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公开(公告)号：US20140221616A1
公开(公告)日：2014-08-07
申请号：US13970667
申请日：2013-08-20
发明人： Matthew Garrett DONAHUE , Yong Gong , Rhys Salter , Eric Hryhorenko , Thomas R. DeCory , Bart Remmerie , Banumathi Sankaran
IPC分类号： G01N33/53
CPC分类号： G01N33/5308 , A61K47/64 , A61K47/643 , A61K47/646 , C07D281/16 , C07D417/12 , C07D417/14
摘要： The invention relates to compounds of Formula I, wherein R1, R2, and R3 are defined in the specification, useful for the synthesis of novel conjugates and immunogens derived from quetiapine. The invention also relates to conjugates of a quetiapine hapten and a protein.
摘要翻译： 本发明涉及式I化合物，其中R 1，R 2和R 3在本说明书中定义，可用于合成衍生自喹硫平的新缀合物和免疫原。 本发明还涉及喹硫平半抗原和蛋白质的缀合物。
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公开(公告)号：US09494608B2
公开(公告)日：2016-11-15
申请号：US13971536
申请日：2013-08-20
发明人： Eric Hryhorenko , Banumathi Sankaran , Thomas R. DeCory , Theresa Tubbs , Linda Colt , Bart M. Remmerie , Rhys Salter , Matthew Garrett Donahue , Yong Gong
CPC分类号： C07K16/44 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/626 , G01N33/94 , G01N2800/302
摘要： Disclosed is an antibody which binds to olanzapine, which can be used to detect olanzapine in a sample such as in a competitive immunoassay method. The antibody can be used in a lateral flow assay device for point-of-care detection of olanzapine, including multiplex detection of aripiprazole, olanzapine, quetiapine, and risperidone in a single lateral flow assay device.
摘要翻译： 公开了结合奥氮平的抗体，其可以用于检测样品中的奥氮平，例如在竞争性免疫测定法中。 该抗体可以用于侧流测定装置中用于奥氮平的护理点检测，包括在单侧流测定装置中多次检测阿立哌唑，奥氮平，喹硫平和利培酮。
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公开(公告)号：US09494607B2
公开(公告)日：2016-11-15
申请号：US13971448
申请日：2013-08-20
发明人： Eric Hryhorenko , Banumathi Sankaran , Thomas R. DeCory , Theresa Tubbs , Linda Colt , Bart M. Remmerie , Rhys Salter , Ronghui Lin
CPC分类号： G01N33/94 , C07K16/44 , C07K2317/56 , C07K2317/565 , G01N2800/302 , G01N2800/52
摘要： Disclosed is an antibody which binds to aripiprazole, which can be used to detect aripiprazole in a sample such as in a competitive immunoassay method. The antibody can be used in a lateral flow assay device for point-of-care detection of aripiprazole, including multiplex detection of aripiprazole, olanzapine, quetiapine, and risperidone in a single lateral flow assay device.
摘要翻译： 公开了与阿立哌唑结合的抗体，其可用于检测样品中的阿立哌唑，例如在竞争性免疫测定法中。 该抗体可用于侧流测定装置中用于阿立哌唑的护理点检测，包括在单侧流测定装置中多次检测阿立哌唑，奥氮平，喹硫平和利培酮。
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公开(公告)号：US09303041B2
公开(公告)日：2016-04-05
申请号：US13970653
申请日：2013-08-20
发明人： Matthew Garrett Donahue , Yong Gong , Rhys Salter , Eric Hryhorenko , Thomas R. DeCory , Bart Remmerie , Banumathi Sankaran
IPC分类号： A61K31/551 , C07D495/04 , A61K47/48 , C07K14/47 , C07K14/77
CPC分类号： C07D495/04 , A61K47/643 , A61K47/646 , C07K14/47 , C07K14/77
摘要： The invention relates to compounds of Formula I, wherein R1, R2, and R3 are defined in the specification, useful for the synthesis of novel conjugates and immunogens derived from olanzapine. The invention also relates to conjugates of an olanzapine hapten and a protein.
摘要翻译： 本发明涉及式I化合物，其中R 1，R 2和R 3在本说明书中定义，可用于合成来自奥氮平的新缀合物和免疫原。 本发明还涉及奥氮平半抗原和蛋白质的缀合物。
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公开(公告)号：US20140057305A1
公开(公告)日：2014-02-27
申请号：US13971546
申请日：2013-08-20
发明人： Eric Hryhorenko , Banumathi Sankaran , Thomas R. DeCory , Theresa Tubbs , Linda Colt , Bart M. Remmerie , Rhys Salter , Matthew Garrett Donahue , Yong Gong
CPC分类号： C07K16/44 , G01N33/94 , G01N33/9466
摘要： Disclosed is an antibody which binds to quetiapine, which can be used to detect quetiapine in a sample such as in a competitive immunoassay method. The antibody can be used in a lateral flow assay device for point-of-care detection of quetiapine, including multiplex detection of aripiprazole, olanzapine, quetiapine, and risperidone in a single lateral flow assay device.
