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公开(公告)号：US20220260532A1
公开(公告)日：2022-08-18
申请号：US17733218
申请日：2022-04-29
摘要： Described are an interface module for two-dimensional chromatography and a method of performing a chromatographic separation that may use the interface module. The interface module includes a valve module, a collection needle, a modifier module and a sample storage element. The valve module has a first port configured to receive an eluent from a first chromatography system, a second port configured to provide a fraction obtained from the eluent, a third port and a fourth port. The collection needle and the modifier module are in fluidic communication with the valve module at the third and fourth ports, respectively. The modifier module includes a source of a modifier solvent. The sample storage element is in fluidic communication with the valve module and is configured to receive a volume of the fraction for injection as a sample into a second chromatography system.
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2.发明申请公开(公告)号：US20160195564A1
公开(公告)日：2016-07-07
申请号：US14979066
申请日：2015-12-22
CPC分类号： G01N30/20 , G01N30/06 , G01N30/24 , G01N35/1097 , G01N2030/067 , G01N2030/207 , G01N2035/00514 , G01N2035/1032
摘要： Automated sampling and reaction systems and methods of using the same are provided. The automated sampling and reaction system has a microreactor in fluidic communication with an external sampling valve. The external sampling valve is connected to a priming valve and can be configured to draw sample from a reactor or a reactor stream. The microreactor is connected to a reagent valve and an injection valve. The reagent valve can be configured to draw reagent from a reagent reservoir and discharge reagent to the microreactor to react with sample. The priming valve can be configured to draw wash from a wash reservoir and discharge wash to the external sampling valve to move sample from the external sampling valve to the microreactor. The injection valve is in fluidic communication with a column or detector and discharges the secondary sample into a solvent composition stream.
摘要翻译： 提供了自动采样和反应系统及其使用方法。 自动采样和反应系统具有与外部采样阀流体连通的微反应器。 外部采样阀连接到起动阀，并且可以被配置为从反应器或反应器流中抽取样品。 微反应器连接到试剂阀和注射阀。 试剂阀可以被配置为从试剂储存器中抽取试剂，并将试剂排放到微反应器以与样品反应。 起动阀可以被配置为从洗涤容器中抽出洗涤液并将洗涤液排出到外部取样阀，以将样品从外部取样阀移动到微反应器。 注射阀与柱或检测器流体连通，并将次要样品排放到溶剂组合物流中。
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公开(公告)号：US20230094740A1
公开(公告)日：2023-03-30
申请号：US18070859
申请日：2022-11-29
摘要： A liquid chromatography system includes a solvent delivery system, a sample manager including a sample delivery system in fluidic communication with the solvent delivery system, the sample delivery system configured to inject a sample from a sample-vial into a chromatographic flow stream, a liquid chromatography column located downstream from the sample delivery system, and a detector located downstream from the liquid chromatography column. The sample delivery system further includes a first needle drive including a first sample needle configured to extract the sample from the sample-vial and deliver the sample to the liquid chromatography column, and a first syringe in communication with the first sample needle configured to meter extraction of the sample from the sample-vial. The sample manager further includes a sample automation system that includes a second needle drive including a second sample needle configured to add a volume of reagent to the sample-vial.
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公开(公告)号：US20210302395A1
公开(公告)日：2021-09-30
申请号：US17209502
申请日：2021-03-23
摘要： A liquid chromatography system includes a solvent delivery system, a sample manager including a sample delivery system in fluidic communication with the solvent delivery system, the sample delivery system configured to inject a sample from a sample-vial into a chromatographic flow stream, a liquid chromatography column located downstream from the sample delivery system, and a detector located downstream from the liquid chromatography column. The sample delivery system further includes a first needle drive including a first sample needle configured to extract the sample from the sample-vial and deliver the sample to the liquid chromatography column, and a first syringe in communication with the first sample needle configured to meter extraction of the sample from the sample-vial. The sample manager further includes a sample automation system that includes a second needle drive including a second sample needle configured to add a volume of reagent to the sample-vial.
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公开(公告)号：US20200072800A1
公开(公告)日：2020-03-05
申请号：US16556532
申请日：2019-08-30
摘要： Described are an interface module for two-dimensional chromatography and a method of performing a chromatographic separation that may use the interface module. The interface module includes a valve module, a collection needle, a modifier module and a sample storage element. The valve module has a first port configured to receive an eluent from a first chromatography system, a second port configured to provide a fraction obtained from the eluent, a third port and a fourth port. The collection needle and the modifier module are in fluidic communication with the valve module at the third and fourth ports, respectively. The modifier module includes a source of a modifier solvent. The sample storage element is in fluidic communication with the valve module and is configured to receive a volume of the fraction for injection as a sample into a second chromatography system.
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公开(公告)号：US20190101513A1
公开(公告)日：2019-04-04
申请号：US16139356
申请日：2018-09-24
摘要： Methods of chromatographic detection are provided that include the step of providing a chromatography instrument without an autosampler, an external device, a pressurized sample injection device and a chromatographic data system. The chromatographic instrument has a sample valve, a column manager and a solvent manager. The present methods further include the steps: injecting sample into the sample valve with a pressurized sample injection device; transmitting a signal from the chromatographic data system to the external device, receiving the signal by the external device, producing an event output with the external device, discharging solvent from the solvent manager into the sample valve, and discharging sample into the column for chromatographic detection.
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7.发明申请公开(公告)号：US20180149625A1
公开(公告)日：2018-05-31
申请号：US15851101
申请日：2017-12-21
CPC分类号： G01N30/20 , G01N30/06 , G01N30/24 , G01N35/1097 , G01N2030/067 , G01N2030/207 , G01N2035/00514 , G01N2035/1032
摘要： Automated sampling and reaction systems and methods of using the same are provided. The automated sampling and reaction system has a microreactor in fluidic communication with an external sampling valve. The external sampling valve is connected to a priming valve and can be configured to draw sample from a reactor or a reactor stream. The microreactor is connected to a reagent valve and an injection valve. The reagent valve can be configured to draw reagent from a reagent reservoir and discharge reagent to the microreactor to react with sample. The priming valve can be configured to draw wash from a wash reservoir and discharge wash to the external sampling valve to move sample from the external sampling valve to the microreactor. The injection valve is in fluidic communication with a column or detector and discharges the secondary sample into a solvent composition stream.
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