公开(公告)号：US11237101B2

公开(公告)日：2022-02-01

申请号：US16115178

申请日：2018-08-28

申请人： MLS ACQ, Inc.

发明人： Eddie Dean Wyatt ,  Martin L. Spartz

IPC分类号： G01N21/3504 ,  G01N30/02 ,  G01N30/86 ,  G01N33/00 ,  G01N21/35 ,  G01N30/04 ,  G01N30/72

摘要： A process for identifying an unknown compound in a sample includes matching a peak in a primary Fourier Transform Infrared spectral region of the sample spectrum with reference spectra in the same spectral region to generate an initial list of potential candidates, based, for example on goodness of fit criteria. The initial list can be reduced by retention time information and/or global peak matching techniques that analyze the sample spectrum in regions outside the primary region.

公开(公告)号：US20220011281A1

公开(公告)日：2022-01-13

申请号：US17475372

申请日：2021-09-15

申请人： SOULBRAIN CO., LTD.

发明人： Dong-Ho JO ,  Sung Kyun YU

IPC分类号： G01N30/96 ,  H01M10/48 ,  G01N30/64 ,  G01N30/04

摘要： The present disclosure relates to a nanoscale thin film structure and implementing method thereof, more specifically nanoscale thin film structure of which target structure is designed with quantized thickness and a method to implement the nanoscale thin film structure by which the performance of the manufactured nanodevice can be implemented the same as the designed performance, thereby applicable to high sensitivity high performance electronic/optical sensor devices.

公开(公告)号：US20220003726A1

公开(公告)日：2022-01-06

申请号：US17293978

申请日：2019-11-18

申请人： UNIVERSITEIT LEIDEN

发明人： Thomas HANKEMEIER ,  Anne Charlotte DUBBELMAN ,  Amy C. HARMS ,  Oskar GONZÁLEZ

IPC分类号： G01N30/72 ,  G01N30/86 ,  G01N30/04

摘要： The present invention relates to a method for quantifying one or more analytes in a sample by an analysis system comprising a separation unit (LC column), a means of adding a solution post-column (Connector), and a detection unit comprising a mass spectrometer coupled through an ionization source, the method comprising: ⋅ (i) inducing matrix effect on the analytes in the sample and on the post-column infused internal standards (PCI-ISs); ⋅ (ii) matching one or more post-column infused internal standard (PCI-IS) to each analyte that best matches the analyte's response to the matrix effect, and ⋅ (iii) storing the analyte-matched PCI-IS identification and, optionally, associated response data in a library; and ⋅ (iv) applying the analyte-matched PCI-IS to the analyte in other samples to correct the analyte peak responses for the matrix effect during ionization and to obtain (absolute) quantitation of the analyte using the response data.

公开(公告)号：US11204342B2

公开(公告)日：2021-12-21

申请号：US15862789

申请日：2018-01-05

申请人： SHIMADZU CORPORATION

发明人： Fumitaka Maruyama ,  Shigehiko Fujimaki

IPC分类号： G01N30/72 ,  G01N30/04 ,  G01N30/12 ,  H01J49/00

摘要： A reference sample for analysis that is optimal for calibration of a pyrolysis gas chromatograph-mass spectrometer and with which precise calibration is always possible by preventing a reference substance from evaporating is provided. A reference sample sheet 1 is provided by distributing a target component or target components with a uniform normality in a base made of a high polymer material, and the reference sample sheet 1 is rolled up so that the target component or target components can be prevented from evaporating from the reference sample sheet 1 even in the case where a component has volatility. A reference sample for calibration of a pyrolysis gas chromatograph-mass spectrometer can be easily, quickly, and efficiently collected by punching out the reference sample sheet 1 using a micro-puncher 2.

公开(公告)号：US20210333244A1

公开(公告)日：2021-10-28

申请号：US17366467

申请日：2021-07-02

申请人： Shimadzu Corporation

发明人： Tomoyuki YAMAZAKI

IPC分类号： G01N30/04 ,  B01D15/20 ,  G01N30/26 ,  G01N30/80 ,  G01N30/84 ,  G01N30/06 ,  B01D15/22 ,  G01N30/82

摘要： A preparative liquid chromatograph includes a liquid chromatograph section, a trap section, an eluent supply section, a collector, and a flow path switching section. The flow path switching section is configured to be selectively switched to a component trap mode that connects the liquid chromatograph section and the trap section in such a way that a sample component separated in a separation column is trapped by a trap column of the trap section; and a collection mode that connects the eluent supply section and the trap section and connects the trap section and the collector in such a way that the components trapped in the trap column are eluted by an eluent from the eluent supply section and are guided to the collector.

