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    Smartphone Biosensor
    52.
    发明申请
    Smartphone Biosensor 审中-公开
    智能手机生物传感器

    公开(公告)号：US20150104860A1

    公开(公告)日：2015-04-16

    申请号：US14579804

    申请日：2014-12-22

    Applicant: The Board of Trustees of the University of Illinois

    Inventor： Brian T. Cunningham

    IPC: H04M1/725 ,  G01N21/25 ,  G01N21/64

    CPC classification number: H04M1/72527 ,  G01J3/0202 ,  G01J3/0264 ,  G01J3/0272 ,  G01J3/28 ,  G01J3/44 ,  G01J3/4406 ,  G01N21/25 ,  G01N21/31 ,  G01N21/553 ,  G01N21/63 ,  G01N21/6428 ,  G01N21/6445 ,  G01N21/6486 ,  G01N21/658 ,  G01N21/7746 ,  G01N2021/6417 ,  G01N2201/0612 ,  G01N2201/062

    Abstract: A mobile computing device that includes an image sensor may be used to detect the result of a biomolecular assay. The biomolecular assay may be performed in an optical assay medium that provides an optical output in response to light from a light source, with the optical output indicating result. A wavelength-dispersive element may be used to disperse the optical output into spatially-separated wavelength components. The mobile computing device may be positioned relative to the wavelength-dispersive element such that different wavelength components are received at different locations on the image sensor. With the mobile computing device positioned in this way, the image sensor may be used to obtain one or more images that include the separated wavelength components of the optical output. A wavelength spectrum of the optical output may be determined from the one or more images, and the result may be determined from the wavelength spectrum.

    Abstract translation: 可以使用包括图像传感器的移动计算设备来检测生物分子测定的结果。 生物分子测定可以在光学测定介质中进行，光学测定介质响应于来自光源的光而提供光学输出，光学输出指示结果。 波长分散元件可以用于将光输出分散到空间分离的波长分量中。 移动计算设备可以相对于波长分散元件定位，使得在图像传感器上的不同位置处接收不同的波长分量。 利用以这种方式定位的移动计算设备，可以使用图像传感器来获得包括光输出的分离的波长分量的一个或多个图像。 可以从一个或多个图像确定光学输出的波长谱，并且可以根据波长谱确定结果。

    Spectral and temporal laser fluorescence analysis such as for natural aquatic environments
    53.
    发明授权
    Spectral and temporal laser fluorescence analysis such as for natural aquatic environments 有权
    光谱和时间激光荧光分析，如天然水生环境

    公开(公告)号：US08970841B2

    公开(公告)日：2015-03-03

    申请号：US13513786

    申请日：2010-12-03

    Applicant: Alexander Chekalyuk

    Inventor： Alexander Chekalyuk

    IPC: G01J3/30 ,  G01J3/28 ,  G01N21/25 ,  G01N21/64 ,  G01J3/02 ,  G01J3/44 ,  G01N21/65 ,  G01N21/63

    CPC classification number: G01N21/6408 ,  G01J3/02 ,  G01J3/0264 ,  G01J3/4406 ,  G01N21/6486 ,  G01N21/65 ,  G01N2021/635 ,  G01N2021/6419

    Abstract: An Advanced Laser Fluorometer (ALF) can combine spectrally and temporally resolved measurements of laser-stimulated emission (LSE) for characterization of dissolved and particulate matter, including fluorescence constituents, in liquids. Spectral deconvolution (SDC) analysis of LSE spectral measurements can accurately retrieve information about individual fluorescent bands, such as can be attributed to chlorophyll-a (Chl-a), phycobiliprotein (PBP) pigments, or chromophoric dissolved organic matter (CDOM), among others. Improved physiological assessments of photosynthesizing organisms can use SDC analysis and temporal LSE measurements to assess variable fluorescence corrected for SDC-retrieved background fluorescence. Fluorescence assessments of Chl-a concentration based on LSE spectral measurements can be improved using photo-physiological information from temporal measurements. Quantitative assessments of PBP pigments, CDOM, and other fluorescent constituents, as well as basic structural characterizations of photosynthesizing populations, can be performed using SDC analysis of LSE spectral measurements.

