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公开(公告)号：US20180325842A1
公开(公告)日：2018-11-15
申请号：US15972532
申请日：2018-05-07
发明人： Jan Stonis , Ivan Mikes , Andrea Dolezalova , Jarmila Kralova , Milan Jakubek , Pavel Martasek , Vladimir Kral
IPC分类号： A61K31/12 , A61K9/00 , A61K36/9066 , A61K9/20 , A61P35/00
CPC分类号： A61K31/12 , A61K9/0056 , A61K9/2059 , A61K9/5123 , A61K36/9066 , A61P35/00
摘要： Orodispersible tablet with biologically available curcumin containing particles of extract of rhizome of plant Curciuma longa containing, at least, 95% by weight of curcumin ground to size 100 to 250 nm in mixture with mannitol in ratio 1 to 3:1 (mannitol:curcumin) on orodispersible carrier, and curcumin of the extract 100% biologically available through oral mucosa.
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公开(公告)号：US11331281B2
公开(公告)日：2022-05-17
申请号：US15972532
申请日：2018-05-07
发明人： Jan Stonis , Ivan Mikes , Andrea Dolezalova , Jarmila Kralova , Milan Jakubek , Pavel Martasek , Vladimir Kral
摘要： Mixture of stabilised biologically available curcumin for orodispersible formulations, formulations of biologically available curcumin and orodispersible tablet with biologically available curcumin and its application. An orodispersible tablet with biologically available curcumin contains particles of extract of rhizome of plant Curcuma longa, which contains, at least, 95% by weight of curcumin, grounded to size 100 to 250 nm in mixture with mannitol in weight ratio 1 to 3:1 (mannitol:curcumin). Orodispersible tablet also contains an orodispersible carrier, and curcumin 100% biologically available through oral mucosa.
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