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公开(公告)号：US11114290B1
公开(公告)日：2021-09-07
申请号：US16868783
申请日：2020-05-07
发明人： Joshua A. Silveira , Eloy R. Wouters , Alexander A. Makarov , Mikhail G. Skoblin , Viacheslav I. Kozlovskiy
摘要： An ion transport system comprises: (I) an ion transfer tube extending between an atmospheric-pressure ionization chamber and a partially evacuated chamber; and (II) an ion funnel within the chamber comprising: (1) an exit electrode that has an exit aperture configured to deliver the gas and charged particles to a high-vacuum chamber; and (2) a funnel portion comprising a plurality of plate electrodes configured as a stack, each electrode comprising a respective aperture, wherein an aperture diameter of each of the plurality of electrodes is greater than or equal to three times an inter-electrode pitch and wherein no DC electrical potential gradient is applied between the exit electrode and an adjacent one of the plurality of plate electrodes.
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公开(公告)号：US12125692B2
公开(公告)日：2024-10-22
申请号：US17345549
申请日：2021-06-11
发明人： Alexander A. Makarov , Eloy R. Wouters , Joshua A. Silveira , Mikhail G. Skoblin , Viacheslav Kozlovskiy
CPC分类号： H01J49/066 , H01J49/0031 , H01J49/24
摘要： A mass spectrometry method comprises: (1) introducing ions and gas into an first electrode section of an ion transport apparatus through a slot of an ion transfer tube, the ion tunnel section comprising a first longitudinal axis that is contained within a slot plane of the ion transfer tube, the first longitudinal axis not intersecting an outlet of the ion transfer tube, wherein the apparatus further comprises: (a) a second electrode section configured to receive the ions from the first electrode section and comprising a second longitudinal axis that is not coincident with the first longitudinal axis; and (b) an ion outlet aperture; (2) providing voltages to electrodes of the ion transport apparatus that urge the ions to migrate towards the first longitudinal axis within the first electrode section; and (3) exhausting gas through a port that is offset from the ion outlet aperture.
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公开(公告)号：US11581179B2
公开(公告)日：2023-02-14
申请号：US17467033
申请日：2021-09-03
发明人： Joshua A. Silveira , Eloy R. Wouters , Alexander A. Makarov , Mikhail G. Skoblin , Viacheslav I. Kozlovskiy , Christopher Mullen , Brian D. Adamson
IPC分类号： H01J49/06
摘要： A method of reducing fragmentation of ions generated from a sample during transport of the ions through an ion transport apparatus that comprises an ion funnel portion, comprises: applying a selected DC potential difference between an outlet end of the ion transport apparatus and an exit ion lens that is disposed adjacent to the outlet end, wherein a sign of the selected DC potential difference is chosen so as to accelerate the ions from the outlet end of the ion transport apparatus towards and through the exit ion lens.
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公开(公告)号：US11791144B2
公开(公告)日：2023-10-17
申请号：US17197986
申请日：2021-03-10
申请人： Thermo Finnigan LLC
CPC分类号： H01J49/0036 , H01J49/426
摘要： An optimization control system may receive mass spectra of ions emitted from an ionization emitter toward an inlet of a mass spectrometer and control, based on the mass spectra, an automated motion system to adjust a position of the emitter relative to the inlet.
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公开(公告)号：US11087964B2
公开(公告)日：2021-08-10
申请号：US16690710
申请日：2019-11-21
申请人： Thermo Finnigan LLC
摘要： A method for cleaning an electrospray emitter of a mass spectrometer, comprises: (a) changing a mode of operation of the electrospray emitter from a stable jet mode of operation to a dripping mode or a pulsating mode of operation by lowering a magnitude of a voltage applied between an counter electrode and the electrospray emitter; (b) causing a cleaning solvent to flow through the electrospray emitter at least until a droplet of the cleaning solvent forms on an exterior surface of the electrospray emitter while operating the electrospray emitter in the dripping mode of operation; and (c) causing the droplet to dislodge from the electrospray emitter exterior.
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公开(公告)号：US10651025B1
公开(公告)日：2020-05-12
申请号：US16231227
申请日：2018-12-21
申请人： Thermo Finnigan LLC
摘要： An ion separation device comprising a plurality of electrodes arranged in a two-dimensional grid, a gas supply configured to provide a gas flow along the first direction, and an ion inlet arranged to receive ions. The plurality of electrodes is configured to create one or more pseudopotential barriers of increasing magnitude along a first direction. A drag force is applied to the ions by the gas flow is opposed by a pseudopotential gradient of the plurality of electrodes.
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公开(公告)号：US20230030920A1
公开(公告)日：2023-02-02
申请号：US17391880
申请日：2021-08-02
申请人： Thermo Finnigan LLC
摘要： An electrospray ionization system used in mass spectrometry provides for improved current measurement. The system includes a fluid union, a fluid column coupled with a first port of the fluid union, a power source coupled with the fluid union and configured to apply a voltage potential to the fluid union, and an electrospray emitter coupled with a second port of the fluid union. The power source is coupled with the first port and configured to apply the voltage potential to the first port to restrict current leakage from the fluid union. The current sensing circuit is configured to determine an electrical current flow between the power source and the at least one of the fluid union and the first port.
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公开(公告)号：US20220293405A1
公开(公告)日：2022-09-15
申请号：US17197986
申请日：2021-03-10
申请人： Thermo Finnigan LLC
摘要： An optimization control system may receive mass spectra of ions emitted from an ionization emitter toward an inlet of a mass spectrometer and control, based on the mass spectra, an automated motion system to adjust a position of the emitter relative to the inlet.
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公开(公告)号：US20240264131A1
公开(公告)日：2024-08-08
申请号：US18431305
申请日：2024-02-02
申请人： Thermo Finnigan LLC
CPC分类号： G01N30/8662 , G06V10/82
摘要： Disclosed herein are scientific instrument support systems, as well as related methods, computing devices, and computer-readable media. For example, in some embodiments, a chromatography instrument support apparatus may include: first logic to receive, from an imaging device, image data regarding chromatography instrumentation; second logic to determine a state of the chromatography instrumentation by processing the imaging device through a machine-learning computational model; and third logic to display the state of the chromatography instrumentation.
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公开(公告)号：US11562893B2
公开(公告)日：2023-01-24
申请号：US17371702
申请日：2021-07-09
申请人： Thermo Finnigan LLC
摘要： A method for cleaning a first electrospray emitter of a mass spectrometer comprises: changing an operating mode of the first electrospray emitter from a stable jet mode of operation to a dripping or pulsating mode of operation by lowering a magnitude of a voltage applied between a counter electrode and the first electrospray emitter, |V1|; moving the first electrospray emitter from a first emitter position from which electrospray ions are delivered to a mass spectrometer inlet to a second emitter position and, simultaneously, moving a second electrospray emitter from a third emitter position to a fourth emitter position; causing a cleaning solvent to flow through the first electrospray emitter at least until a droplet of the cleaning solvent forms on an exterior surface of the first electrospray emitter while operating the electrospray emitter in the dripping mode of operation; and causing the droplet to dislodge from the emitter exterior.
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