公开(公告)号：US09588088B2

公开(公告)日：2017-03-07

申请号：US13966765

申请日：2013-08-14

Applicant: SHIMADZU CORPORATION

Inventor： Akira Aono

IPC: G01N1/22 ,  G01N30/20 ,  G01N30/02 ,  G01N30/08

CPC classification number: G01N30/20 ,  G01N1/2214 ,  G01N2030/025 ,  G01N2030/085 ,  G01N2030/207

Abstract: In a gas sample analysis device including a metering tube, sample gas supply channel, carrier gas supply channel, evacuation channel and collection tube, there is provided a first channel switching valve which switches between a load state in which the metering tube is interposed between said sample gas supply channel and the evacuation channel and an injection state in which the metering tube is interposed between the sample gas supply channel and gas analysis device; and a second channel switching valve which, in the load state or injection state, switches between a collection tube interposition state in which the collection tube is interposed between the sample gas supply channel and the metering tube or between the metering tube and the gas analysis device, and a collection tube shunt state in which the collection tube is not interposed.

Abstract translation: 在包括计量管，样品气体供给通道，载气供给通道，排气通道和收集管的气体样品分析装置中，设置有第一通道切换阀，其在计量管介于所述 样品气体供给通道和排气通道以及计量管插入在样品气体供给通道和气体分析装置之间的注入状态; 以及第二通道切换阀，所述第二流路切换阀在所述负荷状态或注入状态下，在收集管插入状态之间切换，在所述收集管插入状态中，所述收集管插入在所述样品气体供给流路和所述计量管之间，或者在所述计量管与所述气体分析装置 ，收集管未插入收集管分流状态。

公开(公告)号：US09435773B2

公开(公告)日：2016-09-06

申请号：US13375884

申请日：2009-06-03

Applicant: Bernd Glatz ,  Wolfgang Kretz

Inventor： Bernd Glatz ,  Wolfgang Kretz

IPC: G01N30/20 ,  G01N30/32 ,  G01N30/36 ,  G01N30/02

CPC classification number: G01N30/20 ,  G01N30/32 ,  G01N30/36 ,  G01N2030/027 ,  G01N2030/207

Abstract: A sample injector (200) for use in a fluid separation system (10) for separating compounds of a fluidic sample in a mobile phase, the sample injector (200) comprising a switchable valve (202), a sample loop (204) in fluid communication with the valve (202) and configured for receiving the fluidic sample, a metering device (206) in fluid communication with the sample loop (204) and configured for introducing a metered amount of the fluidic sample on the sample loop (204), and a control unit (208) configured for controlling switching of the valve (202) to transfer the sample loop (204) between a low pressure state and a high pressure state via an intermediate state and for controlling the metering device (206) during the intermediate state to at least partially equilibrate a pressure difference in the sample loop (204) between the low pressure state and the high pressure state.

Abstract translation: 一种用于流体分离系统（10）的样品注射器（200），用于分离流动相中的流体样品的化合物，样品注射器（200）包括可切换阀（202），流体中的样品环（204） 与所述阀（202）的连通并且被配置为接收流体样品;计量装置（206），其与所述样品环（204）流体连通并且被配置用于将计量量的所述流体样品引入所述样品环（204）上， 以及控制单元（208），其被配置为用于控制所述阀（202）的切换以经由中间状态在低压状态和高压状态之间传送所述样品回路（204），并且用于在所述中间状态期间控制所述计量装置（206） 中间状态以至少部分平衡低压状态和高压状态之间的样品回路（204）中的压力差。

公开(公告)号：US20160195564A1

公开(公告)日：2016-07-07

申请号：US14979066

申请日：2015-12-22

Applicant: Waters Technologies Corporation

Inventor： Hillary B. Hewitson ,  Sylvain G. Cormier ,  Charles H. Phoebe, JR. ,  Aaron D. Phoebe

IPC: G01N35/10 ,  G01N30/22 ,  G01N30/20 ,  G01N30/06

CPC classification number: G01N30/20 ,  G01N30/06 ,  G01N30/24 ,  G01N35/1097 ,  G01N2030/067 ,  G01N2030/207 ,  G01N2035/00514 ,  G01N2035/1032

