-
公开(公告)号:US20120282673A1
公开(公告)日:2012-11-08
申请号:US13474409
申请日:2012-05-17
Applicant: Hong JIN , Robert Brazas , Bin Lu
Inventor: Hong JIN , Robert Brazas , Bin Lu
IPC: C12N7/01
CPC classification number: C12N7/045 , A61K39/12 , A61K39/155 , A61K2039/5254 , A61K2039/543 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2760/18522 , C12N2760/18534 , C12N2760/18543 , C12N2760/18561 , C12N2800/40 , G01N33/56983 , G01N2469/20 , G01N2500/00
Abstract: The present invention provides recombinant respiratory syncytial viruses that have an attenuated phenotype and that comprise one or more mutations in the viral P, M2-1 and/or M2-2 proteins, as well as live attenuated vaccines comprising such viruses and nucleic acids encoding such viruses. Recombinant RSV P, M2-1 and M2-2 proteins are described. Methods of producing attenuated recombinant RSV, and methods of quantitating neutralizing antibodies that utilize recombinant viruses of family Paramyxoviridae, are also provided.
Abstract translation: 本发明提供具有减毒表型并且包含病毒P,M2-1和/或M2-2蛋白中的一个或多个突变的重组呼吸道合胞病毒,以及包含这样的病毒的活减毒疫苗和编码这种病毒的核酸 病毒 描述了重组RSV P,M2-1和M2-2蛋白。 还提供了产生减毒重组RSV的方法,以及定量利用副粘病毒科重组病毒的中和抗体的方法。
-
52.
公开(公告)号:US20120280645A1
公开(公告)日:2012-11-08
申请号:US13551973
申请日:2012-07-18
Applicant: Eric Jon Olsson , Bin Lu , Ting Yan , Steven John Fredette , Charles John Luebke
Inventor: Eric Jon Olsson , Bin Lu , Ting Yan , Steven John Fredette , Charles John Luebke
IPC: H02P27/04
CPC classification number: H02P23/02 , H02P23/0077 , H02P23/14 , H02P27/047
Abstract: A system and method for controlling an AC motor drive includes a control system programmed with an algorithm configured to optimize operation of the motor drive. Specifically, the control system is programmed to input an initial voltage-frequency command to the drive. The initial voltage-frequency command includes a voltage reference and a frequency reference corresponding to an operating point of an initial voltage/frequency (V/Hz) curve. The control system monitors a real-time output of the drive, modifies the voltage reference based on the real-time output of the drive, and transmits a modified voltage-frequency command to the drive. The modified voltage-frequency command corresponds to an operating point of a modified V/Hz curve defined by the modified voltage reference and the initial V/Hz curve.
Abstract translation: 用于控制AC电动机驱动器的系统和方法包括用配置成优化电动机驱动器的操作的算法来编程的控制系统。 具体地,控制系统被编程为向驱动器输入初始电压 - 频率命令。 初始电压 - 频率指令包括对应于初始电压/频率(V / Hz)曲线的工作点的电压基准和频率基准。 控制系统监控驱动器的实时输出,根据驱动器的实时输出修改参考电压,并向驱动器发送修改的电压 - 频率指令。 修改的电压 - 频率指令对应于由修改的电压基准和初始V / Hz曲线定义的修改的V / Hz曲线的工作点。
-
公开(公告)号:US20120063032A1
公开(公告)日:2012-03-15
申请号:US12879791
申请日:2010-09-10
Applicant: Eric Meloche , Bin Lu , Lixin Jia , Jianhua Xue , John David Westwood , Mark Anthony Gubbins , Alexandru Cazacu
Inventor: Eric Meloche , Bin Lu , Lixin Jia , Jianhua Xue , John David Westwood , Mark Anthony Gubbins , Alexandru Cazacu
IPC: G11B5/127
CPC classification number: G11B5/11 , G11B5/1278 , G11B5/3116 , G11B5/315
Abstract: Data storage systems having barriers that may reduce erasure flux and increase write-ability are provided. Data storage systems include a writing element. The writing element has a write pole with a flare region. A magnetic flux barrier is located along the write pole flare region. The magnetic flux barrier is illustratively made from an in-plane magnetically anisotropic material that has an easy plane of magnetization. In another embodiment, a data storage system includes a writing element having an air bearing surface and a shield at the air bearing surface. The shield has a magnetic permeability of approximately zero. The shield illustratively includes alternating layers of positive and negative permeabilities. The shield optionally includes a plurality of shields that may include top, bottom, and side shields.
Abstract translation: 提供了具有可能减少擦除通量并增加写入能力的障碍的数据存储系统。 数据存储系统包括写入元件。 写入元件具有带闪光区域的写入极。 磁通势垒位于写磁极耀斑区域。 磁通势垒示意性地由具有易磁化平面的面内磁各向异性材料制成。 在另一个实施例中,数据存储系统包括具有空气轴承表面和在空气支承表面处的屏蔽的书写元件。 屏蔽具有大约零的磁导率。 屏蔽件示例性地包括正和负磁导率的交替层。 屏蔽件可选地包括可以包括顶部,底部和侧部屏蔽件的多个屏蔽件。
-
54.