公开(公告)号：US20210318275A1

公开(公告)日：2021-10-14

申请号：US17229186

申请日：2021-04-13

申请人： Regeneron Pharmaceuticals, Inc.

发明人： Eric Shierly ,  Kevin Brennan ,  Nathan Mao

IPC分类号： G01N30/74 ,  G01N30/04 ,  G01N1/34 ,  G06F17/18 ,  G01N21/33 ,  G01N30/88 ,  G01N33/48

摘要： Disclosed are methods for monitoring column chromatography performance. The methods can include acquiring one or more chromatogram ultraviolet (UV) traces generated by a chromatography system during sample purification and/or separation; and analyzing the one or more acquired chromatogram UV traces with an orthogonal partial least squares (OPLS) model, thereby allowing detection of column deterioration prior to column failure and quantitative analysis of UV signal in the one or more chromatogram UV traces.

公开(公告)号：US11125731B2

公开(公告)日：2021-09-21

申请号：US15882473

申请日：2018-01-29

申请人： IEC Electronics Corp.

发明人： Mark Northrup

IPC分类号： G01R31/28 ,  H01L23/00 ,  G01N30/88 ,  G01N30/86 ,  B01D15/36 ,  G01N30/06 ,  G01N30/96 ,  G01N30/04 ,  G01N30/56

摘要： Parts are exposed to liquid chromatography to generate a corresponding chromatogram, wherein the chromatogram is compared to a chromatogram of a genuine part to determine if the tested part is suspect counterfeit. Depending on the selected predetermined target analytes, the generated chromatogram can be used to assess an associated manufacturing process as conforming or non-conforming.

公开(公告)号：US10900939B2

公开(公告)日：2021-01-26

申请号：US16275417

申请日：2019-02-14

申请人： Promega Corporation

发明人： Joshua Jacques Coon ,  Michael M. Rosenblatt ,  Marjeta Urh

IPC分类号： G01N30/86 ,  G01N30/02 ,  H01J49/00 ,  G01N30/04 ,  G01N30/88

摘要： The present invention provides reagents for instrumentation quality control and methods of use thereof. In particular, sets of peptides or other molecules are provided for evaluating the performance of instruments with mass spectrometry (MS) and/or liquid chromatography (LC) functionalities.

公开(公告)号：US10753916B2

公开(公告)日：2020-08-25

申请号：US15872842

申请日：2018-01-16

申请人： Waters Technologies Corporation

发明人： Moon Chul Jung ,  Jonathan L. Belanger ,  Xiangjin Song ,  Abhijit Tarafder ,  Joseph A. Jarrell ,  Wade P. Leveille

IPC分类号： G01N30/88 ,  G01M3/20 ,  G01N30/60 ,  G01N30/86 ,  G01M3/26 ,  G01N30/02 ,  G01N30/26 ,  G01N30/04

摘要： Systems, methods, and devices for detecting leaks in chromatography systems are disclosed. The leak detection system includes a sealable compartment disposed to surround at least one component of a chromatography system. The detector is in communication, e.g., fluid communication, with an interior of the sealable compartment and configured to detect the leak by various mean including the presence of liquid or the presence of vapor, or both within the sealable compartment.

公开(公告)号：US20200173967A1

公开(公告)日：2020-06-04

申请号：US16634529

申请日：2018-07-24

申请人： KYOCERA Corporation

发明人： Shinichi ABE

IPC分类号： G01N30/28 ,  G01N30/04 ,  G01N33/00 ,  G01N30/02 ,  G01N30/30

摘要： A sensor module includes a sensor configured to detect a specific substance in a sample, a first channel, and a second channel The first channel supplies a first fluid as the sample to the sensor. The second channel supplies a second fluid different from the first fluid to the sensor. The second channel includes a second fluid buffer tank for holding the second fluid for a fixed time interval.