-
公开(公告)号：US11982673B2
公开(公告)日：2024-05-14
申请号：US17832341
申请日：2022-06-03
申请人： AUTOLUS LIMITED
发明人： Martin Pulé , Paul Maciocia
IPC分类号： G01N33/574 , C12Q1/6886 , G16H50/30 , A61K39/00 , C12Q1/686
CPC分类号： G01N33/57492 , C12Q1/6886 , G16H50/30 , A61K2039/515 , C12Q1/686
摘要： The present invention relates to a chimeric antigen receptor (CAR) which comprises an antigen-binding domain which selectively binds TCR beta constant region 1 (TRBC1) or TRBC2; cells; such a T cells comprising such a CAR; and the use of such cells for the treatment of a T-cell lymphoma or leukaemia in a subject.
-
公开(公告)号：US11885806B2
公开(公告)日：2024-01-30
申请号：US17832225
申请日：2022-06-03
申请人： AUTOLUS LIMITED
发明人： Martin Pulé , Paul Maciocia
IPC分类号： G01N33/574 , G16H50/30 , C12Q1/6886 , C12Q1/686 , A61K39/00
CPC分类号： G01N33/57492 , C12Q1/6886 , G16H50/30 , A61K2039/515 , C12Q1/686
摘要： The present invention relates to a chimeric antigen receptor (CAR) which comprises an antigen-binding domain which selectively binds TCR beta constant region 1 (TRBC1) or TRBC2; cells; such a T cells comprising such a CAR; and the use of such cells for the treatment of a T-cell lymphoma or leukaemia in a subject.
-
公开(公告)号：US20230265165A1
公开(公告)日：2023-08-24
申请号：US18187268
申请日：2023-03-21
申请人： Cornell University
发明人： Moonsoo JIN
IPC分类号： C07K14/72 , A61K38/17 , A61K51/08 , A61K39/00 , A61K35/17 , C07K14/725 , C07K14/705 , C12N5/0783
CPC分类号： C07K14/723 , A61K35/17 , A61K38/1796 , A61K39/0011 , A61K39/001166 , A61K51/083 , A61K51/088 , C07K14/7051 , C07K14/70521 , C07K14/70553 , C12N5/0636 , A61K2039/515 , A61K2039/54 , C07K2319/03 , C07K2319/74 , C12N2510/00
摘要： The present invention is directed to transduced T cells expressing at least 100,000 molecules of human somatostatin receptor 2 (SSTR2), which improves PET/CT imaging sensitivity. The present invention is also directed to transduced T cells expressing SSTR2 and chimeric antigen receptor (CAR). In one embodiment, the CAR is specific to human ICAM-1 and the CAR comprises a binding domain that is scFv of anti-human ICAM-1, or an I domain of the αL subunit of human lymphocyte function-associated antigen-1. In another embodiment, the CAR is specific to human CD19, and the CAR comprises a binding domain that is scFv of anti-human CD19. The present invention is further directed to using the above transduced T cells for monitoring T cell distribution in a patient by PET/CT imaging and/or treating cancer.
-
公开(公告)号：US11679148B2
公开(公告)日：2023-06-20
申请号：US16766438
申请日：2018-11-23
申请人： INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (INSERM) , ASSISTANCE PUBLIQUE—HÔPITAUX DE PARIS , UNIVERSITÉ PARIS-SACLAY , UNIVERSITÉ PARIS CITÉ
CPC分类号： A61K39/00118 , A61K31/19 , A61K39/39 , A61P35/00 , A61K2039/515
摘要： The inventors provide a new therapeutic strategy to treat cancers expressing embryonic antigens. Accordingly, the present invention relates to a method of treating a subject suffering from a cancer comprising a step of administration simultaneously, separately or sequentially to said subject a therapeutically amount of i) a population of derived engineered fetal stem cells carrying cancer associated fetal neo-antigen and ii) a compound selected from a group which activates immune response, as a combined preparation.
-
公开(公告)号：US20230159897A1
公开(公告)日：2023-05-25
申请号：US17992372
申请日：2022-11-22
发明人： Richard KLEMKE , Huawei WANG
IPC分类号： C12N5/0775 , A61K9/00 , A61K35/28 , C12N15/85 , A61K38/20 , A61K39/00 , A61K35/12 , A61K39/215
CPC分类号： C12N5/0662 , A61K9/0019 , A61K35/28 , C12N15/85 , A61K38/2066 , A61K39/001102 , A61K35/12 , A61K39/215 , C12N2501/999 , C12N2510/00 , A61K2039/515 , A61K2039/545
摘要： Provided herein are cytoplasts, compositions comprising cytoplasts, methods of using cytoplasts, and methods of treating a subject, such as providing benefits to a healthy or unhealthy subject, or treating or diagnosing a disease or condition in a subject. In some embodiments, methods of treating a subject include: administering to the subject a therapeutically effective amount of a composition comprising a cytoplast. Also, provided herein are compositions (e.g., pharmaceutical compositions) that include a cytoplast. Also, provided herein are kits comprising instructions for using the compositions or methods.
