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31 条记录 (耗时 0.013 秒)

    Aminobenzamide derivatives
    6.
    发明授权
    Aminobenzamide derivatives 失效
    氨基苯甲酰胺衍生物

    公开(公告)号：US4985595A

    公开(公告)日：1991-01-15

    申请号：US279256

    申请日：1988-12-01

    申请人： Tosaku Miki ,  Masahide Asano ,  Toru Hosokami

    发明人： Tosaku Miki ,  Masahide Asano ,  Toru Hosokami

    IPC分类号： A61K31/165 ,  A61K31/185 ,  A61K31/27 ,  A61K31/535 ,  A61K31/5375 ,  A61P1/04 ,  C07C67/00 ,  C07C231/00 ,  C07C237/06 ,  C07C237/10 ,  C07C237/22 ,  C07C239/00 ,  C07C271/28 ,  C07C301/00 ,  C07C309/14 ,  C07D295/18 ,  C07D295/192

    CPC分类号： C07D295/192

    摘要： Aminobenzamide derivatives of the formula (I) ##STR1## wherein: R.sub.1 and R.sub.2 each represents a lower alkoxy group,R.sub.3 represents a hydrogen atom, a lower alkyl group, a lower acyl group, a lower alkoxycarbonyl group or --R.sub.5 --SO.sub.3 Z, wherein R.sub.5 represents a lower alkylene group and Z represents an alkali metal or an alkaline earth metal,R.sub.4 represents an amino group, a morpholino group or a lower alkylamino group which may be substituted with a hydroxyl group at the alkyl moiety thereof, with the proviso that, when R.sub.3 represents a hydrogen atom, R.sub.4 cannot be an amino group,Y represents a hydrogen atom, a halogen atom or a lower alkoxy group,n represents an integer of from 1 to 6,and salts thereof; are disclosed. These compounds have excellent anti-peptic ulcer activities, and chemical and physical stabilities.

    摘要翻译： 式（I）的氨基苯甲酰胺衍生物其中：R 1和R 2各自表示低级烷氧基，R 3表示氢原子，低级烷基，低级酰基，低级烷氧基羰基或-R 5 - SO 3 Z，其中R 5表示低级亚烷基，Z表示碱金属或碱土金属，R 4表示可以在其烷基部分被羟基取代的氨基，吗啉代基或低级烷基氨基， 条件是当R3表示氢原子时，R4不能为氨基，Y表示氢原子，卤原子或低级烷氧基，n表示1〜6的整数，及其盐类; 被披露。 这些化合物具有优异的抗消化性溃疡活性，以及​​化学和物理稳定性。

    N-Phenethylacetamide compounds and process for preparation thereof
    7.
    发明授权
    N-Phenethylacetamide compounds and process for preparation thereof 失效
    N-苯乙基乙酰胺化合物及其制备方法

    公开(公告)号：US4297357A

    公开(公告)日：1981-10-27

    申请号：US70085

    申请日：1979-08-27

    申请人： Tosaku Miki ,  Masahide Asano

    发明人： Tosaku Miki ,  Masahide Asano

    IPC分类号： C07D213/74 ,  C07D239/46 ,  C07D239/48 ,  C07D263/44 ,  A61K31/505 ,  A61K31/165 ,  A61K31/44

    CPC分类号： C07D213/74 ,  C07D239/47 ,  C07D239/48 ,  C07D263/44

    摘要： N-phenethylacetamide compounds of the formula: ##STR1## wherein X.sub.1 represents a lower alkoxy group, X.sub.2 represents a hydrogen atom or a lower alkoxy group and R represents a phenyl group, a pyridyl group, a pyrimidinyl group or a benzoyl group, each of which may have one or more substituents selected from a halogen atom, a carbamoyl group, a lower alkoxy group, a sulfamoyl group, an amino group, a lower alkylamino group, a lower alkylthio group, a hydroxy group and a lower alkoxycarbonyl group; the parmaceutically acceptable acid addition salts and hydrates thereof; as well as the process for preparing such compounds and salts and hydrates thereof; the compounds, their salts and their hydrates having a distinct anti-peptic ulcer activity in human and animals.

    摘要翻译： 下式的N-苯乙基乙酰胺化合物：其中X1表示低级烷氧基，X2表示氢原子或低级烷氧基，R表示苯基，吡啶基，嘧啶基或苯甲酰基， 其可以具有一个或多个选自卤素原子，氨基甲酰基，低级烷氧基，氨磺酰基，氨基，低级烷基氨基，低级烷硫基，羟基和低级烷氧基羰基的取代基。 其药学上可接受的酸加成盐和水合物; 以及制备这些化合物及其盐和水合物的方法; 化合物，其盐及其水合物在人和动物中具有明显的抗消化性溃疡活性。