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    FINDING RELATIVES IN A DATABASE
    73.
    发明申请
    FINDING RELATIVES IN A DATABASE 有权
    在数据库中查找相关性

    公开(公告)号：US20100223281A1

    公开(公告)日：2010-09-02

    申请号：US12644791

    申请日：2009-12-22

    Applicant: Lawrence Hon ,  Serge Saxonov ,  Brian Thomas Naughton ,  Joanna Louise Mountain ,  Anne Wojcicki ,  Linda Avey

    Inventor： Lawrence Hon ,  Serge Saxonov ,  Brian Thomas Naughton ,  Joanna Louise Mountain ,  Anne Wojcicki ,  Linda Avey

    IPC: G06F17/30

    CPC classification number: G06F19/14 ,  G06F17/30522 ,  G06F17/30867 ,  G06F19/22 ,  G06F19/28 ,  G06N5/048

    Abstract: Determining relative relationship includes receiving recombinable deoxyribonucleic acid (DNA) information of a first user and recombinable DNA information of a second user, determining, based at least in part on the recombinable DNA information of the first user and recombinable DNA information of the second user, a predicted degree of relationship between the first user and the second user, and in the event that the expected degree of relationship between the first user and the second user at least meets the threshold, notifying at least the first user about a relative relationship with the second user.

    Abstract translation: 确定相对关系包括接收第一用户的可重复脱氧核糖核酸（DNA）信息和第二用户的可重复DNA信息，至少部分基于第一用户的可重复DNA信息和第二用户的可重复DNA信息， 第一用户和第二用户之间的预测关系程度，并且在第一用户和第二用户之间的预期关系程度至少满足阈值的情况下，至少通知第一用户关于与第 第二个用户

    System and Method for Sequence Distance Measure for Phylogenetic Tree Construction
    77.
    发明申请
    System and Method for Sequence Distance Measure for Phylogenetic Tree Construction 失效
    系统发育树构建序列距离测度系统与方法

    公开(公告)号：US20070225918A1

    公开(公告)日：2007-09-27

    申请号：US10561889

    申请日：2004-06-21

    Applicant: Khalid Sayood ,  Hasan Otu ,  Steven Hinrichs

    Inventor： Khalid Sayood ,  Hasan Otu ,  Steven Hinrichs

    IPC: G06F19/00

    CPC classification number: G06F19/14 ,  G06F19/22

    Abstract: The present invention permits identification of biological materials following recovery of DNA using standard techniques by comparing a mathematical characterization of the unknown sequence with the mathematical characterization of DNA sequences of known genera and species. The clinical identification of infectious organisms is required for accurate diagnosis and selection of antimicrobial therapeutics. The invention allows an ab initio approach with the potential for rapid identification of biological materials of unknown origin. The approach provides for identification and classification of emergent or new organisms without previous phenotypic identification. The technique may also be used in monitoring situations where the need exists for classification of material into broad categories of bacteria which could have an immediate impact on bio-terrorism prevention.

    Abstract translation: 本发明允许使用标准技术回收DNA后鉴定生物材料，通过比较未知序列的数学表征与已知属和物种的DNA序列的数学表征。 传染性生物体的临床鉴定是精确诊断和选择抗菌药物所必需的。 本发明允许从头开始的方法具有用于快速鉴定未知来源的生物材料的潜力。 该方法提供了对未出现先前表型鉴定的突变体或新生物的鉴定和分类。 该技术也可用于监测需要将材料分类为可能对生物恐怖主义预防产生直接影响的大类细菌的情况。

    GENE DISCOVERY THROUGH COMPARISONS OF NETWORKS OF STRUCTURAL AND FUNCTIONAL RELATIONSHIPS AMONG KNOWN GENES AND PROTEINS
    78.
    发明申请
    GENE DISCOVERY THROUGH COMPARISONS OF NETWORKS OF STRUCTURAL AND FUNCTIONAL RELATIONSHIPS AMONG KNOWN GENES AND PROTEINS 失效
    通过已知基因和蛋白质的结构和功能关系网络的比较发现基因

    公开(公告)号：US20020049542A1

    公开(公告)日：2002-04-25

    申请号：US09327983

    申请日：1999-06-08

    Inventor： ANDREY RZHETSKY ,  SERGEY KALACHIKOV

    IPC: G01N033/48 ,  G06F019/00 ,  C12Q001/68

    CPC classification number: G06F19/12 ,  G06F19/14 ,  G06F19/18 ,  G06F19/22 ,  G06F19/24 ,  G06F19/28 ,  G06Q50/24 ,  Y02A90/22

    Abstract: The present invention relates to methods for identifying novel genes comprising: (i) generating one or more specialized databases containing information on gene/protein structure, function and/or regulatory interactions; and (ii) searching the specialized databases for homology or for a particular motif and thereby identifying a putative novel gene of interest. The invention may further comprise performing simulation and hypothesis testing to identify or confirm that the putative gene is a novel gene of interest.

    Abstract translation: 本发明涉及用于鉴定新基因的方法，其包括：（i）生成含有关于基因/蛋白质结构，功能和/或调节相互作用信息的一个或多个专门数据库; 和（ii）搜索专门的数据库以获得同源性或特定基序，从而鉴定出推定的新型感兴趣的基因。 本发明还可以包括执行模拟和假设检验以鉴定或确认推定的基因是新的感兴趣的基因。

    Virus discovery by sequencing and assembly of virus-derived siRNAS, miRNAs, piRNAs
    80.
    发明授权
    Virus discovery by sequencing and assembly of virus-derived siRNAS, miRNAs, piRNAs 有权
    病毒发现通过病毒衍生的siRNAS，miRNAs，piRNA的测序和装配

    公开(公告)号：US09493846B2

    公开(公告)日：2016-11-15

    申请号：US13375467

    申请日：2010-06-01

    Applicant: Shou-Wei Ding ,  Qingfa Wu

    Inventor： Shou-Wei Ding ,  Qingfa Wu

    IPC: C12Q1/68 ,  C12Q1/70 ,  G06F19/22 ,  G06F19/14

    CPC classification number: C12Q1/70 ,  C12Q2600/178 ,  G06F19/14 ,  G06F19/22

    Abstract: In one embodiment, the disclosure provides methods and systems for identifying viral nucleic acids in a sample. In another embodiment the invention provides methods for viral genome assembly and viral discovery using small inhibitory RNAs, or “small silencing,” RNAs (siRNAS), micro-RNAs (miRNAs) and/or PIWI-interacting RNAs (piRNAs), including siRNAS, miRNAs and/or piRNAs isolated or sequenced from invertebrate organisms such as insects (Anthropoda), nematodes (Nemapoda), Mollusca, Porifera, and other invertebrates, and/or plants, fungi or algae, Cyanobacteria and the like.

    Abstract translation: 在一个实施方案中，本公开提供了用于鉴定样品中的病毒核酸的方法和系统。 在另一个实施方案中，本发明提供使用小的抑制性RNA或“小沉默”RNA（siRNAS），微RNA（miRNA）和/或PIWI相互作用的RNA（piRNA）（包括siRNAS）的病毒基因组装配和病毒发现的方法， 从无脊椎动物（例如昆虫（Anthropoda）），线虫（Nemapoda），软体动物，Porifera和其他无脊椎动物，和/或植物，真菌或藻类，蓝细菌等中分离或测序的miRNA和/或piRNA。

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