公开(公告)号：US20040266861A1

公开(公告)日：2004-12-30

申请号：US10496431

申请日：2004-05-20

Inventor： Anders Lehmann

IPC: A61K031/353 ,  A61K031/16

CPC classification number: A61K31/05 ,  A61K31/00 ,  A61K31/16 ,  A61K31/352 ,  A61K31/403 ,  A61K31/5375 ,  A61K31/538 ,  A61K31/557

Abstract: The present invention relates to the use of cannabinoid receptor agonists for the inhibition of transient lower esophageal sphincter relaxations. A further aspect of the invention is directed to the use of cannabinoid receptor agonists for the treatment of gastroesophageal reflux disease, as well as for the treatment of regurgitation such as regurgitation in infants, lung disease, chronic laryngitis and asthma.

Abstract translation: 本发明涉及大麻素受体激动剂用于抑制短暂食管下括约肌松弛的用途。 本发明的另一方面涉及大麻素受体激动剂在治疗胃食管反流疾病中的用途，以及用于治疗诸如婴儿，肺部疾病，慢性喉炎和哮喘中的反流的反流。

公开(公告)号：US20040258622A1

公开(公告)日：2004-12-23

申请号：US10759280

申请日：2004-01-20

Inventor： Joanne Peart ,  Peter R. Byron ,  Aron H. Lichtman ,  Billy R. Martin

IPC: A61L009/04 ,  A61K031/353

CPC classification number: A61K9/008 ,  A61K31/352

Abstract: The present invention provides therapeutic formulations for solutions of null9-tetrahydrocannabinol (null9 THC) to be delivered by metered dose inhalers. The formulations, which use non-CFC propellants, provide a stable aerosol-deliverable source of null9 THC for the treatment of various medical conditions, such as: nausea and vomiting associated with chemotherapy-muscle spasticity; pain; anorexia associated with AIDS wasting syndrome, epilepsy; glaucoma; bronchial asthma; and mood disorders.

Abstract translation: 本发明提供了通过计量吸入器递送的Delta9-四氢大麻酚（Delta 9C THC）的溶液的治疗制剂。 使用非CFC推进剂的配方提供稳定的气溶胶递送源，用于治疗各种医疗状况，例如与化疗相关的恶心和呕吐 - 肌肉痉挛状态的Delta <9> THC。 疼痛; 与艾滋病综合征相关的厌食症，癫痫; 青光眼; 支气管哮喘; 和情绪障碍。

公开(公告)号：US20040248821A1

公开(公告)日：2004-12-09

申请号：US10497563

申请日：2004-06-03

Inventor： Randy H Ziegler

IPC: A61K031/7048 ,  A61K031/375 ,  A61K031/353

CPC classification number: A61K31/7048 ,  A61K31/352 ,  A61K31/353 ,  A61K31/375 ,  A61K38/4873 ,  A61K2300/00

Abstract: A composition and a method for the amelioration of Lupus, related rheumatic diseases and inflammatory joint diseases. The composition consists of a bioflavonoid combined with Bromelain. Vitamin C may be added to the composition to improve its efficacy. The preferred flavonoid is Luteolin or Quercetin. Myricetin may also be used as may be a glycoside such as Rutin that contains either Luteolin, Quercetin or Myricetin as an aglycone. Other effective flavonoids can be selected by their ability to interact with the Kv1.3 channel of lymphocytes. In preferred method of treatment a mixture of flavonoid, Bromelain and Vitamin C is administered at least daily by an oral route. A mixture of 500 mg Quercetin, 500 mg Bromelain and 500 mg Vitamin C administered three times daily is effective.

Abstract translation: 一种用于改善狼疮，相关风湿性疾病和炎性关节疾病的组合物和方法。 组合物由生物类黄酮与菠萝蛋白酶组合组成。 可以将维生素C加入到组合物中以改善其功效。 优选的类黄酮是木犀草素或槲皮素。 也可以使用杨梅素作为糖苷例如含有木犀草素，槲皮素或杨梅素作为糖苷配基的芦丁。 其他有效的黄酮可以通过与淋巴细胞的Kv1.3通道相互作用的能力来选择。 在优选的治疗方法中，通过口服途径至少每天施用类黄酮，菠萝蛋白酶和维生素C的混合物。 每天三次施用500mg槲皮素，500mg菠萝蛋白酶和500mg维生素C的混合物是有效的。

公开(公告)号：US20040235758A1

公开(公告)日：2004-11-25

申请号：US10625934

申请日：2003-07-24

Inventor： Kenneth David Reginald Setchell ,  Sidney John Cole

IPC: A61K031/7048 ,  A61K031/353

CPC classification number: A61K31/352 ,  A23L33/10 ,  A61K8/498 ,  A61K9/0014 ,  A61K31/353 ,  A61K2800/10 ,  A61Q19/00 ,  C07D311/58 ,  C07D311/74

Abstract: A composition for use in making commercial food and skin products comprising S-equol or mixtures, including both a non-racemic mixture and a racemic mixture, of S-equol and R-equol. The composition can be used to make articles of commerce such as food supplements, pharmaceuticals, and medicaments. The compositions are useful in a method of delivering S-equol to a mammal to prevent or treat a disease or associated condition, including hormone-dependent diseases or conditions such as cardiovascular disease, lipid disorder, osteopenia, osteoporosis, liver disease, and acute ovarian estrogen deficiency. The S-equol enantiomer can be produced in a biological synthesis from the metabolism of an isoflavone by an organism.

