公开(公告)号：US20240091244A1

公开(公告)日：2024-03-21

申请号：US18264158

申请日：2021-04-24

申请人： SAVA HEALTHCARE LIMITED

发明人： Vinod Ramchandra JADHAV ,  Sriram PADMANABHAN

IPC分类号： A61K31/7048 ,  A61K9/00 ,  A61K9/20 ,  A61K36/68 ,  A61K47/34 ,  A61P37/04

CPC分类号： A61K31/7048 ,  A61K9/0019 ,  A61K9/2013 ,  A61K36/68 ,  A61K47/34 ,  A61P37/04

摘要： The present invention discloses a pharmaceutical composition comprising picroside isolated from Picrorhiza kurroa. The composition contains Picroside I as an active ingredient for treating drug-induced immunopathy such as neutropenia. Methods of isolating Picroside I and Picroside II, and preparing the compositions have also been disclosed herein. The said composition of Picroside I can be a solid oral or an injectable composition of a pre-determined dose. The said composition of Picroside I exhibited reversal of drug-induced immunopathy such as neutropenia through in vivo tests as well as in vitro tests. Therefore, it can be used as a herbal therapeutic agent for treating drug-induced immunopathy such as neutropenia.

公开(公告)号：US11857626B2

公开(公告)日：2024-01-02

申请号：US18111702

申请日：2023-02-20

申请人： Next2Me, LLC

发明人： Ralph L Peterson ,  Renee D Williman

IPC分类号： A61K41/00 ,  A61K31/51 ,  A61K31/714 ,  A61K31/4415 ,  A61K36/68 ,  A61K36/23 ,  A61K36/06 ,  A61K31/4188 ,  A61K31/525 ,  A61K31/455 ,  A61K31/197 ,  A61K31/661 ,  A61K31/519 ,  A61K36/9068

CPC分类号： A61K41/0004 ,  A61K31/197 ,  A61K31/4188 ,  A61K31/4415 ,  A61K31/455 ,  A61K31/51 ,  A61K31/519 ,  A61K31/525 ,  A61K31/661 ,  A61K31/714 ,  A61K36/06 ,  A61K36/23 ,  A61K36/68 ,  A61K36/9068

摘要： Biochemical scaffolds for regulating mammalian cell function. The biochemical scaffolds include a base liquid medium, a bioenergetic platform and a vibrational platform. The bioenergetic platform includes at least one Krebs cycle modulator and/or neurotransmitter modulator. The vibrational platform includes at least one energy signature component, e.g., an herb. The biochemical scaffold is subjected to harmonic oscillation for a defined, predetermined period of time, wherein the energy signature of the energy signature component is imparted to, captured, replicated, and retained by the liquid medium, and, when the biochemical scaffolds are delivered to and, thus, in communication with biological tissue, the biochemical scaffolds induce specific biochemical activities via the resonant transfer of the retained energy signature to the biological tissue and, hence, endogenous cells thereof.

公开(公告)号：US20180289765A1

公开(公告)日：2018-10-11

申请号：US15945389

申请日：2018-04-04

申请人： Muniyal Ayurvedic Research Centre

发明人： M Vijayabhanu Shetty

IPC分类号： A61K36/9066 ,  A61P35/00 ,  A61K36/81 ,  A61K36/185 ,  A61K36/88 ,  A61K36/59 ,  A61K36/68 ,  A61K36/53 ,  A61K35/04 ,  A61K35/02 ,  A61K33/00 ,  A61K33/30 ,  A61K35/614 ,  A61K33/26 ,  A61K9/20 ,  A61K45/06

CPC分类号： A61K36/9066 ,  A61K9/205 ,  A61K33/00 ,  A61K33/26 ,  A61K33/30 ,  A61K35/02 ,  A61K35/04 ,  A61K35/614 ,  A61K36/185 ,  A61K36/47 ,  A61K36/53 ,  A61K36/59 ,  A61K36/67 ,  A61K36/68 ,  A61K36/81 ,  A61K36/88 ,  A61K36/8965 ,  A61K36/9068 ,  A61K45/06 ,  A61P35/00 ,  A61K2300/00

摘要： Herbo-mineral formulation for the treatment of cancer and method of preparation are disclosed herein. The disclosed formulation includes a combination of herb and mineral components that facilitate in controlling abnormal cell proliferation. The formulation can thus be used in treatment of cancer and related mobidities.

