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公开(公告)号：US20160376308A1
公开(公告)日：2016-12-29
申请号：US15145901
申请日：2016-05-04
Applicant: CARA THERAPEUTICS, INC.
Inventor： Claudio D. Schteingart , Frédérique Menzaghi , Guangcheng Jiang , Roberta Vezza Alexander , Javier Sueiras-Diaz , Robert H. Spencer , Derek T. Chalmers , Zhiyong Luo
CPC classification number: C07K5/1016 , A61K38/00 , C07K5/1005 , C07K5/1008 , C07K5/1024 , C07K7/06
Abstract: The invention relates to synthetic peptide amide ligands of the kappa opioid receptor and particularly to agonists of the kappa opioid receptor that exhibit low P450 CYP inhibition and low penetration into the brain. The synthetic peptide amides of the invention conform to the structure: The compounds are useful in the prophylaxis and treatment of pain and inflammation associated with a variety of diseases and conditions.
Abstract translation: 该化合物可用于预防和治疗与各种疾病和病症相关的疼痛和炎症。
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82.发明申请SELF-ASSEMBLING PEPTIDES, PEPTIDOMIMETICS AND PEPTIDIC CONJUGATES AS BUILDING BLOCKS FOR BIOFABRICATION AND PRINTING 审中-公开自组装肽，生物制剂和印刷的建筑块的肽组装和复合材料公开(公告)号：US20160375177A1
公开(公告)日：2016-12-29
申请号：US15039952
申请日：2014-12-01
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor： Charlotte HAUSER , Yihua LOO
CPC classification number: A61L27/52 , A61K38/06 , A61K38/07 , A61K38/08 , A61L27/3834 , A61L27/50 , A61L27/54 , A61L2400/06 , A61L2430/34 , B33Y10/00 , C07K5/06034 , C07K5/06052 , C07K5/0808 , C07K5/1005 , C07K5/101 , C07K7/06 , Y02A50/385 , Y02A50/411
Abstract: The present invention relates to the use of peptides, peptoids and/or peptidomimetics capable of self-assembling and forming a (nanofibrous) hydrogel in biofabrication. The present invention further relates to methods for preparing hydrogels and to methods for preparing continuous fibres and to methods for obtaining multi-cellular constructs with defined, precise geometrics. The present invention further relates to various uses of such hydrogels for obtaining mini-hydrogel arrays and 3D organoid structures or 3D macromolecular biological constructs.
Abstract translation: 本发明涉及在生物制造中能够自组装和形成（纳米纤维）水凝胶的肽，拟肽和/或肽模拟物的用途。 本发明还涉及制备水凝胶的方法和制备连续纤维的方法以及获得具有确定的精确几何的多细胞构建体的方法。 本发明还涉及这种水凝胶用于获得微型水凝胶阵列和3D组织结构或3D大分子生物构建体的各种用途。
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83.发明授权公开(公告)号：US09321808B2
公开(公告)日：2016-04-26
申请号：US14379675
申请日：2012-02-20
Applicant: Pierfausto Seneci , Laura Belvisi , Federica Cossu , Domenico Delia , Carmelo Drago , Daniele Lecis , Stefano Maiorana , Leonardo Pierpaolo Manzoni , Eloise Mastrangelo , Mario Milani de Mayo de Mari , Paola Maria Chiara Perego , Francesca Vasile
Inventor： Pierfausto Seneci , Laura Belvisi , Federica Cossu , Domenico Delia , Carmelo Drago , Daniele Lecis , Stefano Maiorana , Leonardo Pierpaolo Manzoni , Eloise Mastrangelo , Mario Milani de Mayo de Mari , Paola Maria Chiara Perego , Francesca Vasile
IPC: C07D487/04 , C07K5/103 , C07K5/083 , C07D519/00 , A61K38/06 , A61K38/07 , A61K45/06 , A61K38/00
CPC classification number: A61K38/07 , A61K38/00 , A61K38/06 , A61K45/06 , C07D519/00 , C07K5/0804 , C07K5/0806 , C07K5/0808 , C07K5/1005 , C07K5/1008 , C07K5/101
Abstract: The present invention relates to conformationally constrained homo- and heterodimeric mimetics of Smac with function as inhibitors of Inhibitor of Apoptosis Proteins (IAPs), the invention also relates to the use of these compounds in therapy, wherein the induction of apoptotic cell death is beneficial, especially in the treatment of cancer, alone or in combination with other active ingredients.
Abstract translation: 本发明涉及具有作为细胞凋亡蛋白抑制剂（IAP）抑制剂的功能的Smac的构象约束的同型和异二聚体模拟物，本发明还涉及这些化合物在治疗中的用途，其中凋亡细胞死亡的诱导是有益的， 特别是在癌症的治疗中，单独或与其它活性成分组合。
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公开(公告)号：US09243257B2
公开(公告)日：2016-01-26
申请号：US12921735
申请日：2009-03-12
Applicant: Masaru Takagi , Miho Ikeda
Inventor： Masaru Takagi , Miho Ikeda
CPC classification number: C12N15/8216 , C07K5/1005 , C07K7/06 , C07K7/08 , C12N15/62 , C12N15/8217 , C12N15/8261 , C12N15/827 , Y02A40/146
Abstract: Provided is a peptide which is capable of repressing transcription in a plant and which can be used in the CRES-T (a simple and widely applicable means for repressing gene transcription). Also provided is a gene encoding the peptide.
