公开(公告)号：US07780953B2

公开(公告)日：2010-08-24

申请号：US10739400

申请日：2003-12-19

Applicant: Marc Port ,  Claire Corot ,  Isabelle Raynal ,  Olivier Rousseaux

Inventor： Marc Port ,  Claire Corot ,  Isabelle Raynal ,  Olivier Rousseaux

IPC: A61B5/055 ,  A61B5/05 ,  A01N57/18

CPC classification number: B82Y5/00 ,  A61K49/1842

Abstract: The invention relates to a composition comprising acid magnetic particles (p) based on an iron compound, the acid magnetic particles (p) being complexed by one or more gem-bisphosphonate compounds, of formula I: X-L-CH(PO3H2)2  (I) in which: L represents an organic group connecting the X group to the gem-bisphosphonate group —CH(PO3H2)2; X represents a chemical group capable of reacting with a biovector; all or some of the X groups of the particles optionally being coupled to a biovector. The invention relates, also to a process for the preparation of the compositions and their use, in particular as contrast products for Magnetic Resonance Imaging (MRI).

Abstract translation: 本发明涉及一种组合物，其包含基于铁化合物的酸性磁性颗粒（p），酸性磁性颗粒（p）由一种或多种式偕二膦酸盐化合物络合：式I：XL-CH（PO 3 H 2）2 ）其中：L表示连接X基团与偕 - 双膦酸基团-CH（PO3H2）2的有机基团; X表示能够与生物载体反应的化学基团; 所有或一些X组的颗粒任选地与生物载体偶联。 本发明还涉及制备组合物及其用途的方法，特别是用于磁共振成像（MRI）的对比产物。

公开(公告)号：US08986650B2

公开(公告)日：2015-03-24

申请号：US13205352

申请日：2011-08-08

Applicant: Marc Port ,  Claire Corot ,  Thierry Gautheret

Inventor： Marc Port ,  Claire Corot ,  Thierry Gautheret

IPC: A61K51/00 ,  A61M36/14 ,  A61K51/04 ,  C07D209/48 ,  C07D239/95 ,  C07D295/15 ,  C07D487/04

CPC classification number: A61K51/0459 ,  C07D209/48 ,  C07D239/95 ,  C07D295/15 ,  C07D487/04

Abstract: The present invention concerns a Ga68 complex of formula FOLATE-(LINKER)i-NOTA-Ga68 in which: 1) FOLATE is a folate compound or a derivative thereof capable of targeting a folate receptor, 2) NOTA is a chelate capable of complexing Ga68 having a NOTA scaffold or derivatives thereof 3) LINKER is a chemical group linking FOLATE and NOTA 4) i is an integer chosen between 0 and 1 wherein NOTA is complexing Ga68.

Abstract translation: 本发明涉及式FOLATE-（LINKER）i-NOTA-Ga68的Ga68复合物，其中：1）FOLATE是能够靶向叶酸受体的叶酸化合物或其衍生物，2）NOTA是能够络合Ga68的螯合物 具有NOTA支架或其衍生物3）LINKER是连接FOLATE和NOTA的化学基团4）i是选自0和1之间的整数，其中NOTA与Ga68络合。

公开(公告)号：US20120064003A1

公开(公告)日：2012-03-15

申请号：US13205352

申请日：2011-08-08

Applicant: Marc PORT ,  Claire COROT ,  Thierry GAUTHERET

Inventor： Marc PORT ,  Claire COROT ,  Thierry GAUTHERET

IPC: A61K51/08 ,  A61P35/00 ,  C07D255/00 ,  C07F5/00

CPC classification number: A61K51/0459 ,  C07D209/48 ,  C07D239/95 ,  C07D295/15 ,  C07D487/04

Abstract: The present invention concerns a Ga68 complex of formula FOLATE-(LINKER)i-NOTA-Ga68 in which: 1) FOLATE is a folate compound or a derivative thereof capable of targeting a folate receptor, 2) NOTA is a chelate capable of complexing Ga68 having a NOTA scaffold or derivatives thereof 3) LINKER is a chemical group linking FOLATE and NOTA 4) i is an integer chosen between 0 and 1 wherein NOTA is complexing Ga68

Abstract translation: 本发明涉及式FOLATE-（LINKER）i-NOTA-Ga68的Ga68复合物，其中：1）FOLATE是能够靶向叶酸受体的叶酸化合物或其衍生物，2）NOTA是能够络合Ga68的螯合物 具有NOTA支架或其衍生物3）LINKER是连接FOLATE和NOTA的化学基团4）i是选自0和1之间的整数，其中NOTA络合Ga68

