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    DRUG-DELIVERY ENDOVASCULAR STENT AND METHOD OF FORMING THE SAME
    1.
    发明申请
    DRUG-DELIVERY ENDOVASCULAR STENT AND METHOD OF FORMING THE SAME 有权
    药物递送内支架及其形成方法

    公开(公告)号：US20130035754A1

    公开(公告)日：2013-02-07

    申请号：US13647977

    申请日：2012-10-09

    Applicant: John E. SHULZE ,  Ronald E. BETTS ,  Douglas R. SAVAGE

    Inventor： John E. SHULZE ,  Ronald E. BETTS ,  Douglas R. SAVAGE

    IPC: A61F2/06

    CPC classification number: A61L31/16 ,  A61F2/90 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/072 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2230/0054 ,  A61F2240/001 ,  A61F2250/0067 ,  A61K9/0024 ,  A61L31/022 ,  A61L31/06 ,  A61L31/10 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2420/08 ,  C08L29/04 ,  C08L67/04

    Abstract: An intravascular stent and method for inhibiting restenosis, following vascular injury, is disclosed. The stent has an expandable, linked-filament body and a drug-release coating formed on the stent-body filaments, for contacting the vessel injury site when the stent is placed in-situ in an expanded condition. The coating releases, for a period of at least 4 weeks, a restenosis-inhibiting amount of a monocyclic triene immunosuppressive compound having an alkyl group substituent at carbon position 40 in the compound. The stent, when used to treat a vascular injury, gives good protection against clinical restenosis, even when the extent of vascular injury involves vessel overstretching by more than 30% diameter. Also disclosed is a stent having a drug-release coating composed of (i) 10 and 60 weight percent poly-dl-Iactide polymer substrate and (ii) 40-90 weight percent of an anti-restenosis compound, and a polymer undercoat having a thickness of between 1-5 microns.

    Abstract translation: 公开了血管内支架和用于抑制血管损伤后再狭窄的方法。 支架具有可扩张的连接长丝体和形成在支架体细丝上的药物释放涂层，用于当支架在扩张状态下原位放置时接触血管损伤部位。 该涂层释放至少4周的再狭窄抑制量的化合物中在碳位置40具有烷基取代基的单环三烯免疫抑制化合物。 当支架用于治疗血管损伤时，即使在血管损伤程度超过30％直径的血管破裂的情况下，也能对抗临床再狭窄提供良好的保护。 还公开了一种支架，其具有由（i）10重量％和60重量％的聚-DL-酰胺聚合物基材和（ii）40-90重量％的抗再狭窄化合物组成的药物释放包衣，以及聚合物底涂层，其具有 厚度介于1-5微米之间。

    Fiber optic catheter system with fluorometric sensor and integral flexure compensation
    6.
    发明授权
    Fiber optic catheter system with fluorometric sensor and integral flexure compensation 失效
    具有荧光传感器和整体屈曲补偿的光纤导管系统

    公开(公告)号：US5012809A

    公开(公告)日：1991-05-07

    申请号：US917399

    申请日：1986-10-10

    Applicant: John E. Shulze

    Inventor： John E. Shulze

    IPC: A61B5/00 ,  G01D5/26 ,  G01K11/32 ,  G01N21/77 ,  G02B6/28 ,  G02B6/42

    CPC classification number: G02B6/2804 ,  A61B5/1459 ,  G01D5/268 ,  G01K11/3213 ,  G01N21/7703 ,  G02B6/421 ,  G02B6/4298 ,  G01N2021/7786

    Abstract: A sensor for measuring fluid concentrations or the temperature of body. A fiber-optic catheter having a fluorometric sensor attached at a distal end is excited by a light source outside the body. The sensor fluoresces with an intensity or with a lifetime related to the concentration of the fluid or the temperature. The catheter has one light pipe for exciting the sensor and a second light pipe for generating a reference signal to calibrate signals from the fluorometric sensor. One embodiment has two sensors that fluoresce with different intensities and lifetimes to simultaneously give information about both the temperature and the fluid concentration.

    Abstract translation: 用于测量体液浓度或体温的传感器。 具有附接在远端的荧光传感器的光纤导管被身体外的光源激发。 传感器以与流体浓度或温度相关的强度或一定寿命发出荧光。 导管具有用于激发传感器的一个光管和用于产生参考信号以校准来自荧光测量传感器的信号的第二光管。 一个实施例具有两个具有不同强度和寿命的传感器，以同时提供关于温度和流体浓度的信息。

    Drug-delivery endovascular stent and method of forming the same
    7.
    发明授权
    Drug-delivery endovascular stent and method of forming the same 有权
    药物输送血管内支架及其形成方法

