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    P-alkoxyphenyl esters of 4-capronyloxy benzoic acid
    71.
    发明授权
    P-alkoxyphenyl esters of 4-capronyloxy benzoic acid 失效
    4-巯基苯甲酸的α-对羟基苯甲酸酯

    公开(公告)号：US3689525A

    公开(公告)日：1972-09-05

    申请号：US3689525D

    申请日：1971-02-26

    申请人： HOECHST AG

    发明人： SCHEURLE BRUNO ,  KELKER KANS

    IPC分类号： C09K19/20 ,  C09K19/22 ,  C09K19/46 ,  G01R33/28 ,  C07C69/78

    CPC分类号： G01R33/281 ,  C09K19/2007 ,  C09K19/22 ,  C09K19/46

    摘要： N-(4-methoxybenzylidene)-4''-O-n-butyrylaminophenol and 4methoxy- or 4-ethoxybenzylidene-4''-n-butyl aniline form enantiotropic nematic phases which are stable at room temperature or slightly above. If as third component 4-capronylhydroxy benzoic acid-4-4''-alkoxy phenol ester is added wherein alkoxy stands for ethoxy and butoxy, nematic phases are obtained which have melting points below O* C. The new nematogenic mixtures are useful for example as solvents for the NMR-spectroscopy.

    摘要翻译： 4-（4-甲氧基亚苄基）-4'-O-正丁酰氨基苯酚和4-甲氧基 - 或4-乙氧基亚苄基-4'-正丁基苯胺形成在室温或稍高于稳定的对映向列相。 如果作为第三组分加入4-间 - 己基羟基苯甲酸-4-4'-烷氧基苯酚酯，其中烷氧基代表乙氧基和丁氧基，则得到熔点低于0℃的向列相。新的生成混合物可用于例如 溶剂用于NMR光谱学。

    Means and methods using paramagnetic agents for in vitro diagnostic applications
    77.
    发明授权
    Means and methods using paramagnetic agents for in vitro diagnostic applications 有权
    使用顺磁性药物进行体外诊断应用的手段和方法

    公开(公告)号：US09482643B2

    公开(公告)日：2016-11-01

    申请号：US14090298

    申请日：2013-11-26

    申请人： Aspect Imaging Ltd.

    发明人： Uri Rapoport ,  Camila Cavallotti ,  Simonetta Geninatti Crich

    IPC分类号： G01R33/12 ,  G01N27/74 ,  A61B5/05

    CPC分类号： G01N27/745 ,  A61B5/05 ,  G01N24/088 ,  G01R33/1269 ,  G01R33/1276 ,  G01R33/281

    摘要： A method of detecting a target biochemical molecular species or at least one property correlated with the occurrence of the biochemical molecular species in a sample whose main component is water. The method includes: obtaining a sample whose main component is water; providing Functionalized Paramagnetic Particles (FPP) including a paramagnetic core and a moiety configured to interact with the target biochemical molecular species or with molecules collectively reporting on a property of the target biochemical molecular species; contacting the FPP with the sample; exposing the sample to an applied magnetic field; measuring a change in a nuclear relaxation property of the sample; and correlating the change to the presence of the biochemical molecular species in the sample or to at least one property correlated with the occurrence of the biochemical molecular species in the sample.

    摘要翻译： 一种检测目标生化分子种类或与主要成分为水的样品中与生化分子种类的发生相关的至少一种性质的方法。 该方法包括：获得主要成分为水的样品; 提供功能性顺磁性颗粒（FPP），其包括顺磁性核和被配置成与靶生物化学分子物质相互作用的部分，或与共同报告靶生物化学分子种类的性质的分子相结合; 将FPP与样品接触; 将样品暴露于施加的磁场; 测量样品的核松弛性质的变化; 并将该变化与样品中生化分子物质的存在相关联，或与样品中生化分子物质的发生相关的至少一种性质相关联。

    MEANS AND METHODS USING PARAMAGNETIC AGENTS FOR IN VITRO DIAGNOSTIC APPLICATIONS
    79.
    发明申请
    MEANS AND METHODS USING PARAMAGNETIC AGENTS FOR IN VITRO DIAGNOSTIC APPLICATIONS 有权
    使用参考试剂在体外诊断应用中的手段和方法

    公开(公告)号：US20150147746A1

    公开(公告)日：2015-05-28

    申请号：US14090298

    申请日：2013-11-26

    申请人： ASPECT IMAGING LTD.