    Abstract translation: 先进的激光荧光计（ALF）可以结合光谱和时间分辨的激光激发辐射测量（LSE），用于表征液体中溶解和颗粒物质，包括荧光成分。 LSE光谱测量的光谱去卷积（SDC）分析可以准确检索关于单个荧光带的信息，例如可归因于叶绿素a（Chl-a），藻胆蛋白（PBP）颜料或发色团溶解有机物（CDOM）），其中 其他。 改进的光合生物生理学评估可以使用SDC分析和时间LSE测量来评估针对SDC检索的背景荧光校正的可变荧光。 基于LSE光谱测量的Chl-a浓度的荧光评估可以使用来自时间测量的光生物学信息来改善。 可以使用LSE光谱测量的SDC分析来进行PBP颜料，CDOM和其他荧光成分的定量评估，以及光合作用群体的基本结构表征。

    Laser cavity two-photon spectroscopy
    54.
    发明授权
    Laser cavity two-photon spectroscopy 有权
    激光腔双光子光谱

    公开(公告)号：US08890088B2

    公开(公告)日：2014-11-18

    申请号：US13733878

    申请日：2013-01-03

    Applicant: National Central University

    Inventor： Wang-Yau Cheng ,  Chien-Ming Wu ,  Tze-Wei Liu ,  You-Huan Chen

    IPC: G01J1/58 ,  G01J3/44 ,  H01S3/13 ,  H01S5/024 ,  H01S5/14

    CPC classification number: G01J3/4406 ,  H01S3/1303 ,  H01S5/02415 ,  H01S5/02446 ,  H01S5/141

    Abstract: A laser cavity two-photon spectroscopy includes a gain medium, a first reflector, a second reflector, an electrical pumping module, and a two-photon absorption cell. The first reflector is disposed at a side of the gain medium. The second reflector is movably disposed at a side of the gain medium relative to the first reflector. The electrical pumping module is electrically connected to the gain medium. Therefore, the gain medium is able to emit a light beam, which bounces back and forth between the first reflector and the second reflector and forms a laser beam through enhanced by the gain medium. The two-photon absorption cell disposed between the gain medium and the second reflector includes a plurality of two-photon absorption mediums. The two-photon absorption mediums absorb a portion of the laser beam reflected between the first reflector and the second reflector and then emit fluorescence.

    Abstract translation: 激光腔双光子光谱包括增益介质，第一反射器，第二反射器，电泵浦模块和双光子吸收单元。 第一反射器设置在增益介质的一侧。 第二反射器相对于第一反射器可移动地设置在增益介质的一侧。 电抽运模块电连接到增益介质。 因此，增益介质能够发射光束，该光束在第一反射器和第二反射器之间来回弹起并形成通过增益介质增强的激光束。 设置在增益介质和第二反射器之间的双光子吸收单元包括多个双光子吸收介质。 双光子吸收介质吸收在第一反射器和第二反射器之间反射的激光束的一部分，然后发射荧光。

    Detection optical system and scanning microscope
    55.
    发明授权
    Detection optical system and scanning microscope 有权
    检测光学系统和扫描显微镜

    公开(公告)号：US08885162B2

    公开(公告)日：2014-11-11

    申请号：US13669634

    申请日：2012-11-06

    Applicant: Olympus Corporation

    Inventor： Masaharu Tomioka

    IPC: G01J3/28 ,  G01J3/18 ,  G02B21/00 ,  G01J3/06 ,  G01J3/02 ,  G01J3/44

    CPC classification number: G02B21/0076 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0237 ,  G01J3/06 ,  G01J3/1838 ,  G01J3/4406 ,  G02B21/0064

    Abstract: Provided is a detection optical system that is provided with a dispersed-light detection function and that can increase the amount of detected light by enhancing the diffraction efficiency. A detection optical system is employed which includes a transmissive VPH diffraction grating that disperses fluorescence from a specimen into a plurality of wavelength bands; a rotating mechanism that rotates the VPH diffraction grating about an axial line that is perpendicular to an incident optical axis of the fluorescence from the specimen and an emission optical axis from the VPH diffraction grating; a light detection portion that detects the fluorescence from the specimen that has been dispersed by the VPH diffraction grating; and a correcting portion that corrects an incident position on the light detection portion in accordance with a displacement of the optical axis caused by the rotation of the VPH diffraction grating in synchronization with the rotating mechanism.

