公开(公告)号：US5001152A

公开(公告)日：1991-03-19

申请号：US288979

申请日：1988-12-23

Applicant: Paivi A. Aho ,  Pentti Pohto ,  Inge-Britt Y. Linden ,  Reijo J. Backstrom ,  Erkki J. Honkanen ,  Erkki A. O. Nissenen

Inventor： Paivi A. Aho ,  Pentti Pohto ,  Inge-Britt Y. Linden ,  Reijo J. Backstrom ,  Erkki J. Honkanen ,  Erkki A. O. Nissenen

IPC: A61K31/05 ,  A61K31/00 ,  A61K31/047 ,  A61K31/06 ,  A61K31/085 ,  A61K31/10 ,  A61K31/11 ,  A61K31/12 ,  A61K31/135 ,  A61K31/15 ,  A61K31/165 ,  A61K31/18 ,  A61K31/19 ,  A61K31/215 ,  A61K31/275 ,  A61K31/33 ,  A61K31/445 ,  A61P1/04 ,  C07C205/13 ,  C07C255/49 ,  C07D295/18 ,  C07D317/62

CPC classification number: A61K31/06 ,  A61K31/00 ,  A61K31/12 ,  Y10S514/925 ,  Y10S514/926 ,  Y10S514/927

Abstract: The invention is concerned with the new use of known catechol derivatives of the formula ##STR1## wherein R.sub.1 and R.sub.2 are each hydrogen, alkyl having 1 to 4 carbon atoms or alkanoyl having 2 to 5 carbon atoms; X is nitro, halogen or cyano and R.sub.3 is chlorine, nitro, cyano or a radical of the formula ##STR2## wherein R.sub.4 is hydrogen, cyano, alkyl having 1 to 4 carbon atoms or alkanoyl having 2 to 5 carbon atoms and R.sub.5 is cyano, alkanoyl having 2 to 5 carbon atoms, hydroxyalkyl having 1 to 4 carbon atoms, carboxyl or phenylcarbonyl unsubstituted or substituted with one to three methoxy groups or pharmaceutically acceptable salt thereof. The new use is the treatment and prophylaxis of ulcers and lesions in the gastrointestinal tract.

