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    Quinoline compound, and composition containing centipede extract or compounds isolated therefrom for prevention and treatment of cardiovascular disease
    1.
    发明授权
    Quinoline compound, and composition containing centipede extract or compounds isolated therefrom for prevention and treatment of cardiovascular disease 有权
    喹啉化合物和含有蜈蚣提取物或其分离的化合物的组合物用于预防和治疗心血管疾病

    公开(公告)号：US08362034B2

    公开(公告)日：2013-01-29

    申请号：US13462727

    申请日：2012-05-02

    申请人： Ho Yong Park ,  Tae-Sook Jeong ,  Hyun-Woo Oh ,  Woo-Song Lee ,  Doo-Sang Park ,  Jong-Min Han

    发明人： Ho Yong Park ,  Tae-Sook Jeong ,  Hyun-Woo Oh ,  Woo-Song Lee ,  Doo-Sang Park ,  Jong-Min Han

    IPC分类号： C07D215/26 ,  A61P3/06 ,  A61P9/10 ,  A61P9/00 ,  A61K31/47

    CPC分类号： C07D215/26

    摘要： The present invention relates to a composition for the prevention and treatment of cardiovascular diseases containing the novel quinoline compound, the centipede extracts or compounds isolated from the extracts. The novel quinoline compound, the centipede extracts or a quinoline compound and a phenol compound isolated from the extracts of the invention exhibit excellent LDL-antioxidant activity, ACAT inhibiting activity, and anti-inflammatory activities, so that they can be included as an effective ingredient in a composition for the prevention and treatment of cardiovascular disease including hyperlipidemia, atherosclerosis, coronary heart disease, and myocardial infarction mediated by LDL-oxidation, cholesteryl ester synthesis and accumulation, and inflammation.

    摘要翻译： 本发明涉及用于预防和治疗含有新喹啉化合物，蜈蚣提取物或从提取物分离的化合物的心血管疾病的组合物。 从本发明提取物中分离的新颖喹啉化合物，蜈蚣提取物或喹啉化合物和酚化合物表现出优异的LDL-抗氧化活性，ACAT抑制活性和抗炎活性，因此它们可以作为有效成分 用于预防和治疗心血管疾病的组合物，包括高脂血症，动脉粥样硬化，冠心病和LDL氧化，胆固醇酯合成和积累介导的心肌梗死以及炎症。

    Chalcone derivatives, pharmaceutically acceptable salt, method for preparation and uses thereof
    2.
    发明授权
    Chalcone derivatives, pharmaceutically acceptable salt, method for preparation and uses thereof 有权
    查耳酮衍生物，药学上可接受的盐，其制备方法和用途

    公开(公告)号：US07851654B2

    公开(公告)日：2010-12-14

    申请号：US12295669

    申请日：2006-04-03

    申请人： Ki Hun Park ,  Jin Hyo Kim ,  Woo Duck Seo ,  Young Bae Ryu ,  Hyung Won Ryu ,  Woo Song Lee ,  Sang Wan Gal

    发明人： Ki Hun Park ,  Jin Hyo Kim ,  Woo Duck Seo ,  Young Bae Ryu ,  Hyung Won Ryu ,  Woo Song Lee ,  Sang Wan Gal

    IPC分类号： C07C211/00 ,  A61K31/13 ,  A61K31/135

    CPC分类号： C07C49/796 ,  C07C45/74 ,  C07C49/835 ,  C07C225/22 ,  C07C311/08 ,  C07C311/21

    摘要： Disclosed relates to a novel chalcone derivative, pharmaceutically acceptable salt thereof, a method for preparing the same and uses thereof, the chalcone derivative being readily obtained through the steps of: reacting aminoacetophenone with sulfonylchloride under the presence of an appropriate salt; and reacting the compound prepared in the above step with hydroxybenzaldehide under the presence of an appropriate catalyst. The chalcone derivative of formula 1 in accordance with the present invention having strong enzyme inhibitory activities for glycosidase can be effectively used in preventing and treating various diseases induced by glycosidase, and the chalcone derivative of the invention having tyrosinase and melanin synthesis inhibitory activities can be effectively used as a skin-whitening compound.