    Abstract translation: 提供了一种具有分散光检测功能并且可以通过提高衍射效率来增加检测光量的检测光学系统。 使用检测光学系统，其包括将来自样本的荧光分散到多个波长带中的透射VPH衍射光栅; 围绕垂直于来自样本的荧光的入射光轴的轴线和来自VPH衍射光栅的发射光轴旋转VPH衍射光栅的旋转机构; 光检测部，其检测由所述VPH衍射光栅分散的所述样本的荧光; 以及校正部，其根据与旋转机构同步的VPH衍射光栅的旋转引起的光轴的位移校正光检测部上的入射位置。

    Energy dispersion device
    56.
    发明授权
    Energy dispersion device 有权
    能量分散装置

    公开(公告)号：US08885161B2

    公开(公告)日：2014-11-11

    申请号：US13596242

    申请日：2012-08-28

    Applicant: Alexander Scheeline ,  Thu Anh Bui

    Inventor： Alexander Scheeline ,  Thu Anh Bui

    IPC: G01J3/28 ,  G01J3/44 ,  G01J3/10 ,  G01K13/00 ,  G01J3/18 ,  G02B27/44 ,  G01J3/42

    CPC classification number: G01J3/1804 ,  G01J3/10 ,  G01J3/28 ,  G01J3/42 ,  G01J3/4406 ,  G01K13/00 ,  G02B27/4244 ,  G02B27/4272 ,  G02B27/44

    Abstract: The invention provides an energy dispersion device, spectrograph and method that can be used to evaluate the composition of matter on site without the need for specialized training or expensive equipment. The energy dispersion device or spectrograph can be used with a digital camera or cell phone. A device of the invention includes a stack of single- or double-dispersion diffraction gratings that are rotated about their normal giving rise to a multiplicity of diffraction orders from which meaningful measurements and determinations can be made with respect to the qualitative or quantitative characteristics of matter.

    Abstract translation: 本发明提供了一种能量分散装置，光谱仪和方法，可用于现场评估物质的组成，而无需专门培训或昂贵的设备。 能量分散装置或光谱仪可与数码相机或手机一起使用。 本发明的装置包括一组单分散或双分散衍射光栅，其围绕其正常旋转，产生多个衍射级，从该衍射级可以对物质的定性或定量特性进行有意义的测量和确定 。

    Multi wavelength excitation/emission authentication and detection scheme
    57.
    发明授权
    Multi wavelength excitation/emission authentication and detection scheme 有权
    多波长激发/发射认证和检测方案

    公开(公告)号：US08840029B2

    公开(公告)日：2014-09-23

    申请号：US13352953

    申请日：2012-01-18

    Applicant: Nabil Lawandy ,  Andrei Smuk ,  Leif Olson ,  Charles Zepp

    Inventor： Nabil Lawandy ,  Andrei Smuk ,  Leif Olson ,  Charles Zepp

    IPC: G06K19/06

    CPC classification number: G01N21/25 ,  B42D25/355 ,  G01J3/4406 ,  G01N21/643 ,  G01N2021/6419 ,  G07D7/1205

    Abstract: A system and method for authentication of secure products is disclosed. The security feature contains a first component in the form of an emitter capable of emitting light in response to external pump light. The security feature also contains a second component in the form of a taggant that absorbs light in a spectrally narrow range compared to the broader excitation spectrum of the first material. In this manner the emitter and taggant work in combination with one another to create an emission response significantly dependent on the illumination wavelengths and unique to the specific combination of the components. The emitter and taggant can be in the form of a mixture. Further the emitter and taggant may be applied in close proximity to one another, such as within two separate coating layers on a suitable substrate.

    Abstract translation: 公开了一种用于认证安全产品的系统和方法。 安全特征包含能够响应于外部泵浦光而发光的发射器形式的第一部件。 安全特征还包含标签牌形式的第二组分，其与第一材料的较宽的激发光谱相比吸收光谱窄范围内的光。 以这种方式，发射器和标签牌彼此组合工作以产生明显取决于照明波长的发射响应，并且对于组件的具体组合是唯一的。 发射体和标记物可以是混合物的形式。 此外，发射器和标签剂可以彼此紧邻地施加，例如在合适的衬底上的两个单独的涂层内。

