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    Analysis of mixtures including proteins
    72.
    发明授权
    Analysis of mixtures including proteins 失效
    含蛋白质的混合物分析

    公开(公告)号：US08547536B2

    公开(公告)日：2013-10-01

    申请号：US12746830

    申请日：2008-12-09

    Applicant: Sandro D'Ascenzi ,  Giuseppe De Conciliis ,  Claudia Magagnoli ,  Giovanni Luigi Mattioli

    Inventor： Sandro D'Ascenzi ,  Giuseppe De Conciliis ,  Claudia Magagnoli ,  Giovanni Luigi Mattioli

    IPC: G01N21/00

    CPC classification number: G01N21/33 ,  A61K39/095 ,  A61K2039/6037 ,  G01J3/433 ,  G01J3/4406 ,  G01N21/6486

    Abstract: The quality control of vaccines is an important step in the release of vaccines to patients. Problems when dealing with vaccines include stability, batch-to-batch consistency and contamination. The invention provides a method of analyzing the composition of a protein-containing sample by electromagnetic spectroscopy, and derivatizing the obtained spectrum to obtain a derivative spectrum of the sample. The derivative spectrum may optionally be compared to a reference spectrum, to assess stability, contamination etc. relative to the reference. The derivative analysis technique allows the separation and discrimination between the spectral contributions of different components, thereby allowing differences in the spectra to be assigned to particular groups of the protein, or particular contaminants etc.

    Abstract translation: 疫苗的质量控制是向患者释放疫苗的重要一步。 处理疫苗时的问题包括稳定性，批次间的一致性和污染。 本发明提供了一种通过电磁光谱分析含蛋白质样品的组成并衍生得到的光谱以获得样品的衍生光谱的方法。 衍生光谱可以任选地与参考光谱进行比较，以评估相对于参考物的稳定性，污染等。 衍生分析技术允许分离和区分不同成分的光谱贡献，从而允许光谱中的差异被分配给蛋白质的特定组或特定的污染物等。

    MULTI WAVELENGTH EXCITATION/EMISSION AUTHENTICATION AND DETECTION SCHEME
    74.
    发明申请
    MULTI WAVELENGTH EXCITATION/EMISSION AUTHENTICATION AND DETECTION SCHEME 有权
    多波长激励/排放认证和检测方案

    公开(公告)号：US20130182241A1

    公开(公告)日：2013-07-18

    申请号：US13352953

    申请日：2012-01-18

    Applicant: Nabil Lawandy ,  Andrei Smuk ,  Leif Olson ,  Charles Zepp

    Inventor： Nabil Lawandy ,  Andrei Smuk ,  Leif Olson ,  Charles Zepp

    IPC: G01N21/64 ,  G01N21/55

    CPC classification number: G01N21/25 ,  B42D25/355 ,  G01J3/4406 ,  G01N21/643 ,  G01N2021/6419 ,  G07D7/1205

    Abstract: A system and method for authentication of secure products is disclosed. The security feature contains a first component in the form of an emitter capable of emitting light in response to external pump light. The security feature also contains a second component in the form of a taggant that absorbs light in a spectrally narrow range compared to the broader excitation spectrum of the first material. In this manner the emitter and taggant work in combination with one another to create an emission response significantly dependent on the illumination wavelengths and unique to the specific combination of the components. The emitter and taggant can be in the form of a mixture. Further the emitter and taggant may be applied in close proximity to one another, such as within two separate coating layers on a suitable substrate.

    Abstract translation: 公开了一种用于认证安全产品的系统和方法。 安全特征包含能够响应于外部泵浦光而发光的发射器形式的第一部件。 安全特征还包含标签牌形式的第二组分，其与第一材料的较宽的激发光谱相比吸收光谱窄范围内的光。 以这种方式，发射器和标签牌彼此组合工作以产生明显取决于照明波长的发射响应，并且对于组件的具体组合是唯一的。 发射体和标记物可以是混合物的形式。 此外，发射器和标签剂可以彼此紧邻地施加，例如在合适的衬底上的两个单独的涂层内。

    VERSATILE SURFACE PLASMON RESONANCE ANALYZER WITH AN INTEGRAL SURFACE PLASMON RESONANCE ENHANCED FLUORESCENCE MODE
    76.
    发明申请
    VERSATILE SURFACE PLASMON RESONANCE ANALYZER WITH AN INTEGRAL SURFACE PLASMON RESONANCE ENHANCED FLUORESCENCE MODE 有权
    具有整体表面等离子体表面等离子体共振分析仪增强荧光增白模式

    公开(公告)号：US20130169954A1

    公开(公告)日：2013-07-04

    申请号：US13751181

    申请日：2013-01-28

    Applicant: CIENCIA, INC.

