公开(公告)号：US20140316265A1

公开(公告)日：2014-10-23

申请号：US14353810

申请日：2012-10-24

Applicant: TORUS MEDICAL LTD.

Inventor： Boris Levin ,  Bnaiahu Levin ,  Levy Ulanovsky ,  Vlad Lerner

IPC: A61B17/00 ,  A61B1/06 ,  A61N5/10 ,  A61B1/00 ,  A61M25/10 ,  A61B6/00 ,  A61M5/00 ,  A61H21/00 ,  A61B8/12 ,  A61N7/00 ,  A61B1/04 ,  A61B6/03

CPC classification number: A61B17/00234 ,  A61B1/00135 ,  A61B1/00154 ,  A61B1/0055 ,  A61B1/041 ,  A61B1/06 ,  A61B1/31 ,  A61B6/037 ,  A61B6/4057 ,  A61B8/12 ,  A61B2017/00336 ,  A61B2217/005 ,  A61B2217/007 ,  A61H21/00 ,  A61M5/007 ,  A61M25/10 ,  A61N5/1007 ,  A61N7/00

Abstract: The present invention provides an endoscopic apparatus reversibly insertable into a curved lumen of a patient, comprising: a. a flexible sleeve characterized by a proximal end and a distal end; said distal end of said flexible sleeve comprising: i. a flexible folded sleeve part comprising a portion of said flexible sleeve in a compact and folded arrangement; said compact and folded sleeve portion unfolds and evert; said folded sleeve part is characterized by a predetermined length Lfold; ii. an unfolded sleeve portion in communication with said compact folded sleeve part, characterized by a length Lunfold; Lunfold increases as at least a portion of said compact and folded sleeve portion unfolds and everts; wherein said compact and folded sleeve portion is enclosed and within said folded sleeve part such that a single topologically cylindrical sleeve is provided

Abstract translation: 本发明提供了可逆地插入到患者的弯曲内腔中的内窥镜装置，包括：a。 柔性套管，其特征在于近端和远端; 所述柔性套管的所述远端包括：i。 柔性折叠套筒部分，其包括紧凑且折叠布置的所述柔性套筒的一部分; 所述紧凑和折叠的套筒部分展开和翻转; 所述折叠套筒部分的特征在于预定长度Lfold; ii。 与所述紧凑折叠套筒​​部分连通的展开套筒部分，其特征在于长度Lunfold; Lunfold随着所述紧凑和折叠的套筒部分的至少一部分展开和延伸而增加; 其中所述紧凑和折叠的套筒部分被封闭并且在所述折叠的套筒部分内，使得提供单个拓扑圆柱形套筒

公开(公告)号：US20140249402A1

公开(公告)日：2014-09-04

申请号：US14058363

申请日：2013-10-21

Applicant: Blosensor International Group, Ltd.

Inventor： Yoav Kimchy ,  Roni Amarmi ,  Yona Bouskila ,  Udi Antebi ,  Nick Sidorenko ,  Gal Ben-David ,  Yoel Ziberstein

IPC: A61B6/03 ,  A61B5/055 ,  A61B5/06 ,  A61B6/00

CPC classification number: A61B6/037 ,  A61B5/055 ,  A61B5/06 ,  A61B5/064 ,  A61B5/07 ,  A61B5/415 ,  A61B5/418 ,  A61B5/6835 ,  A61B6/12 ,  A61B6/4057 ,  A61B6/4258 ,  A61B6/4417 ,  A61B6/4423 ,  A61B6/482 ,  A61B6/583 ,  A61B8/0833 ,  A61B8/4245 ,  A61B8/4254 ,  A61B2090/392 ,  G01T1/161

Abstract: A radioactive emission probe in communication with a position tracking system and the use thereof in a variety of systems and methods of medical imaging and procedures, are provided. Specifically, wide-aperture collimation-deconvolution algorithms are provided, for obtaining a high-efficiency, high resolution image of a radioactivity emitting source, by scanning the radioactivity emitting source with a probe of a wide-aperture collimator, and at the same time, monitoring the position of the radioactive emission probe, at very fine time intervals, to obtain the equivalence of fine-aperture collimation. The blurring effect of the wide aperture is then corrected mathematically. Furthermore, an imaging method by depth calculations is provided, based on the attenuation of photons of different energies, which are emitted from the same source, coupled with position monitoring.