公开(公告)号：US4997937A

公开(公告)日：1991-03-05

申请号：US422339

申请日：1989-10-16

Applicant: Athanassios Tzikas ,  Peter Aeschlimann

Inventor： Athanassios Tzikas ,  Peter Aeschlimann

IPC: C07D295/18 ,  C07C317/04 ,  C07C317/18 ,  C07C317/28 ,  C07C323/25 ,  C07D498/04 ,  C09B62/503 ,  D06P1/38

CPC classification number: C09B62/5033 ,  C07C317/04

Abstract: Dyes suitable for dyeing and printing cellulose-containing fiber materials which produce blue dyeings and prints having good fastness properties. These dyes are of the formula ##STR1## wherein R.sub.1 and R.sub.2 are each independently of the other hydrogen, halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, phenoxy, carboxyl carbamoyl or C.sub.1 -C.sub.4 alkanoylamino; R.sub.3 is hydrogen, sulfo, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, halogen, carboxyl, carbamoyl, N-C.sub.1 -C.sub.4 alkylcarbamoyl, N,N-di-C.sub.1 -C.sub.4 alkylcarbamoyl, C.sub.1 -C.sub.4 alkylsulfonyl, sulfamoyl, N-C.sub.1 -C.sub.4 alkylsulfamoyl or N,N-di-C.sub.1 -C.sub.4 alkylsulfamoyl; R.sub.4 is a radical of the formula ##STR2## R.sub.5 and R.sub.6 are independently of each other hydrogen or unsubstituted or hydroxyl-, sulfo-, sulfato-, carboxyl-, cyano-, halogen-, C.sub.1 -C.sub.4 alkoxycarbonyl-, C.sub.1 -C.sub.4 alkanoyloxy- or carbamoyl-substituted and uninterrupted or, except in the case of methyl, --O--, --S-- or --NH--interrupted C.sub.1 -C.sub.6 alkyl; R' is hydrogen or C.sub.1 -C.sub.6 alkyl; t is an integer from 0 to 4; the phenyl radical (a) is unsubstituted or substituted by C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkyl substituted by hydroxyl-, sulfo or sulfato, C.sub.1 -C.sub.4 alkoxy, halogen, sulfo, carboxyl or hydroxy, and A is a radical of the formula ##STR3## where R' is as defined above, (alk) is C.sub.1 -C.sub.6 alkylene, T is hydrogen, halogen, hydroxyl, sulfato, carboxyl, cyano, C.sub.1 -C.sub.4 alkanoyloxy, C.sub.1 -C.sub.4 alkoxycarbonyl, carbamoyl or a radical --SO.sub.2 --Z, V is hydrogen, substituted or unsubstituted C.sub.1 -C.sub.4 alkyl or a radical of the formula -(alk)--CH.sub.2 --SO.sub.2 --Z, where (alk) is as defined above, Z is a radical of the formula --CH.dbd.CH.sub.2 l or --CH.sub.2 --CH.sub.2 --Y, Y is a leaving group selected from the group consisting of --OSO.sub.3 H, --SSO.sub.3 H, --OCOCH.sub.3, --OCO--C.sub.6 H.sub.5, OPO.sub.3 H.sub.2, --Cl, Br, --F, ##STR4## p, q and r are each independently of the others an integer from 1 to 6.

公开(公告)号：US4985595A

公开(公告)日：1991-01-15

申请号：US279256

申请日：1988-12-01

Applicant: Tosaku Miki ,  Masahide Asano ,  Toru Hosokami

Inventor： Tosaku Miki ,  Masahide Asano ,  Toru Hosokami

IPC: A61K31/165 ,  A61K31/185 ,  A61K31/27 ,  A61K31/535 ,  A61K31/5375 ,  A61P1/04 ,  C07C67/00 ,  C07C231/00 ,  C07C237/06 ,  C07C237/10 ,  C07C237/22 ,  C07C239/00 ,  C07C271/28 ,  C07C301/00 ,  C07C309/14 ,  C07D295/18 ,  C07D295/192

CPC classification number: C07D295/192

Abstract: Aminobenzamide derivatives of the formula (I) ##STR1## wherein: R.sub.1 and R.sub.2 each represents a lower alkoxy group,R.sub.3 represents a hydrogen atom, a lower alkyl group, a lower acyl group, a lower alkoxycarbonyl group or --R.sub.5 --SO.sub.3 Z, wherein R.sub.5 represents a lower alkylene group and Z represents an alkali metal or an alkaline earth metal,R.sub.4 represents an amino group, a morpholino group or a lower alkylamino group which may be substituted with a hydroxyl group at the alkyl moiety thereof, with the proviso that, when R.sub.3 represents a hydrogen atom, R.sub.4 cannot be an amino group,Y represents a hydrogen atom, a halogen atom or a lower alkoxy group,n represents an integer of from 1 to 6,and salts thereof; are disclosed. These compounds have excellent anti-peptic ulcer activities, and chemical and physical stabilities.

Abstract translation: 式（I）的氨基苯甲酰胺衍生物其中：R 1和R 2各自表示低级烷氧基，R 3表示氢原子，低级烷基，低级酰基，低级烷氧基羰基或-R 5 - SO 3 Z，其中R 5表示低级亚烷基，Z表示碱金属或碱土金属，R 4表示可以在其烷基部分被羟基取代的氨基，吗啉代基或低级烷基氨基， 条件是当R3表示氢原子时，R4不能为氨基，Y表示氢原子，卤原子或低级烷氧基，n表示1〜6的整数，及其盐类; 被披露。 这些化合物具有优异的抗消化性溃疡活性，以及​​化学和物理稳定性。