    Inventor： George N. Gibson ,  Ernest F. Guignon ,  Michael T. Reilly

    IPC: G01N21/55

    CPC classification number: G01N21/55 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/10 ,  G01J3/4406 ,  G01N21/553 ,  G01N21/648 ,  G01N21/7743

    Abstract: An instrument for measuring and analyzing surface plasmon resonance on a sensor surface has a polarized light source optically connected to the sensor surface by a plurality of optical elements, including in one embodiment an optical telescope that transfers light from a rotatable reflecting surface to the sensor surface. Selective positioning of a cylindrical lens into a first position within the path of light transforms collimated light to a rectangular wedge that is incident upon the sensor surface at numerous angles. In another embodiment, the light source is operated as a laser to excite fluorescence on the sensor surface and the fluorescence is selectively directed to a detector by appropriate optical elements positioned in specific configurations.

    Abstract translation: 用于测量和分析传感器表面上的表面等离子体共振的仪器具有通过多个光学元件光学连接到传感器表面的偏振光源，在一个实施例中包括将光从可旋转反射表面传输到传感器表面的光学望远镜 。 将柱面透镜选择性地定位在光路内的第一位置将准直光转换成以多个角度入射在传感器表面上的矩形楔形物。 在另一个实施例中，光源作为激光器操作以在传感器表面上激发荧光，并且通过以特定配置定位的适当的光学元件将荧光选择性地导向检测器。

    IMAGING SYSTEM USING OPTICAL FIBER ARRAY INTEGRATED WITH LENSES
    77.
    发明申请
    IMAGING SYSTEM USING OPTICAL FIBER ARRAY INTEGRATED WITH LENSES 审中-公开
    使用与镜片集成的光纤阵列的成像系统

    公开(公告)号：US20130146754A1

    公开(公告)日：2013-06-13

    申请号：US13708388

    申请日：2012-12-07

    Applicant: Korea Basic Science Institute

    Inventor： Ki Soo Chang ,  Seon Young Ryu ,  Sun Cheol Yang ,  Geon Hee Kim ,  Hae Young Choi

    IPC: G01J1/42 ,  G01J1/04

    CPC classification number: G01J1/42 ,  A61B5/0062 ,  A61B5/0071 ,  A61B5/0084 ,  G01J1/0488 ,  G01J3/0218 ,  G01J3/4406 ,  G01N21/645 ,  G01N2021/6484 ,  G02B6/2552 ,  G02B6/262

    Abstract: Provided is an imaging system using an optical fiber array probe integrated with lenses for emitting light transmitted from a light source to a sample, and guiding light generated from the sample. The imaging system includes an optical fiber array probe integrated with lenses including an optical fiber lens with a lens surface of a predetermined radius of curvature in which one ends of two optical fibers are integrally connected with each other by heating a predetermined region including the one ends of the two optical fibers using a heating means. Therefore, a compact imaging system may be realized while effectively improving optical coupling efficiency through a simple manufacturing process.

    Abstract translation: 提供了一种使用与透镜集成的光纤阵列探针的成像系统，用于发射从光源向样本透射的光，并且引导从样品产生的光。 成像系统包括与透镜组合的光纤阵列探针，该透镜包括具有预定曲率半径的透镜表面的光纤透镜，其中两个光纤的一端通过加热包括一端的预定区域而彼此一体地连接 的两根光纤。 因此，可以通过简单的制造过程有效地提高光耦合效率，实现紧凑的成像系统。

    Spectrometer, spectrometry, and spectrometry program
    78.
    发明授权
    Spectrometer, spectrometry, and spectrometry program 有权
    光谱仪，光谱测定和光谱测定程序

