公开(公告)号：US09275451B2

公开(公告)日：2016-03-01

申请号：US12448473

申请日：2007-12-20

Applicant: Shlomo Ben-Haim ,  Benny Rousso

Inventor： Shlomo Ben-Haim ,  Benny Rousso

IPC: G06T7/00 ,  G06F19/00

CPC classification number: G06T7/0012 ,  G06F19/00 ,  G06F19/321 ,  G06F19/324

Abstract: A method for analyzing a functional map of at least one tissue of a patient. The method comprises managing a plurality of functional maps each being associated with a plurality of first biological activity indications, receiving a functional map which is associated with a plurality of second biological activity indications, identifying a matching set of the managed functional maps by matching between the plurality of first and second biological activity indications, and using the matching set for a member of a group consisting of: an image data acquisition, a diagnosis of the received functional map, a classification of the received functional map.

Abstract translation: 一种用于分析患者的至少一个组织的功能图的方法。 该方法包括管理多个功能图，每个功能图与多个第一生物活动指示相关联，接收与多个第二生物活动指示相关联的功能图，通过匹配 多个第一和第二生物活动指示，并且使用用于由以下各项组成的组的成员的匹配集：图像数据获取，所接收的功能图的诊断，所接收的功能图的分类。

公开(公告)号：US08871292B2

公开(公告)日：2014-10-28

申请号：US13556893

申请日：2012-07-24

Applicant: Douglas R. Savage ,  Ronald E. Betts

Inventor： Douglas R. Savage ,  Ronald E. Betts

IPC: B05D3/12 ,  B05D3/10 ,  A61L33/00 ,  A61F2/06 ,  A61L31/16 ,  A61F2/91

CPC classification number: A61L31/16 ,  A61F2/91 ,  A61L2300/416

Abstract: A radially expandable, endovascular stent designed for placement at a site of vascular injury, for inhibiting restenosis at the site, a method of using, and a method of making the stent. The stent includes a radially expandable body formed of one or more metallic filaments and a liquid-infusible mechanical anchoring layer attached to or formed in outer surface of the filaments. A drug coating in the stent is composed of a substantially polymer-free composition of an anti-restenosis drug, and has a substratum infused in the anchoring layer and a substantially continuous surface stratum of drug that is brought into direct contact with the vessel walls at the vascular site. Thus, the rate of release of the anti-restenosis drug from the surface stratum into said vascular site is determined solely by the composition of said drug coating.

Abstract translation: 设计用于放置在血管损伤部位，用于抑制现场再狭窄的径向可扩张的血管内支架，使用方法和制造支架的方法。 该支架包括由一个或多个金属细丝形成的径向可扩张体，以及附着于细丝的外表面或形成于细丝的外表面的液体不可渗透的机械锚定层。 支架中的药物涂层由基本上无聚合物的抗再狭窄药物组合物组成，并且具有输注在锚定层中的基质和药物的基本上连续的表面层，其与血管壁直接接触 血管部位。 因此，抗再狭窄药物从表层到所述血管部位的释放速率仅由所述药物包衣的组成确定。

公开(公告)号：US20140193336A1

公开(公告)日：2014-07-10

申请号：US14147682

申请日：2014-01-06

Applicant: Biosensors International Group, Ltd.

Inventor： Benny ROUSSO ,  Dalia Dickman ,  Yael Nir ,  Michael Nagler ,  Zohar Bronshtine ,  Shankar Vallabhajosula ,  Shlomo Ben-Haim ,  Simona Ben-Haim

IPC: A61K51/04

CPC classification number: A61K51/0476 ,  A61B6/037 ,  A61B6/4258 ,  A61B6/503 ,  G01T1/1644

Abstract: Protocols for radioimaging an event or disorder are provided. An exemplary protocol comprises a method of radioimaging a myocardial perfusion, the method comprising in sequence: (a) administering to a subject about 3 mCi Tl201 thallous chloride; (b) allowing said subject to rest; (c) radioimaging a heart of said subject; (d) subjecting said subject to a physical stress; (e) administering to said subject at a peak of said physical stress about 20-30 mCi Tc99m sestamibi; and (f) radioimaging said heart of said subject, thereby radioimaging a myocardial perfusion.

