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Patent Agency Ranking
51.发明授权Method for modifying the wettability and/or other biocompatibility characteristics of a surface of a biological material by the application of gas cluster ion beam technology and biological materials made thereby 有权通过应用气体簇离子束技术和由此制备的生物材料来改变生物材料表面的润湿性和/或其它生物相容性特征的方法公开(公告)号：US08377460B2
公开(公告)日：2013-02-19
申请号：US12722114
申请日：2010-03-11
Applicant: Joseph Khoury , Laurence B. Tarrant , Sean R. Kirkpatrick , Richard C. Svrluga
Inventor： Joseph Khoury , Laurence B. Tarrant , Sean R. Kirkpatrick , Richard C. Svrluga
CPC classification number: A61L27/3604 , A61B2017/00969 , A61L27/3691 , A61L27/38 , A61L2430/10 , A61L2430/40 , H01J2237/0812 , H01J2237/0827 , H01J2237/20207 , H01J2237/20214
Abstract: The invention provides a method for preparing a biological material for implanting. The invention also provides a biological material for surgical implantation. The invention further provides a biological composition for surgical implantation.
Abstract translation: 本发明提供了一种用于制备用于植入的生物材料的方法。 本发明还提供了用于手术植入的生物材料。 本发明还提供了用于外科植入的生物组合物。
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52.发明授权Method and system for coating a surface of a medical device with a therapeutic agent and drug eluting medical devices made thereby 有权用于用治疗剂涂覆医疗器械表面的方法和系统以及由此制成的药物洗脱医疗器械公开(公告)号：US08282982B2
公开(公告)日：2012-10-09
申请号：US12243285
申请日：2008-10-01
Applicant: Sean R. Kirkpatrick , Richard C. Svrluga
Inventor： Sean R. Kirkpatrick , Richard C. Svrluga
IPC: A61L33/00
CPC classification number: B05D1/02 , A61F2/82 , A61F2240/001 , B05B5/08 , B05D3/0493 , B05D3/06 , B05D3/107 , B05D3/145 , H01J37/3053 , H01J2237/0812 , H01J2237/3151
Abstract: A multi-layer drug coated medical device such as for example an expandable vascular drug eluting stent is formed by vacuum pulse spray techniques wherein each layer is irradiated to improve adhesion and/or drug elution properties prior to formation of subsequent layers. Layers may be homogeneous or of diverse drugs. Layers may incorporate a non-polymer elution-retarding material. Layers may alternate with one or more layers of non-polymer elution-retarding materials. Polymer binders and/or matrices are not used in the formation of the coatings, yet the pure drug coatings have good mechanical and elution rate properties. Systems, methods and medical device articles are disclosed.
Abstract translation: 通过真空脉冲喷雾技术形成多层药物涂覆的医疗装置，例如可扩张血管药物洗脱支架，其中每层照射以在形成后续层之前提高粘附性和/或药物洗脱性质。 层可能是同质的或不同的药物。 层可以掺入非聚合物洗脱阻滞材料。 层可以与一层或多层非聚合物洗脱阻滞材料交替。 聚合物粘合剂和/或基质不用于形成涂层，而纯药物涂层具有良好的机械和洗脱速率性能。 公开了系统，方法和医疗装置的物品。
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53.发明申请METHODS FOR IMPROVING THE BIOACTIVITY CHARACTERISTICS OF A SURFACE AND OBJECTS WITH SURFACES IMPROVED THEREBY 审中-公开改善表面表面和物体的生物活性特征的方法改进的表面公开(公告)号：US20100234948A1
公开(公告)日：2010-09-16
申请号：US12722473
申请日：2010-03-11
Applicant: Joseph Khoury , Laurence B. Tarrant , Sean R. Kirkpatrick , Richard C. Svrluga
Inventor： Joseph Khoury , Laurence B. Tarrant , Sean R. Kirkpatrick , Richard C. Svrluga
IPC: A61F2/02 , C12N11/00 , C12N11/14 , C12N11/08 , H01J37/317
CPC classification number: A61F2/30771 , A61F2/0077 , A61F2/07 , A61F2/30767 , A61F2002/0086 , A61F2002/30031 , A61F2002/3084 , A61F2002/3093 , A61F2250/0056 , A61F2310/00976 , A61L31/14 , A61L2400/18 , B29C59/16 , B29C2035/0872 , C03C23/006 , D06M10/00 , D06M10/008 , D06M10/04 , D06M16/00
Abstract: The invention provides for a method of improving bioactivity of a surface of an implantable object. The invention also provides for a method of improving bioactivity of a surface of biological laboratory ware. The invention further provide a method of attaching cells to an object. The invention even further provides for a method of preparing an object for medical implantation. The invention also provides for an article with attached cells, and for an article for medical implantation.
