公开(公告)号：US07780953B2

公开(公告)日：2010-08-24

申请号：US10739400

申请日：2003-12-19

Applicant: Marc Port ,  Claire Corot ,  Isabelle Raynal ,  Olivier Rousseaux

Inventor： Marc Port ,  Claire Corot ,  Isabelle Raynal ,  Olivier Rousseaux

IPC: A61B5/055 ,  A61B5/05 ,  A01N57/18

CPC classification number: B82Y5/00 ,  A61K49/1842

Abstract: The invention relates to a composition comprising acid magnetic particles (p) based on an iron compound, the acid magnetic particles (p) being complexed by one or more gem-bisphosphonate compounds, of formula I: X-L-CH(PO3H2)2  (I) in which: L represents an organic group connecting the X group to the gem-bisphosphonate group —CH(PO3H2)2; X represents a chemical group capable of reacting with a biovector; all or some of the X groups of the particles optionally being coupled to a biovector. The invention relates, also to a process for the preparation of the compositions and their use, in particular as contrast products for Magnetic Resonance Imaging (MRI).

Abstract translation: 本发明涉及一种组合物，其包含基于铁化合物的酸性磁性颗粒（p），酸性磁性颗粒（p）由一种或多种式偕二膦酸盐化合物络合：式I：XL-CH（PO 3 H 2）2 ）其中：L表示连接X基团与偕 - 双膦酸基团-CH（PO3H2）2的有机基团; X表示能够与生物载体反应的化学基团; 所有或一些X组的颗粒任选地与生物载体偶联。 本发明还涉及制备组合物及其用途的方法，特别是用于磁共振成像（MRI）的对比产物。

公开(公告)号：US20100297025A1

公开(公告)日：2010-11-25

申请号：US12801980

申请日：2010-07-06

Applicant: Marc Port ,  Claire Corot ,  Isabelle Raynal ,  Olivier Rousseaux

Inventor： Marc Port ,  Claire Corot ,  Isabelle Raynal ,  Olivier Rousseaux

IPC: A61K49/10

CPC classification number: B82Y5/00 ,  A61K49/1842

Abstract: The invention relates to a composition comprising acid magnetic particles (p) based on an iron compound, the acid magnetic particles (p) being complexed by one or more gem-bisphosphonate compounds, of formula I: X-L-CH(PO3H2)2   (I) in which: L represents an organic group connecting the X group to the gem-bisphosphonate group —CH(PO3H2)2; X represents a chemical group capable of reacting with a biovector; all or some of the X groups of the particles optionally being coupled to a biovector. The invention relates also to a process for the preparation of the compositions and their use, in particular as contrast products for Magnetic Resonance Imaging (MRI).

Abstract translation: 本发明涉及一种组合物，其包含基于铁化合物的酸性磁性颗粒（p），酸性磁性颗粒（p）由一种或多种式偕二膦酸盐化合物络合：式I：XL-CH（PO 3 H 2）2 ）其中：L表示连接X基团与偕 - 双膦酸基团-CH（PO3H2）2的有机基团; X表示能够与生物载体反应的化学基团; 所有或一些X组的颗粒任选地与生物载体偶联。 本发明还涉及制备组合物及其用途的方法，特别是作为磁共振成像（MRI）的对比产品。

公开(公告)号：US20070098643A1

公开(公告)日：2007-05-03

申请号：US10505875

申请日：2003-03-05

Applicant: Isabelle Nachman ,  Marc Port ,  Isabelle Raynal ,  Olivier Rousseaux

Inventor： Isabelle Nachman ,  Marc Port ,  Isabelle Raynal ,  Olivier Rousseaux

IPC: A61K49/10 ,  C07F5/00

CPC classification number: C07D403/14 ,  A61K49/124 ,  C07D257/02 ,  C07D471/08 ,  C07F9/65815

Abstract: The invention relates to high-relaxivity macrocyclic gadolinium chelate oligomers of formula W-(A)m in which W, A and m are as defined in claim 1, and their use as a blood pool contrast product for magnetic resonance imaging.

Abstract translation: 本发明涉及公式<β的高弛豫度大环钆螯合物低聚物，描述=“In-line formula”end =“lead”？> W-（A）＆lt; 在线公式描述=“在线公式”end =“尾”→其中W，A和m如权利要求1中所定义，并且它们用作磁共振成像的血池对比产物。