Abstract translation: 提供用于放射成像事件或障碍的协议。 示例性方案包括放射成像心肌灌注的方法，该方法依次包括：（a）向受试者施用约3mCi Tl201硫酸氯化物; （b）允许所述受试者休息; （c）对所述受试者的心脏进行放射成像; （d）使所述受试者受到身体压力; （e）在所述身体应激的峰值处施用约20-30mCi Tc99m sestamibi的所述受试者; 和（f）对所述受试者的所述心脏进行放射成像，从而放射成像心肌灌注。

公开(公告)号：US20140151563A1

公开(公告)日：2014-06-05

申请号：US14082314

申请日：2013-11-18

Applicant: Biosensors International Group, Ltd.

Inventor： Benny ROUSSO ,  Shlomo BEN-HAIM ,  Ran RAVHON ,  Yoel ZILBERSTEIN ,  Simona BEN-HAIM ,  Nathaniel ROTH

IPC: G01T1/164

CPC classification number: G01T1/1603 ,  A61B6/037 ,  A61B6/4258 ,  G01T1/161 ,  G01T1/1647

Abstract: Radioimaging methods, devices and radiopharmaceuticals therefor.

Abstract translation: 放射成像方法，装置和放射性药物。

公开(公告)号：US08606349B2

公开(公告)日：2013-12-10

申请号：US11980653

申请日：2007-10-31

Applicant: Benny Rousso ,  Shlomo Ben-Haim ,  Michael Nagler ,  Omer Ziv ,  Ran Ravhon ,  Dalia Dickman ,  Yoel Zilberstein ,  Eli Dichterman ,  Simona Ben-Haim ,  Shankar Vallabhajosula ,  Daniel Berman ,  Zohar Bronshtine ,  Ziv Popper ,  Nir Weissberg ,  Nathaniel Roth ,  Haim Melman

Inventor： Benny Rousso ,  Shlomo Ben-Haim ,  Michael Nagler ,  Omer Ziv ,  Ran Ravhon ,  Dalia Dickman ,  Yoel Zilberstein ,  Eli Dichterman ,  Simona Ben-Haim ,  Shankar Vallabhajosula ,  Daniel Berman ,  Zohar Bronshtine ,  Ziv Popper ,  Nir Weissberg ,  Nathaniel Roth ,  Haim Melman

IPC: A61B6/00

CPC classification number: A61B6/44 ,  A61B5/06 ,  A61B5/415 ,  A61B5/416 ,  A61B5/418 ,  A61B5/7285 ,  A61B6/037 ,  A61B6/0414 ,  A61B6/425 ,  A61B6/4258 ,  A61B6/4266 ,  A61B6/4275 ,  A61B6/4291 ,  A61B6/488 ,  A61B6/501 ,  A61B6/502 ,  A61B6/507 ,  A61B6/541 ,  A61B6/547 ,  A61B6/548 ,  A61B6/583 ,  A61B8/0808 ,  A61B8/0825 ,  A61B8/12 ,  A61B8/4416 ,  A61B8/543 ,  A61K51/00 ,  A61K51/0478 ,  A61K51/1048 ,  G01R33/481 ,  G01T1/1615 ,  G01T1/1642 ,  G01T1/2985

Abstract: A method of imaging, comprising: (a) providing an isotope at a low dosage in a body of a patient; (b) receiving radiation generated by said isotope from said body using a radiation camera; and (c) reconstructing a 3D distribution of said isotope from said received radiation, wherein the dosage is less than ⅓ of a standard dose set forth in Table 5.

Abstract translation: 一种成像方法，包括：（a）在患者体内以低剂量提供同位素; （b）使用辐射照相机从所述身体接收由所述同位素产生的辐射; 和（c）从所述接收的辐射重建所述同位素的3D分布，其中所述剂量小于表5中列出的标准剂量的1/3。

公开(公告)号：US20130308749A1

公开(公告)日：2013-11-21

申请号：US13947198

申请日：2013-07-22

Applicant: Biosensors International Group, Ltd.

