公开(公告)号：US20040038952A1

公开(公告)日：2004-02-26

申请号：US10450359

申请日：2003-07-21

Inventor： Janos Feher

IPC: A61K031/56 ,  A61K031/7048 ,  A61K031/353

CPC classification number: A61K36/80 ,  A61K31/575 ,  A61K35/413 ,  A61K36/16 ,  A61K36/185 ,  A61K36/28 ,  A61K36/38 ,  A61K36/45 ,  A61K36/482 ,  A61K36/53 ,  A61K36/534 ,  A61K36/537 ,  A61K36/86 ,  A61K35/12 ,  A61K31/07 ,  A61K2300/00

Abstract: The invention is related to the preparation of a pharmaceutical composition containing a bile acid component and a bioflavonoid component. The pharmaceutical composition according to the invention may be used for the treatment of digestive disoreders, systemic diseases associated with digestive disorders and diseases, furthermore for improving the digestion and absorption of the fat-soluble vitamins of foods, essential fatty acid and food components as well as food additives.

Abstract translation: 本发明涉及制备含有胆汁酸组分和生物类黄酮组分的药物组合物。 根据本发明的药物组合物可用于治疗消化失调者，与消化系统疾病和疾病相关的全身性疾病，此外还用于改善食物，必需脂肪酸和食物成分的脂溶性维生素的消化和吸收 作为食品添加剂。

公开(公告)号：US20020071872A1

公开(公告)日：2002-06-13

申请号：US09924319

申请日：2001-08-08

Inventor： Gerard P. McNally ,  Charles E. Pendley II ,  Brid T. Burruano ,  Nancy B. Rainey ,  Steven A. Jacobs ,  Shun Por Li ,  Michael E. Mertzman ,  David W. Wynn ,  Anthony J. Le Storti

IPC: A61K009/16 ,  A61K009/50 ,  A61K031/16

CPC classification number: A61K31/4402 ,  A61K31/80 ,  A61K36/482 ,  A61K2300/00

Abstract: The present invention provides a composition comprising a) a laxative selected from the group consisting of bisacodyl and enteric coated vanilloid compounds; and b) simethicone in an amount effective to enhance the efficacy of the laxative. The simethicone enhances the transit of the laxatives through the small bowel.

Abstract translation: 本发明提供了一种组合物，其包含a）选自比索酸和肠溶衣壳毒素化合物的泻药; 和b）二甲硅油，其量有效提高泻药的功效。 二甲硅油增强了泻药通过小肠的过程。

公开(公告)号：US20020055620A1

公开(公告)日：2002-05-09

申请号：US09984392

申请日：2001-10-30

Applicant: KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO

Inventor： Hajime Aga ,  Takashi Shibuya ,  Shigeharu Fukuda ,  Toshio Miyake

IPC: C07G003/00 ,  A01N043/04

CPC classification number: A61K31/7016 ,  A61K36/03 ,  A61K36/07 ,  A61K36/11 ,  A61K36/15 ,  A61K36/16 ,  A61K36/185 ,  A61K36/21 ,  A61K36/23 ,  A61K36/232 ,  A61K36/27 ,  A61K36/28 ,  A61K36/282 ,  A61K36/287 ,  A61K36/31 ,  A61K36/315 ,  A61K36/42 ,  A61K36/45 ,  A61K36/46 ,  A61K36/48 ,  A61K36/482 ,  A61K36/484 ,  A61K36/515 ,  A61K36/52 ,  A61K36/53 ,  A61K36/534 ,  A61K36/535 ,  A61K36/67 ,  A61K36/68 ,  A61K36/70 ,  A61K36/73 ,  A61K36/734 ,  A61K36/736 ,  A61K36/75 ,  A61K36/752 ,  A61K36/77 ,  A61K36/81 ,  A61K36/82 ,  A61K36/87 ,  A61K36/88 ,  A61K36/886 ,  A61K36/888 ,  A61K36/8945 ,  A61K36/8962 ,  A61K36/899 ,  A61K36/8994 ,  A61K36/8998 ,  A61K36/9066 ,  A61K36/9068 ,  A61K2300/00

Abstract: A reduction inhibitory agent for active oxygen eliminating activity comprises trehalose as an active ingredient. This agent can be incorporated into plant edible products and/or plant antioxidants.

