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公开(公告)号：US11114290B1
公开(公告)日：2021-09-07
申请号：US16868783
申请日：2020-05-07
发明人： Joshua A. Silveira , Eloy R. Wouters , Alexander A. Makarov , Mikhail G. Skoblin , Viacheslav I. Kozlovskiy
摘要： An ion transport system comprises: (I) an ion transfer tube extending between an atmospheric-pressure ionization chamber and a partially evacuated chamber; and (II) an ion funnel within the chamber comprising: (1) an exit electrode that has an exit aperture configured to deliver the gas and charged particles to a high-vacuum chamber; and (2) a funnel portion comprising a plurality of plate electrodes configured as a stack, each electrode comprising a respective aperture, wherein an aperture diameter of each of the plurality of electrodes is greater than or equal to three times an inter-electrode pitch and wherein no DC electrical potential gradient is applied between the exit electrode and an adjacent one of the plurality of plate electrodes.
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公开(公告)号：US12125692B2
公开(公告)日：2024-10-22
申请号：US17345549
申请日：2021-06-11
发明人： Alexander A. Makarov , Eloy R. Wouters , Joshua A. Silveira , Mikhail G. Skoblin , Viacheslav Kozlovskiy
CPC分类号： H01J49/066 , H01J49/0031 , H01J49/24
摘要： A mass spectrometry method comprises: (1) introducing ions and gas into an first electrode section of an ion transport apparatus through a slot of an ion transfer tube, the ion tunnel section comprising a first longitudinal axis that is contained within a slot plane of the ion transfer tube, the first longitudinal axis not intersecting an outlet of the ion transfer tube, wherein the apparatus further comprises: (a) a second electrode section configured to receive the ions from the first electrode section and comprising a second longitudinal axis that is not coincident with the first longitudinal axis; and (b) an ion outlet aperture; (2) providing voltages to electrodes of the ion transport apparatus that urge the ions to migrate towards the first longitudinal axis within the first electrode section; and (3) exhausting gas through a port that is offset from the ion outlet aperture.
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公开(公告)号：US11581179B2
公开(公告)日：2023-02-14
申请号：US17467033
申请日：2021-09-03
发明人： Joshua A. Silveira , Eloy R. Wouters , Alexander A. Makarov , Mikhail G. Skoblin , Viacheslav I. Kozlovskiy , Christopher Mullen , Brian D. Adamson
IPC分类号： H01J49/06
摘要： A method of reducing fragmentation of ions generated from a sample during transport of the ions through an ion transport apparatus that comprises an ion funnel portion, comprises: applying a selected DC potential difference between an outlet end of the ion transport apparatus and an exit ion lens that is disposed adjacent to the outlet end, wherein a sign of the selected DC potential difference is chosen so as to accelerate the ions from the outlet end of the ion transport apparatus towards and through the exit ion lens.
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公开(公告)号：US20240264131A1
公开(公告)日：2024-08-08
申请号：US18431305
申请日：2024-02-02
申请人： Thermo Finnigan LLC
CPC分类号： G01N30/8662 , G06V10/82
摘要： Disclosed herein are scientific instrument support systems, as well as related methods, computing devices, and computer-readable media. For example, in some embodiments, a chromatography instrument support apparatus may include: first logic to receive, from an imaging device, image data regarding chromatography instrumentation; second logic to determine a state of the chromatography instrumentation by processing the imaging device through a machine-learning computational model; and third logic to display the state of the chromatography instrumentation.