Abstract translation: 本发明提供能够抑制植物转录并可用于CRES-T（用于抑制基因转录的简单且广泛适用的方法）的肽。 还提供了编码肽的基因。
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85.发明申请New Homo- and Heterodimeric SMAC Mimetic Compounds as Apoptosis Inducers 有权新型均质和异二聚体SMAC模拟化合物作为细胞凋亡诱导剂公开(公告)号：US20150119342A1
公开(公告)日：2015-04-30
申请号：US14379675
申请日：2012-02-20
Applicant: Pierfausto Seneci , Laura Belvisi , Federica Cossu , Domenico Delia , Carmelo Drago , Daniele Lecis , Stefano Maiorana , Leonardo Pierpaolo Manzoni , Eloise Mastrangelo , Mario Milani de Mayo de Mari , Paola Maria Chiara Perego , Francesca Vasile
Inventor： Pierfausto Seneci , Laura Belvisi , Federica Cossu , Domenico Delia , Carmelo Drago , Daniele Lecis , Stefano Maiorana , Leonardo Pierpaolo Manzoni , Eloise Mastrangelo , Mario Milani de Mayo de Mari , Paola Maria Chiara Perego , Francesca Vasile
CPC classification number: A61K38/07 , A61K38/00 , A61K38/06 , A61K45/06 , C07D519/00 , C07K5/0804 , C07K5/0806 , C07K5/0808 , C07K5/1005 , C07K5/1008 , C07K5/101
Abstract: The present invention relates to conformationally constrained homo- and heterodimeric mimetics of Smac with function as inhibitors of Inhibitor of Apoptosis Proteins (IAPs), the invention also relates to the use of these compounds in therapy, wherein the induction of apoptotic cell death is beneficial, especially in the treatment of cancer, alone or in combination with other active ingredients.
Abstract translation: 本发明涉及具有作为细胞凋亡蛋白抑制剂（IAP）抑制剂的功能的Smac的构象约束的同型和异二聚体模拟物，本发明还涉及这些化合物在治疗中的用途，其中凋亡细胞死亡的诱导是有益的， 特别是在癌症的治疗中，单独或与其它活性成分组合。
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Patent Agency Ranking
86.发明申请GRANZYME B INHIBITOR COMPOSITIONS, METHODS AND USES FOR PROMOTING WOUND HEALING 审中-公开GRANZYME B抑制剂组合物，促进创伤治疗的方法和用途公开(公告)号：US20140056964A1
公开(公告)日：2014-02-27
申请号：US13992139
申请日：2011-12-06
Applicant: Paul R. Hiebert , Darryl A. Knight , David J. Granville , Wendy A. Boivin , Dawn M. Cooper
Inventor： Paul R. Hiebert , Darryl A. Knight , David J. Granville , Wendy A. Boivin , Dawn M. Cooper
IPC: A61K38/00 , C07K5/117 , C07K5/103 , C07D487/04 , A61K45/00 , C07D307/33 , A61K38/06 , A61K38/07 , A61K31/55 , A61K31/365 , C07K5/097 , C07D307/83
CPC classification number: A61K38/005 , A61K31/167 , A61K31/365 , A61K31/55 , A61K38/06 , A61K38/07 , A61K38/55 , A61K45/05 , A61K45/06 , C07D307/33 , C07D307/83 , C07D487/04 , C07K5/0823 , C07K5/1005 , C07K5/1024 , G01N2333/96436 , G01N2500/02
Abstract: Methods of promoting wound healing in a subject is disclosed. The method include applying a Granzyme B (Granzyme B) inhibitor to the wound. The wound may be a skin wound. The Granzyme B inhibitor may be comprised of nucleic acids, or peptides, including but not limited to antibodies, or small molecules.
Abstract translation: 公开了在受试者中促进伤口愈合的方法。 该方法包括将Granzyme B（Granzyme B）抑制剂施用于伤口。 伤口可能是皮肤伤口。 颗粒酶B抑制剂可以由核酸或肽组成，包括但不限于抗体或小分子。
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公开(公告)号：US20110223625A1
公开(公告)日：2011-09-15
申请号：US13046374
申请日：2011-03-11
Applicant: Jessica Kelts , Poncho Meisenheimer , John Shultz , James J. Cali , Dongping Ma
Inventor： Jessica Kelts , Poncho Meisenheimer , John Shultz , James J. Cali , Dongping Ma
IPC: C12Q1/66
CPC classification number: C07D277/68 , C07D417/12 , C07K5/1005 , C07K5/1021 , G01N21/763 , G01N33/582
Abstract: The invention provides methods that employ derivatives of 2-cyano-6-hydroxy- or 2-cyano-6-amino-benzothiazole, for example, in a bioluminogenic reaction. The invention further provides methods for detecting or determining the presence of molecules and/or enzymes, the modulator activity of such molecules, and/or the activity of such enzymes. The methods are adaptable to high-throughput format.
