公开(公告)号：US20110251484A1

公开(公告)日：2011-10-13

申请号：US13066190

申请日：2011-04-08

Applicant: Colin M. Carpenter ,  Lei Xing ,  Guillem Pratx ,  Conroy Ghin Chee Sun

Inventor： Colin M. Carpenter ,  Lei Xing ,  Guillem Pratx ,  Conroy Ghin Chee Sun

IPC: A61B6/00

CPC classification number: A61B6/4057 ,  A61B6/032 ,  A61B6/425 ,  A61B6/508

Abstract: Molecular imaging of radioluminescent nanoparticle probes injected into biological tissue is performed by irradiated the tissue with ionizing radiation to induce radioluminescence at optical wavelengths, preferably at predetermined near infrared wavelengths. The optical light is detected and processed to determine a spatial distribution of the probes. The radioluminescent nanoparticles may be inorganic or organic phosphors, scintillators, or quantum dots. Imaging systems realizing this technique include tomographic systems using an x-ray beam to sequentially irradiate selected regions, systems with a radioactive source producing the ionizing radiation from outside the tissue, such as with a beam, or inside the tissue, such as with an endoscope or injected radiopharmaceutical. The optical signals may be detected by a photodetector array external to the tissue, a photodetector integrated with an endoscope or mammographic paddle, integrated into a capsule endoscope, or an array positioned near the biological tissue.

Abstract translation: 注射到生物组织中的放射性发光纳米颗粒探针的分子成像通过用电离辐射照射组织来进行，以在光波长下诱导放射性发光，优选在预定的近红外波长处。 检测和处理光学光以确定探针的空间分布。 放射性发光纳米颗粒可以是无机或有机磷光体，闪烁体或量子点。 实现该技术的成像系统包括使用X射线束依次照射所选择的区域的断层摄影系统，具有从组织外部产生电离辐射的放射源的系统，例如用光束或在组织内部，例如用内窥镜 或注射放射性药物。 光信号可以通过组织外部的光电检测器阵列检测，与内窥镜或乳房X射线检查器集成的光电检测器集成到胶囊型内窥镜中，或者位于靠近生物组织的阵列中。

公开(公告)号：US09456794B2

公开(公告)日：2016-10-04

申请号：US13066190

申请日：2011-04-08

Applicant: Colin M Carpenter ,  Lei Xing ,  Guillem Pratx ,  Conroy Ghin Chee Sun

Inventor： Colin M Carpenter ,  Lei Xing ,  Guillem Pratx ,  Conroy Ghin Chee Sun

IPC: A61B6/00 ,  A61B6/03

CPC classification number: A61B6/4057 ,  A61B6/032 ,  A61B6/425 ,  A61B6/508

Abstract: Molecular imaging of radioluminescent nanoparticle probes injected into biological tissue is performed by irradiated the tissue with ionizing radiation to induce radioluminescence at optical wavelengths, preferably at predetermined near infrared wavelengths. The optical light is detected and processed to determine a spatial distribution of the probes. The radioluminescent nanoparticles may be inorganic or organic phosphors, scintillators, or quantum dots. Imaging systems realizing this technique include tomographic systems using an x-ray beam to sequentially irradiate selected regions, systems with a radioactive source producing the ionizing radiation from outside the tissue, such as with a beam, or inside the tissue, such as with an endoscope or injected radiopharmaceutical. The optical signals may be detected by a photodetector array external to the tissue, a photodetector integrated with an endoscope or mammographic paddle, integrated into a capsule endoscope, or an array positioned near the biological tissue.

Abstract translation: 注射到生物组织中的放射性发光纳米颗粒探针的分子成像通过用电离辐射照射组织来进行，以在光波长下诱导放射性发光，优选在预定的近红外波长处。 检测和处理光学光以确定探针的空间分布。 放射性发光纳米颗粒可以是无机或有机磷光体，闪烁体或量子点。 实现该技术的成像系统包括使用X射线束依次照射所选择的区域的断层摄影系统，具有从组织外部产生电离辐射的放射源的系统，例如用光束或在组织内部，例如用内窥镜 或注射放射性药物。 光信号可以通过组织外部的光电检测器阵列检测，与内窥镜或乳房X射线检查器集成的光电检测器集成到胶囊型内窥镜中，或者位于靠近生物组织的阵列中。

公开(公告)号：US20110250128A1

公开(公告)日：2011-10-13

申请号：US13066351

申请日：2011-04-12

Applicant: Colin M Carpenter ,  Lei Xing ,  Conroy Ghin Chee Sun ,  Guillem Pratx

Inventor： Colin M Carpenter ,  Lei Xing ,  Conroy Ghin Chee Sun ,  Guillem Pratx

IPC: A61K51/00 ,  C12Q1/02

CPC classification number: A61K51/04

Abstract: A method of characterizing a tissue sample is provided that includes injecting a tissue sample with radiotracers, where the radiotracers include beta-emitter radio tracers, the beta-emitter radio tracers emit beta particles according to a decay of the beta-emitter radio tracers, and measuring the beta particles or Cherenkov radiation from the beta particles in the tissue sample, and determining a condition of the radio tracers in the tissue sample according to the measured beta particles or the measured Cherenkov radiation, where the determined condition includes a depth and/or a concentration of the radiotracers in the tissue sample.

Abstract translation: 提供了表征组织样本的方法，其包括用放射性示踪剂注射组织样本，其中放射性示踪剂包括β-发射体无线电示踪剂，β-发射体无线电示踪剂根据β-发射体无线电示踪剂的衰变发射β粒子，以及 测量来自组织样本中的β粒子的β粒子或切伦科夫辐射，以及根据测量的β粒子或所测量的切伦科夫辐射来确定组织样本中的无线电示踪剂的状态，其中所确定的条件包括深度和/或 组织样品中放射性示踪剂的浓度。