公开(公告)号：US10231992B2

公开(公告)日：2019-03-19

申请号：US15283759

申请日：2016-10-03

申请人： HISTOCELL, S.L.

发明人： María Begoña Castro Feo ,  Iker Azcoitia Ramsden ,  Teodoro Palomares Casado ,  Jone Herrero De Miguel ,  Ana Isabel Alonso Varona ,  Maite Del Olmo Basterrechea

IPC分类号： A61K8/00 ,  A61K31/736 ,  A61K31/12 ,  A61K31/198 ,  A61K36/483 ,  A61K36/9066 ,  A61K35/33 ,  A61K8/73 ,  A61K35/12 ,  A61K35/30 ,  A61K35/32 ,  A61K35/36 ,  A61Q19/00 ,  A61K8/35 ,  A61K8/44 ,  A61Q17/04 ,  A61Q19/08 ,  A61K8/04 ,  A61K8/46 ,  A61K8/98 ,  A61K9/00

摘要： The present invention relates to an antioxidant composition comprising a combination of galatomannan and N-acetyl cysteine for its use in the treatment of a skin disease or condition resulting from reactive oxygen species production in the skin or involving reactive oxygen species production in the skin, to a hydrogel containing said combination as well as to dressing wounds comprising said hydrogel and its use in the healing of ulcers, wounds, burns and scalds.

公开(公告)号：US10226441B2

公开(公告)日：2019-03-12

申请号：US15534319

申请日：2015-12-01

申请人： NIHON SIZEN HAKKOH CO., LTD.

发明人： Naoki Higashi ,  Masahiro Nakanishi

IPC分类号： A61K31/198 ,  A23K10/12 ,  A23L33/105 ,  A61K8/99 ,  A61K35/744 ,  A61K36/03 ,  A61K36/062 ,  A61K36/064 ,  A61K36/07 ,  A61K36/16 ,  A61K36/185 ,  A61K36/23 ,  A61K36/28 ,  A61K36/282 ,  A61K36/31 ,  A61K36/39 ,  A61K36/42 ,  A61K36/44 ,  A61K36/48 ,  A61K36/49 ,  A61K36/52 ,  A61K36/75 ,  A61K36/899 ,  A61K31/19 ,  A61K31/192 ,  A61K31/194 ,  A61K31/196 ,  A61K31/197 ,  A61K31/352 ,  A61K31/353 ,  A61K31/401 ,  A61K31/405 ,  A61K31/4172 ,  A23K50/50 ,  A23L2/52 ,  A61K36/535 ,  A61K36/60 ,  A61K36/605 ,  A61K36/73 ,  A61K36/736 ,  A61K36/752 ,  A61K36/78 ,  A61K36/81 ,  A61K36/87 ,  A61K36/88 ,  A61K36/888 ,  A61K36/8945 ,  A61K36/8962 ,  A61K36/8967 ,  A61K36/8994 ,  A61K36/8998 ,  A61K36/9066 ,  A61K36/9068

摘要： An object of the present invention is to provide a senescence retarding agent that delays the onset of senescence symptoms and extends longevity, and is superior in safety. The senescence retarding agent of the present invention that achieves the object is characterized by containing a plant fermentation product as an active ingredient, the plant fermentation product being a mixture of the following: (a) a koji mold-fermented product of one or more kinds of beans and/or cereals selected from the group consisting of barley, black soybean, red rice, black rice, adzuki bean, adlay, Japanese millet, foxtail millet, and millet; (b) a yeast- and/or lactic acid bacterium-fermented product of one or more kinds of fruits selected from the group consisting of mikan (mandarin orange), grape, apple, yama-budo (crimson glory grape), peach, kaki (Japanese persimmon), papaya, nashi (Japanese pear), watermelon, ume (Japanese apricot), fig, karin (Chinese quince), pumpkin, kumquat, yuzu (Chinese lemon), loquat, apricot, jujube, chestnut, matatabi (silvervine), and sumomo (Japanese plum); (c) a yeast- and/or lactic acid bacterium-fermented product of one or more kinds of root crops and/or potatoes selected from the group consisting of murasaki-imo (purple sweet potato), kikuimo (Jerusalem artichoke), carrot, onion, satsuma-imo (sweet potato), satoimo (taro), jinenzyo (Japanese yam), daikon (Japanese radish), akakabu (red turnip), gobo (burdock root), renkon (lotus root), yacon, yuri-ne (lily bulb), kuwai (arrowhead), ginger, garlic, and turmeric; (d) a yeast- and/or lactic acid bacterium-fermented product of one or more kinds of flowers and/or leaf vegetables selected from the group consisting of cabbage, shiso (perilla), mulberry leaves, dokudami (Korean houttuynia), yomogi (wormwood), kumazasa (kuma bamboo grass), and dandelion; (e) a yeast- and/or lactic acid bacterium-fermented product of one or more kinds of seaweeds selected from the group consisting of kombu (sea tangle), wakame (Undaria pinnatifida), and mozuku (Nemacystus decipiens); (f) a yeast- and/or lactic acid bacterium-fermented product of one or more kinds of seeds selected from the group consisting of black sesame seeds, walnuts, and ginkgo nuts; and (g) a yeast- and/or lactic acid bacterium-fermented product of one or two kinds of mushrooms selected from the group consisting of maitake (Grifola frondosa) and shiitake (Lentinus edodes).