公开(公告)号：US20090208421A1

公开(公告)日：2009-08-20

申请号：US12155997

申请日：2008-06-12

Applicant: Dominique Meyer ,  Claire Corot

Inventor： Dominique Meyer ,  Claire Corot

IPC: A61K49/10

CPC classification number: A61K49/108 ,  A61K9/0019 ,  A61K31/28 ,  A61K45/06 ,  A61K47/18 ,  A61K49/106 ,  G01N33/15

Abstract: The invention relates to a process for preparing a liquid pharmaceutical formulation containing a complex of macrocyclic chelate with a lanthanide and a mol/mol amount of free macrocyclic chelate of between 0.002% and 0.4%, advantageously between 0.02% and 0.3% and very advantageously between 0.025% and 0.25%, the macrocyclic chelate advantageously being chosen from DOTA, NOTA, DOTAGA, DO3A, BT-DO3A, HP-DO3A and PCTA, and is preferably DOTA, the said process comprising the following successive steps: a) determination of a theoretical target concentration of free macrocyclic chelate Ctcl in the final liquid pharmaceutical formulation; b) preparation of a liquid pharmaceutical composition containing, firstly, the complex of macrocyclic chelate with a lanthanide, and, secondly, free macrocyclic chelate and/or free lanthanide; c) measurement in the pharmaceutical formulation obtained in step b) of the concentration of free macrocyclic chelate Ccl and/or of free lanthanide Cll; d) adjustment of Ccl and/or of Cll so as to obtain Ccl=Ctcl and Cll=0.

Abstract translation: 本发明涉及制备含有大环螯合物与镧系元素络合物和摩尔/摩尔量的游离大环螯合物的液体药物制剂的方法，其含量为0.002％至0.4％，有利地为0.02％至0.3％，非常有利地介于 0.025％和0.25％，大环螯合物有利地选自DOTA，NOTA，DOTAGA，DO3A，BT-DO3A，HP-DO3A和PCTA，并且优选为DOTA，所述方法包括以下连续步骤：a） 最终液体药物制剂中游离大环螯合物Ctcl的理论目标浓度; b）制备液体药物组合物，其首先包含大环螯合物与镧系元素的复合物，其次，游离的大环螯合物和/或游离的镧系元素; c）在步骤b）中获得的药物制剂中游离大环螯合物Ccl和/或游离镧​​系元素C11的浓度的测量; d）调整Ccl和/或Cll，以获得Ccl = Ctcl和Cll = 0。

公开(公告)号：US08349293B2

公开(公告)日：2013-01-08

申请号：US12532353

申请日：2008-03-21

Applicant: Claire Corot

Inventor： Claire Corot

IPC: A61B5/055

CPC classification number: A61K49/1842 ,  A61K49/1812 ,  A61K49/186 ,  A61K49/1863 ,  B82Y5/00

Abstract: The invention relates to the use of metal nanoparticles for the preparation of a composition for diagnosing Alzheimer's disease by MRI.

Abstract translation: 本发明涉及金属纳米粒子用于制备用于通过MRI诊断阿尔茨海默病的组合物的用途。

公开(公告)号：US20100297025A1

公开(公告)日：2010-11-25

申请号：US12801980

申请日：2010-07-06

Applicant: Marc Port ,  Claire Corot ,  Isabelle Raynal ,  Olivier Rousseaux

Inventor： Marc Port ,  Claire Corot ,  Isabelle Raynal ,  Olivier Rousseaux

IPC: A61K49/10

CPC classification number: B82Y5/00 ,  A61K49/1842

Abstract: The invention relates to a composition comprising acid magnetic particles (p) based on an iron compound, the acid magnetic particles (p) being complexed by one or more gem-bisphosphonate compounds, of formula I: X-L-CH(PO3H2)2   (I) in which: L represents an organic group connecting the X group to the gem-bisphosphonate group —CH(PO3H2)2; X represents a chemical group capable of reacting with a biovector; all or some of the X groups of the particles optionally being coupled to a biovector. The invention relates also to a process for the preparation of the compositions and their use, in particular as contrast products for Magnetic Resonance Imaging (MRI).