公开(公告)号：US09999647B2

公开(公告)日：2018-06-19

申请号：US14973308

申请日：2015-12-17

申请人： Ethnodyne ,  Centre National de la Recherche Scientifique (CNRS)

发明人： Chérif Rabhi ,  Léon Cariel ,  Jamal Ouanzzani ,  Guillaume Arcile

IPC分类号： A61K36/00 ,  A61K36/81 ,  A61K36/185 ,  A61K36/68 ,  A23L33/105 ,  A23L33/135

CPC分类号： A61K36/81 ,  A23L33/105 ,  A23L33/135 ,  A23V2002/00 ,  A61K36/185 ,  A61K36/68 ,  A61K2236/19

摘要： The invention relates to a method for obtaining a composition from a plant extract, to assist in the treatment or prevention of disorders or diseases related to neovascularisation.

公开(公告)号：US20180042979A1

公开(公告)日：2018-02-15

申请号：US15560975

申请日：2015-03-23

申请人： Ethnodyne ,  Centre National de la Recherche Scientifique (CNRS)

发明人： Chérif Rabhi ,  Léon Cariel ,  Jamal Ouanzzani ,  Guillaume Arcile

IPC分类号： A61K36/81 ,  A61K36/68 ,  A61K9/00 ,  A61K36/67 ,  A61K36/28 ,  A61K36/185 ,  A61K36/9066

CPC分类号： A61K36/81 ,  A61K9/0019 ,  A61K9/0053 ,  A61K36/068 ,  A61K36/185 ,  A61K36/28 ,  A61K36/47 ,  A61K36/67 ,  A61K36/68 ,  A61K36/80 ,  A61K36/9066 ,  A61K2236/19 ,  A61K2236/39 ,  A61K2300/00

摘要： The invention relates to the use of a composition from a plant extract of Withania somnifera, to treat or prevent amyloid-related diseases, including Alzheimer disease.

公开(公告)号：US20180036360A1

公开(公告)日：2018-02-08

申请号：US15550600

申请日：2016-02-10

申请人： Renate Wilmanowicz

发明人： Renate Wilmanowicz

IPC分类号： A61K36/28 ,  A61K8/97 ,  A61K36/85 ,  A61K36/886 ,  A61K36/32 ,  A61K36/68

CPC分类号： A61K36/28 ,  A61K8/97 ,  A61K36/32 ,  A61K36/68 ,  A61K36/85 ,  A61K36/886 ,  A61K2300/00

摘要： The present invention relates to an immunologically active phyto-mixture comprising at least one plant extract selected from the family a) Asteraceae, b) Verbenaceae, and/or c) Burseraceae, preferably at least one plant extract from the genus a) Bidens, b) Stachytarpheta, and/or c) Bursera. Particularly preferred species include a) Bidens alba, Bidens pilosa, b) Stachytarpheta jamaicensis, Stachytarpheta cayennensis, Stachytarpheta indica, and/or c) Bursera simaruba, Bursera microphylla, Bursera glabrifolia. The phyto-mixture optionally comprises d) at least one further biologically active plant extract, such as Aloe vera and/or Stemodia maritima. The afore-mentioned phyto-mixture according to the invention exhibits good antimicrobial and anti-inflammatory efficiency and is particularly suitable for prevention and treatment of efflorescences. Therefore, the present invention also relates to a preparation for oral and topical administration for prevention and treatment of efflorescences of the skin and the mucous membrane.