公开(公告)号：US20190054093A1

公开(公告)日：2019-02-21

申请号：US15780527

申请日：2015-04-02

申请人： Nektium Pharma SL

发明人： Miguel Jimenez del RIO ,  Jose Maria ZUBEL-DIA FERNANDEZ ,  Aaron HERNANDEZ SANTANA ,  Julia Charlotte WIEBE

IPC分类号： A61K31/575 ,  A61K36/21 ,  A61K36/53 ,  A61K36/28 ,  A61K36/88 ,  A61K31/7048 ,  A61K36/9066 ,  A61K31/12 ,  A61K36/67 ,  A61K31/357 ,  A61K31/353 ,  A61K36/16 ,  A61K36/9068 ,  A61K36/258 ,  A61K31/05 ,  A61K36/33 ,  A61K36/8945 ,  A61K36/752 ,  A61K31/565 ,  A61P21/00

摘要： The current disclosure relates to methods for treating loss of muscle mass, by administering compositions comprising a combination of: 20-hydroxy-ecdysone (20HE) or a pharmaceutically acceptable salt thereof; and at least one ecdysteroid selected from the group consisting of polypodine, makisterone A, integristerone, taxisterone, lesterone, rapisterone, inokonesterone, carthamosterone, rubrosterone, leuzeasterone, ayugasterone, turkestrone, salts thereof, and derivatives thereof. The composition optionally further comprises an effective amount of hesperidin.

公开(公告)号：US10201583B2

公开(公告)日：2019-02-12

申请号：US15342627

申请日：2016-11-03

申请人： Access Business Group International LLC

发明人： David J. Fast ,  Jennifer Patterson ,  Arun Rajgopal ,  Donald J. Pusateri ,  Kevin W. Gellenbeck ,  Jeffrey Scholten ,  Stephen R. Missler ,  Russell K. Randolph ,  Jennifer Chuang ,  Yumei Lin ,  Valiantsina Kazlova

IPC分类号： A61K36/60 ,  A61K36/82 ,  A61K36/906 ,  A61K36/53 ,  A61K36/9066 ,  A61K36/31 ,  A23L2/52 ,  A61K31/352 ,  A61K45/06 ,  A23L33/105 ,  A23L33/16 ,  A23L33/15 ,  A23L33/155

摘要： A supplement including a blend of turmeric, quercetin and rosemary, or holy basil, wasabi, and broccoli seed extract which are present in a balanced and predetermined ratio, and which stimulate the Antioxidant Response Element (ARE), Quinone Reductase, and/or induce related gene expression, for example, heme oxygenase-1 (HMOX-1) expression. The blend of ingredients can be formed as or in a dietary supplement adapted for administration to a subject. The dietary supplement can be formulated so that the turmeric, quercetin and rosemary are present in a predetermined ratio of 1:3:5, or holy basil, wasabi, and broccoli seed extract in a predetermined ratio of 1:1:0.2. Additional ingredients can be included in the supplement. The supplement can synergistically affect natural antioxidant response pathways within cells of a subject to whom the supplement is administered. A related method of use is also provided.