Abstract translation: 用于制备包含S-牛尿酚或S-牛尿酚和R-牛尿酚的含有非外消旋混合物和外消旋混合物的混合物的商业食品和皮肤产品的组合物。 该组合物可用于制造商品，如食品添加剂，药物和药物。 该组合物可用于向哺乳动物递送S-牛尿酚以预防或治疗疾病或相关病症（包括激素依赖性疾病或病症如心血管疾病，脂质障碍，骨质减少，骨质疏松症，肝脏疾病和急性卵巢）的方法 雌激素缺乏症。 S-牛尿酚对映异构体可以通过生物体从异黄酮代谢产生于生物合成中。

公开(公告)号：US20040224034A1

公开(公告)日：2004-11-11

申请号：US10870187

申请日：2004-06-17

Inventor： Kuang Yu Chen ,  Chi-Tang Ho ,  Robert T. Rosen ,  Geetha Ghai

IPC: A61K035/78 ,  A61K031/7048 ,  A61K031/353

CPC classification number: A61K36/53 ,  A61K31/35 ,  A61K31/353 ,  A61K36/704 ,  A61K36/752 ,  A61K36/82 ,  A61K36/899 ,  A61K2300/00

Abstract: Compositions and methods for preventing and treating disease are provided. The compositions are extracts of black tea that include a mixture of theaflavin-3-gallate and theaflavin-3null-gallate.

Abstract translation: 提供了预防和治疗疾病的组合物和方法。 该组合物是含有茶黄素-3-没食子酸酯和茶黄素-3没食子酸酯的混合物的红茶提取物。

公开(公告)号：US20040220257A1

公开(公告)日：2004-11-04

申请号：US10817975

申请日：2004-04-05

Inventor： Andrea Cesura ,  Emmanuel Pinard

IPC: A61K031/353 ,  A61K031/155

CPC classification number: C07C255/47 ,  A61K31/12 ,  A61K31/35 ,  C07C49/665 ,  C07C49/683 ,  C07C2601/10 ,  C07C2603/32 ,  C07C2603/98 ,  C07D311/22

Abstract: Methods of utilizing compounds of general formulas I and II as modulators and affinity labels of the MPTP complex are elucidated. Furthermore, methods for modulating the activity of the MPTP complex, methods for determining the presence of a component of the MPTP complex, and methods for identifying an active agent that modulates the activity of the MPTP complex, specifically methods for identifying an active agent that modulates the activity of the MPTP complex by interacting with the VDAC1 component are identified. Moreover, novel compounds of general formulas I and II are disclosed.

Abstract translation: 阐述了将通式I和II的化合物用作MPTP复合物的调节剂和亲和标记物的方法。 此外，用于调节MPTP复合物的活性的方法，用于确定MPTP复合物的组分的存在的方法，以及用于鉴定调节MPTP复合物的活性的活性剂的方法，特别是用于鉴定调节的活性剂的方法 识别通过与VDAC1组分相互作用的MPTP复合物的活性。 此外，公开了通式I和II的新化合物。

公开(公告)号：US20040208941A1

公开(公告)日：2004-10-21

申请号：US10486817

申请日：2004-04-15

Inventor： Michael Hargreaves Riley ,  Jane Clarissa Fletcher

IPC: A61K035/78 ,  A61K031/7048 ,  A61K031/59 ,  A61K031/355 ,  A61K031/375 ,  A61K031/353

CPC classification number: A61K36/87 ,  A61K8/67 ,  A61K8/922 ,  A61K8/97 ,  A61K36/07 ,  A61K36/14 ,  A61K36/15 ,  A61K36/16 ,  A61K36/185 ,  A61K36/23 ,  A61K36/235 ,  A61K36/258 ,  A61K36/28 ,  A61K36/282 ,  A61K36/296 ,  A61K36/32 ,  A61K36/346 ,  A61K36/43 ,  A61K36/48 ,  A61K36/484 ,  A61K36/53 ,  A61K36/532 ,  A61K36/535 ,  A61K36/54 ,  A61K36/575 ,  A61K36/61 ,  A61K36/65 ,  A61K36/69 ,  A61K36/718 ,  A61K36/736 ,  A61K36/752 ,  A61K36/79 ,  A61K36/85 ,  A61K36/882 ,  A61K36/886 ,  A61K36/8965 ,  A61K36/8967 ,  A61K36/899 ,  A61K36/9068 ,  A61K2800/92 ,  A61Q17/00 ,  A61K2300/00

Abstract: A medicinal or cosmetic composition comprising Aloe vera in combination with at least one vitamin, a minerals concentrate, an organic oils concentrate, at least one Chinese Herb, at least one essential oil and at least one spice. The composition may be administered orally or topically.