Abstract: Automated sampling and reaction systems and methods of using the same are provided. The automated sampling and reaction system has a microreactor in fluidic communication with an external sampling valve. The external sampling valve is connected to a priming valve and can be configured to draw sample from a reactor or a reactor stream. The microreactor is connected to a reagent valve and an injection valve. The reagent valve can be configured to draw reagent from a reagent reservoir and discharge reagent to the microreactor to react with sample. The priming valve can be configured to draw wash from a wash reservoir and discharge wash to the external sampling valve to move sample from the external sampling valve to the microreactor. The injection valve is in fluidic communication with a column or detector and discharges the secondary sample into a solvent composition stream.

Abstract translation: 提供了自动采样和反应系统及其使用方法。 自动采样和反应系统具有与外部采样阀流体连通的微反应器。 外部采样阀连接到起动阀，并且可以被配置为从反应器或反应器流中抽取样品。 微反应器连接到试剂阀和注射阀。 试剂阀可以被配置为从试剂储存器中抽取试剂，并将试剂排放到微反应器以与样品反应。 起动阀可以被配置为从洗涤容器中抽出洗涤液并将洗涤液排出到外部取样阀，以将样品从外部取样阀移动到微反应器。 注射阀与柱或检测器流体连通，并将次要样品排放到溶剂组合物流中。

公开(公告)号：US20160187304A1

公开(公告)日：2016-06-30

申请号：US14586882

申请日：2014-12-30

Applicant: AGILENT TECHNOLOGIES, INC.

Inventor： Edwin E. Wikfors ,  Brian A. Bidlingmeyer ,  Klaus Witt

IPC: G01N30/06 ,  G01N1/28

CPC classification number: G01N1/28 ,  G01N30/20 ,  G01N30/36 ,  G01N2030/202 ,  G01N2030/207 ,  G01N2030/342

Abstract: A method and a system for introducing a sample into a mobile phase of a chromatography system is provided. The method includes initially directing the mobile phase directly into a separation unit of the chromatography system, bypassing a sample loop, the mobile phase including a combined solvent, metered from a pressurized first solvent and a second solvent; loading the sample into the sample loop, while the mobile phase continues to be directed directly into the separation unit; pressurizing the sample in the sample loop with the pressurized first solvent, while the mobile phase continues to be directed directly into the separation unit; and switching the sample loop into the mobile phase, thereby introducing the pressurized sample to the separation unit.

Abstract translation: 提供了一种用于将样品引入色谱系统的流动相的方法和系统。 该方法包括首先将流动相直接引入色谱系统的分离单元，绕过样品环，流动相包括从加压的第一溶剂和第二溶剂计量的组合溶剂; 将样品加载到样品回路中，同时流动相继续直接导入分离单元; 在加压的第一溶剂中对样品环中的样品加压，同时流动相继续被直接引导到分离单元中; 并将样品环切换到流动相中，从而将加压的样品引入分离单元。

公开(公告)号：US20150316516A1

公开(公告)日：2015-11-05

申请号：US14648065

申请日：2013-10-28

Applicant: AGILENT TECHNOLOGIES, INC.

Inventor： Robert William ALBRECHT, JR.

IPC: G01N30/20

CPC classification number: G01N30/20 ,  B01L3/502784 ,  G01N30/34 ,  G01N30/38 ,  G01N2030/027 ,  G01N2030/207 ,  G01N2030/347

Abstract: In a liquid chromatography system, a sample is injected into a column by flowing a solvent mixture from a mixer into the column along a solvent mixture flow path; and injecting a sample into the solvent mixture flow path downstream of the mixer. In another liquid chromatography system, a sample is injected into a column by loading an isolator fluid into a sample loop, loading a sample into the sample loop, and flowing the sample into the column as a plug in front of the isolator fluid.