公开(公告)号：US4902835A

公开(公告)日：1990-02-20

申请号：US142630

申请日：1988-01-11

Applicant: Andrew S. Kende ,  Noritada Matsuo

Inventor： Andrew S. Kende ,  Noritada Matsuo

IPC: C07D295/18 ,  C07B61/00 ,  C07C17/00 ,  C07C17/25 ,  C07C21/18 ,  C07C41/00 ,  C07C41/06 ,  C07C43/17 ,  C07C67/00 ,  C07C67/343 ,  C07C69/65 ,  C07C233/09 ,  C07C233/11 ,  C07C235/32 ,  C07C315/00 ,  C07C317/08 ,  C07C317/14 ,  C07C317/18 ,  C07C317/44 ,  C07C319/14 ,  C07C323/05 ,  C07C323/09 ,  C07D317/60 ,  C07F9/40 ,  C07F9/54

CPC classification number: C07F9/5428 ,  C07C17/25 ,  C07C43/17 ,  C07D317/60

Abstract: New chemical reactions of 1,1,2-trifluoro-1,3-butadiene provide simple access to a series of new fluorinated alkene derivatives. These derivatives provide a simple, general methodology for the stereocontrolled preparation of 2-fluoro-2-alkenoate esters and related monofluoroalkene derivatives which include fluoro analogs of known insecticides, pheromones or pharmaceuticals. A new method for the preparation of 1,1,2-trifluoro-1,3-butadiene is also provided.

Abstract translation: 1,1,2-三氟-1,3-丁二烯的新化学反应提供了一系列新的氟化烯烃衍生物的简单获取。 这些衍生物提供了用于2-氟-2-烯酸酯和相关单氟烯烃衍生物的立体控制制备的简单的一般方法，其包括已知杀虫剂，信息素或药物的氟类似物。 还提供了制备1,1,2-三氟-1,3-丁二烯的新方法。

公开(公告)号：US4898883A

公开(公告)日：1990-02-06

申请号：US75890

申请日：1987-07-21

Applicant: Gerard Lang ,  Serge Forestier ,  Alain Lagrange ,  Braham Shroot

Inventor： Gerard Lang ,  Serge Forestier ,  Alain Lagrange ,  Braham Shroot

IPC: C07D261/04 ,  A61K8/00 ,  A61K8/11 ,  A61K8/25 ,  A61K8/30 ,  A61K8/31 ,  A61K8/36 ,  A61K8/49 ,  A61K8/65 ,  A61K8/73 ,  A61K8/86 ,  A61K8/99 ,  A61K31/085 ,  A61K31/11 ,  A61K31/12 ,  A61K31/16 ,  A61K31/165 ,  A61K31/19 ,  A61K31/215 ,  A61K31/275 ,  A61K31/70 ,  A61K31/7024 ,  A61P17/00 ,  A61P27/02 ,  A61P27/14 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q7/00 ,  A61Q19/00 ,  C07C41/00 ,  C07C41/30 ,  C07C43/215 ,  C07C43/23 ,  C07C45/00 ,  C07C45/29 ,  C07C45/68 ,  C07C47/277 ,  C07C47/575 ,  C07C49/255 ,  C07C49/84 ,  C07C51/00 ,  C07C59/64 ,  C07C65/28 ,  C07C67/00 ,  C07C69/738 ,  C07C231/00 ,  C07C231/12 ,  C07C235/32 ,  C07C235/40 ,  C07C253/00 ,  C07C255/37 ,  C07D295/18 ,  C07D309/12 ,  C07H13/04 ,  C11D9/50

CPC classification number: C07C65/28 ,  C07C43/23 ,  C07C45/298 ,  C07C45/68 ,  C07C47/277 ,  C07C47/575 ,  C07C49/255 ,  C07C49/84 ,  C07C59/64 ,  Y10S424/13 ,  Y10S514/844 ,  Y10S514/859 ,  Y10S514/864 ,  Y10S514/88 ,  Y10S514/881 ,  Y10S514/886 ,  Y10S514/887 ,  Y10S514/912 ,  Y10S514/946

Abstract: The present invention relates to 1-substituted derivatives of 4-methoxy-2,3,6-trimethylbenzene which are useful in cosmetic or pharmaceutical preparations for use in the treamtnet of dermatological complaints connected with a keratinisation disorder, dermatological complaints having an inflammatory and/or immuno-alleric component or ophthalmological complaints.

