公开(公告)号：US09381257B2

公开(公告)日：2016-07-05

申请号：US14414224

申请日：2013-07-04

Applicant: BRACCO IMAGING S.P.A.

Inventor： Pernille Rose Jensen ,  Magnus Karlsson ,  Mathilde H. Lerche ,  Roberta Napolitano ,  Fabio Tedoldi ,  Massimo Visigalli

IPC: A61K49/10 ,  A61K49/20 ,  C07F7/08 ,  G01R33/28

CPC classification number: A61K49/10 ,  A61K49/20 ,  C07F7/0812 ,  C07F7/0814 ,  G01R33/282

Abstract: New radical compounds, useful in the field of MRI imaging of formula (I). The radical compounds are in particular new triarylmethyl (“trityl”) radicals which can be used as polarizing agents for polarizing a molecule in the DNP process.

Abstract translation: 新的自由基化合物，可用于式（I）的MRI成像领域。 自由基化合物特别是新的三芳基甲基（“三苯甲基”）基团，其可以用作在DNP方法中使分子偏振的偏振剂。

公开(公告)号：US09228220B2

公开(公告)日：2016-01-05

申请号：US14097867

申请日：2013-12-05

Applicant: Bracco Imaging S.p.A

Inventor： Robert C. Williams, Jr. ,  Patrice Marchildon

IPC: C12Q1/22 ,  C12Q1/18 ,  G01N31/22 ,  G01N33/50 ,  A61M5/00 ,  A61M5/14 ,  A61M5/142 ,  A61L2/28 ,  A61L2/18 ,  G01N13/00

CPC classification number: G01M3/2853 ,  A61L2/18 ,  A61L2/28 ,  A61M5/00 ,  A61M5/1408 ,  A61M5/1413 ,  A61M5/14232 ,  C12Q1/18 ,  C12Q1/22 ,  G01N31/226 ,  G01N33/50 ,  G01N2013/003 ,  Y10T436/13

Abstract: A fluid delivery system may include a container that houses a medical fluid, a fluid pressurizing unit, and a fluid transfer set that transfers the medical fluid from the container to the fluid pressurizing unit. To validate the integrity and sterility of the fluid delivery system, the system may undergo testing protocols to evaluate the susceptibility of the system to pathogenic ingress, chemical degradation, and/or fluid cross-contamination between patient fluid delivery procedures. The testing protocols may help ensure that delivery system components used during multiple different fluid delivery procedures perform as well as if the components were replaced after each fluid delivery procedure.

公开(公告)号：US20150158887A1

公开(公告)日：2015-06-11

申请号：US14623202

申请日：2015-02-16

Applicant: BRACCO IMAGING S.P.A.

Inventor： Federico MAISANO ,  Federico CRIVELLIN

IPC: C07F5/00

CPC classification number: C07F5/003 ,  C07C227/16 ,  C07C227/40 ,  C07C229/76

Abstract: The present invention generally relies on a process for the preparation of chelated compounds, comprising the selective interaction between a solid matrix and a chelating agent. In more details, the present invention enables the preparation of chelated compounds useful as diagnostic agents, in high yields and in a reliable way.

Abstract translation: 本发明通常依赖于制备螯合化合物的方法，其包括固体基质和螯合剂之间的选择性相互作用。 更详细地说，本发明能够以高产率和可靠的方式制备用作诊断剂的螯合化合物。

公开(公告)号：US20140257085A1

公开(公告)日：2014-09-11

申请号：US14350478

申请日：2012-10-11

Applicant: BRACCO IMAGING S.P.A.

Inventor： Silvio Aime ,  Sonia Colombo Serra ,  Giovanni Battista Giovenzana ,  Pernille Rose Jensen ,  Magnus Karlsson ,  Mathilde H. Lerche ,  Fabio Tedoldi

IPC: A61K49/10 ,  G01R33/56

CPC classification number: A61K49/10 ,  C07B59/001 ,  G01R33/5601

Abstract: The present invention relates to a process for the preparation of aqueous solutions of hyperpolarized carboxylic organic acids ready for use in in-vivo MR diagnostic imaging, and the use of the corresponding anhydrides or esters as glass-forming agents.

Abstract translation: 本发明涉及准备用于体内MR诊断成像的超极化羧酸有机酸的水溶液的制备方法，以及相应的酸酐或酯作为玻璃形成剂的用途。

公开(公告)号：US20250051292A1

公开(公告)日：2025-02-13

申请号：US18718945

申请日：2022-12-13

Applicant: BRACCO IMAGING S.P.A.