Inventor： Yoel Zilberstein ,  Nathaniel Roth ,  Benny Rousso ,  Shlomo Ben-Haim

IPC: A61B6/00 ,  G21K1/02

CPC classification number: A61B6/42 ,  A61B6/037 ,  A61B6/04 ,  A61B6/4258 ,  A61B6/4266 ,  A61B6/507 ,  G01T1/1611 ,  G01T1/1635 ,  G01T1/1644 ,  G21K1/02

Abstract: A system of performing a volumetric scan. The system comprises a surface of positioning a patient in a space parallel thereto, a plurality of extendable detector arms each the detector arm having a detection unit having at least one radiation detector, and an actuator which moves the detection unit along a linear path, and a gantry which supports the plurality of extendable detector arms around the surface so that each the linear path of each respective the extendable detector arm being directed toward the space.

公开(公告)号：US08565860B2

公开(公告)日：2013-10-22

申请号：US10616307

申请日：2003-07-10

Applicant: Yoav Kimchy ,  Roni Amrami ,  Yona Bouskila ,  Udi Antebi ,  Nick Sidorenko ,  Gal Ben-David ,  Yoel Zilberstein

Inventor： Yoav Kimchy ,  Roni Amrami ,  Yona Bouskila ,  Udi Antebi ,  Nick Sidorenko ,  Gal Ben-David ,  Yoel Zilberstein

IPC: A61B6/00

CPC classification number: A61B6/037 ,  A61B5/055 ,  A61B5/06 ,  A61B5/064 ,  A61B5/07 ,  A61B5/415 ,  A61B5/418 ,  A61B5/6835 ,  A61B6/12 ,  A61B6/4057 ,  A61B6/4258 ,  A61B6/4417 ,  A61B6/4423 ,  A61B6/482 ,  A61B6/583 ,  A61B8/0833 ,  A61B8/4245 ,  A61B8/4254 ,  A61B2090/392 ,  G01T1/161

Abstract: A radioactive emission probe in communication with a position tracking system and the use thereof in a variety of systems and methods of medical imaging and procedures, are provided. Specifically, wide aperture collimation—deconvolution algorithms are provided, for obtaining a high-efficiency, high resolution image of a radioactivity emitting source, by scanning the radioactivity emitting source with a probe of a wide-aperture collimator, and at the same time, monitoring the position of the radioactive emission probe, at very fine time intervals, to obtain the equivalence of fine-aperture collimation. The blurring effect of the wide aperture is then corrected mathematically. Furthermore, an imaging method by depth calculations is provided, based on the attenuation of photons of different energies, which are emitted from the same source, coupled with position monitoring.

Abstract translation: 提供了一种与位置跟踪系统通信的放射性发射探测器及其在医疗成像和程序的各种系统和方法中的应用。 具体地说，通过用宽孔径准直仪的探头扫描放射性发射源，提供宽孔径准直 - 去卷积算法，用于获得放射性发射源的高效率高分辨率图像，并且同时监视 以非常精细的时间间隔放射性发射探针的位置，以获得细孔准直的等效性。 然后在数学上校正宽光圈的模糊效果。 此外，基于从相同源发射的不同能量的光子的衰减与位置监测相结合，提供了通过深度计算的成像方法。

公开(公告)号：US20130150952A1

公开(公告)日：2013-06-13

申请号：US13765501

申请日：2013-02-12

Applicant: Biosensors International Group Ltd.

Inventor： Shih-Horng Su ,  Debashis Dutta

IPC: A61F2/86

CPC classification number: A61F2/86 ,  A61F2/88 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/828 ,  A61F2002/91525 ,  A61F2002/91541 ,  A61F2002/91558 ,  A61F2002/91566 ,  A61F2002/91591 ,  A61F2210/0076 ,  B29C41/14 ,  B29C41/34 ,  B29K2067/046

Abstract: A biodegradable polymer stent with radiopacity and a method of making and using a stent with enhanced mechanical strength and/or controlled degradation for use in a bodily lumen is described.