Abstract translation: 本发明涉及4-甲氧基-2,3,6-三甲基苯的1-取代衍生物，其可用于化妆品或药物制剂，用于与角质化障碍有关的皮肤病学投诉，皮肤病学上的炎症和/ 或免疫 - 阿拉伯组分或眼科投诉。

公开(公告)号：US4889849A

公开(公告)日：1989-12-26

申请号：US294997

申请日：1989-01-09

Applicant: Ineke Van Wijngaarden ,  Johannes M. A. Zwagemakers ,  Jan Van Dijk

Inventor： Ineke Van Wijngaarden ,  Johannes M. A. Zwagemakers ,  Jan Van Dijk

IPC: C07D211/46 ,  A61K31/445 ,  A61K31/4468 ,  A61K31/451 ,  A61K31/455 ,  C07D211/32 ,  C07D211/58 ,  C07D211/62 ,  C07D295/18 ,  C07D295/194

CPC classification number: C07D295/194 ,  C07D211/32 ,  C07D211/58

Abstract: The invention relates to new spasmolytically active tertiary amine derivatives and the salts thereof, of the formula (1) ##STR1## wherein the symbols have the following meanings: .circle.A is phenyl, or a 5- or 6-membered aromatic group containing 1 or 2 of the following hetero atoms: oxygen and/or sulphur and/or nitrogen;R.sub.1 and R.sub.2 may be equal or different and are hydrogen or substituents;R.sub.3 is a hydrogen atom or, together with R.sub.4, may form a ring consisting of 6 or 7 carbon atoms;R.sub.4 is a hydrogen atom or alkyl group having 1-3 carbon atoms;R.sub.5 is a straight, branched or cyclic alkyl group having 1-4 carbon atoms;R.sub.6 is a straight or branched, saturated or unsaturated alkylene group having a chain length of 2-6 carbon atoms;Z is the group NR.sub.12, wherein R.sub.12 is a hydrogen atom or an alkyl group having 1-3 carbon atoms, or Z is an oxygen atom;n has the value 0 or 1;X is a carbonyl group, thiocarbonyl group or SO.sub.2 group;R.sub.7 and R.sub.8, together with the nitrogen atom to which they are bound, constitute a fully or partly saturated heterocyclic ring consisting of 5-8 ring atoms and which may comprise in addition an O, N or S-atom as the second hetero atom, and may be substituted.

Abstract translation: 本发明涉及式（1）的新的解压活性叔胺衍生物及其盐，其中符号具有以下含义：＆amp; A是苯基或5-或6-元芳基 含有1或2个以下杂原子：氧和/或硫和/或氮; R 1和R 2可以相同或不同，为氢或取代基; R3是氢原子，或者与R4一起可以形成由6或7个碳原子组成的环; R4是氢原子或具有1-3个碳原子的烷基; R5是具有1-4个碳原子的直链，支链或环状烷基; R6是链长2-6个碳原子的直链或支链饱和或不饱和亚烷基; Z是NR12基团，其中R12是氢原子或具有1-3个碳原子的烷基，或Z是氧原子; n的值为0或1; X是羰基，硫代羰基或SO2基团; R7和R8与它们所结合的氮原子一起构成由5-8个环原子组成的完全或部分饱和的杂环，并且另外可以包含作为第二杂原子的O，N或S-原子， 并且可以被替代。

公开(公告)号：US4877789A

公开(公告)日：1989-10-31

申请号：US881776

申请日：1986-07-03

Applicant: Braham Shroot ,  Christopher Hensby ,  Jean Maignan ,  Gerard Lang ,  Serge Restle ,  Michel Colin