公开(公告)号:US08114415B2
公开(公告)日:2012-02-14
申请号:US12254131
申请日:2008-10-20
Applicant: Erich Hoffmann , Hong Jin , Bin Lu , Gregory Duke , George Kemble , Zhongying Chen
Inventor: Erich Hoffmann , Hong Jin , Bin Lu , Gregory Duke , George Kemble , Zhongying Chen
IPC: A61K39/145 , A61K39/00 , A61K39/12 , C12P21/04
CPC classification number: C12N15/86 , A61K2039/5254 , C07K14/005 , C12N7/00 , C12N15/85 , C12N2760/16122 , C12N2760/16134 , C12N2760/16143 , C12N2760/16162 , C12N2760/16222 , C12N2760/16234 , C12N2760/16243 , C12N2760/16262 , C12N2840/20
Abstract: Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing influenza viruses with enhanced ability to replicate in embryonated chicken eggs and/or cells (e.g., Vero and/or MDCK) and further provides influenza viruses with enhanced replication characteristics. A method of producing a cold adapted (ca) influenza virus that replicates efficiently at, e.g., 25° C. (and immunogenic compositions comprising the same) is also provided.
Abstract translation: 提供了用于在细胞培养中生产适合作为重组流感疫苗的流感病毒的载体和方法。 提供了用于多质粒流感病毒表达系统的双向表达载体。 另外,本发明提供了生产能够在含胚鸡蛋和/或细胞(例如Vero和/或MDCK)中复制的流感病毒的方法,并进一步提供具有增强的复制特征的流感病毒。 还提供了生产在例如25℃下有效复制的冷适应(ca)流感病毒的方法(和包含其的免疫原性组合物)。
-
公开(公告)号:US08063306B2
公开(公告)日:2011-11-22
申请号:US12444071
申请日:2007-09-21
Applicant: Jingwen Zhong , Pierre Bonvallat , Zhiyong Xu , Bin Lu
Inventor: Jingwen Zhong , Pierre Bonvallat , Zhiyong Xu , Bin Lu
IPC: H02G15/113
CPC classification number: H02G15/046 , H02G15/113
Abstract: A re-enterable enclosure for a cable splice includes a first cover member and a second cover member configured for engagement with each other, and movable between an open position and a closed position. The first and second cover members form a cavity for enclosing the cable splice when the cover members are in the closed position. Internal walls in at least one of the first and second cover members are configured to define a sealant containment space that at least partially surrounds the cavity. At least one latch is configured to maintain the first and second cover members in the closed position, the at least one latch configured to exert a compression force along a line extending through the sealant containment space.
Abstract translation: 用于电缆接头的可重新进入的外壳包括第一盖构件和第二盖构件,第二盖构件和第二盖构件被构造成彼此接合并可在打开位置和关闭位置之间移动。 当盖构件处于关闭位置时,第一和第二盖构件形成用于封闭电缆接头的空腔。 第一和第二盖构件中的至少一个中的内壁构造成限定至少部分地围绕空腔的密封剂容纳空间。 至少一个闩锁构造成将第一和第二盖构件保持在关闭位置,所述至少一个闩锁构造成沿着延伸穿过密封剂容纳空间的线施加压缩力。
-
56.
公开(公告)号:US08012736B2
公开(公告)日:2011-09-06
申请号:US10423828
申请日:2003-04-25
Applicant: Erich Hoffman , Hong Jin , Bin Lu , Greg Duke , George Kemble
Inventor: Erich Hoffman , Hong Jin , Bin Lu , Greg Duke , George Kemble
IPC: C12N7/02
CPC classification number: A61K39/145 , A61K2039/5254 , C07K14/005 , C12N7/00 , C12N15/85 , C12N15/86 , C12N15/87 , C12N2760/16122 , C12N2760/16143 , C12N2760/16162 , C12N2760/16222 , C12N2760/16243 , C12N2760/16262
Abstract: Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided.
Abstract translation: 提供了用于在细胞培养中生产适合作为重组流感疫苗的流感病毒的载体和方法。 提供了用于多质粒流感病毒表达系统的双向表达载体。
-
公开(公告)号:US07829208B2
公开(公告)日:2010-11-09
申请号:US11947288
申请日:2007-11-29
Applicant: Yingguo Peng , Bin Lu
Inventor: Yingguo Peng , Bin Lu
IPC: G11B5/66
CPC classification number: G11B5/732 , C23C14/0036 , C23C14/0641 , G11B5/7325 , G11B5/82 , G11B5/8404
Abstract: A magnetic recording media with a multilayer structure and methods for forming the media are described. The magnetic recording media includes a substrate, an underlayer on top of the substrate and a magnetic layer over the underlayer. The underlayer includes a CrN film formed by sputter depositing chromium in the presence of nitrogen or nitrogen containing compounds.