Abstract translation: 提供了一种与位置跟踪系统通信的放射性发射探测器及其在医疗成像和程序的各种系统和方法中的应用。 具体地说，提供宽孔径准直 - 去卷积算法，通过用宽孔径准直仪的探头扫描放射性发射源，获得放射性发射源的高效率高分辨率图像，同时， 以非常精细的时间间隔监测放射性发射探针的位置，以获得细孔准直的等效性。 然后在数学上校正宽光圈的模糊效果。 此外，基于从相同源发射的不同能量的光子的衰减与位置监测相结合，提供了通过深度计算的成像方法。

公开(公告)号：US20140005521A1

公开(公告)日：2014-01-02

申请号：US13885791

申请日：2011-11-15

Applicant: Max Oskar Köhler ,  Peter Dirksen ,  Shunmugavelu Sokka ,  Ronald Dekker

Inventor： Max Oskar Köhler ,  Peter Dirksen ,  Shunmugavelu Sokka ,  Ronald Dekker

IPC: A61N7/02 ,  A61B5/055 ,  A61B5/01 ,  A61B6/00 ,  A61B8/12 ,  A61B8/00 ,  A61B5/00 ,  A61B6/03

CPC classification number: A61B5/015 ,  A61B5/055 ,  A61B5/064 ,  A61B5/4836 ,  A61B6/03 ,  A61B6/12 ,  A61B6/4057 ,  A61B8/0841 ,  A61B8/12 ,  A61B8/445 ,  A61B8/4488 ,  A61B8/54 ,  A61B8/58 ,  A61B2018/00023 ,  A61B2090/064 ,  A61B2090/374 ,  A61B2562/028 ,  A61N7/022 ,  A61N2007/0095 ,  B06B1/0292 ,  G06F19/00

Abstract: A catheter (700, 800, 1206) comprising: a shaft with distal (808, 906, 1004, 208) and proximal ends (1006),wherein the distal end comprises at least one array of capacitive micromachined ultrasound transducers (308, 402, 404, 500, 512, 600, 604, 802, 008) with an adjustable focus for controllably heating a target zone (806, 1014, 1210); and a connector (1012) at the proximal end for supplying the at least one array of capacitive micromachined ultrasound transducers with electrical power and for controlling the adjustable focus.

Abstract translation: 导管（700,800,1206）包括：具有远端（808,906,1004,208）和近端（1006）的轴，其中所述远端包括至少一个电容微加工超声换能器阵列（308,402， 具有可调焦点，用于可控制地加热目标区域（806,104,1210）; 以及在所述近端处的用于向所述至少一个电容微加工超声换能器阵列供电并用于控制所述可调焦点的连接器（1012）。

公开(公告)号：US08565860B2

公开(公告)日：2013-10-22

申请号：US10616307

申请日：2003-07-10

Applicant: Yoav Kimchy ,  Roni Amrami ,  Yona Bouskila ,  Udi Antebi ,  Nick Sidorenko ,  Gal Ben-David ,  Yoel Zilberstein

Inventor： Yoav Kimchy ,  Roni Amrami ,  Yona Bouskila ,  Udi Antebi ,  Nick Sidorenko ,  Gal Ben-David ,  Yoel Zilberstein

IPC: A61B6/00

CPC classification number: A61B6/037 ,  A61B5/055 ,  A61B5/06 ,  A61B5/064 ,  A61B5/07 ,  A61B5/415 ,  A61B5/418 ,  A61B5/6835 ,  A61B6/12 ,  A61B6/4057 ,  A61B6/4258 ,  A61B6/4417 ,  A61B6/4423 ,  A61B6/482 ,  A61B6/583 ,  A61B8/0833 ,  A61B8/4245 ,  A61B8/4254 ,  A61B2090/392 ,  G01T1/161

Abstract: A radioactive emission probe in communication with a position tracking system and the use thereof in a variety of systems and methods of medical imaging and procedures, are provided. Specifically, wide aperture collimation—deconvolution algorithms are provided, for obtaining a high-efficiency, high resolution image of a radioactivity emitting source, by scanning the radioactivity emitting source with a probe of a wide-aperture collimator, and at the same time, monitoring the position of the radioactive emission probe, at very fine time intervals, to obtain the equivalence of fine-aperture collimation. The blurring effect of the wide aperture is then corrected mathematically. Furthermore, an imaging method by depth calculations is provided, based on the attenuation of photons of different energies, which are emitted from the same source, coupled with position monitoring.