Inventor： Braham Shroot ,  Christopher Hensby ,  Jean Maignan ,  Gerard Lang ,  Serge Restle ,  Michel Colin

IPC: A61K8/00 ,  A61K8/11 ,  A61K8/30 ,  A61K8/33 ,  A61K8/36 ,  A61K8/37 ,  A61K8/42 ,  A61K8/49 ,  A61K8/86 ,  A61K31/16 ,  A61K31/165 ,  A61K31/195 ,  A61K31/20 ,  A61K31/202 ,  A61K31/22 ,  A61K31/23 ,  A61K31/40 ,  A61K31/445 ,  A61K31/495 ,  A61P17/00 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  A61Q5/00 ,  A61Q19/00 ,  C07C17/26 ,  C07C51/353 ,  C07C57/18 ,  C07C57/68 ,  C07C67/00 ,  C07C69/606 ,  C07C231/00 ,  C07C231/02 ,  C07C233/02 ,  C07C233/09 ,  C07C233/16 ,  C07C233/20 ,  C07D295/16 ,  C07D295/18 ,  C07D295/185 ,  C07D317/20 ,  C12N9/99

CPC classification number: A61K8/375 ,  A61K8/42 ,  A61Q19/00 ,  A61Q19/004 ,  C07C17/26 ,  C07C57/18 ,  C07C57/68 ,  C07D295/185 ,  C07D317/20 ,  Y10S514/886

Abstract: Compound, corresponding to the formulaC.sub.8 H.sub.17 --(C.tbd.C--CH.sub.2).sub.3 --CH.sub.2 CH.sub.2 CH.sub.2 R O (I)in which R is a C.sub.1 -C.sub.8 lower alkoxy or C.sub.4 -C.sub.6 cycloalkoxy group, substituted with one or more hydroxyl groups and/or interrupted by one or more hetero atoms chosen from oxygen and sulphur, an amino group of structure ##STR1## in which R.sub.1 or R.sub.2, which may be identical or different, denote a hydrogen atom or a linear or branched C.sub.1 -C.sub.8 lower alkyl radical, optionally interrupted by one or more hetero atoms chosen from oxygen, sulphur and nitrogen, this alkyl radical being able to be substituted with one or more hydroxyl groups, R.sub.1 and R.sub.2 not being able to denote hydrogen simultaneously, or alternatively R.sub.1 and R.sub.2 form, together with the nitrogen atom, a heterocyclic system optionally containing oxygen, sulphur or nitrogen as an additional hetero atom, one of the radicals R.sub.1 and R.sub.2 also being able to denote, when the other is a hydrogen atom, an aryl radical of formula (II): ##STR2## or alternatively a benzyl radical of formula (III): ##STR3## in which formulae R.sub.3 and R.sub.4, denote, independently of each other, a hydrogen atom, a C.sub.1 -C.sub.4 alkyl radical, a hydroxyl group, a halogen atom or a carboxyl or trifluoromethyl group, the amine group also being able to originate from a sugar, and also the isomers and salts thereof which are pharmaceutically and cosmetically acceptable.

Abstract translation: 对应于式C 8 H 17 1-（C 3 B c C -CH 2）3 -CH 2 CH 2 CH 2 COR（I）的化合物，其中R是被一个或多个羟基取代和/或被一个或多个羟基取代的C 1 -C 8低级烷氧基或C 4 -C 6环烷氧基 一个或多个选自氧和硫的杂原子，结构“IMAGE”的氨基，其中可以相同或不同的R 1或R 2表示氢原子或直链或支链C 1 -C 8低级烷基，任选地中断 通过一个或多个选自氧，硫和氮的杂原子，该烷基能够被一个或多个羟基取代，R1和R2不能同时表示氢，或者R1和R2与 氮原子，任选地含有氧，硫或氮作为另外的杂原子的杂环体系，当另一个是氢原子时，基团R 1和R 2之一也可以表示式（II）的芳基： （II）或苄基r 式（III）的化合物：其中式R3和R4彼此独立地表示氢原子，C1-C4烷基，羟基，卤素原子或羧基或三氟甲基的式（III） 基团，也可以来自糖的胺基，以及其药学和化学上可接受的异构体和盐。