Abstract translation: 一种药用或化妆品组合物，其包含与至少一种维生素，矿物质浓缩物，有机油浓缩物，至少一种中草药，至少一种精油和至少一种香料组合的芦荟。 组合物可以口服或局部施用。

公开(公告)号：US20040198673A1

公开(公告)日：2004-10-07

申请号：US10485248

申请日：2004-01-29

Inventor： Chyi-Cheng Chen ,  Bruno Leuenberger

IPC: A61K031/7048 ,  A61K031/736 ,  A61K031/353

CPC classification number: A61K31/353 ,  A61K47/36

Abstract: Epigallocatechin gallate (EGCG) formulations with improved flowability are obtained by compounding EGCG with a polysaccharide, particularly pectin, into a powder or granulate.

Abstract translation: 具有改善的流动性的表没食子儿茶素没食子酸酯（EGCG）制剂通过将EGCG与多糖，特别是果胶混合成粉末或颗粒而获得。

公开(公告)号：US20040186062A1

公开(公告)日：2004-09-23

申请号：US10785704

申请日：2004-02-24

Applicant: UNIGEN PHARMACEUTICALS, INC.

Inventor： Bruce P. Burnett ,  Qi Jia

IPC: A61K031/7048 ,  A61K031/353

CPC classification number: A61K36/906 ,  A61K31/352 ,  A61K31/366 ,  A61K36/11 ,  A61K36/15 ,  A61K36/185 ,  A61K36/28 ,  A61K36/47 ,  A61K36/48 ,  A61K36/484 ,  A61K36/486 ,  A61K36/53 ,  A61K36/539 ,  A61K36/54 ,  A61K36/60 ,  A61K36/9062 ,  A61K2300/00

Abstract: The present invention provides a novel method for inhibiting sugar-induced weight gain resulting from fructose and glucose driven lipogenesis. The method for inhibiting sugar-induced weight gain is comprised of administering a composition comprising a mixture of Free-B-Ring flavonoids and flavans synthesized and/or isolated from a single plant or multiple plants, preferably in the Scutellaria and Acacia genus of plants to a host in need thereof. The present also includes novel methods for the prevention and treatment of diseases and conditions resulting from high carbohydrate ingestion. The method for preventing and treating these sugar-induced diseases and conditions is comprised of administering to a host in need thereof a therapeutically effective amount of a composition comprising a mixture of Free-B-Ring flavonoids and flavans synthesized and/or isolated from a single plant or multiple plants, preferably in the Scutellaria and Acacia genus of plants and a pharmaceutically acceptable carrier.

Abstract translation: 本发明提供了抑制由果糖和葡萄糖驱动的脂肪生成引起的糖诱导的体重增加的新方法。 用于抑制糖诱导的体重增加的方法包括施用包含游离B环类黄酮和从单一植物或多种植物合成和/或分离的黄酮的混合物，优选在植物的黄芩和相思属中分离的组合物的组合物 需要的主机。 本发明还包括用于预防和治疗由高碳水化合物摄取引起的疾病和病症的新方法。 用于预防和治疗这些糖诱发的疾病和病症的方法包括向有需要的宿主施用治疗有效量的组合物，其包含游离B环类黄酮和从单一的合成和/或分离的黄烷的混合物 植物或多种植物，优选在植物的黄芩和相思属中以及药学上可接受的载体。

公开(公告)号：US20040176441A1

公开(公告)日：2004-09-09

申请号：US10798131

申请日：2004-03-11

Applicant: Mars Incorporated

Inventor： Leo J. Romanczyk JR. ,  Amit Basak ,  Craig A. Townsend

IPC: C07D45/14 ,  A61K031/353

CPC classification number: C07D311/32 ,  Y02P20/55

Abstract: Processes are disclosed for the production of linear and branched procyanidin oligomers having nullnnull procyanidin monomeric units where n is 2 to 18. The processes include coupling protected, activated monomers with an unprotected monomer to produce a partially protected (4null8) dimer. The dimer is optionally blocked, coupled with an activated protected monomer to produce a partially protected, optionally blocked trimer, and deprotected. The steps can be repeated to produce higher oligomers. Processes are also provided for producing (8null8), (8null6), and (6null6) dimers and doubly branched oligomers. Crystalline 8-bromo tetra-O-benzyl (null)-epicatechin is produced under certain conditions.

Abstract translation: 公开了用于生产具有“n”原花青素单体单元（其中n为2至18）的直链和支链原花青素低聚物的方法。该方法包括将保护的活化单体与未保护的单体偶联以产生部分保护的（4-> 8）二聚体 。 将二聚体任选地封闭，与活化的受保护的单体偶联以产生部分保护的，任选被封闭的三聚体并脱保护。 可以重复这些步骤以产生更高级的低聚物。 还提供了制备（8-> 8），（8-> 6）和（6-> 6）二聚体和双支链低聚物的方法。 在某些条件下制备8-溴四-O-苄基（ - ） - 表儿茶素的结晶。