Inventor： Sonia GAZZETTO ,  Valeria BOI ,  Andrea BANIN ,  Andrea BARALE

IPC: C07D257/00 ,  C07F11/00

Abstract: The present invention relates to a process for the manufacturing of a mixture comprising the intermediate 1-[bis[2-hydroxy-3-[4,7,10-tris[2-(1,1-dimethylethoxy)-2-oxoethyl]-1,4,7,10-tetraazacyclododec-1-yl]propyl]amino]-1-deoxy-D-glucitol. Such intermediate is useful for the synthesis of the dimeric gadolinium complex [μ-[1-[bis[2-(hydroxy-κO)-3-[4,7,10-tris[(carboxy-κO)methyl]-1,4,7,10-tetraazacyclododec-1-yl-κN1,κN4,κN7,κN10]propyl]amino]-1-deoxy-D-glucitolate(6-)]]digadolinium complex, which can be employed as a contrast agent in the field of diagnostic imaging, and in particular of Magnetic Resonance Imaging (MRI).

公开(公告)号：US20240366802A1

公开(公告)日：2024-11-07

申请号：US18734341

申请日：2024-06-05

Applicant: BRACCO IMAGING S.P.A.

Inventor： Roberta NAPOLITANO ,  Luciano LATTUADA ,  Zsolt BARANYAI ,  Nicole GUIDOLIN ,  Giuseppe MARAZZI

IPC: A61K49/10 ,  C07D471/08 ,  C07F5/00

Abstract: The present invention relates to the RRR/SSS pair of enantiomers of the of Gd(PCTA-tris-glutamic acid), the single enantiomers of the pair, the pharmaceutically acceptable salts thereof, their amide derivatives, and compositions comprising at least 50% of these compounds.

公开(公告)号：US11905257B2

公开(公告)日：2024-02-20

申请号：US18039540

申请日：2021-12-01

Applicant: BRACCO IMAGING S.P.A.

Inventor： Roberta Fretta ,  Luciano Lattuada ,  Gabriele Meli

IPC: C07D257/02

CPC classification number: C07D257/02

Abstract: The invention relates to a process for preparing Gadoteridol of formula (I). In particular, the process comprises the use of propylene oxide in the alkylation step of the compound of formula (II), wherein propylene oxide is directly reacted with the compound of formula (II) without being isolated, and wherein propylene oxide is obtained on demand by decomposition of propylene carbonate in the presence of an alkaline or alkaline earth metal halide as catalyst.

公开(公告)号：US20230391735A1

公开(公告)日：2023-12-07

申请号：US18039540

申请日：2021-12-01

Applicant: BRACCO IMAGING S.P.A.

Inventor： Roberta FRETTA ,  Luciano LATTUADA ,  Gabriele MELI

IPC: C07D257/02

CPC classification number: C07D257/02

Abstract: The invention relates to a process for preparing Gadoteridol of formula (I). In particular, the process comprises the use of propylene oxide in the alkylation step of the compound of formula (II), wherein propylene oxide is directly reacted with the compound of formula (II) without being isolated, and wherein propylene oxide is obtained on demand by decomposition of propylene carbonate in the presence of an alkaline or alkaline earth metal halide as catalyst.

公开(公告)号：US11667601B2

公开(公告)日：2023-06-06

申请号：US17786623

申请日：2020-12-17

Applicant: BRACCO IMAGING S.P.A.

Inventor： Andrea Banin ,  Laura Galimberti ,  Roberta Napolitano ,  Roberta Fretta

IPC: C07C229/22 ,  C07C227/18

CPC classification number: C07C229/22 ,  C07C227/18

Abstract: The present invention relates to the calcium complex of (4RS)(4-carboxy-5,8,11-tris(carboxymethyl)-1-phenyl oxa-5,8,11-triazatridecan-13-oato(5-))pentahydrogen (BOPTA) in the form of a salt, to the process for its preparation and to a formulation comprising said salt.

公开(公告)号：US20230078638A1

公开(公告)日：2023-03-16

申请号：US17793459

申请日：2021-01-19

Applicant: BRACCO IMAGING S.P.A.

Inventor： Camilla CAVALLOTTI

IPC: C07F15/02

Abstract: The present invention relates to an iron complex having the general formula (I) or a pharmaceutically acceptable salt thereof. The present invention also relates to a pharmaceutical composition formulated for oral and/or parenteral administration, preferably intravenous, said pharmaceutical composition preferably being formulated as an aqueous solution comprising said complex or salt. The present invention further relates to said complex or a salt thereof or said pharmaceutical composition for use as a contrast agent for magnetic resonance imaging (MRI), as well as a method and a kit for in situ preparation of said complex or salt and said pharmaceutical composition.