公开(公告)号：US20170360701A2

公开(公告)日：2017-12-21

申请号：US15287346

申请日：2016-10-06

申请人： BRAINGEAR ENTERPRISES, INC.

发明人： Patricia Gutierrez ,  Christina Beer

IPC分类号： A61K9/00 ,  A61K31/355 ,  A61K31/455 ,  A61K31/4415 ,  A61K31/714 ,  A23L2/52 ,  A61K31/14 ,  A61K31/047 ,  A61K31/198 ,  A61K31/133 ,  A61K36/82 ,  A61K31/4745 ,  A61K31/593 ,  A61K31/225

CPC分类号： A61K9/0095 ,  A23L2/52 ,  A23L2/68 ,  A23L33/10 ,  A23L33/105 ,  A23L33/15 ,  A23V2002/00 ,  A61K31/047 ,  A61K31/13 ,  A61K31/133 ,  A61K31/14 ,  A61K31/194 ,  A61K31/198 ,  A61K31/225 ,  A61K31/355 ,  A61K31/385 ,  A61K31/4406 ,  A61K31/4415 ,  A61K31/455 ,  A61K31/473 ,  A61K31/4745 ,  A61K31/59 ,  A61K31/593 ,  A61K31/714 ,  A61K36/16 ,  A61K36/258 ,  A61K36/68 ,  A61K36/81 ,  A61K36/82 ,  A61K36/87 ,  A61K47/18 ,  A61K47/183 ,  A61K2300/00

摘要： Compositions that can be used to improve human health, and in particular brain health are provided. In some embodiments the composition comprises Inositol, N-Acetyl L-Tyrosine, pyrroloquinoline quinone (PQQ), Choline bitartrate, L-Theanine and Acetyl-L-Carnitine. The compositions may be administered to a subject, for example in the form of a liquid drink, to improve brain health.

公开(公告)号：US09629887B1

公开(公告)日：2017-04-25

申请号：US14298414

申请日：2014-06-06

申请人： Gary Lasneski ,  William S. Sparks ,  Daryl L. De Luca ,  Denis R. De Luca

发明人： Gary Lasneski ,  William S. Sparks ,  Daryl L. De Luca ,  Denis R. De Luca

IPC分类号： A61K38/46 ,  A61K36/73 ,  A61K36/185 ,  A61K36/64 ,  A61K36/68 ,  A61K38/48

CPC分类号： A61K36/73 ,  A61K36/185 ,  A61K36/64 ,  A61K36/68 ,  A61K36/80 ,  A61K38/488 ,  A61K2300/00

摘要： A composition of matter useful for preventing or reducing the incidence of acid reflux comprises a mixture of meadowsweet herb extract, okra fruit powder, eyebright herb extract, marshmallow root extract, and plantago asiatica extract, in powdered form.

公开(公告)号：US20170028010A1

公开(公告)日：2017-02-02

申请号：US15261998

申请日：2016-09-11

申请人： YUNGJIN PHARMACEUTICAL CO., LTD ,  KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

发明人： Yongnam LEE ,  Ji-seok YOO ,  Dae-hee SHIN ,  Byung-hwan RYOO ,  Sei-ryang OH ,  Kyung-seop AHN ,  Hyeongkyu LEE ,  Ok-kyoung KWON ,  Doo-young KIM ,  Jung-hee KIM ,  Hyuk-hwan SONG

IPC分类号： A61K36/68 ,  A23L33/105 ,  A61K9/00 ,  A61K31/7048 ,  A61K31/192

CPC分类号： A61K36/68 ,  A23L1/296 ,  A23L27/10 ,  A23L33/105 ,  A23V2002/00 ,  A61K9/0056 ,  A61K31/192 ,  A61K31/7048 ,  A61K36/80 ,  A61K2236/15 ,  A61K2236/33 ,  A61K2236/331 ,  A61K2236/333 ,  A61K2236/39 ,  A61K2236/51 ,  A61K2236/55