Abstract translation: 在液相色谱系统中，通过将溶剂混合物从混合器沿着溶剂混合物流动路径流入柱中，将样品注入柱中; 并将样品注入混合器下游的溶剂混合物流动路径。 在另一种液相色谱系统中，将样品通过将隔离器流体加载到样品环中，将样品装入样品环中并将样品作为隔离器流体前面的塞子流入柱中而注入柱中。

公开(公告)号：US20150308986A1

公开(公告)日：2015-10-29

申请号：US14651247

申请日：2013-10-21

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Shinya ITO ,  Shigeo MUTO

IPC: G01N30/20 ,  G01N30/72 ,  H01J49/04

CPC classification number: G01N30/20 ,  G01N30/24 ,  G01N30/7233 ,  G01N30/7266 ,  G01N35/08 ,  G01N2030/009 ,  G01N2030/207 ,  H01J49/0431

Abstract: Provided herein is a sample injection method that enables efficient injection of a trace sample solution while reducing the measurement time. A sample solution is injected into a sample loop with air layers disposed on both sides of the sample solution, and the total amount of the sample solution, including the air layers, is injected into a detector. The start and the end of data collection are determined from the detection signal intensity changes that occur upon the air layers being injected into the detector, and the velocity of the flowing liquid is increased to reduce the measurement time. A washing solution is injected after the air layer to improve the washing efficiency and reduce the washing time.

Abstract translation: 本文提供了一种样品注射方法，其能够在减少测量时间的同时有效注入痕量样品溶液。 将样品溶液注入样品环，其中设置在样品溶液两侧的空气层，并将样品溶液（包括空气层）的总量注入检测器中。 数据采集​​的开始和结束是从在空气层被注入检测器中发生的检测信号强度变化确定的，流动液体的速度增加以减少测量时间。 在空气层之后注入洗涤液以提高洗涤效率并减少洗涤时间。

公开(公告)号：US20150128685A1

公开(公告)日：2015-05-14

申请号：US14534027

申请日：2014-11-05

Applicant: DIONEX SOFTRON GMBH

Inventor： Adolf SATZINGER ,  Hermann HOCHGRAEBER ,  Thomas Armin Alexander EICHHORN

IPC: G01N30/20 ,  G01N35/10

CPC classification number: G01N30/20 ,  F04B13/00 ,  G01N30/22 ,  G01N2030/207

Abstract: The invention relates to a sampler for providing a sample for high-performance liquid chromatography, in which a volume of liquid to be taken up into a cylinder can be aspirated by means of a first drive and can be compressed to a high pressure level by means of a second drive independent of the first drive or can be decompressed from this level in a controlled manner.

Abstract translation: 本发明涉及一种用于提供用于高效液相色谱的样品的采样器，其中待吸入气缸的液体体积可以通过第一驱动器吸入，并且可以通过装置被压缩到高压水平 独立于第一驱动器的第二驱动器，或者可以以受控的方式从该级别解压缩。

公开(公告)号：US20140338431A1

公开(公告)日：2014-11-20

申请号：US14454563

申请日：2014-08-07

Applicant: Dionex Softron GmbH

Inventor： Hermann Hochgraeber

IPC: G01N30/20 ,  G01N35/10 ,  G01N30/32

CPC classification number: G01N30/20 ,  G01N30/24 ,  G01N30/32 ,  G01N35/1097 ,  G01N2030/027 ,  G01N2030/201 ,  G01N2030/207

Abstract: A sample injection method for liquid chromatography is performed with an injection valve having a waste port, two sample loop ports, and two high-pressure ports. One high-pressure port can be connected to a pump and the other high-pressure port can be connected to a chromatography column. A sample loop is connected to one of the sample loop ports on one end and to a pump volume of a sample conveying device on the other end. A section of the sample loop can be separated to facilitate receiving a sample fluid in the sample loop. A control unit controls the injection valve and the sample conveying device. The sample injector allows a sample to be loaded into the sample loop and then pressurized to an operating pressure prior to injecting the sample into the chromatography column. The sample loop may also be isolated from the operating pressure for facilitating depressurization of the loop.