Abstract translation: 提供了一种与位置跟踪系统通信的放射性发射探测器及其在医疗成像和程序的各种系统和方法中的应用。 具体地说，通过用宽孔径准直仪的探头扫描放射性发射源，提供宽孔径准直 - 去卷积算法，用于获得放射性发射源的高效率高分辨率图像，并且同时监视 以非常精细的时间间隔放射性发射探针的位置，以获得细孔准直的等效性。 然后在数学上校正宽光圈的模糊效果。 此外，基于从相同源发射的不同能量的光子的衰减与位置监测相结合，提供了通过深度计算的成像方法。

公开(公告)号：US20130197360A1

公开(公告)日：2013-08-01

申请号：US13825018

申请日：2011-09-22

Applicant: Gideon Baum ,  Yoav Kimchy

Inventor： Gideon Baum ,  Yoav Kimchy

IPC: A61B5/107 ,  A61B1/04 ,  A61B1/00 ,  A61B1/31 ,  A61B5/00 ,  A61B6/00 ,  A61M31/00

CPC classification number: A61B5/1076 ,  A61B1/00016 ,  A61B1/041 ,  A61B1/043 ,  A61B1/31 ,  A61B5/073 ,  A61B5/4255 ,  A61B5/7278 ,  A61B6/4057 ,  A61B6/425 ,  A61B6/481 ,  A61B6/483 ,  A61B6/485 ,  A61B6/547 ,  A61M31/005

Abstract: A method of estimating distances in a colon of a subject, including: orally administering to a subject a contrast agent, orally administering an imaging capsule to the subject, emitting radiation from the imaging capsule at a location in the colon, detecting photons that are returned from an interaction of the radiation with an inner wall of the colon and contents of the colon, summating the detected photons with energies corresponding to X-ray florescence interactions to form a first count, summating the detected photons with energies corresponding to Compton back-scattering interactions to form a second count, determining the distance from the imaging capsule to the inner wall of the colon and a concentration of the contrast agent at the location of the imaging capsule in the colon using the values of the first count and the second count.

Abstract translation: 一种估计受试者的结肠中的距离的方法，包括：向受试者口服施用造影剂，向所述受试者口服施用成像胶囊，在所述结肠的位置处发射来自所述成像胶囊的辐射，检测返回的光子 从辐射与结肠的内壁和结肠内容物的相互作用中，用对应于X射线荧光相互作用的能量对检测到的光子求和以形成第一计数，将检测到的光子与对应于康普顿背散射的能量相加 相互作用以形成第二计数，使用第一计数和第二计数的值确定从成像胶囊到结肠的内壁的距离以及在冒号中的成像胶囊的位置处的造影剂的浓度。

公开(公告)号：US20120070371A1

公开(公告)日：2012-03-22

申请号：US12883813

申请日：2010-09-16

Applicant: Delbert E. Day ,  Yiyong He

Inventor： Delbert E. Day ,  Yiyong He

IPC: A61K51/02 ,  A61P35/00

CPC classification number: A61K51/1255 ,  A61B6/037 ,  A61B6/4057 ,  A61K9/0019 ,  A61K51/025 ,  A61K51/1244 ,  A61N5/1001 ,  A61N2005/1021

Abstract: This invention relates to low density radioactive magnesium-aluminum-silicate (MAS) microparticles that contain either samarium-yttrium, samarium, or lutetium as medical isotopes for radiotherapy and/or radioimaging.

Abstract translation: 本发明涉及含有钐 - 钇，钐或镥作为放射治疗和/或放射成像的医学同位素的低密度放射性镁 - 硅酸铝（MAS）微粒。

公开(公告)号：US20110251484A1

公开(公告)日：2011-10-13

申请号：US13066190

申请日：2011-04-08

Applicant: Colin M. Carpenter ,  Lei Xing ,  Guillem Pratx ,  Conroy Ghin Chee Sun

Inventor： Colin M. Carpenter ,  Lei Xing ,  Guillem Pratx ,  Conroy Ghin Chee Sun

IPC: A61B6/00

CPC classification number: A61B6/4057 ,  A61B6/032 ,  A61B6/425 ,  A61B6/508

Abstract: Molecular imaging of radioluminescent nanoparticle probes injected into biological tissue is performed by irradiated the tissue with ionizing radiation to induce radioluminescence at optical wavelengths, preferably at predetermined near infrared wavelengths. The optical light is detected and processed to determine a spatial distribution of the probes. The radioluminescent nanoparticles may be inorganic or organic phosphors, scintillators, or quantum dots. Imaging systems realizing this technique include tomographic systems using an x-ray beam to sequentially irradiate selected regions, systems with a radioactive source producing the ionizing radiation from outside the tissue, such as with a beam, or inside the tissue, such as with an endoscope or injected radiopharmaceutical. The optical signals may be detected by a photodetector array external to the tissue, a photodetector integrated with an endoscope or mammographic paddle, integrated into a capsule endoscope, or an array positioned near the biological tissue.