摘要： The present invention relates to inventive novel industrialized method for preparing purified extract containing more abundant active ingredients such as catalpol derivatives from the extract of Pseudolysimachion rotundum var subintegrum than that prepared by the conventional preparation method disclosed in the prior art and the therapeutics or functional health food comprising the purified extract for treating and preventing inflammatory, allergic or asthmatic disease. The purified extract showed more potent anti-inflammatory, anti-allergy and anti-asthma activity than that prepared by the conventional preparation method disclosed in the prior art through various in vivo tests such as inhibition test on the reproduction of eosinophil, the release of immunoglobulin and inflammatory chemokines in plasma and bronchoalveolar fluid as well as the suppression of airway hyperresponsiveness and goblet cell hyperplasia in a OVA-sensitized/challenged mouse model.

摘要翻译： 本发明涉及本发明新颖的制备纯化提取物的方法，该纯化提取物含有比现有技术中公开的常规制备方法制备的纯假提取物更丰富的活性成分，例如来自假单胞菌属圆锥体提取物的梓醇衍生物，以及治疗或功能保健食品 包括用于治疗和预防炎性，过敏性或哮喘性疾病的纯化提取物。 纯化的提取物比通过各种体内试验例如现有技术公开的常规制备方法制备的抗炎，抗过敏和抗哮喘活性更强，如嗜酸性粒细胞的再生抑制试验，免疫球蛋白的释放 和血浆和支气管肺泡液中的炎性趋化因子以及在OVA致敏/攻击小鼠模型中抑制气道高反应性和杯状细胞增生。

公开(公告)号：US20160243186A1

公开(公告)日：2016-08-25

申请号：US15022732

申请日：2014-09-18

申请人： PIERRE FABRE DERMO-COSMETIQUE ,  PIERRE FABRE MEDICAMENT

发明人： Anne MANDEAU ,  Christian TALON

IPC分类号： A61K36/9068 ,  A23L2/72 ,  A23N1/02 ,  A61K36/899 ,  A61K8/97 ,  A61K36/28 ,  A61K36/53 ,  A61K36/9066 ,  A61K36/68 ,  A61K36/18 ,  A61K9/48 ,  A61K8/11 ,  A61K9/06 ,  A61K8/04 ,  A61K9/00 ,  A23L2/04

CPC分类号： A61K36/9068 ,  A23L2/04 ,  A23L2/72 ,  A23L33/105 ,  A23N1/02 ,  A23P30/20 ,  A23V2002/00 ,  A61K8/04 ,  A61K8/11 ,  A61K8/97 ,  A61K9/0014 ,  A61K9/0053 ,  A61K9/06 ,  A61K9/48 ,  A61K36/11 ,  A61K36/18 ,  A61K36/185 ,  A61K36/28 ,  A61K36/45 ,  A61K36/53 ,  A61K36/68 ,  A61K36/899 ,  A61K36/9066 ,  A61K2236/00 ,  A61K2236/31 ,  A61K2236/37 ,  A61K2800/10 ,  A61Q19/00

摘要： The present invention relates to a process for obtaining a juice of fresh plants, characterized in that said fresh plants, with the exclusion of the seeds only, are subjected to a thermomechanical treatment consisting in extruding the fresh plants in an extruder, combined with a heat treatment which makes it possible to inactivate the endogenous enzymes and to preserve the molecules of compounds of interest in the native form thereof, in the absence of solvent, followed by a juice recovery operation.

摘要翻译： 本发明涉及一种获得新鲜植物汁液的方法，其特征在于，仅将排除种子的所述新鲜植物进行热机械处理，其中包括在新鲜植物中挤出新鲜植物并与热量组合 处理，其使得可以在不存在溶剂的情况下灭活内源性酶并保留其天然形式的目标化合物分子，随后进行果汁回收操作。