    发明人： Uri RAPOPORT ,  Camilla CAVALLOTTI ,  Simonetta GENINATTI CRICH

    IPC分类号： G01N27/74

    CPC分类号： G01N27/745 ,  A61B5/05 ,  G01N24/088 ,  G01R33/1269 ,  G01R33/1276 ,  G01R33/281

    摘要： A method of detecting a target biochemical molecular species or at least one property correlated with the occurrence of the biochemical molecular species in a sample whose main component is water. The method includes: obtaining a sample whose main component is water; providing Functionalized Paramagnetic Particles (FPP) including a paramagnetic core and a moiety configured to interact with the target biochemical molecular species or with molecules collectively reporting on a property of the target biochemical molecular species; contacting the FPP with the sample; exposing the sample to an applied magnetic field; measuring a change in a nuclear relaxation property of the sample; and correlating the change to the presence of the biochemical molecular species in the sample or to at least one property correlated with the occurrence of the biochemical molecular species in the sample.

    摘要翻译： 一种检测目标生化分子种类或与主要成分为水的样品中与生化分子种类的发生相关的至少一种性质的方法。 该方法包括：获得主要成分为水的样品; 提供功能性顺磁性颗粒（FPP），其包括顺磁性核和被配置成与靶生物化学分子物质相互作用的部分，或与共同报告靶生物化学分子种类的性质的分子相结合; 将FPP与样品接触; 将样品暴露于施加的磁场; 测量样品的核松弛性质的变化; 并将该变化与样品中生化分子物质的存在相关联，或与样品中生化分子物质的发生相关的至少一种性质相关联。

    COMPUTER AIDED DIAGNOSTIC METHOD AND DEVICE
    80.
    发明申请
    COMPUTER AIDED DIAGNOSTIC METHOD AND DEVICE 审中-公开
    计算机辅助诊断方法和设备

    公开(公告)号：US20150119697A1

    公开(公告)日：2015-04-30

    申请号：US14554301

    申请日：2014-11-26

    申请人： Alan Penn & Associates, Inc.

    发明人： Alan PENN

    IPC分类号： G06F19/00 ,  G01R33/48 ,  G01R33/28 ,  A61B5/055

    CPC分类号： G01R33/281 ,  A61B5/055 ,  G01R33/48 ,  G01R33/56341 ,  G16H50/20

    摘要： A method for characterizing regions on a map or image generated from diffusion image data of a region of a patient's body, including: loading into a data processing device image data achieved by calculation from MR diffusion imaging; providing a first threshold level to distinguish pixels with image data values that are above or below the values found that are not representative of pathological portions of the region; providing a second threshold level higher than the first threshold; deriving a measure related to the gradient pattern of those pixels that lie within a margin zone defined by those pixels that satisfy a criterion of the second threshold but do not satisfy a criterion of the first threshold and; outputting the measure related to the gradient as a parameter indicative of the likelihood that the pixels that are within the margin zone and/or a region of the body part are cancerous.

    摘要翻译： 一种用于表征从患者身体区域的扩散图像数据生成的地图或图像上的区域的方法，包括：通过从MR扩散成像计算获得的图像数据加载到数据处理设备中; 提供第一阈值水平以区分高于或低于不是代表该区域的病理部分的值的图像数据值的像素; 提供高于所述第一阈值的第二阈值水平; 导出与由满足第二阈值的标准但不满足第一阈值的标准的那些像素限定的边缘区域内的那些像素的梯度图案相关的度量; 输出与梯度相关的度量，作为指示在边缘区域内和/或身体部位的区域内的像素是癌症的可能性的参数。