    FLUORESCENCE OBSERVATION SYSTEM AND SET OF FILTERS
    58.
    发明申请
    FLUORESCENCE OBSERVATION SYSTEM AND SET OF FILTERS 审中-公开
    荧光观察系统和滤光片组

    公开(公告)号：US20140211306A1

    公开(公告)日：2014-07-31

    申请号：US14242339

    申请日：2014-04-01

    Applicant: CARL ZEISS MEDITEC AG

    Inventor： Helge JESS ,  Roland GUCKLER

    IPC: G02B21/06 ,  G02B5/20 ,  G01N21/64

    CPC classification number: G02B21/06 ,  G01J3/0235 ,  G01J3/4406 ,  G01N21/64 ,  G01N21/6447 ,  G01N21/6458 ,  G02B5/20 ,  G02B5/288 ,  G02B21/0076 ,  G02B21/16

    Abstract: A set of filters for fluorescence observation comprises an illumination light filter and an observation light filter, wherein the following is holds: ∫ S  T L  ( r -> ) · T O  ( r -> ) · r -> ·  r ∫ S  T L  ( r -> ) · T O  ( r -> ) ·  r = R ->   and ( 3 )  W -> - R ->  ≤ 0.2 ; ( 4 ) wherein: λ designates the wavelength, TL(λ) is the transmission characteristic of the illumination light filter, TO(λ) is the transmission characteristic of the observation light filter, and A1, A2 are numbers between 0 and 1, {right arrow over (r)} is a coordinate in the CIE xy chromaticity diagram of the CIE 1931 XYZ color space, S is a line called the spectral locus in the CIE xy chromaticity diagram of the CIE 1931 XYZ color space, and {right arrow over (W)} is the white point in the CIE xy chromaticity diagram of the CIE 1931 XYZ color space.

    Abstract translation: 用于荧光观察的一组滤光器包括照明光滤光器和观察光滤光片，其中以下是：∫S TL（r->）·TO（r->）·r···∫r∫ （r - >）·r = R→>>≤≤≤≤ （4）其中：λ表示波长，TL（λ）是照明光滤波器的透射特性，TO（λ）是观察光滤波器的透射特性，A1，A2是0和1之间的数，{ 右侧箭头（r）}是CIE 1931 XYZ色彩空间的CIE xy色度图中的坐标，S是CIE 1931 XYZ色彩空间的CIE xy色度图中称为光谱轨迹的线，{右箭头 over（W）}是CIE 1931 XYZ色彩空间的CIE xy色度图中的白点。

    MULTIPLE CONCURRENT SPECTRAL ANALYSES
    59.
    发明申请
    MULTIPLE CONCURRENT SPECTRAL ANALYSES 有权
    多光谱分析

    公开(公告)号：US20140211199A1

    公开(公告)日：2014-07-31

    申请号：US13754283

    申请日：2013-01-30

    Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

    Inventor： Huei Pei Kuo ,  Zhiyong Li ,  Shih-Yuan Wang ,  Steven J. Barcelo ,  Ansoon Kim ,  Gary Gibson ,  Alexandre M. Bratkovski

    IPC: G01J3/28 ,  G01J3/44

    CPC classification number: G01J3/44 ,  G01J3/0208 ,  G01J3/0294 ,  G01J3/2803 ,  G01J3/4406

    Abstract: According to an example, apparatuses for performing multiple concurrent spectral analyses on a sample under test include an optical system to concurrently direct a plurality of light beams onto analytes at multiple locations on the sample under test, in which the plurality of light beams cause light in either or both of a Raman spectra and a non-Raman spectra to be emitted from the analytes at the multiple locations of the sample under test. The apparatuses also include a detector to concurrently acquire a plurality of spectral measurements of the light emitted from the analytes at the multiple locations of the sample under test. Example methods of performing spectral analysis include use of the apparatuses.

    Abstract translation: 根据一个示例，用于对被测试样品进行多次同时光谱分析的装置包括：一个光学系统，用于将多个光束同时引导到被测样品上的多个位置上的分析物上，其中多个光束使得光 在待测样品的多个位置处从分析物中发射的拉曼光谱和非拉曼光谱中的任一者或两者。 这些装置还包括一个检测器，用于同时获取在待测试样品的多个位置处从分析物发射的光的多个光谱测量。 执行光谱分析的示例方法包括使用这些装置。

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