Abstract translation: 活性氧消除活性的还原抑制剂包括海藻糖作为活性成分。 该药剂可以并入植物性食品和/或植物抗氧化剂中。

公开(公告)号：US5958417A

公开(公告)日：1999-09-28

申请号：US736392

申请日：1996-10-24

Applicant: Chau-shin Hsu

Inventor： Chau-shin Hsu

IPC: A61K36/287 ,  A61K36/482 ,  A61K36/62 ,  A61K36/704 ,  A61K36/708 ,  A61K36/734 ,  A61K36/884 ,  A61P3/06 ,  A61K35/78

CPC classification number: A61K36/704 ,  A61K36/287 ,  A61K36/482 ,  A61K36/62 ,  A61K36/708 ,  A61K36/734 ,  A61K36/884

Abstract: Herbal combinations which reduce serum cholesterol and triglyceride levels comprise (1) herbs having substantial recognized activity in enhancing circulatory function (ECF herbs) and (2) herbs having substantial recognized effects in promoting bowel motility (PBM herbs). Preferred combinations have a combined total of at least 16% (dry weight basis) of at least two ECS herbs in combination with a combined total of at least 16% (dry weight basis) of at least two PBM herbs. Particularly preferred combinations are selected from the following herbs: Crataegus, Ho Shou Wu, Chrysanthemum, Lotus Leaf, Alisma and Hu-Zhang, Cassia Seed, and Rhubarb.

Abstract translation: 降低血清胆固醇和甘油三酯水平的草药组合包括（1）具有显着增强循环功能的活性的草药（ECF草药）和（2）具有明显的促进肠蠕动作用的草药（PBM草药）。 优选的组合具有至少两种ECS草药至少16％（干重量）的组合，以及至少两种PBM草药的至少16％（干重）的组合。 特别优选的组合选自以下草药：山楂，何守武，菊花，莲花叶，阿里斯玛和胡章，决明子和大黄。

公开(公告)号：US5674498A

公开(公告)日：1997-10-07

申请号：US494316

申请日：1995-06-23

Applicant: Shuji Inoue ,  Masato Egawa ,  Susumu Shimura ,  Yoshio Itoh

Inventor： Shuji Inoue ,  Masato Egawa ,  Susumu Shimura ,  Yoshio Itoh

IPC: A23G1/30 ,  A21D2/36 ,  A21D13/08 ,  A23G1/00 ,  A23G3/34 ,  A23G4/00 ,  A23L1/30 ,  A23L2/38 ,  A61K36/00 ,  A61K36/48 ,  A61K36/482 ,  A61P3/06 ,  A61K35/78

CPC classification number: A61K36/482 ,  A21D13/08 ,  A21D2/36 ,  A23L33/105 ,  Y10S514/824

Abstract: In a blood-lipid depressant for depressing a blood-lipid level, an effective component of the depressant is an extract extracted with an extracting solvent from a senna species (Cassia mimosoides L. var. nomame Makino). An effective component of the depressant is an extract obtained by fractionating via chromatographic methods an extract extracted with an extracting solvent from a senna species (Cassia mimosoides L. var. nomame Makino).

Abstract translation: 在用于抑制血脂水平的血脂抑制剂中，抑制剂的有效成分是使用来自番泻叶种类（Cassia mimosoides L. var. nomame Makino）的提取溶剂提取的提取物。 抑制剂的有效成分是通过色谱法将来自番茄种（Cassia mimosoides L. var. nomame Makino）的提取溶剂提取的提取物分馏得到的提取物。

公开(公告)号：US5587167A

公开(公告)日：1996-12-24

申请号：US304855

申请日：1994-09-13

Applicant: Hyung K. Choi ,  Zhong C. Xin

Inventor： Hyung K. Choi ,  Zhong C. Xin

IPC: A61K35/56 ,  A61K36/232 ,  A61K36/234 ,  A61K36/258 ,  A61K36/268 ,  A61K36/36 ,  A61K36/482 ,  A61K36/64 ,  A61K36/75 ,  A61K35/78

CPC classification number: A61K36/482 ,  A61K36/232 ,  A61K36/234 ,  A61K36/258 ,  A61K36/268 ,  A61K36/36 ,  A61K36/64 ,  A61K36/75

Abstract: The present invention relates to an ointment composition for prophylaxis and treatment of premature ejaculation in a male patient and more particularly to a composition for applying to the glans penis, which contains the alcohol and/or aqueous extracts of ginseng radix, angelicae gigantis radix, broomrape, cassiae cortex, asiasari radix and bufonis venenum as the essential galenic components and, if necessary, one or more additional components selected from the extracts of xanthoxyli fructus, cnidium fructus, caryophylli flos and moschus.