-
公开(公告)号：US20190192561A1
公开(公告)日：2019-06-27
申请号：US16291477
申请日：2019-03-04
发明人： Samuel Strober , Robert Lowsky
IPC分类号： A61K35/12 , A61K35/22 , A61K35/28 , A61K39/395 , A61N5/10 , A61K38/13 , A61K31/573 , A61K31/436 , A61K45/06 , A61K41/00 , A61K38/19 , A61K35/14 , A61K35/17 , A61K39/00 , A61K31/365
CPC分类号： A61K35/12 , A61K31/365 , A61K31/436 , A61K31/573 , A61K35/14 , A61K35/17 , A61K35/22 , A61K35/28 , A61K38/13 , A61K38/193 , A61K39/001 , A61K39/395 , A61K39/39541 , A61K41/00 , A61K45/06 , A61K2035/122 , A61K2035/124 , A61K2039/515 , A61K2039/54 , A61K2039/57 , A61N5/10 , A61K2300/00
摘要： Methods and compositions are provided for combined transplantation of a solid organ and hematopoietic cells to a recipient, where tolerance to the graft is established through development of a persistent mixed chimerism. An individual with persistent mixed chimerism, usually for a period of at least six months, is able to withdraw from the use of immunosuppressive drugs after a period of time sufficient to establish tolerance.
-
公开(公告)号：US20180344766A1
公开(公告)日：2018-12-06
申请号：US16100828
申请日：2018-08-10
发明人： Samuel Strober , Robert Lowsky
IPC分类号： A61K35/12 , A61K31/436 , A61K31/573 , A61K35/14 , A61K35/17 , A61K35/22 , A61K31/365 , A61K35/28 , A61K41/00 , A61K39/395 , A61N5/10 , A61K39/00 , A61K38/19 , A61K38/13 , A61K45/06
CPC分类号： A61K35/12 , A61K31/365 , A61K31/436 , A61K31/573 , A61K35/14 , A61K35/17 , A61K35/22 , A61K35/28 , A61K38/13 , A61K38/193 , A61K39/001 , A61K39/395 , A61K39/39541 , A61K41/00 , A61K45/06 , A61K2035/122 , A61K2035/124 , A61K2039/515 , A61K2039/54 , A61K2039/57 , A61N5/10 , A61K2300/00
摘要： Methods and compositions are provided for combined transplantation of a solid organ and hematopoietic cells to a recipient, where tolerance to the graft is established through development of a persistent mixed chimerism. An individual with persistent mixed chimerism, usually for a period of at least six months, is able to withdraw from the use of immunosuppressive drugs after a period of time sufficient to establish tolerance.
-
88.发明申请公开(公告)号：US20180238880A1
公开(公告)日：2018-08-23
申请号：US15958638
申请日：2018-04-20
发明人： Jeffrey A. Bluestone , Weihong Liu , Amy Putnam
IPC分类号： G01N33/569 , A61K39/00 , G01N33/50 , C12N5/0783 , A61K35/17 , A61K35/12
CPC分类号： G01N33/56972 , A61K35/17 , A61K39/0008 , A61K2035/122 , A61K2039/515 , C12N5/0636 , G01N33/505 , G01N2333/70514 , G01N2333/70517 , G01N2333/70596 , G01N2333/7155
摘要： The invention provides methods of isolating CD127lo/− immunosuppressive regulatory T cells which can be greatly enriched for FoxP3, methods of expanding the isolated cells, pharmaceutical compositions of such cells, and methods of their use in the treatment of autoimmune and other immune system mediated disorders.
-
公开(公告)号：US10052377B2
公开(公告)日：2018-08-21
申请号：US15397214
申请日：2017-01-03
发明人： Eric James Gowans
IPC分类号： A61K35/12 , A61K39/29 , A61K31/711 , A61K39/12 , A61K39/21 , C12N7/00 , A61K35/15 , A61K39/00
CPC分类号： A61K39/29 , A61K31/711 , A61K35/12 , A61K35/15 , A61K39/12 , A61K39/21 , A61K2039/515 , A61K2039/5154 , A61K2039/5156 , A61K2039/53 , A61K2039/6037 , A61K2039/605 , A61K2039/6068 , C07K2319/00 , C07K2319/40 , C07K2319/50 , C07K2319/55 , C12N7/00 , C12N2740/16234 , C12N2770/00034 , C12N2770/24234 , A61K2300/00
摘要： The present invention relates to methods of inducing or enhancing an immune response against an immunogen in a subject. The invention further includes isolated nucleic acid vaccines, cellular vaccines, fusion proteins, expression vectors, vaccines, and immunogenic compositions for use therein.
-
90.发明申请公开(公告)号：US20180085402A1
公开(公告)日：2018-03-29
申请号：US15716141
申请日：2017-09-26
发明人： Avak Kahvejian , Jordi Mata-Fink , Robert J. Deans , Tiffany F. Chen , John Round , Noubar B. Afeyan , Torben Straight Nissen , Nathan Dowden , Tom Wickham , Sivan Elloul
IPC分类号： A61K35/18 , A61K39/395 , A61K38/19 , A61K39/00 , C12N5/078
CPC分类号： A61K35/18 , A61K35/12 , A61K38/191 , A61K39/0011 , A61K39/3955 , A61K2039/505 , A61K2039/515 , A61P17/00 , C07K14/705 , C07K2319/00 , C12N5/0641 , C12N2510/00
摘要： The invention includes compositions and methods related to multimodal therapies, e.g., for treating a cancer. A multimodal therapy described herein provides and/or administers a plurality of agents that function in a coordinated manner to provide a therapeutic benefit to a subject in need thereof, e.g., a subject having a cancer.
-
-
-
-
-
-
-
-
-
搜索结果
439 条记录 (耗时 0.022 秒)