    公开(公告)号：US08462337B2

    公开(公告)日：2013-06-11

    申请号：US13141152

    申请日：2009-09-08

    Applicant: Motoyuki Watanabe ,  Kazuya Iguchi ,  Kengo Suzuki

    Inventor： Motoyuki Watanabe ,  Kazuya Iguchi ,  Kengo Suzuki

    IPC: G01J1/04 ,  G01J3/30

    CPC classification number: G01N21/645 ,  G01J3/02 ,  G01J3/0262 ,  G01J3/0267 ,  G01J3/0291 ,  G01J3/4406 ,  G01J3/443 ,  G01N2201/0632 ,  G01N2201/065

    Abstract: A spectroscopic measurement apparatus 1A comprises an integrating sphere 20 in which a sample S is located, a spectroscopic analyzer 30 dispersing the light to be measured from the sample S and obtaining a wavelength spectrum, and a data analyzer 50. The analyzer 50 includes an object range setting section which sets a first object range corresponding to excitation light and a second object range corresponding to light emission from the sample S in a wavelength spectrum, and a sample information analyzing section which determines a luminescence quantum yield of the sample S, determines a measurement value Φ0 of the luminescence quantum yield from results of a reference measurement and a sample measurement, and determines, by using factors β, γ regarding stray light in the reference measurement, an analysis value Φ of the luminescence quantum yield with the effect of stray light reduced by Φ=βΦ0+γ. This realizes a spectroscopic measurement apparatus, a measurement method, and a measurement program which can reduce the effect of stray light generated in a spectrometer.

    Abstract translation: 分光测量装置1A包括其中位于样品S的积分球20，从样品S分散被测光并获得波长谱的光谱分析仪30和数据分析器50.分析器50包括物体 范围设定部，其设定与激发光对应的第一对象范围和与波长光谱中的来自样品S的发光对应的第二对象范围，以及确定样品S的发光量子产率的样本信息分析部， 通过参考测量和样品测量的结果测量发光量子产率的测量值Phi0，并且通过使用参考测量中关于杂散光的因子β，γ来确定具有杂散效应的发光量子产率的分析值Phi 光减少Phi = betaPhi0 +γ。 这实现了可以降低在光谱仪中产生的杂散光的影响的光谱测量装置，测量方法和测量程序。

    Electrothermal Vaporization Atomic Fluorescence Spectroscopy and Spectrometer for Determination of Cadmium
    79.
    发明申请
    Electrothermal Vaporization Atomic Fluorescence Spectroscopy and Spectrometer for Determination of Cadmium 有权
    电热蒸发原子荧光光谱和镉测定光谱仪

    公开(公告)号：US20130119271A1

    公开(公告)日：2013-05-16

    申请号：US13810147

    申请日：2010-07-15

    Applicant: Jixin Liu ,  Li Feng

    Inventor： Jixin Liu ,  Li Feng

    IPC: G01J3/44

    CPC classification number: G01J3/4406 ,  G01N1/4022 ,  G01N21/6402 ,  G01N2001/4033 ,  G01N2021/6417

    Abstract: An electrothermal vaporization atomic fluorescence spectrometer for determination of Cadmium comprising a sampling system, a light source, an atomizer, a light path system, a detection system, and a display device. The sampling system includes an electrothermal vaporization device and a capture trap; the capture trap comprises a Tungsten or Molybdenum coil (6), a holder (15), a cover (7) and a power supply (17); the cover (7) and the holder (15) form a sealed space; the Tungsten or Molybdenum coil (6) is arranged on the holder (15); the Tungsten or Molybdenum coil (6) is located inside the sealed space formed by the cover (7) and the holder (15); and the cover (7) is provided with an inlet (12) and an outlet (13) thereon. An electrothermal vaporization atomic fluorescence spectroscopy for determination of Cadmium is also provided.

    Abstract translation: 一种用于测定镉的电热蒸发原子荧光光谱仪，包括采样系统，光源，雾化器，光路系统，检测系统和显示装置。 采样系统包括电热蒸发装置和捕集阱; 捕获阱包括钨或钼线圈（6），保持器（15），盖（7）和电源（17）; 盖（7）和保持器（15）形成密封空间; 钨或钼线圈（6）布置在支架（15）上; 钨或钼线圈（6）位于由盖（7）和保持器（15）形成的密封空间的内部; 并且盖（7）上设置有入口（12）和出口（13）。 还提供了用于测定镉的电热蒸发原子荧光光谱。

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