公开(公告)号：US4874765A

公开(公告)日：1989-10-17

申请号：US41206

申请日：1987-04-22

Applicant: Erzsebet Lapis ,  Edit Toth ,  Bela Kiss ,  Jozsef Torley ,  Eva Palosi ,  Istvan Hajdu ,  Laszlo Szporny ,  Dora Groo ,  Istvan Laszlovszky

Inventor： Erzsebet Lapis ,  Edit Toth ,  Bela Kiss ,  Jozsef Torley ,  Eva Palosi ,  Istvan Hajdu ,  Laszlo Szporny ,  Dora Groo ,  Istvan Laszlovszky

IPC: C07D295/08 ,  A61K31/495 ,  A61P25/00 ,  A61P25/24 ,  A61P25/26 ,  C07D295/088 ,  C07D295/18 ,  C07D295/185 ,  C07D295/10

CPC classification number: C07D295/185 ,  C07D295/088

Abstract: The invention relates to novel 1,4-disubstituted piperazine derivatives of the general formula (I), pharmaceutically acceptable acid addition and quaternary ammonium salts thereof, pharmaceutical compositions containing them and a process for their preparation. In the general formula (I) ##STR1## R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are the same or different and stand for hydrogen or halogen or a trihalomethyl, lower alkyl, lower alkoxy, nitro, hydroxyl, aralkyloxy or an 1-(2-propenyl-4-piperazinyl) group;R.sub.5 stands for hydrogen or a C.sub.1-4 alkyl group;R.sub.6 represents a C.sub.3-6 alkyl, alkenyl, alkynyl group or a ##STR2## group, wherein R.sub.7 means a C.sub.2-5 alkyl, alkenyl or alkinyl group; andis 2 or 3,with the provisos that:R.sub.6 is different from isopropyl, n-butyl and isobutyl group when R.sub.2, R.sub.3, R.sub.4 and R.sub.5 stand for hydrogen, R.sub.1 means 2-chloro and n is 2;R.sub.6 is different from isopropyl group when R.sub.2, R.sub.3, R.sub.4 and R.sub.5 stand for hydrogen, R.sub.1 means 2-chloro and n is 2; or when R.sub.2, R.sub.3, R.sub.4 and R.sub.5 stand for hydrogen, R.sub.1 means 2-methyl group and n is 2; andR.sub.6 is different from propionyl group when R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are hydrogen and n means 2.The compounds of the general formula (I) are therapeutically useful for the treatment of diseases arising from a hypofunction of the dopaminergic system.

Abstract translation: 本发明涉及通式（I）的新的1,4-二取代哌嗪衍生物，其药学上可接受的酸加成盐和季铵盐，含有它们的药物组合物及其制备方法。 在通式（I）中，R 1，R 2，R 3和R 4相同或不同，代表氢或卤素或三卤代甲基，低级烷基，低级烷氧基，硝基，羟基，芳烷氧基或1- （2-丙烯基-4-哌嗪基）基团; R5代表氢或C1-4烷基; R6表示C3-6烷基，烯基，炔基或者IMAGE基团，其中R7表示C2-5烷基，烯基或炔基; 并且为2或3，条件是：当R 2，R 3，R 4和R 5代表氢时，R 6不同于异丙基，正丁基和异丁基，R 1表示2-氯且n为2; 当R2，R3，R4和R5代表氢时，R6不同于异丙基，R1表示2-氯，n是2; 或当R2，R3，R4和R5代表氢时，R1表示2-甲基，n表示2; 当R 1，R 2，R 3，R 4和R 5为氢且n表示2时，R 6与丙酰基不同。通式（I）的化合物可治疗用于治疗多巴胺能系统功能低下的疾病。