Abstract translation: 注射到生物组织中的放射性发光纳米颗粒探针的分子成像通过用电离辐射照射组织来进行，以在光波长下诱导放射性发光，优选在预定的近红外波长处。 检测和处理光学光以确定探针的空间分布。 放射性发光纳米颗粒可以是无机或有机磷光体，闪烁体或量子点。 实现该技术的成像系统包括使用X射线束依次照射所选择的区域的断层摄影系统，具有从组织外部产生电离辐射的放射源的系统，例如用光束或在组织内部，例如用内窥镜 或注射放射性药物。 光信号可以通过组织外部的光电检测器阵列检测，与内窥镜或乳房X射线检查器集成的光电检测器集成到胶囊型内窥镜中，或者位于靠近生物组织的阵列中。

公开(公告)号：US20100312072A1

公开(公告)日：2010-12-09

申请号：US12811381

申请日：2009-01-01

Applicant: Amos Breskin ,  Rachel Chechik ,  Sana Shilstein ,  Marco Cortesi

Inventor： Amos Breskin ,  Rachel Chechik ,  Sana Shilstein ,  Marco Cortesi

IPC: A61B5/00 ,  C40B30/02 ,  C40B60/12

CPC classification number: A61B6/50 ,  A61B6/4057 ,  A61B6/4092 ,  A61B6/425 ,  A61B6/4488 ,  A61B6/485 ,  G06T7/0012 ,  G06T2207/10121 ,  G06T2207/30081

Abstract: A method of estimating a grade of a prostate cancer from zinc data associated with the prostate, the zinc data being arranged gridwise in a plurality of picture-elements representing a zinc map of the prostate. The method comprises, clustering the zinc map according to zinc levels associated with the picture-elements, and estimating a cancer grade of at least one tissue region, based, at least in part, on zinc levels associated with a cluster of picture-elements representing the tissue region.

Abstract translation: 从与前列腺相关的锌数据估计前列腺癌的分级的方法，锌数据以表示前列腺锌图的多个图像元素格格排列。 该方法包括：至少部分地基于与图像元素簇相关联的锌水平，根据与图像元素相关联的锌水平对锌图进行聚类，以及估计至少一个组织区域的癌症等级 组织区域。

公开(公告)号：US20100303200A1

公开(公告)日：2010-12-02

申请号：US12825797

申请日：2010-06-29

Applicant: Yoav Kimchy ,  Yitzak Klein ,  Gideon Baum ,  Rafi Sommer

Inventor： Yoav Kimchy ,  Yitzak Klein ,  Gideon Baum ,  Rafi Sommer

IPC: G01N23/223

CPC classification number: A61B5/073 ,  A61B5/036 ,  A61B5/42 ,  A61B6/4057 ,  A61B6/4241 ,  A61B6/425 ,  A61B6/4258 ,  A61B6/482

Abstract: An apparatus and a method for detecting clinically-relevant features of the gastrointestinal (GI) tract of a subject are disclosed. The apparatus includes a capsule to be swallowed by a subject and passing through the GI tract of the subject, a capsule housing, a radiation source emitting radiation, a rotatable collimator configured to rotate with respect to the housing and to collimate the radiation emitted by the radiation source, and a radiation detector configured to detect particles, such as photons, gamma radiation, beta radiation and electrons photons generated responsive to the emitted radiation. The apparatus also includes a control unit configured to analyze data regarding the photons. Movement of the capsule in the GI tract can be detected. The radiation source, radiation detector and control unit may advantageously be integrated inside a single housing.

Abstract translation: 公开了一种用于检测受试者的胃肠（GI）道的临床相关特征的装置和方法。 该装置包括被被检体吞咽并穿过被检体的胃肠道的胶囊，胶囊壳体，发射辐射的辐射源，被配置为相对于壳体旋转的可旋转准直器，并准直由第 辐射源和被配置为检测诸如光子，γ辐射，β辐射和响应于所发射的辐射产生的电子光子的颗粒的辐射检测器。 该装置还包括被配置为分析关于光子的数据的控制单元。 可以检测胶囊在GI道中的移动。 辐射源，辐射检测器和控制单元可以有利地集成在单个壳体内。

公开(公告)号：US07813786B2

公开(公告)日：2010-10-12

申请号：US11400146

申请日：2006-04-07

Applicant: Jan S. Iwanczyk ,  Bradley E. Patt ,  Edward J. Hoffman

Inventor： Jan S. Iwanczyk ,  Bradley E. Patt ,  Edward J. Hoffman

IPC: A61B5/05 ,  A61B6/00

CPC classification number: A61B6/4057 ,  A61B6/425 ,  A61B6/4258 ,  G01T1/161

Abstract: An apparatus for intravascular imaging to detect and characterize early stage, unstable coronary arty plaques. The detector works by identifying and localizing plaque-binding beta-emitting radiopharmaceuticals.