshua A. Silveira , Eloy R. Wouters , Alexander A. Makarov , Mikhail G. Skoblin , Viacheslav I. Kozlovskiy
摘要： An ion transport system comprises: (I) an ion transfer tube extending between an atmospheric-pressure ionization chamber and a partially evacuated chamber; and (II) an ion funnel within the chamber comprising: (1) an exit electrode that has an exit aperture configured to deliver the gas and charged particles to a high-vacuum chamber; and (2) a funnel portion comprising a plurality of plate electrodes configured as a stack, each electrode comprising a respective aperture, wherein an aperture diameter of each of the plurality of electrodes is greater than or equal to three times an inter-electrode pitch and wherein no DC electrical potential gradient is applied between the exit electrode and an adjacent one of the plurality of plate electrodes.
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公开(公告)号：US10510525B2
公开(公告)日：2019-12-17
申请号：US16245023
申请日：2019-01-10
摘要： An apparatus for separating ions includes an electrode arrangement having a length extending between first and second ends. The first end is configured to introduce a beam of ions into an ion transmission space of the arrangement. An electronic controller applies an RF potential and a DC potential to an electrode of the electrode arrangement, for generating a ponderomotive RF electric field and a mass-independent DC electric field. The application of the potentials is controlled such that a ratio of the strength of the ponderomotive RF electric field to the strength of the mass-independent DC electric field varies along the length of the electrode arrangement. The generated electric field supports extraction of ions having different m/z values at respective different positions along the length of the electrode arrangement. Ions are extracted in one of increasing and decreasing sequential order of m/z ratio with increasing distance from the first end.
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公开(公告)号：US09812310B2
公开(公告)日：2017-11-07
申请号：US15489301
申请日：2017-04-17
申请人： Thermo Finnigan LLC
CPC分类号： H01J49/0422 , H01J49/0027 , H01J49/04 , H01J49/062 , H01J49/165 , H01J49/4295
摘要： Ions provided from an ion source are separated ions into a plurality of different ion groups according to at least one ion property. At least some of the different ion groups are stored in an ion storage array, which comprises a plurality of independently operable storage cells, each storage cell being arranged to receive and store a different ion group. A controller is programmed to cause selective switching of each of the storage cells between an ion receiving mode and an ion storage mode, and between the ion storage mode and an ion release mode. In particular, the switching of each storage cell is controllable independently of the switching of any of the other storage cells. Upon release from a respective storage cell of the array, ions are provided to one or more mass analyzers for subsequent analysis.
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公开(公告)号：US09472385B2
公开(公告)日：2016-10-18
申请号：US14677857
申请日：2015-04-02
申请人： Thermo Finnigan LLC
CPC分类号： H01J49/0031 , H01J49/022 , H01J49/36 , H01J49/423 , H01J49/427
摘要： The present invention provides a radio frequency (RF) power supply in a mass spectrometer. The power supply provides an RF signal to electrodes of a storage device to create a trapping field. The RF field is usually collapsed prior to ion ejection. In an illustrative embodiment the RF power supply includes a RF signal supply; a coil arranged to receive the signal provided by the RF signal supply and to provide an output RF signal for supply to electrodes of an ion storage device; and a shunt including a switch operative to switch between a first open position and a second closed position in which the shunt shorts the coil output.
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公开(公告)号：US11988635B2
公开(公告)日：2024-05-21
申请号：US17744408
申请日：2022-05-13
IPC分类号： G01N27/622
CPC分类号： G01N27/622
摘要： An ion mobility analyser is disclosed having a gas flow directed along the ion travel axis and a set of electrodes to which DC voltages are applied to establish a DC field. The opposing forces of the gas flow and DC field cause ions to be trapped within a separation region in axial regions determined by their ion mobilities. A gas recirculator, having inlet and outlet ends respectively located downstream and upstream of the separation region, supplies at least fifty percent of the gas flow within the separation region, thereby reducing vacuum pumping requirements.
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公开(公告)号：US11610768B2
公开(公告)日：2023-03-21
申请号：US17326956
申请日：2021-05-21
申请人： Thermo Finnigan LLC
IPC分类号： G01N27/623 , H01J49/40 , H01J49/42 , H01J49/00
摘要： A mass spectrometer system comprises: (a) an ion source; (b) a mass filter or a time-of-flight (TOF) ion separator configured to receive a stream of first-generation ions from the ion source; (c) an ion storage device having an ion inlet configured to receive a stream of filtered ions comprising a plurality of ion species from the mass filter or TOF separator and to accumulate the plurality of ion species therein; (d) an ion mobility cell having an ion inlet configured to receive an accumulated batch of ion species from the ion storage device and an ion outlet configured to release, one at a time, the individual ion species therefrom; and (e) a mass analyzer configured to receive and mass analyze each first-generation ion species or each fragment ion species generated by fragmentation or other reaction of the various first-generation ion species.