Abstract translation: 使用具有废物口，两个样品回路端口和两个高压端口的注射阀进行液相色谱法的样品注射方法。 一个高压端口可以连接到泵，另一个高压端口可以连接到色谱柱。 样品回路连接到一端的一个样品回路端口和另一端的样品输送装置的泵体积。 样品回路的一部分可以分开，以便于在样品回路中接收样品流体。 控制单元控制喷射阀和样品输送装置。 样品注射器允许将样品装载到样品环中，然后在将样品注入色谱柱之前加压至操作压力。 样品回路也可以与操作压力隔离，以便于循环的减压。

公开(公告)号：US08881582B2

公开(公告)日：2014-11-11

申请号：US13227078

申请日：2011-09-07

Applicant: Theodore A. Dourdeville ,  Russell L. Keene ,  Theodore D. Ciolkosz ,  James E. Usowicz

Inventor： Theodore A. Dourdeville ,  Russell L. Keene ,  Theodore D. Ciolkosz ,  James E. Usowicz

IPC: G01N30/38 ,  G01N30/20

CPC classification number: F16K11/0853 ,  G01N30/20 ,  G01N2030/201 ,  G01N2030/202 ,  G01N2030/207 ,  Y10T137/0396 ,  Y10T137/86871

Abstract: The present invention provides a method and apparatus for substantially eliminating destructive transients of pressure or flow rate which can degrade the efficiency and useful lifetime of chromatography columns. The present invention enables a substantially constant flow of mobile phase liquid to be maintained through the chromatography system by eliminating the flow blockage interval associated with the actuation of sample injection valves. The present invention further provides a method to reduce the pressure and flow rate transients associated with pressurization of the sample loop contents when the sample loop is introduced to chromatography system delivery pressure.

Abstract translation: 本发明提供了用于基本上消除压力或流速的破坏性瞬变的方法和装置，其可能降低色谱柱的效率和使用寿命。 通过消除与致动样品注射阀相关联的流动阻塞间隔，本发明能够通过色谱系统保持流动相液体的基本上恒定的流动。 本发明还提供了一种方法，当将样品环引入色谱系统输送压力时，减少与样品环含量的加压相关的压力和流速瞬变。

公开(公告)号：US20130333491A1

公开(公告)日：2013-12-19

申请号：US13971029

申请日：2013-08-20

Applicant: Yoshiaki SEKI ,  Kimihiko ISHII ,  Mitsuhiko UEDA ,  Katsutoshi SHIMIZU ,  Hiroshi SUZUKI

Inventor： Yoshiaki SEKI ,  Kimihiko ISHII ,  Mitsuhiko UEDA ,  Katsutoshi SHIMIZU ,  Hiroshi SUZUKI

IPC: G01N30/16

CPC classification number: G01N30/16 ,  G01N30/20 ,  G01N30/24 ,  G01N2030/207

Abstract: A liquid sample introducing apparatus capable of executing a process with high reliability and high speed is realized. An injection valve includes a sample storage loop connected to a mobile phase flow passage for supplying a sample to a detector of a liquid chromatograph apparatus. A sample is sucked in a needle through a valve and a pipe by a syringe, being introduced to the sample storage loop, being supplied to the mobile phase flow passage. A washing solution from a washing solution bottle is supplied to the needle by a washing unit through the valve and the pipe to wash the inner wall of the needle. The washing solution from the washing solution bottle is supplied to a washing tank by the washing unit through the valve and a pipe to wash the external wall of the needle in the washing tank.

Abstract translation: 实现能够执行高可靠性和高速度的处理的液体样品引入装置。 注射阀包括连接到流动相流动通道的样本储存环，用于将样品供应到液相色谱仪的检测器。 将样品通过注射器通过阀和管吸入针中，并被引入到样品储存环中，供给流动相流动通道。 来自洗涤溶液瓶的洗涤液通过洗涤单元通过阀和管道供应到针中以洗涤针的内壁。 来自洗涤溶液瓶的洗涤溶液通过洗涤单元通过阀门和洗涤槽中的针的外壁来洗涤的洗涤槽。