Abstract translation: 本发明提供了一种提高可植入物体表面的生物活性的方法。 本发明还提供了一种提高生物实验室器皿表面生物活性的方法。 本发明还提供了将细胞附着到对象的方法。 本发明甚至进一步提供了一种制备用于医学植入的物体的方法。 本发明还提供具有附着细胞的物品和用于医疗植入物品。
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54.发明申请公开(公告)号：US20100226958A1
公开(公告)日：2010-09-09
申请号：US12722114
申请日：2010-03-11
Applicant: Joseph Khoury , Laurence B. Tarrant , Sean R. Kirkpatrick , Richard C. Svrluga
Inventor： Joseph Khoury , Laurence B. Tarrant , Sean R. Kirkpatrick , Richard C. Svrluga
CPC classification number: A61L27/3604 , A61B2017/00969 , A61L27/3691 , A61L27/38 , A61L2430/10 , A61L2430/40 , H01J2237/0812 , H01J2237/0827 , H01J2237/20207 , H01J2237/20214
Abstract: The invention provides a method for preparing a biological material for implanting. The invention also provides a biological material for surgical implantation. The invention further provides a biological composition for surgical implantation.
Abstract translation: 本发明提供了一种用于制备用于植入的生物材料的方法。 本发明还提供了用于手术植入的生物材料。 本发明还提供了用于外科植入的生物组合物。
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公开(公告)号：US20100036482A1
公开(公告)日：2010-02-11
申请号：US12537388
申请日：2009-08-07
Applicant: Richard C. Svrluga , Sean R. Kirkpatrick
Inventor： Richard C. Svrluga , Sean R. Kirkpatrick
CPC classification number: A61F2/91 , A61F2002/30064 , A61F2210/0076 , A61F2250/0068 , B23K26/382 , B23K26/389 , B23K26/40 , B23K2103/05 , B23K2103/08 , B23K2103/14 , B23K2103/15 , B23K2103/26 , B23K2103/42 , B23K2103/50 , B23K2103/52
Abstract: A medical device for surgical implantation adapted to serve as a drug delivery system has one or more drug loaded holes with barrier layers to control release or elution of the drug from the holes or to control inward diffusion of fluids into the holes. The barrier layers are non-polymers and are formed from the drug material itself by ion beam processing. The holes may be in patterns to spatially control drug delivery. Flexible options permit combinations of drugs, variable drug dose per hole, multiple drugs per hole, temporal control of drug release sequence and profile. Methods for forming such a drug delivery system are also disclosed.
Abstract translation: 适于用作药物递送系统的用于手术植入物的医疗装置具有一个或多个具有阻挡层的药物负载孔，以控制药物从孔中的释放或洗脱，或者控制流体向孔中的向内扩散。 阻挡层是非聚合物，并且由药物本身通过离子束加工形成。 孔可以是空间控制药物递送的图案。 灵活的选择允许药物组合，每孔可变药物剂量，每孔多种药物，药物释放顺序和形态的时间控制。 还公开了形成这种药物递送系统的方法。
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