Abstract translation: 描述了具有多层结构的磁记录介质和用于形成介质的方法。 磁记录介质包括衬底,衬底顶部的底层和衬底上的磁性层。 底层包括在氮或含氮化合物存在下溅射沉积铬形成的CrN膜。
-
公开(公告)号:US20100274813A1
公开(公告)日:2010-10-28
申请号:US12428491
申请日:2009-04-23
Applicant: Bin Lu , Mehul Y. Shah
Inventor: Bin Lu , Mehul Y. Shah
IPC: G06F17/30
CPC classification number: G06F17/3056
Abstract: A modular framework for data import/export in an application that allows modules/components to be independently developed for importing and exporting data related to specific entities, including the handling of dependencies between entities. The framework is metadata driven which allows new entities to be introduced in the application with new modules for importing/exporting data related to those entities, without updating modules for exporting existing entities. Each type of entity is defined with a schema that represents the logical entity such that the entity is agnostic as to how the entity data is stored in database tables. A master configuration file is created for the application that lists each entity that can be imported or exported by the application, and defines how the framework imports or exports the business entity. Additionally, dynamic batching is provided to divide large datasets into multiple batches for suitable consumption by consumers of the exported data.
Abstract translation: 用于在应用程序中数据导入/导出的模块化框架,允许模块/组件独立开发,用于导入和导出与特定实体相关的数据,包括处理实体之间的依赖关系。 该框架是元数据驱动的,允许在应用程序中引入新实体,用于导入/导出与这些实体相关的数据的新模块,而不更新用于导出现有实体的模块。 每种类型的实体都使用代表逻辑实体的模式进行定义,使得实体对于数据库表中的实体数据的存储方式是不可知的。 为应用程序创建主配置文件,其中列出了可由应用程序导入或导出的每个实体,并定义框架如何导入或导出业务实体。 另外,提供了动态批处理,将大数据集分成多个批次,以便消费者适当地消耗导出的数据。
-
公开(公告)号:US20100190232A1
公开(公告)日:2010-07-29
申请号:US12537288
申请日:2009-08-07
Applicant: Hong Jin , Robert Brazas , Bin Lu
Inventor: Hong Jin , Robert Brazas , Bin Lu
IPC: C12N7/01
CPC classification number: C12N7/045 , A61K39/12 , A61K39/155 , A61K2039/5254 , A61K2039/543 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2760/18522 , C12N2760/18534 , C12N2760/18543 , C12N2760/18561 , C12N2800/40 , G01N33/56983 , G01N2469/20 , G01N2500/00
Abstract: The present invention provides recombinant respiratory syncytial viruses that have an attenuated phenotype and that comprise one or more mutations in the viral P, M2-1 and/or M2-2 proteins, as well as live attenuated vaccines comprising such viruses and nucleic acids encoding such viruses. Recombinant RSV P, M2-1 and M2-2 proteins are described. Methods of producing attenuated recombinant RSV, and methods of quantitating neutralizing antibodies that utilize recombinant viruses of family Paramyxoviridae, are also provided.
Abstract translation: 本发明提供具有减毒表型并且包含病毒P,M2-1和/或M2-2蛋白中的一个或多个突变的重组呼吸道合胞病毒,以及包含这样的病毒的活减毒疫苗和编码这种病毒的核酸 病毒 描述了重组RSV P,M2-1和M2-2蛋白。 还提供了产生减毒重组RSV的方法,以及定量利用副粘病毒科重组病毒的中和抗体的方法。
-
公开(公告)号:US20100179692A1
公开(公告)日:2010-07-15
申请号:US12351582
申请日:2009-01-09
CPC classification number: H02P23/0077
Abstract: A system and method for determining unknown values of certain motor parameters includes a motor input device connectable to an electric motor having associated therewith values for known motor parameters and an unknown value of at least one motor parameter. The motor input device includes a processing unit that receives a first input from the electric motor comprising values for the known motor parameters for the electric motor and receive a second input comprising motor data on a plurality of reference motors, including values for motor parameters corresponding to the known motor parameters of the electric motor and values for motor parameters corresponding to the at least one unknown motor parameter value of the electric motor. The processor determines the unknown value of the at least one motor parameter from the first input and the second input and determines a motor management strategy for the electric motor based thereon.
Abstract translation: 用于确定某些电动机参数的未知值的系统和方法包括可连接到具有与已知电动机参数的值相关联的电动机的电动机输入装置和至少一个电动机参数的未知值。 电动机输入装置包括处理单元,其接收来自电动机的第一输入,包括用于电动机的已知电动机参数的值,并且接收包括多个参考电动机上的电动机数据的第二输入,包括对应于 电动机的已知电动机参数和对应于电动机的至少一个未知电动机参数值的电动机参数值。 处理器从第一输入端和第二输入端确定至少一个电动机参数的未知值,并且基于此确定用于电动机的电动机管理策略。
-
-
-
-
-
-
-
-
-