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公开(公告)号：US11562893B2
公开(公告)日：2023-01-24
申请号：US17371702
申请日：2021-07-09
申请人： Thermo Finnigan LLC
摘要： A method for cleaning a first electrospray emitter of a mass spectrometer comprises: changing an operating mode of the first electrospray emitter from a stable jet mode of operation to a dripping or pulsating mode of operation by lowering a magnitude of a voltage applied between a counter electrode and the first electrospray emitter, |V1|; moving the first electrospray emitter from a first emitter position from which electrospray ions are delivered to a mass spectrometer inlet to a second emitter position and, simultaneously, moving a second electrospray emitter from a third emitter position to a fourth emitter position; causing a cleaning solvent to flow through the first electrospray emitter at least until a droplet of the cleaning solvent forms on an exterior surface of the first electrospray emitter while operating the electrospray emitter in the dripping mode of operation; and causing the droplet to dislodge from the emitter exterior.
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公开(公告)号：US11791144B2
公开(公告)日：2023-10-17
申请号：US17197986
申请日：2021-03-10
申请人： Thermo Finnigan LLC
CPC分类号： H01J49/0036 , H01J49/426
摘要： An optimization control system may receive mass spectra of ions emitted from an ionization emitter toward an inlet of a mass spectrometer and control, based on the mass spectra, an automated motion system to adjust a position of the emitter relative to the inlet.
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公开(公告)号：US20220373512A1
公开(公告)日：2022-11-24
申请号：US17705167
申请日：2022-03-25
申请人： Thermo Finnigan LLC
IPC分类号： G01N27/622 , G01N30/72 , G01N33/68 , H01J49/04 , H01J49/16
摘要： Using ion mobility separation to improve a duty cycle of a mass spectrometer is described. In one aspect, a mass spectrometer can use an ion-mobility spectrometer to allow for more multiply-charged ions to transmit through than singly-charged ions. This results in a mass analyzer to perform a mass analysis with more multiply-charged ions.
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公开(公告)号：US11029291B2
公开(公告)日：2021-06-08
申请号：US16925514
申请日：2020-07-10
申请人： Thermo Finnigan LLC
摘要： A system for analyzing a sample includes a chromatographic device, an electrospray source, and a mass resolving device. The chromatographic device is configured to separate components of the sample as a function of retention time within a chromatographic column. The electrospray source is configured to direct a first portion of a flow from the chromatographic device via a waste outlet to a pressurized waste reservoir, direct a second portion of the flow to an electrospray ionization outlet to form a spray, and charge and desolvate the spray to form ions of the components of the sample. A flow rate of the second portion of the liquid flow is substantially determined by a pressure of the pressurized waste reservoir. The mass resolving device configured to receive the ions and characterize the mass-to-charge ratio of the ions.
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公开(公告)号：US09761427B2
公开(公告)日：2017-09-12
申请号：US15139939
申请日：2016-04-27
申请人： Thermo Finnigan LLC
IPC分类号： H01J49/06
CPC分类号： H01J49/066
摘要： A system for transporting ions includes: an ion transfer tube having an axis and an internal bore having a width and a height less than the width; and an apparatus comprising a plurality of electrodes, each having a respective ion aperture having an aperture center, the apertures defining an ion channel configured to receive the ions from the ion transfer tube and to transport the ions to an outlet end of the apparatus, wherein at least a subset of the apertures progressively decrease in size in a direction towards the apparatus outlet end, wherein the ion transfer tube is configured such that the ion transfer tube axis is non-coincident with an axis of the ion channel or such that the width dimension of the ion transfer tube bore is parallel to a plane defined by the ion transfer tube axis and the ion channel axis.
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公开(公告)号：US11222778B2
公开(公告)日：2022-01-11
申请号：US16668414
申请日：2019-10-30
申请人： Thermo Finnigan LLC
IPC分类号： H01J49/16
摘要： An electrospray ion source for a mass spectrometer comprises: (i) a plurality of N electrospray emitters within an ionization compartment, wherein N≥2; (ii) a mixing chamber; (iii) a plurality of N inlets, each inlet comprising a conduit configured to receive charged particles from a respective one of the electrospray emitters and to emit the charged particles into the mixing chamber; (iv) an outlet port either facing or within an intermediate-vacuum compartment; and (v) a heater in thermal contact with at least a portion of the mixing chamber.
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