Abstract translation: 本发明涉及一种用于预防和治疗男性患者的早泄的软膏组合物，更具体地涉及一种用于应用于阴茎的组合物，其包含人参，当归，甘草的醇和/或水提取物 ，桂皮皮质，亚硫酸根和罂粟素作为必需的含葛根成分，如果需要，还有一种或多种另外的组分，其选自黄花楸提取物，c藜，枸杞和紫草。

公开(公告)号：US5389372A

公开(公告)日：1995-02-14

申请号：US149813

申请日：1993-11-10

Applicant: Luigi deMaria ,  Claudio Lasciarrea ,  Pietro Micheli ,  Hein-Uwe Schmersahl

Inventor： Luigi deMaria ,  Claudio Lasciarrea ,  Pietro Micheli ,  Hein-Uwe Schmersahl

IPC: A61K9/00 ,  A61K9/16 ,  A61K31/70 ,  A61K36/00 ,  A61K36/482 ,  A61K47/26 ,  B65D51/28 ,  B65D81/32 ,  A61K35/78

CPC classification number: A61K9/0095 ,  A61K31/70 ,  A61K36/482 ,  A61K47/26 ,  A61K9/1623 ,  Y10S514/892

Abstract: A stable formulation of Sennosides with increased shelf-life and good solubility comprising a granulate containing Senna extract concentrate and, for each part by weight of Senna extract concentrate, 1 to 3 parts of weight of sucrose.

Abstract translation: 具有增加的保质期和良好溶解度的稳定的番泻叶配方，其包含含有番泻叶提取物浓缩物的颗粒，对于每一份重量的番泻叶提取物浓缩物，重量为1至3份的蔗糖。

公开(公告)号：US4595592A

公开(公告)日：1986-06-17

申请号：US676203

申请日：1984-11-28

Applicant: Pentti Hietala

Inventor： Pentti Hietala

IPC: A61K36/482 ,  A61K35/78

CPC classification number: A61K36/482

Abstract: The present invention provides a process for obtaining laxative compounds from senna drug, wherein(a) the senna drug is extracted with aqueous methanol by countercurrent percolation and the extract concentrated at a temperature of .ltoreq.50.degree. C. until the methanol has been completely removed from the extract;(b) the extract obtained is purified by continuous liquid-liquid extraction with an organic solvent;(c) the refined material (raffinate) obtained is transferred to a crystallization apparatus, acidified, while stirring, to a pH of 1.5 to 2.0, seeded with sennoside crystals, left to crystallize while stirring and the crystalline crude sennoside obtained separated off;(d) whereafter, the crude sennoside are, if desired, recrystallized and optionally converted with a pharmacologically compatible base into a pharmacologically compatible salt.

Abstract translation: 本发明提供了一种从番泻药物获得泻药化合物的方法，其中（a）通过逆流渗透用甲醇水溶液萃取番泻药物，并将提取物在

公开(公告)号：US4256875A

公开(公告)日：1981-03-17

申请号：US29007

申请日：1979-04-11

Applicant: Jean P. Gabriel ,  Marcel Dumont ,  Robert Guille

Inventor： Jean P. Gabriel ,  Marcel Dumont ,  Robert Guille

IPC: A61K31/70 ,  A61K36/00 ,  A61K36/48 ,  A61K36/482 ,  C07G3/00 ,  C07H15/24 ,  C07H15/244

CPC classification number: C07H15/244 ,  A61K36/482

Abstract: A process for the extraction of sennosides from senna folioles and follicles, comprising the rapid exhaustion of the plant by means of cold water, in a neutral or slightly alkaline medium, followed by acidification and extraction with butanol.This process minimizes oxidation and hydrolysis of the product and achieves improved yields and purity.

Abstract translation: 一种从番泻叶卵泡和卵泡中提取番泻叶苷的方法，包括在中性或微碱性培养基中通过冷水快速耗尽植物，然后酸化并用丁醇萃取。 该方法使产物的氧化和水解最小化并且获得了提高的产率和纯度。

公开(公告)号：US3274053A

公开(公告)日：1966-09-20

申请号：US19960562

申请日：1962-06-04

Applicant: SYNERGISTICS INC

Inventor： ALFRED HALPERN ,  SACKLER MORTIMER D

IPC: A61K36/482 ,  C07H15/244 ,  C07H15/256

CPC classification number: C07H15/256 ,  A61K36/482 ,  C07H15/244