公开(公告)号：US20190008907A1

公开(公告)日：2019-01-10

申请号：US16023050

申请日：2018-06-29

申请人： Noori AL-WAILI

发明人： Noori AL-WAILI

IPC分类号： A61K35/644 ,  A61K36/9066 ,  A61K9/00 ,  A61K31/122 ,  A61K36/71 ,  A61P31/04

摘要： A composition including a mixture of honey, curcumin, propolis or CAPE or any two of them is used to treat a variety of medical conditions. The composition can be administered topically, orally, by inhalation or parenterally. The composition is useful in treating wounds, infections, diabetes, skin conditions, renal conditions, dehydration, malnutrition, hypertension and various other conditions. The mixture of honey, curcumin, and propolis or CAPE, either alone or in combination with other natural products is more effective than the administration of single ingredient.

公开(公告)号：US10166266B2

公开(公告)日：2019-01-01

申请号：US15958654

申请日：2018-04-20

申请人： Benny Antony

发明人： Benny Antony

IPC分类号： A61K36/81 ,  A61K9/14 ,  A61K36/71 ,  A61K9/50 ,  A61K9/28 ,  A61K36/87 ,  A61K36/9066 ,  A61K36/23 ,  A61K36/47 ,  A61K36/67 ,  A61K36/185 ,  A61K36/53 ,  A61K36/534 ,  A61K36/54 ,  A61K36/48 ,  A61K36/9068 ,  A61K36/82

摘要： The invention relates to an extract of Ashwagandha that exhibit enhanced bioactivity and bioavailability comprising of enriched withanolide glycosides and saponins; with negligible amount of alkaloids, withanolide aglycones and oligosaccharides. The extract as disclosed prepared from root, stems, leaves and whole plant of Ashwagandha further shows improved immunomodulatory activity, anti-inflammatory activity, anti stress activity, antidiabetic activity and sleep quality. The disclosure also provides a method of improving bioactivity of withanolide glycosides even at lower doses, by the administration of an enteric coated formulation of extract of Ashwagandha to humans. The enteric coating protects the composition from hydrolysis in the acidic environment of the stomach to release the withanolide glycoside in neutral/alkaline pH in gastrointestinal tract (GIT) thus enhancing the absorption. Further the process of preparation of the extract of Ashwagandha enriched with withanolide glycosides and saponins are disclosed along with various formulations.

公开(公告)号：US10137164B2

公开(公告)日：2018-11-27

申请号：US14986846

申请日：2016-01-04

申请人： Melaleuca, Inc.

发明人： Alexander B. Rabovsky ,  Stephanie Y. Nielson

IPC分类号： A61K36/9066 ,  A61K36/68 ,  A61K36/185 ,  A61K36/80 ,  A61K9/20 ,  A61K9/48 ,  A61K31/12 ,  A61K31/14 ,  A61K31/355 ,  A61K31/4748 ,  A61K31/519 ,  A61K31/221 ,  A23L33/10 ,  A23L33/105 ,  A23L33/15 ,  A23L33/175

摘要： This document provides dietary supplement compositions. For example, dietary supplement compositions having an acetylcholinesterase inhibitor (e.g., huperzine A), a Bacopa monnieri extract, acetyl-L-carnitine or acetyl CoA, and a curcuminoid (e.g., curcumin) are provided.

公开(公告)号：US10136663B2

公开(公告)日：2018-11-27

申请号：US14126106

申请日：2012-06-13

申请人： Woo-Song Lee ,  Young-Bae Ryu ,  Young-Min Kim ,  Su-Jin Park ,  Mun-Chual Rho ,  Hyung-Jae Jeong ,  Hyung-Jun Kwon

发明人： Woo-Song Lee ,  Young-Bae Ryu ,  Young-Min Kim ,  Su-Jin Park ,  Mun-Chual Rho ,  Hyung-Jae Jeong ,  Hyung-Jun Kwon

IPC分类号： A61K36/00 ,  A61K36/906 ,  A61K36/28 ,  A23L1/30 ,  A61K31/12 ,  A61K31/704 ,  A61K36/9066 ,  A23K20/111 ,  A23K20/163 ,  A23K50/10 ,  A23K50/75 ,  A23K50/30 ,  A23L33/105 ,  A61K47/69

摘要： The present invention relates to a complex comprising a compound of formula (I), or a plant extract comprising the compound or a fraction thereof; and stevioside, or a plant extract comprising the stevioside or a fraction thereof, and relates to a pharmaceutical composition for preventing or treating an influenza virus infection comprising the complex as an active ingredient. Also, the present invention relates to a food composition for preventing or improving an influenza virus infection, a virucidal quasi-drug composition, a virucidal feed additive, and a feed, which comprises the complex as an active ingredient. According to the present invention, the complex comprising a compound of formula (I), or a plant extract comprising the compound or a fraction thereof; and stevioside, or a plant extract comprising the stevioside or a fraction thereof exhibits a virucidal effect and an effect of inhibiting cell degradation against an influenza virus as well as antiviral efficacy in a specific pathogen-free (SPF) chicken, and thus can be usefully used in the prevention and treatment of an influenza virus infection.