Abstract translation: 本发明涉及一种组合物，其包含基于铁化合物的酸性磁性颗粒（p），酸性磁性颗粒（p）由一种或多种式偕二膦酸盐化合物络合：式I：XL-CH（PO 3 H 2）2 ）其中：L表示连接X基团与偕 - 双膦酸基团-CH（PO3H2）2的有机基团; X表示能够与生物载体反应的化学基团; 所有或一些X组的颗粒任选地与生物载体偶联。 本发明还涉及制备组合物及其用途的方法，特别是作为磁共振成像（MRI）的对比产品。

公开(公告)号：US20060239926A1

公开(公告)日：2006-10-26

申请号：US10560830

申请日：2004-06-17

Applicant: Marc Port ,  Olivier Rousseaux ,  Claire Corot ,  Philippe Prigent ,  Eric Lancelot

Inventor： Marc Port ,  Olivier Rousseaux ,  Claire Corot ,  Philippe Prigent ,  Eric Lancelot

IPC: A61K49/10 ,  A61K31/555 ,  C07F5/00

CPC classification number: A61K51/0491 ,  A61K49/0002 ,  A61K49/085 ,  A61K49/122 ,  A61K49/124 ,  A61K49/14 ,  C07D471/08 ,  C07F9/10 ,  C07K5/1005

Abstract: The invention relates to novel compounds that are useful for the diagnosis of many pathologies, in particular cardiovascular, cancer-related and inflammatory pathologies, and to pharmaceutical compositions comprising said compounds. These compounds comprise a component for targeting a pathological region, linked to a detection component which is effective in diagnostic terms.

Abstract translation: 本发明涉及可用于诊断许多病症，特别是心血管，癌症相关和炎性病理学的新化合物，以及包含所述化合物的药物组合物。 这些化合物包含用于靶向病理区域的组分，其与检测组分相连，其在诊断方面是有效的。

公开(公告)号：US20110092806A1

公开(公告)日：2011-04-21

申请号：US12083269

申请日：2006-10-09

Applicant: Marc Port ,  Claire Corot ,  Thierry Gautheret

Inventor： Marc Port ,  Claire Corot ,  Thierry Gautheret

IPC: A61B5/055 ,  C07F5/00 ,  A61K51/04 ,  G01N23/00 ,  A61B6/03

CPC classification number: A61K49/10 ,  A61K49/085 ,  A61K49/14 ,  A61K51/0497 ,  A61K51/088 ,  C07D471/08

Abstract: The invention concerns compounds comprising a biological target recognizing part, coupled to a signal part capable of complexing gallium. The invention also concerns methods for obtaining said compounds, screening methods capable of selecting such compounds for chemical synthesis thereof and their diagnostic applications, in particular in PET, PET/IRM, PET CT imaging.

Abstract translation: 本发明涉及包含与能够络合镓的信号部分耦合的生物靶识别部分的化合物。 本发明还涉及获得所述化合物的方法，能够选择用于其化学合成的化合物的筛选方法及其诊断应用，特别是在PET，PET / IRM，PET CT成像中。

公开(公告)号：US20100111876A1

公开(公告)日：2010-05-06

申请号：US12532353

申请日：2008-03-21

Applicant: Claire Corot

Inventor： Claire Corot

IPC: A61K9/127 ,  A61K9/00 ,  A61P25/28

CPC classification number: A61K49/1842 ,  A61K49/1812 ,  A61K49/186 ,  A61K49/1863 ,  B82Y5/00

Abstract: The invention relates to the use of metal nanoparticles for the preparation of a composition for diagnosing Alzheimer's disease by MRI.

Abstract translation: 本发明涉及金属纳米粒子用于制备用于通过MRI诊断阿尔茨海默病的组合物的用途。

公开(公告)号：US20090299172A1

公开(公告)日：2009-12-03

申请号：US12308089

申请日：2007-06-06

Applicant: Claire Corot ,  Marc Port ,  Philippe Robert ,  Michel Schaefer ,  Denis Le Bihan ,  Johannes M. Fröhlich

Inventor： Claire Corot ,  Marc Port ,  Philippe Robert ,  Michel Schaefer ,  Denis Le Bihan ,  Johannes M. Fröhlich

IPC: A61B5/055

CPC classification number: A61B5/055 ,  A61B5/415 ,  A61B5/416 ,  A61B5/418 ,  G01R33/281 ,  G01R33/5601 ,  G01R33/56341

Abstract: The invention relates to a method of water diffusion imaging in magnetic resonance imaging in an area of diagnostic interest, characterized in that it comprises, in combination, the administration of a contrast product capable of generating a signal specifically in its specific location area, said location area being included in said area of interest, the application of a water diffusion imaging sequence to the whole area of interest, and the reading of the images in the area of interest, the specific signal due to the contrast product significantly and specifically modifying the signal in the specific location area relative to the signal of the whole area of interest.

Abstract translation: 本发明涉及一种在诊断感兴趣区域的磁共振成像中的水扩散成像方法，其特征在于，其组合包括能够特异地在其特定位置区域中产生信号的造影剂的施用，所述位置 包括在所述感兴趣区域中的区域，将水扩散成像序列应用于感兴趣的整个区域，以及在感兴趣区域中读取图像，由于对比度产物引起的特定信号显着地并且具体地修改信号 在相对于感兴趣的整个区域的信号的特定位置区域。