摘要翻译： 公开了结合喹硫平的抗体，其可用于检测样品中的喹硫平，例如在竞争性免疫测定法中。 该抗体可以用于侧面流动测定装置，用于观察喹硫平的检查点，包括在单个侧流测定装置中多次检测阿立哌唑，奥氮平，喹硫平和利培酮。
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公开(公告)号：US20140057303A1
公开(公告)日：2014-02-27
申请号：US13971519
申请日：2013-08-20
发明人： Eric Hryhorenko , Banumathi Sankaran , Thomas R. DeCory , Theresa Tubbs , Linda Colt , Bart M. Remmerie , Rhys Salter , Matthew Garrett Donahue , Yong Gong
摘要： Disclosed is an antibody which binds to olanzapine, which can be used to detect olanzapine in a sample such as in a competitive immunoassay method. The antibody can be used in a lateral flow assay device for point-of-care detection of olanzapine, including multiplex detection of aripiprazole, olanzapine, quetiapine, and risperidone in a single lateral flow assay device.
摘要翻译： 公开了结合奥氮平的抗体，其可以用于检测样品中的奥氮平，例如在竞争性免疫测定法中。 该抗体可以用于侧流测定装置中用于奥氮平的护理点检测，包括在单侧流测定装置中多次检测阿立哌唑，奥氮平，喹硫平和利培酮。
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公开(公告)号：US09504682B2
公开(公告)日：2016-11-29
申请号：US13970650
申请日：2013-08-20
发明人： Ronghui Lin , Rhys Salter , Thomas R. DeCory , Eric Hryhorenko , Bart Remmerie , Banumathi Sankaran
IPC分类号： A61K31/496 , C07D401/14 , C07D401/12 , C07D215/227 , C07D215/22 , A61K47/48
CPC分类号： A61K47/62 , A61K31/496 , A61K31/497 , A61K39/385 , A61K47/6425 , A61K47/643 , A61K47/646 , A61K2039/6081 , C07D215/22 , C07D215/227 , C07D401/12 , C07D401/14
摘要： The invention relates to compounds of Formula I, wherein R1, R2, and R3 are defined in the specification, useful for the synthesis of novel conjugates and immunogens derived from aripiprazole. The invention also relates to conjugates of an aripiprazole hapten and a protein.
摘要翻译： 本发明涉及式I化合物，其中R 1，R 2和R 3在本说明书中定义，可用于合成来自阿立哌唑的新缀合物和免疫原。 本发明还涉及阿立哌唑半抗原和蛋白质的缀合物。
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公开(公告)号：US09394354B2
公开(公告)日：2016-07-19
申请号：US13970660
申请日：2013-08-20
发明人： Pieter Rik Haspeslagh , Maarten Vliegen , Eric Hryhorenko , Thomas R. DeCory , Banumathi Sankaran
IPC分类号： C07D239/70 , C07K14/77 , A61K39/385 , C07D471/04 , A61K47/48 , C07K14/47 , A61K39/00
CPC分类号： C07K14/77 , A61K39/385 , A61K47/64 , A61K47/643 , A61K47/646 , A61K2039/6031 , A61K2039/6081 , C07D471/04 , C07K14/47
摘要： The invention relates to compounds of Formula I, wherein L1, L2, and L3 are defined in the specification, useful for the synthesis of novel conjugates and immunogens derived from paliperidone. The invention also relates to conjugates of a paliperidone hapten and a protein.
摘要翻译： 本发明涉及式I化合物，其中L1，L2和L3在本说明书中定义，可用于合成来自帕培酮的新缀合物和免疫原。 本发明还涉及帕培酮半抗原和蛋白质的缀合物。
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公开(公告)号：US09304126B2
公开(公告)日：2016-04-05
申请号：US13970667
申请日：2013-08-20
发明人： Matthew Garrett Donahue , Yong Gong , Rhys Salter , Eric Hryhorenko , Thomas R. DeCory , Bart Remmerie , Banumathi Sankaran
IPC分类号： A61K31/554 , C07D281/16 , C07D417/04 , G01N33/53 , C07D417/12 , C07D417/14 , A61K47/48
CPC分类号： G01N33/5308 , A61K47/64 , A61K47/643 , A61K47/646 , C07D281/16 , C07D417/12 , C07D417/14
摘要： The invention relates to compounds of Formula I, wherein R1, R2, and R3 are defined in the specification, useful for the synthesis of novel conjugates and immunogens derived from quetiapine. The invention also relates to conjugates of a quetiapine hapten and a protein.
摘要翻译： 本发明涉及式I化合物，其中R 1，R 2和R 3在本说明书中定义，可用于合成衍生自喹硫平的新缀合物和免疫原。 本发明还涉及喹硫平半抗原和蛋白质的缀合物。
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公开(公告)号：US20140057304A1
公开(公告)日：2014-02-27
申请号：US13971536
申请日：2013-08-20
发明人： Eric Hryhorenko , Banumathi Sankaran , Thomas R. DeCory , Theresa Tubbs , Linda Colt , Bart M. Remmerie , Rhys Salter , Matthew Garrett Donahue , Yong Gong
CPC分类号： C07K16/44 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/626 , G01N33/94 , G01N2800/302
摘要： Disclosed is an antibody which binds to olanzapine, which can be used to detect olanzapine in a sample such as in a competitive immunoassay method. The antibody can be used in a lateral flow assay device for point-of-care detection of olanzapine, including multiplex detection of aripiprazole, olanzapine, quetiapine, and risperidone in a single lateral flow assay device.
摘要翻译： 公开了结合奥氮平的抗体，其可以用于检测样品中的奥氮平，例如在竞争性免疫测定法中。 该抗体可以用于侧流测定装置中用于奥氮平的护理点检测，包括在单侧流测定装置中多次检测阿立哌唑，奥氮平，喹硫平和利培酮。
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