公开(公告)号：US20180325842A1

公开(公告)日：2018-11-15

申请号：US15972532

申请日：2018-05-07

申请人： mcePharma s. r. o. ,  IMCoPharma a.s.

发明人： Jan Stonis ,  Ivan Mikes ,  Andrea Dolezalova ,  Jarmila Kralova ,  Milan Jakubek ,  Pavel Martasek ,  Vladimir Kral

IPC分类号： A61K31/12 ,  A61K9/00 ,  A61K36/9066 ,  A61K9/20 ,  A61P35/00

CPC分类号： A61K31/12 ,  A61K9/0056 ,  A61K9/2059 ,  A61K9/5123 ,  A61K36/9066 ,  A61P35/00

摘要： Orodispersible tablet with biologically available curcumin containing particles of extract of rhizome of plant Curciuma longa containing, at least, 95% by weight of curcumin ground to size 100 to 250 nm in mixture with mannitol in ratio 1 to 3:1 (mannitol:curcumin) on orodispersible carrier, and curcumin of the extract 100% biologically available through oral mucosa.

公开(公告)号：US20180318374A1

公开(公告)日：2018-11-08

申请号：US16030408

申请日：2018-07-09

申请人： Muniyal Ayurvedic Research Centre

发明人： M. Vijayabhanu SHETTY

IPC分类号： A61K36/53 ,  A61K36/185 ,  A61K36/328 ,  A61K35/04 ,  A61K33/00 ,  A61K33/34 ,  A61K35/614 ,  A61K35/618 ,  A61K33/26 ,  A61K33/24 ,  A61K33/30 ,  A61K47/44 ,  A61P3/06 ,  A61P3/04 ,  A61K9/20 ,  A61K36/9068 ,  A61K36/67 ,  A61K35/02 ,  A61K36/9066 ,  A61K36/81 ,  A61K36/28 ,  A61K36/35 ,  A61K36/68 ,  A61K36/58 ,  A61K36/264 ,  A61K36/8905 ,  A61K36/24 ,  A61K36/428 ,  A61K36/484 ,  A61K36/48 ,  A61K36/61 ,  A61K36/59

CPC分类号： A61K36/53 ,  A61K9/2068 ,  A61K33/00 ,  A61K33/06 ,  A61K33/24 ,  A61K33/242 ,  A61K33/26 ,  A61K33/30 ,  A61K33/34 ,  A61K35/02 ,  A61K35/04 ,  A61K35/614 ,  A61K35/618 ,  A61K36/185 ,  A61K36/24 ,  A61K36/264 ,  A61K36/28 ,  A61K36/324 ,  A61K36/328 ,  A61K36/35 ,  A61K36/428 ,  A61K36/48 ,  A61K36/484 ,  A61K36/58 ,  A61K36/59 ,  A61K36/61 ,  A61K36/67 ,  A61K36/68 ,  A61K36/81 ,  A61K36/85 ,  A61K36/8905 ,  A61K36/9066 ,  A61K36/9068 ,  A61K47/44 ,  A61K2236/15 ,  A61K2236/331 ,  A61P3/04 ,  A61P3/06 ,  A61K2300/00

摘要： Herbal formulation for treatment/management of metabolic disorders and related complications are disclosed herein. The disclosed herbal formulation includes herb and mineral elements which facilitate in treating lipid metabolism disorders including Dyslipidemia, obesity, etc. The formulation disclosed herein may also be used in treating any condition associated with Dyslipidemia such as cardio vascular diseases, cerebro vascular diseases, stroke, pancreatitis, steatohepatitis, atherosclerosis, hyperglycemia, metabolic syndrome, etc. Further, the disclosed formulation may also be instrumental as anti-atherosclerotic and hypolipidemic agent.