公开(公告)号：US4873350A

公开(公告)日：1989-10-10

申请号：US253955

申请日：1988-10-03

Applicant: Andre Welter ,  Harmut Fischer ,  Leon Christiaens ,  Albrecht Wendel ,  Eugen Etschenberg ,  Norbert Dereu ,  Peter Kuhl ,  Eric Graf

Inventor： Andre Welter ,  Harmut Fischer ,  Leon Christiaens ,  Albrecht Wendel ,  Eugen Etschenberg ,  Norbert Dereu ,  Peter Kuhl ,  Eric Graf

IPC: A61K31/165 ,  A61K31/19 ,  A61K31/27 ,  A61K31/275 ,  A61K31/357 ,  A61K31/36 ,  A61K31/445 ,  A61P1/16 ,  A61P9/08 ,  A61P9/10 ,  A61P29/00 ,  A61P43/00 ,  C07C67/00 ,  C07C325/00 ,  C07C391/02 ,  C07D295/18 ,  C07D317/68

CPC classification number: A61K31/165 ,  C07C391/02

Abstract: The present invention relates to new diselenobis-benzoic acid amides of primary and secondary amines of the general formula (I): ##STR1## and processes for the treatment of diseases in humans caused by a cell injury.

Abstract translation: 本发明涉及通式（I）的伯胺和仲胺的新的二硒代苯甲酰胺和由细胞损伤引起的人类疾病的治疗方法。

公开(公告)号：US4835179A

公开(公告)日：1989-05-30

申请号：US54409

申请日：1987-05-26

Applicant: Xavier D. Cirera ,  Romeo R. Andreoli ,  Pedro P. Lloveras ,  Leonida Bruseghini ,  Jose P. Irurre

Inventor： Xavier D. Cirera ,  Romeo R. Andreoli ,  Pedro P. Lloveras ,  Leonida Bruseghini ,  Jose P. Irurre

IPC: C07D295/02 ,  A61K31/135 ,  A61K31/22 ,  A61K31/44 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/4465 ,  A61K31/4468 ,  A61K31/495 ,  A61K31/535 ,  A61K31/5375 ,  A61P1/04 ,  A61P9/08 ,  A61P11/00 ,  A61P25/24 ,  A61P25/26 ,  C07C67/00 ,  C07C209/00 ,  C07C209/08 ,  C07C211/32 ,  C07D207/32 ,  C07D207/335 ,  C07D211/26 ,  C07D213/38 ,  C07D213/74 ,  C07D241/04 ,  C07D295/03 ,  C07D295/073 ,  C07D295/088 ,  C07D295/10 ,  C07D295/104 ,  C07D295/108 ,  C07D295/112 ,  C07D295/12 ,  C07D295/15 ,  C07D295/18 ,  C07D295/185 ,  C07D295/192 ,  C07D295/205 ,  C07D295/215 ,  C07D307/14 ,  C07D307/52 ,  C07D317/52 ,  C07D317/58 ,  C07D333/20 ,  C07D401/06

CPC classification number: C07D207/335 ,  C07D211/26 ,  C07D213/38 ,  C07D213/74 ,  C07D241/04 ,  C07D295/03 ,  C07D295/073 ,  C07D295/088 ,  C07D295/104 ,  C07D295/108 ,  C07D295/112 ,  C07D295/15 ,  C07D295/185 ,  C07D295/192 ,  C07D295/205 ,  C07D295/215 ,  C07D307/52 ,  C07D317/52 ,  C07D317/58 ,  C07D333/20

Abstract: Dihydrodibenzocycloheptyliden-ethylene derivatives of the general formula: ##STR1## in which, R.sub.1 represents an alkyl group having from 1 to 4 carbon atoms;R.sub.2 represents a hydrogen atom or an alkyl group having from 1 to 4 carbon atoms; andR.sub.3 represents a hydrogen atom, an alkyl group having from 1 to 4 carbon atoms or --CO--(C.sub.1 -C.sub.4 alkyl),are disclosed. These compounds are useful in the treatment of ulcer conditions.