Abstract translation: 本发明提供了使用2-氰基-6-羟基 - 或2-氰基-6-氨基 - 苯并噻唑衍生物的方法，例如在生物发光反应中。 本发明还提供了用于检测或确定分子和/或酶的存在，这种分子的调节活性和/或这些酶的活性的方法。 该方法适用于高吞吐量格式。
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公开(公告)号：US20060239926A1
公开(公告)日：2006-10-26
申请号：US10560830
申请日：2004-06-17
Applicant: Marc Port , Olivier Rousseaux , Claire Corot , Philippe Prigent , Eric Lancelot
Inventor： Marc Port , Olivier Rousseaux , Claire Corot , Philippe Prigent , Eric Lancelot
IPC: A61K49/10 , A61K31/555 , C07F5/00
CPC classification number: A61K51/0491 , A61K49/0002 , A61K49/085 , A61K49/122 , A61K49/124 , A61K49/14 , C07D471/08 , C07F9/10 , C07K5/1005
Abstract: The invention relates to novel compounds that are useful for the diagnosis of many pathologies, in particular cardiovascular, cancer-related and inflammatory pathologies, and to pharmaceutical compositions comprising said compounds. These compounds comprise a component for targeting a pathological region, linked to a detection component which is effective in diagnostic terms.
Abstract translation: 本发明涉及可用于诊断许多病症，特别是心血管，癌症相关和炎性病理学的新化合物，以及包含所述化合物的药物组合物。 这些化合物包含用于靶向病理区域的组分，其与检测组分相连，其在诊断方面是有效的。
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公开(公告)号：US20030157522A1
公开(公告)日：2003-08-21
申请号：US10293371
申请日：2002-11-12
Inventor： Alain Boudreault , Robert G. Korneluk , Eric LaCasse , Peter Liston
IPC: C12Q001/68 , G01N033/53 , C07H021/04 , C12P021/02 , C12N005/06 , C07K014/47
CPC classification number: C07K7/06 , A61K38/00 , C07K1/047 , C07K1/061 , C07K5/1005
Abstract: The invention features a substantially pure polypeptide having a length of less than 100 amino acids and capable of forming a complex with a polypeptide that includes a BIR domain. The invention also features displacement assays in which the ability of a candidate compound to disrupt the interaction between a BIR domain-containing polypeptide and a polypeptide of the invention is indicative of the ability of the candidate compound to modulate IAP biological activity.
Abstract translation: 本发明的特征在于具有小于100个氨基酸的长度的基本上纯的多肽，并且能够与包含BIR结构域的多肽形成复合物。 本发明还特征在于其中候选化合物破坏含有BIR结构域的多肽和本发明的多肽之间的相互作用的能力的置换测定法指示候选化合物调节IAP生物活性的能力。
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公开(公告)号：US5821231A
公开(公告)日：1998-10-13
申请号：US461056
申请日：1995-06-05
Applicant: Thomas S. Arrhenius , Mariano J. Elices , Federico C. A. Gaeta
Inventor： Thomas S. Arrhenius , Mariano J. Elices , Federico C. A. Gaeta
IPC: A61K38/00 , A61K38/06 , A61K38/07 , A61K38/08 , A61P11/00 , A61P17/00 , A61P25/00 , A61P29/00 , C07K5/02 , C07K5/06 , C07K5/072 , C07K5/08 , C07K5/083 , C07K5/087 , C07K5/09 , C07K5/093 , C07K5/097 , C07K5/10 , C07K5/103 , C07K5/107 , C07K5/11 , C07K7/06 , C07K14/78 , A61K38/05 , C07K5/04
CPC classification number: C07K7/06 , C07K14/78 , C07K5/0205 , C07K5/0207 , C07K5/021 , C07K5/06034 , C07K5/06113 , C07K5/0804 , C07K5/0808 , C07K5/081 , C07K5/0812 , C07K5/0815 , C07K5/0819 , C07K5/0821 , C07K5/1005 , C07K5/1008 , C07K5/101 , C07K5/1013 , C07K5/1016 , C07K5/1019 , A61K38/00
Abstract: The present invention contemplates a compound defined by the following formula: ##STR1## that inhibits the binding between the VLA-4 and the fibronectin CS-1 compound. Pharmaceutical compositions containing a contemplated compound and methods for treating immunoinflammatory conditions using the compound are also disclosed.
Abstract translation: 本发明涉及由下式限定的化合物：抑制VLA-4与纤连蛋白CS-1化合物之间结合的“IMAGE”。 还公开了含有预期化合物的药物组合物和使用该化合物治疗免疫炎性病症的方法。
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