    摘要翻译： 本发明涉及一种新型查耳酮衍生物，其药学上可接受的盐，其制备方法及其用途，所述查耳酮衍生物通过以下步骤容易地获得：在适当的盐存在下使氨基苯乙酮与磺酰氯反应; 并在合适的催化剂存在下使上述步骤制备的化合物与羟基苯甲醛反应。 具有强糖酶抑制活性的本发明式1的查耳酮衍生物可有效地用于预防和治疗由糖苷酶诱导的各种疾病，具有酪氨酸酶和黑色素合成抑制活性的本发明查耳酮衍生物可以有效地 用作皮肤美白化合物。

    CURCUMINOID-BASED COMPOUND/STEVIOSIDE-CONTAINING COMPLEX FOR THE PREVENTION AND TREATMENT OF AN INFLUENZA VIRUS INFECTION
    5.
    发明申请
    CURCUMINOID-BASED COMPOUND/STEVIOSIDE-CONTAINING COMPLEX FOR THE PREVENTION AND TREATMENT OF AN INFLUENZA VIRUS INFECTION 审中-公开
    用于预防和治疗流感病毒感染的基于基于CURCUMINIID的化合物/含有维生素E的复合物

    公开(公告)号：US20140248382A1

    公开(公告)日：2014-09-04

    申请号：US14126106

    申请日：2012-06-13

    申请人： Woo-Song Lee ,  Young-Bae Ryu ,  Young-Min Kim ,  Su-Jin Park ,  Mun-Chual Rho ,  Hyung-Jae Jeong ,  Hyung-Jun Kwon

    发明人： Woo-Song Lee ,  Young-Bae Ryu ,  Young-Min Kim ,  Su-Jin Park ,  Mun-Chual Rho ,  Hyung-Jae Jeong ,  Hyung-Jun Kwon

    IPC分类号： A61K31/704 ,  A23L1/30 ,  A61K36/28 ,  A61K31/12 ,  A61K36/9066

    CPC分类号： A61K31/704 ,  A23K20/111 ,  A23K20/163 ,  A23K50/10 ,  A23K50/30 ,  A23K50/75 ,  A23L33/105 ,  A61K31/12 ,  A61K36/28 ,  A61K36/9066 ,  A61K47/6921 ,  A61K2300/00

    摘要： The present invention relates to a complex comprising a compound of formula (I), or a plant extract comprising the compound or a fraction thereof; and stevioside, or a plant extract comprising the stevioside or a fraction thereof, and relates to a pharmaceutical composition for preventing or treating an influenza virus infection comprising the complex as an active ingredient. Also, the present invention relates to a food composition for preventing or improving an influenza virus infection, a virucidal quasi-drug composition, a virucidal feed additive, and a feed, which comprises the complex as an active ingredient. According to the present invention, the complex comprising a compound of formula (I), or a plant extract comprising the compound or a fraction thereof; and stevioside, or a plant extract comprising the stevioside or a fraction thereof exhibits a virucidal effect and an effect of inhibiting cell degradation against an influenza virus as well as antiviral efficacy in a specific pathogen-free (SPF) chicken, and thus can be usefully used in the prevention and treatment of an influenza virus infection.

    摘要翻译： 本发明涉及包含式（I）化合物或包含该化合物或其部分的植物提取物的复合物; 还包括甜菊糖苷或其一部分的植物提取物，涉及用于预防或治疗包含该复合物作为活性成分的流感病毒感染的药物组合物。 此外，本发明涉及用于预防或改善流感病毒感染的食品组合物，杀病毒准药物组合物，杀病毒饲料添加剂和饲料，其包含该复合物作为活性成分。 根据本发明，包含式（I）化合物或包含该化合物或其部分的植物提取物的复合物; 甜菊糖苷或甜菊糖苷或其部分的植物提取物表现出对特定无病原体（SPF）鸡中的抗病毒效果和抑制细胞降解对流感病毒的抗病毒效果的效果，因此可以有用地 用于预防和治疗流感病毒感染。