发明授权
US08362034B2 Quinoline compound, and composition containing centipede extract or compounds isolated therefrom for prevention and treatment of cardiovascular disease
有权
喹啉化合物和含有蜈蚣提取物或其分离的化合物的组合物用于预防和治疗心血管疾病
- 专利标题： Quinoline compound, and composition containing centipede extract or compounds isolated therefrom for prevention and treatment of cardiovascular disease
- 专利标题（中）： 喹啉化合物和含有蜈蚣提取物或其分离的化合物的组合物用于预防和治疗心血管疾病
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申请号： US13462727申请日： 2012-05-02
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公开(公告)号： US08362034B2公开(公告)日： 2013-01-29
- 发明人: Ho Yong Park , Tae-Sook Jeong , Hyun-Woo Oh , Woo-Song Lee , Doo-Sang Park , Jong-Min Han
- 申请人： Ho Yong Park , Tae-Sook Jeong , Hyun-Woo Oh , Woo-Song Lee , Doo-Sang Park , Jong-Min Han
- 申请人地址： KR Daejeon
- 专利权人： Korea Research Institute of Bioscience and Biotechnology
- 当前专利权人： Korea Research Institute of Bioscience and Biotechnology
- 当前专利权人地址： KR Daejeon
- 代理机构： Klarquist Sparkman, LLP
- 优先权： KR10-2005-0110261 20051117
- 主分类号： C07D215/26
- IPC分类号： C07D215/26 ; A61P3/06 ; A61P9/10 ; A61P9/00 ; A61K31/47
摘要：
The present invention relates to a composition for the prevention and treatment of cardiovascular diseases containing the novel quinoline compound, the centipede extracts or compounds isolated from the extracts. The novel quinoline compound, the centipede extracts or a quinoline compound and a phenol compound isolated from the extracts of the invention exhibit excellent LDL-antioxidant activity, ACAT inhibiting activity, and anti-inflammatory activities, so that they can be included as an effective ingredient in a composition for the prevention and treatment of cardiovascular disease including hyperlipidemia, atherosclerosis, coronary heart disease, and myocardial infarction mediated by LDL-oxidation, cholesteryl ester synthesis and accumulation, and inflammation.
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