    公开(公告)号：US08715341B2

    公开(公告)日：2014-05-06

    申请号：US13647977

    申请日：2012-10-09

    Applicant: John E. Shulze ,  Ronald E. Betts ,  Douglas R. Savage

    Inventor： John E. Shulze ,  Ronald E. Betts ,  Douglas R. Savage

    IPC: A61F2/06

    CPC classification number: A61L31/16 ,  A61F2/90 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/072 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2230/0054 ,  A61F2240/001 ,  A61F2250/0067 ,  A61K9/0024 ,  A61L31/022 ,  A61L31/06 ,  A61L31/10 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2420/08 ,  C08L29/04 ,  C08L67/04

    Abstract: An intravascular stent and method for inhibiting restenosis, following vascular injury, is disclosed. The stent has an expandable, linked-filament body and a drug-release coating formed on the stent-body filaments, for contacting the vessel injury site when the stent is placed in-situ in an expanded condition. The coating releases, for a period of at least 4 weeks, a restenosis-inhibiting amount of a monocyclic triene immunosuppressive compound having an alkyl group substituent at carbon position 40 in the compound. The stent, when used to treat a vascular injury, gives good protection against clinical restenosis, even when the extent of vascular injury involves vessel overstretching by more than 30% diameter. Also disclosed is a stent having a drug-release coating composed of (i) 10 and 60 weight percent poly-dl-Iactide polymer substrate and (ii) 40-90 weight percent of an anti-restenosis compound, and a polymer undercoat having a thickness of between 1-5 microns.

    Abstract translation: 公开了血管内支架和用于抑制血管损伤后再狭窄的方法。 支架具有可扩张的连接长丝体和形成在支架体细丝上的药物释放涂层，用于当支架在扩张状态下原位放置时接触血管损伤部位。 该涂层释放至少4周的再狭窄抑制量的化合物中在碳位置40具有烷基取代基的单环三烯免疫抑制化合物。 当支架用于治疗血管损伤时，即使在血管损伤程度超过30％直径的血管破裂的情况下，也能对抗临床再狭窄提供良好的保护。 还公开了一种支架，其具有由（i）10重量％和60重量％的聚-DL-酰胺聚合物基材和（ii）40-90重量％的抗再狭窄化合物组成的药物释放包衣，以及聚合物底涂层，其具有 厚度介于1-5微米之间。

    Drug-delivery endovascular stent and method for treating restenosis
    8.
    发明授权
    Drug-delivery endovascular stent and method for treating restenosis 有权
    药物输送血管内支架和治疗再狭窄的方法

    公开(公告)号：US08545550B2

    公开(公告)日：2013-10-01

    申请号：US13556960

    申请日：2012-07-24

    Applicant: John E. Shulze ,  Ronald E. Betts ,  Douglas R. Savage

    Inventor： John E. Shulze ,  Ronald E. Betts ,  Douglas R. Savage

    IPC: A61F2/06 ,  A61F13/00 ,  A61F2/00

    CPC classification number: A61L31/10 ,  A61F2/915 ,  A61F2002/072 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2230/0054 ,  A61F2240/001 ,  A61F2250/0067 ,  A61K9/0024 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/606 ,  C08L29/04 ,  C08L67/04

    Abstract: An intravascular stent and method for inhibiting restenosis, following vascular injury, is disclosed. The stent has an expandable, linked-filament body and a drug-release coating formed on the stent-body filaments, for contacting the vessel injury site when the stent is placed in-situ in an expanded condition. The coating releases, for a period of at least 4 weeks, a restenosis-inhibiting amount of the macrocyclic triene immunosuppressive compound everolimus. The stent, when used to treat a vascular injury, gives good protection against clinical restenosis, even when the extent of vascular injury involves vessel overstretching by more than 30% diameter. Also disclosed is a stent having a drug-release coating composed of (i) 10 and 60 weight percent poly-dl-lactide polymer substrate and (ii) 40-90 weight percent of an anti-restenosis compound, and a polymer undercoat having a thickness of between 1-5 microns.

    Abstract translation: 公开了血管内支架和用于抑制血管损伤后再狭窄的方法。 支架具有可扩张的连接长丝体和形成在支架体细丝上的药物释放涂层，用于当支架在扩张状态下原位放置时接触血管损伤部位。 该涂层释放至少4周的再狭窄抑制量的大环三烯免疫抑制化合物依维莫司。 当支架用于治疗血管损伤时，即使在血管损伤程度超过30％直径的血管破裂的情况下，也能对抗临床再狭窄提供良好的保护。 还公开了一种支架，其具有由（i）10重量％和60重量％的聚-DL-丙交酯聚合物基材和（ii）40-90重量％的抗再狭窄化合物组成的药物释放包衣，以及聚合物底涂层，其具有 厚度介于1-5微米之间。

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