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    Assay device having uniform flow around corners
    82.
    发明授权
    Assay device having uniform flow around corners 有权

    公开(公告)号：US09625457B2

    公开(公告)日：2017-04-18

    申请号：US14540221

    申请日：2014-11-13

    申请人： Ortho-Clinical Diagnostics, Inc.

    发明人： James D. Kanaley ,  Zhong Ding ,  Philip C. Hosimer ,  Edward R. Scalice ,  Susan Danielson ,  David A. Tomasso ,  Timothy C. Warren

    IPC分类号： B01L3/00 ,  G01N33/543 ,  G01N1/28

    CPC分类号： G01N33/54366 ,  B01L3/5023 ,  B01L3/502746 ,  B01L2200/0636 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2400/086 ,  G01N1/28 ,  Y10T436/2575

    摘要： An assay device includes: a liquid sample zone; a reagent zone downstream and in fluid communication with the sample zone containing a reagent material; a detection zone in fluid communication with the reagent zone having capture elements bound thereto; and a wicking zone in fluid communication with the capture zone having a capacity to receive liquid sample flowing from the detection zone. The sample receiving zone, the reagent zone, the detection zone and the wicking zone define a fluid flow path and at least a part of the fluid flow path has a substrate and projections which extend substantially vertically from the substrate, wherein the projections have a height, cross-section and a distance between one another that defines a space between the projections capable of generating capillary flow parallel to the substrate surface. In addition, the fluid flow path having projections includes a corner section which changes the direction of the flow path. The projections in or around the corner section are modified to maintain the configuration of the flow front of the sample flowing through the flow path after the corner is substantially the same configuration as before the corner.

    REDUNDANT ERROR DETECTION IN A CLINICAL DIAGNOSTIC ANALYZER
    87.
    发明申请
    REDUNDANT ERROR DETECTION IN A CLINICAL DIAGNOSTIC ANALYZER 有权
    临床诊断分析仪中的冗余错误检测

    公开(公告)号：US20160162653A1

    公开(公告)日：2016-06-09

    申请号：US15045852

    申请日：2016-02-17

    申请人： Ortho-Clinical Diagnostics, Inc.

    发明人： Joseph J. Dambra ,  Jean-Christophe Hurpeau ,  Mark D. Reed

    IPC分类号： G06F19/00

    CPC分类号： G16H10/40 ,  G06F11/3668 ,  G06F19/00 ,  G06F19/324 ,  G16H40/40 ,  G16H70/00

    摘要： Disclosed is a clinical diagnostic analyzer employing a redundant error detection capability to further examine the internal message traffic for possible errors or questionable results by comparing the actual parameters against a fingerprint generated for each assay using an assay database and a configuration file. This testing does not rely on inputs from the software module being tested, and hence is an independent test. Further, a testing mechanism is provided to test the Redundant Error Detection (“RED”) capability itself.

    摘要翻译： 公开了一种采用冗余错误检测能力的临床诊断分析仪，通过使用分析数据库和配置文件比较实际参数与针对每个测定生成的指纹，进一步检查内部消息流量以获得可能的错误或可疑结果。 该测试不依赖于被测试软件模块的输入，因此是独立测试。 此外，提供测试机制来测试冗余错误检测（“RED”）能力本身。

    METHOD FOR DETECTING THE IMPENDING ANALYTICAL FAILURE OF NETWORKED DIAGNOSTIC CLINICAL ANALYZERS
    88.
    发明申请
    METHOD FOR DETECTING THE IMPENDING ANALYTICAL FAILURE OF NETWORKED DIAGNOSTIC CLINICAL ANALYZERS 审中-公开
    检测网络诊断临床分析人员分析失败的方法

    公开(公告)号：US20160132375A1

    公开(公告)日：2016-05-12

    申请号：US14994791

    申请日：2016-01-13

    申请人： Ortho-Clinical Diagnostics, Inc.

    发明人： Merrit N. Jacobs ,  Christopher Thomas Doody ,  Edwin Craig Bashaw ,  Joseph Michael Indovina ,  Owen Altland ,  Nicholas John Gould

    IPC分类号： G06F11/07

    CPC分类号： G16H40/40 ,  G16H10/40

    摘要： A method of detecting impending analytical failure in a networked diagnostic clinical analyzer is based upon detecting whether the operation of a particular analyzer is statistically distinguishable based on one or more thresholds. A failure occurs when one or more components or modules of the analyzer fails. A method to detect such an impending failure is disclosed. Baseline data on a pre-selected set of analyzer variables for a population of diagnostic clinical analyzers is used to generate an impending failure threshold. Subsequently, operational data comprising the same pre-selected set of analyzer variables allows generation of a time series of operational statistics. If the operational statistic exceeds the impeding failure threshold in a prescribed manner, an impending analytical failure is predicted. Such detection of impending analytical failures facilitates intelligent scheduling of service for the analyzer in question to maintain high assay throughput and accuracy.

    摘要翻译： 一种在联网诊断临床分析仪中检测即将发生的分析失败的方法是基于检测特定分析仪的操作是否基于一个或多个阈值在统计上可区分。 当分析仪的一个或多个组件或模块发生故障时，会发生故障。 公开了一种检测这种即将发生故障的方法。 用于诊断临床分析仪群体的预先选择的分析器变量集合的基线数据用于产生即将发生的故障阈值。 随后，包括相同的预选择的分析器变量集合的操作数据允许生成时间序列的操作统计信息。 如果操作统计量以规定的方式超过阻碍故障阈值，则预测即将发生的分析故障。 对即将发生的分析故障的这种检测有助于对所讨论的分析仪的服务的智能调度，以保持高的测定吞吐量和精度。

    Reagents For HCV Antigen-Antibody Combination Assays
    89.
    发明申请
    Reagents For HCV Antigen-Antibody Combination Assays 有权
    HCV抗原 - 抗体组合试剂的试剂

    公开(公告)号：US20160109447A1

    公开(公告)日：2016-04-21

    申请号：US14982015

    申请日：2015-12-29

    申请人： ORTHO-CLINICAL DIAGNOSTICS, INC.

    发明人： Jian Zheng ,  Jianping Yang

    IPC分类号： G01N33/569 ,  G01N33/53

    CPC分类号： G01N33/56983 ,  G01N33/5306 ,  G01N33/5767 ,  G01N2333/186 ,  G01N2469/10 ,  G01N2469/20

    摘要： The present invention is directed to combination immunoassays, reagents and kits for simultaneous detection of HCV antigens and anti-HCV antibodies in a sample. The combination immunoassays of the present invention employ a non-ionic detergent that effectively exposes or releases the HCV core antigen from virions in a sample without interfering with the performance of other reagents such as the capture of anti-HCV antibodies by recombinant HCV antigens.

    摘要翻译： 本发明涉及用于在样品中同时检测HCV抗原和抗HCV抗体的组合免疫测定，试剂和试剂盒。 本发明的组合免疫测定使用非离子洗涤剂，其有效地从样品中的病毒粒子暴露或释放HCV核心抗原，而不干扰其它试剂的性能，例如通过重组HCV抗原捕获抗HCV抗体。