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公开(公告)号：US09293316B2
公开(公告)日：2016-03-22
申请号：US14671922
申请日：2015-03-27
申请人： Thermo Finnigan LLC
CPC分类号： H01J49/0422 , H01J49/0027 , H01J49/04 , H01J49/062 , H01J49/165 , H01J49/4295
摘要： Ions provided from an ion source are separated ions into a plurality of different ion groups according to at least one ion property. At least some of the different ion groups are stored in an ion storage array, which comprises a plurality of independently operable storage cells, each storage cell being arranged to receive and store a different ion group. A controller is programmed to cause selective switching of each of the storage cells between an ion receiving mode and an ion storage mode, and between the ion storage mode and an ion release mode. In particular, the switching of each storage cell is controllable independently of the switching of any of the other storage cells. Upon release from a respective storage cell of the array, ions are provided to one or more mass analyzers for subsequent analysis.
摘要翻译： 从离子源提供的离子根据至少一种离子性质将离子分离成多个不同的离子基团。 至少一些不同的离子组存储在离子存储阵列中，离子存储阵列包括多个可独立操作的存储单元，每个存储单元被布置成接收和存储不同的离子组。 控制器被编程为在离子接收模式和离子存储模式之间以及在离子存储模式和离子释放模式之间引起每个存储单元的选择性切换。 特别地，每个存储单元的切换可独立于任何其它存储单元的切换而被控制。 当从阵列的相应存储单元释放时，将离子提供给一个或多个质量分析器用于随后的分析。
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公开(公告)号：US09536717B2
公开(公告)日：2017-01-03
申请号：US14201560
申请日：2014-03-07
申请人： Thermo Finnigan LLC
CPC分类号： H01J49/0009 , H01J49/0031 , H01J49/004 , H01J49/14 , H01J49/4265
摘要： This invention relates to mass spectrometry that includes ion trapping in at least one of the stages of mass analysis. In particular, although not exclusively, this invention relates to tandem mass spectrometry where precursor ions and fragment ions are analyzed. A method of mass spectrometry is provided comprising the sequential steps of: accumulating in an ion store a sample of one type of ions to be analyzed; accumulating in the ion store a sample of another type of ions to be analyzed; and mass analyzing the combined samples of the ions; wherein the method comprises accumulating the sample of the one type of ions and/or the sample of another type of ions to achieve a target number of ions based on the results of a previous measurement of the respective type of ions.
摘要翻译： 本发明涉及在质谱分析的至少一个阶段中包括离子捕获的质谱。 具体地说，尽管并非排他地，本发明涉及分析前体离子和碎片离子的串联质谱法。 提供了一种质谱法，其包括以下顺序步骤：在离子存储中积聚待分析的一种类型离子的样品; 在离子存储中积聚待分析的另一种类型的离子的样品; 并对离子的组合样品进行质量分析; 其中所述方法包括基于先前测量各种类型离子的结果累积一种类型离子的样品和/或另一类型离子的样品以实现目标数目的离子。
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公开(公告)号：US12125692B2
公开(公告)日：2024-10-22
申请号：US17345549
申请日：2021-06-11
发明人： Alexander A. Makarov , Eloy R. Wouters , Joshua A. Silveira , Mikhail G. Skoblin , Viacheslav Kozlovskiy
CPC分类号： H01J49/066 , H01J49/0031 , H01J49/24
摘要： A mass spectrometry method comprises: (1) introducing ions and gas into an first electrode section of an ion transport apparatus through a slot of an ion transfer tube, the ion tunnel section comprising a first longitudinal axis that is contained within a slot plane of the ion transfer tube, the first longitudinal axis not intersecting an outlet of the ion transfer tube, wherein the apparatus further comprises: (a) a second electrode section configured to receive the ions from the first electrode section and comprising a second longitudinal axis that is not coincident with the first longitudinal axis; and (b) an ion outlet aperture; (2) providing voltages to electrodes of the ion transport apparatus that urge the ions to migrate towards the first longitudinal axis within the first electrode section; and (3) exhausting gas through a port that is offset from the ion outlet aperture.
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