Abstract translation: 描述了具有放射不透性的可生物降解的聚合物支架以及用于制造和使用具有增强的机械强度和/或受控降解的用于体腔的支架的方法。

公开(公告)号：US20130035754A1

公开(公告)日：2013-02-07

申请号：US13647977

申请日：2012-10-09

Applicant: John E. SHULZE ,  Ronald E. BETTS ,  Douglas R. SAVAGE

Inventor： John E. SHULZE ,  Ronald E. BETTS ,  Douglas R. SAVAGE

IPC: A61F2/06

CPC classification number: A61L31/16 ,  A61F2/90 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/072 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2230/0054 ,  A61F2240/001 ,  A61F2250/0067 ,  A61K9/0024 ,  A61L31/022 ,  A61L31/06 ,  A61L31/10 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2420/08 ,  C08L29/04 ,  C08L67/04

Abstract: An intravascular stent and method for inhibiting restenosis, following vascular injury, is disclosed. The stent has an expandable, linked-filament body and a drug-release coating formed on the stent-body filaments, for contacting the vessel injury site when the stent is placed in-situ in an expanded condition. The coating releases, for a period of at least 4 weeks, a restenosis-inhibiting amount of a monocyclic triene immunosuppressive compound having an alkyl group substituent at carbon position 40 in the compound. The stent, when used to treat a vascular injury, gives good protection against clinical restenosis, even when the extent of vascular injury involves vessel overstretching by more than 30% diameter. Also disclosed is a stent having a drug-release coating composed of (i) 10 and 60 weight percent poly-dl-Iactide polymer substrate and (ii) 40-90 weight percent of an anti-restenosis compound, and a polymer undercoat having a thickness of between 1-5 microns.

Abstract translation: 公开了血管内支架和用于抑制血管损伤后再狭窄的方法。 支架具有可扩张的连接长丝体和形成在支架体细丝上的药物释放涂层，用于当支架在扩张状态下原位放置时接触血管损伤部位。 该涂层释放至少4周的再狭窄抑制量的化合物中在碳位置40具有烷基取代基的单环三烯免疫抑制化合物。 当支架用于治疗血管损伤时，即使在血管损伤程度超过30％直径的血管破裂的情况下，也能对抗临床再狭窄提供良好的保护。 还公开了一种支架，其具有由（i）10重量％和60重量％的聚-DL-酰胺聚合物基材和（ii）40-90重量％的抗再狭窄化合物组成的药物释放包衣，以及聚合物底涂层，其具有 厚度介于1-5微米之间。

公开(公告)号：US20120330406A1

公开(公告)日：2012-12-27

申请号：US13554296

申请日：2012-07-20

Applicant: Douglas R. Savage ,  John E. Shulze ,  Ronald E. Betts ,  Sepehr Fariabi ,  Shih-Horng Su

Inventor： Douglas R. Savage ,  John E. Shulze ,  Ronald E. Betts ,  Sepehr Fariabi ,  Shih-Horng Su

IPC: A61F2/82 ,  B05D7/14

CPC classification number: A61L31/16 ,  A61F2/82 ,  A61F2/848 ,  A61F2/89 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/825 ,  A61F2002/91541 ,  A61F2002/91566 ,  A61F2210/0004 ,  A61F2210/0014 ,  A61F2220/0025 ,  A61F2230/0013 ,  A61F2240/001 ,  A61F2250/0023 ,  A61F2250/0025 ,  A61F2250/0026 ,  A61F2250/0036 ,  A61F2250/0037 ,  A61F2250/0051 ,  A61F2250/0067 ,  A61F2250/0068 ,  A61F2250/0096 ,  A61L31/022 ,  A61L31/10 ,  A61L2300/416 ,  A61L2300/606 ,  A61L2420/02

Abstract: An improvement in drug-eluting stents, and method of their making, are disclosed. The surface of a metal stent is roughened to have a surface roughness of at least about 20 μin (0.5 μm) and a surface roughness range of between about 300-700 μin (7.5-17.5 μm). The roughened stent surface is covered with a polymer-free coating of a limus drug, to a coating thickness greater than the range of surface roughness of the roughened stent surface.

Abstract translation: 披露了药物洗脱支架的改进及其制作方法。 金属支架的表面被粗糙化以具有至少约20μin（0.5μm）的表面粗糙度和在约300-700μin（7.5-17.5μm）之间的表面粗糙度范围。 粗糙化的支架表面覆盖有无聚合物的斜肌药物涂层，涂层厚度大于粗糙化支架表面的表面粗糙度范围。